LOCUS       NM_152291               2363 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens mucin 7, secreted (MUC7), transcript variant 3, mRNA.
ACCESSION   NM_152291
VERSION     NM_152291.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Zhang,J. and Li,Z.
  TITLE     Diagnostic accuracy of MUC7 expression for bladder cancer: A
            systematic review and meta-analysis
  JOURNAL   Medicine (Baltimore) 102 (35), e34828 (2023)
   PUBMED   37657056
  REMARK    GeneRIF: Diagnostic accuracy of MUC7 expression for bladder cancer:
            A systematic review and meta-analysis.
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Saad,E.A., Elsaid,A.M., Shoaib,R.M.S., Megahed,K.F. and
            Elsharawy,A.N.
  TITLE     MUC7 VNTR polymorphism and association with bronchial asthma in
            Egyptian children
  JOURNAL   Sci Rep 12 (1), 18910 (2022)
   PUBMED   36344553
  REMARK    GeneRIF: MUC7 VNTR polymorphism and association with bronchial
            asthma in Egyptian children.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Chahal,G., Quintana-Hayashi,M.P., Gaytan,M.O., Benktander,J.,
            Padra,M., King,S.J. and Linden,S.K.
  TITLE     Streptococcus oralis Employs Multiple Mechanisms of Salivary Mucin
            Binding That Differ Between Strains
  JOURNAL   Front Cell Infect Microbiol 12, 889711 (2022)
   PUBMED   35782137
  REMARK    GeneRIF: Streptococcus oralis Employs Multiple Mechanisms of
            Salivary Mucin Binding That Differ Between Strains.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Hertel,S., Hannig,M., Hannig,C. and Sterzenbach,T.
  TITLE     Mucins 5b and 7 and secretory IgA in the oral acquired pellicle of
            children with caries and caries-free children
  JOURNAL   Arch Oral Biol 134, 105314 (2022)
   PUBMED   34861462
  REMARK    GeneRIF: Mucins 5b and 7 and secretory IgA in the oral acquired
            pellicle of children with caries and caries-free children.
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   McQuaid,I.K., Dorfman,J.R. and Mall,A.S.
  TITLE     The comparative inhibitory potency of salivary mucins against human
            immunodeficiency virus type 1
  JOURNAL   Virology 553, 1-8 (2021)
   PUBMED   33190061
  REMARK    GeneRIF: The comparative inhibitory potency of salivary mucins
            against human immunodeficiency virus type 1.
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Bobek,L.A. and Situ,H.
  TITLE     MUC7 20-Mer: investigation of antimicrobial activity, secondary
            structure, and possible mechanism of antifungal action
  JOURNAL   Antimicrob Agents Chemother 47 (2), 643-652 (2003)
   PUBMED   12543672
  REMARK    GeneRIF: MUC7 is a salivary mucin with antimicrobial activity
            against bacteria and fungi.
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Prakobphol,A., Thomsson,K.A., Hansson,G.C., Rosen,S.D.,
            Singer,M.S., Phillips,N.J., Medzihradszky,K.F., Burlingame,A.L.,
            Leffler,H. and Fisher,S.J.
  TITLE     Human low-molecular-weight salivary mucin expresses the sialyl
            lewisx determinant and has L-selectin ligand activity
  JOURNAL   Biochemistry 37 (14), 4916-4927 (1998)
   PUBMED   9538010
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Troxler,R.F., Iontcheva,I., Oppenheim,F.G., Nunes,D.P. and
            Offner,G.D.
  TITLE     Molecular characterization of a major high molecular weight mucin
            from human sublingual gland
  JOURNAL   Glycobiology 7 (7), 965-973 (1997)
   PUBMED   9363439
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Bobek,L.A., Liu,J., Sait,S.N., Shows,T.B., Bobek,Y.A. and
            Levine,M.J.
  TITLE     Structure and chromosomal localization of the human salivary mucin
            gene, MUC7
  JOURNAL   Genomics 31 (3), 277-282 (1996)
   PUBMED   8838308
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Bobek,L.A., Tsai,H., Biesbrock,A.R. and Levine,M.J.
  TITLE     Molecular cloning, sequence, and specificity of expression of the
            gene encoding the low molecular weight human salivary mucin (MUC7)
  JOURNAL   J Biol Chem 268 (27), 20563-20569 (1993)
   PUBMED   7690757
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC108518.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_152291.2.
