LOCUS       NM_005961               8016 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens mucin 6, oligomeric mucus/gel-forming
            (gene/pseudogene) (MUC6), mRNA.
ACCESSION   NM_005961 XM_290540 XM_944088
VERSION     NM_005961.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8016)
  AUTHORS   Dwertmann Rico,S., Schliesser,S.J.A., Gorbokon,N., Dum,D., Menz,A.,
            Buscheck,F., Hinsch,A., Lennartz,M., von Bargen,C., Bawahab,A.A.,
            Luebke,A.M., Hube-Magg,C., Fraune,C., Lebok,P., Clauditz,T.S.,
            Jacobsen,F., Sauter,G., Uhlig,R., Steurer,S., Minner,S., Marx,A.H.,
            Simon,R., Burandt,E., Hoeflmayer,D., Krech,T. and Bernreuther,C.
  TITLE     Pattern of MUC6 expression across 119 different tumor types: A
            tissue microarray study on 15 412 tumors
  JOURNAL   Pathol Int 73 (7), 281-296 (2023)
   PUBMED   37057870
  REMARK    GeneRIF: Pattern of MUC6 expression across 119 different tumor
            types: A tissue microarray study on 15 412 tumors.
REFERENCE   2  (bases 1 to 8016)
  AUTHORS   Buyuk,M., Ozluk,Y., Bakkaloglu,D.V., Ozkan,B., Firat,P. and
            Yilmazbayhan,D.
  TITLE     Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression Differences
            in Lung Adenocarcinoma Subtypes by Using a Final Immunoreactivity
            Score (FIRS)
  JOURNAL   Turk Patoloji Derg 39 (1), 64-74 (2023)
   PUBMED   36367122
  REMARK    GeneRIF: Evaluation of MUC1, MUC2, MUC5AC, and MUC6 Expression
            Differences in Lung Adenocarcinoma Subtypes by Using a Final
            Immunoreactivity Score (FIRS).
REFERENCE   3  (bases 1 to 8016)
  AUTHORS   Yamanoi,K., Fujii,C., Yuzuriha,H., Kumazawa,M., Shimoda,M.,
            Emoto,K., Asamura,H. and Nakayama,J.
  TITLE     MUC6 expression is a preferable prognostic marker for invasive
            mucinous adenocarcinoma of the lung
  JOURNAL   Histochem Cell Biol 157 (6), 671-684 (2022)
   PUBMED   35353213
  REMARK    GeneRIF: MUC6 expression is a preferable prognostic marker for
            invasive mucinous adenocarcinoma of the lung.
REFERENCE   4  (bases 1 to 8016)
  AUTHORS   Yuki,A., Fujii,C., Yamanoi,K., Matoba,H., Harumiya,S., Kawakubo,M.
            and Nakayama,J.
  TITLE     Glycosylation of MUC6 by alpha1,4-linked N-acetylglucosamine
            enhances suppression of pancreatic cancer malignancy
  JOURNAL   Cancer Sci 113 (2), 576-586 (2022)
   PUBMED   34808019
  REMARK    GeneRIF: Glycosylation of MUC6 by alpha1,4-linked
            N-acetylglucosamine enhances suppression of pancreatic cancer
            malignancy.
REFERENCE   5  (bases 1 to 8016)
  AUTHORS   Shi,D. and Xi,X.X.
  TITLE     Regulation of MUC6 Methylation Correlates with Progression of
            Gastric Cancer
  JOURNAL   Yonsei Med J 62 (11), 1005-1015 (2021)
   PUBMED   34672134
  REMARK    GeneRIF: Regulation of MUC6 Methylation Correlates with Progression
            of Gastric Cancer.
REFERENCE   6  (bases 1 to 8016)
  AUTHORS   Rousseau,K., Byrne,C., Kim,Y.S., Gum,J.R., Swallow,D.M. and
            Toribara,N.W.
  TITLE     The complete genomic organization of the human MUC6 and MUC2 mucin
            genes
  JOURNAL   Genomics 83 (5), 936-939 (2004)
   PUBMED   15081123
  REMARK    GeneRIF: complete genomic (exon/intron) organization
REFERENCE   7  (bases 1 to 8016)
  AUTHORS   Bartman,A.E., Buisine,M.P., Aubert,J.P., Niehans,G.A.,
            Toribara,N.W., Kim,Y.S., Kelly,E.J., Crabtree,J.E. and Ho,S.B.
  TITLE     The MUC6 secretory mucin gene is expressed in a wide variety of
            epithelial tissues
  JOURNAL   J Pathol 186 (4), 398-405 (1998)
   PUBMED   10209489
REFERENCE   8  (bases 1 to 8016)
  AUTHORS   Debailleul,V., Laine,A., Huet,G., Mathon,P., d'Hooghe,M.C.,
            Aubert,J.P. and Porchet,N.
  TITLE     Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express
            stable and extremely large mRNAs and exhibit a variable length
            polymorphism. An improved method to analyze large mRNAs
  JOURNAL   J Biol Chem 273 (2), 881-890 (1998)
   PUBMED   9422745
REFERENCE   9  (bases 1 to 8016)
  AUTHORS   Toribara,N.W., Ho,S.B., Gum,E., Gum,J.R. Jr., Lau,P. and Kim,Y.S.
  TITLE     The carboxyl-terminal sequence of the human secretory mucin, MUC6.
            Analysis Of the primary amino acid sequence
  JOURNAL   J Biol Chem 272 (26), 16398-16403 (1997)
   PUBMED   9195947
REFERENCE   10 (bases 1 to 8016)
  AUTHORS   Toribara,N.W., Roberton,A.M., Ho,S.B., Kuo,W.L., Gum,E.,
            Hicks,J.W., Gum,J.R. Jr., Byrd,J.C., Siddiki,B. and Kim,Y.S.
  TITLE     Human gastric mucin. Identification of a unique species by
            expression cloning
  JOURNAL   J Biol Chem 268 (8), 5879-5885 (1993)
   PUBMED   7680650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139749.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 28, 2018 this sequence version replaced NM_005961.2.
            
            Summary: This gene encodes a member of the mucin protein family.
            Mucins are high molecular weight glycoproteins produced by many
            epithelial tissues. The protein encoded by this gene is secreted
            and forms an insoluble mucous barrier that protects the gut lumen.
            [provided by RefSeq, Dec 2016].
            
            Sequence Note: The RefSeq transcript was derived from genomic
            sequence based on transcript alignments and the published
            description of the gene structure (PubMed ID 15081123).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968189, SAMEA1968968
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000421673.7/
                                                ENSP00000406861.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC139749.4         107502-107513
            13-115              AC139749.4         107514-107616
            116-178             AC139749.4         111145-111207
            179-419             AC139749.4         112167-112407
            420-546             AC139749.4         112487-112613
            547-637             AC139749.4         112961-113051
            638-747             AC139749.4         113164-113273
            748-955             AC139749.4         113440-113647
            956-1078            AC139749.4         113885-114007
            1079-1199           AC139749.4         114605-114725
            1200-1338           AC139749.4         114854-114992
            1339-1443           AC139749.4         115070-115174
            1444-1516           AC139749.4         115259-115331
            1517-1654           AC139749.4         115437-115574
            1655-1816           AC139749.4         115833-115994
            1817-1911           AC139749.4         116161-116255
            1912-2044           AC139749.4         116403-116535
            2045-2294           AC139749.4         116703-116952
            2295-2347           AC139749.4         117027-117079