            
            Summary: This gene encodes a small salivary mucin, which is thought
            to play a role in facilitating the clearance of bacteria in the
            oral cavity and to aid in mastication, speech, and swallowing. The
            central domain of this glycoprotein contains tandem repeats, each
            composed of 23 amino acids. This antimicrobial protein has
            antibacterial and antifungal activity. The most common allele
            contains 6 repeats, and some alleles may be associated with
            susceptibility to asthma. Alternatively spliced transcript variants
            with different 5' UTR, but encoding the same protein, have been
            found for this gene. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (3) represents the shortest
            transcript and has a different 5' UTR compared to transcript
            variant 1. Transcript variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025688.1, AK312855.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000304887.6/
                                                  ENSP00000302021.5
            Protein has antimicrobial activity :: PMID: 12543672
            RefSeq Select criteria             :: based on expression, longest
                                                  protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC108518.3         11277-11371
            96-164              AC108518.3         13087-13155
            165-2363            AC108518.3         19879-22077
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..2363
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="mucin 7, secreted"
                     /db_xref="GeneID:4589"
                     /db_xref="HGNC:HGNC:7518"
                     /db_xref="MIM:158375"
     exon            1..95
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign:2.1.0"
     exon            96..164
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1244
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="mucin 7, salivary; mucin-7; MUC-7; apo-MG2;
                     salivary mucin-7; mucin MG2"
                     /codon_start=1
                     /product="mucin-7 precursor"
                     /protein_id="NP_689504.2"
                     /db_xref="CCDS:CCDS3541.1"
                     /db_xref="GeneID:4589"
                     /db_xref="HGNC:HGNC:7518"
                     /db_xref="MIM:158375"
                     /translation="MKTLPLFVCICALSACFSFSEGRERDHELRHRRHHHQSPKSHFE
                     LPHYPGLLAHQKPFIRKSYKCLHKRCRPKLPPSPNNPPKFPNPHQPPKHPDKNSSVVN
                     PTLVATTQIPSVTFPSASTKITTLPNVTFLPQNATTISSRENVNTSSSVATLAPVNSP
                     APQDTTAAPPTPSATTPAPPSSSAPPETTAAPPTPSATTQAPPSSSAPPETTAAPPTP
                     PATTPAPPSSSAPPETTAAPPTPSATTPAPLSSSAPPETTAVPPTPSATTLDPSSASA
                     PPETTAAPPTPSATTPAPPSSPAPQETTAAPITTPNSSPTTLAPDTSETSAAPTHQTT
                     TSVTTQTTTTKQPTSAPGQNKISRFLLYMKNLLNRIIDDMVEQ"
     exon            165..2363
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="hexamer: AATAAA"
     polyA_site      2363
                     /gene="MUC7"
                     /gene_synonym="MG2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttctttt gcttctagtt accatcctca aaggattggc taaaagcaag caactggatt
       61 gaacacccta agaagaaaga ttcacactgc accaggagac atcagaaaga atgaaaactc
      121 tgccgctgtt tgtgtgcatc tgtgcactga gtgcttgctt ctcgttcagt gaaggtcgag
      181 aaagggatca tgaactacgt cacagaaggc atcatcacca atcacccaaa tctcactttg
      241 aattaccaca ttatcctgga ctgctagctc accagaagcc gttcattaga aagtcctata
      301 aatgtctgca caaacgctgt aggcctaagc ttccaccttc acctaataac ccccccaaat
      361 tcccaaatcc tcaccagcca cctaaacatc cagataaaaa tagcagtgtg gtcaacccta
      421 ccttagtggc tacaacccaa attccatctg tgactttccc atcagcttcc accaaaatta
      481 ctacccttcc aaatgtgact tttcttcccc agaatgccac caccatatct tcaagagaaa
      541 atgttaacac aagctcttct gtagctacat tagcaccagt gaattcccca gctccacaag
      601 acaccacagc tgccccaccc acaccttctg caactacacc agctccacca tcttcctcag
      661 ctccaccaga gaccacagct gccccaccca caccttctgc aactacacaa gctccaccat
      721 cttcctcagc tccaccagag accacagctg ccccacccac acctcctgca actacaccag
      781 ctccaccatc ttcctcagct ccaccagaga ccacagctgc cccacccaca ccttctgcaa
      841 ctacaccagc tccactatct tcctcagctc caccagagac cacagctgtc ccacccacac
      901 cttctgcaac taccctagac ccatcatccg cctcagctcc accagagacc acagctgccc
      961 cacccacacc ttctgcaact acaccagctc caccgtcttc cccagctcca caagagacca
     1021 cagctgcccc aattaccaca cctaattctt ccccaactac tcttgcacct gacacttctg
     1081 aaacttcagc tgcacccaca caccagacta ctacttcggt cactactcaa actactacta
     1141 ctaaacaacc aacttcagct cctggccaaa ataaaatttc tcgatttctt ttatatatga
     1201 agaatctact aaacagaatt attgacgaca tggtggagca atagtatatt gtatgttgta
     1261 aagtgttctg tcatttacaa gatgtgattc atgagtgcag aactaccacc tttcttttag
     1321 caccaatccc aacatgaaat tatattactc agatttaaag cactatcatt aatctttcaa
     1381 tctaattatt caccaccaca agacctatta acaagacaaa atgcctctat cccacaagcc
     1441 agatgcaggt ctggggttca aaataactct ttggatccta cagagatagc ctactgaggg
     1501 caaagaaagt ccttagataa agagagaata ttgtatgggc catcaaccat ttacttttcc
     1561 ctgaatgtta gaaactacaa aaccactacc ttgtaccccc atcaaaatcc cacctgaacc
     1621 atctaatcct ataaacataa aggggtaaaa ttggaactct ccagatgaac aaagacatct
     1681 aaatatctgt agatagaaac atttatctat ctaaatatat tgatagacct gtcattgtat
     1741 tgattaatga caaaaccctt tagataatta tcttccattt taaataaaat tttatttcac
     1801 aaatatgagc caagaaagag gaaagttgat ttgaagtgag gattagaagt gaatgacaat
     1861 aaagtctgtc agccaagcac gaaccaagac tggcactatt tttcttagtg tatataattg
     1921 tttaaactgc aaggttgaca tttattgtgt tgtgtctaag ttaatttcga tctaatgtac
     1981 ctgattctag cctctgtgaa caacaagaat atgtttgtgt atgttcacat ggtgcttata
     2041 atatttcact atcaattcaa ttaattcaca taaattccat gtgaaatgta ttcaacaatg
     2101 gaatattttc taaaacattt agtatacatt tgaatgtatt ttaaaccatg ccaaactact
     2161 gctttaatgt caagtttgca gaattgtctc tgaaaataaa aaccctgact ttagttgtaa
     2221 aacaataaaa gttagctact tggtatacgg agatgttaat ttgggatatg gaggcatttt
     2281 tatcttctgt cactactact taaaactctg atgattatgt tagatttttt tgctaactaa
     2341 taaagatttc aaatggcaat tta
//