            2348-2457           AC139749.4         117170-117279
            2458-2609           AC139749.4         117742-117893
            2610-2751           AC139749.4         118079-118220
            2752-2862           AC139749.4         118305-118415
            2863-3048           AC139749.4         118853-119038
            3049-3288           AC139749.4         119137-119376
            3289-3445           AC139749.4         120117-120273
            3446-3589           AC139749.4         120568-120711
            3590-3652           AC139749.4         122943-123005
            3653-3703           AC139749.4         123486-123536
            3704-3871           AC139749.4         123963-124130
            3872-4093           AC139749.4         124724-124945
            4094-7102           AC139749.4         125450-128458
            7103-7205           AC139749.4         130219-130321
            7206-8015           AC139749.4         130587-131396
            8016-8016           AC139749.4         131397-131397
FEATURES             Location/Qualifiers
     source          1..8016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..8016
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /note="mucin 6, oligomeric mucus/gel-forming
                     (gene/pseudogene)"
                     /db_xref="GeneID:4588"
                     /db_xref="HGNC:HGNC:7517"
                     /db_xref="MIM:158374"
     exon            1..115
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..7383
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /note="mucin-6; gastric mucin-6"
                     /codon_start=1
                     /product="mucin-6 precursor"
                     /protein_id="NP_005952.2"
                     /db_xref="CCDS:CCDS44513.1"
                     /db_xref="GeneID:4588"
                     /db_xref="HGNC:HGNC:7517"
                     /db_xref="MIM:158374"
                     /translation="MVQRWLLLSCCGALLSAGLANTSYTSPGLQRLKDSPQTAPDKGQ
                     CSTWGAGHFSTFDHHVYDFSGTCNYIFAATCKDAFPTFSVQLRRGPDGSISRIIVELG
                     ASVVTVSEAIISVKDIGVISLPYTSNGLQITPFGQSVRLVAKQLELELEVVWGPDSHL
                     MVLVERKYMGQMCGLCGNFDGKVTNEFVSEEGKFLEPHKFAALQKLDDPGEICTFQDI
                     PSTHVRQAQHARICTQLLTLVAPECSVSKEPFVLSCQADVAAAPQPGPQNSSCATLSE
                     YSRQCSMVGQPVRRWRSPGLCSVGQCPANQVYQECGSACVKTCSNPQHSCSSSCTFGC
                     FCPEGTVLNDLSNNHTCVPVTQCPCVLHGAMYAPGEVTIAACQTCRCTLGRWVCTERP
                     CPGHCSLEGGSFVTTFDARPYRFHGTCTYILLQSPQLPEDGALMAVYDKSGVSHSETS
                     LVAVVYLSRQDKIVISQDEVVTNNGEAKWLPYKTRNITVFRQTSTHLQMATSFGLELV
                     VQLRPIFQAYVTVGPQFRGQTRGLCGNFNGDTTDDFTTSMGIAEGTASLFVDSWRAGN
                     CPAALERETDPCSMSQLNKVCAETHCSMLLRTGTVFERCHATVNPAPFYKRCVYQACN
                     YEETFPHICAALGDYVHACSLRGVLLWGWRSSVDNCTIPCTGNTTFSYNSQACERTCL
                     SLSDRATECHHSAVPVDGCNCPDGTYLNQKGECVRKAQCPCILEGYKFILAEQSTVIN
                     GITCHCINGRLSCPQRPQMFLASCQAPKTFKSCSQSSENKFGAACAPTCQMLATGVAC
                     VPTKCEPGCVCAEGLYENADGQCVPPEECPCEFSGVSYPGGAELHTDCRTCSCSRGRW
                     ACQQGTHCPSTCTLYGEGHVITFDGQRFVFDGNCEYILATDVCGVNDSQPTFKILTEN
                     VICGNSGVTCSRAIKIFLGGLSVVLADRNYTVTGEEPHVQLGVTPGALSLVVDISIPG
                     RYNLTLIWNRHMTILIRIARASQDPLCGLCGNFNGNMKDDFETRSRYVASSELELVNS
                     WKESPLCGDVSFVTDPCSLNAFRRSWAERKCSVINSQTFATCHSKVYHLPYYEACVRD
                     ACGCDSGGDCECLCDAVAAYAQACLDKGVCVDWRTPAFCPIYCGFYNTHTQDGHGEYQ
                     YTQEANCTWHYQPCLCPSQPQSVPGSNIEGCYNCSQDEYFDHEEGVCVPCMPPTTPQP
                     PTTPQLPTTGSRPTQVWPMTGTSTTIGLLSSTGPSPSSNHTPASPTQTPLLPATLTSS
                     KPTASSGEPPRPTTAVTPQATSGLPPTATLRSTATKPTVTQATTRATASTASPATTST
                     AQSTTRTTMTLPTPATSGTSPTLPKSTNQELPGTTATQTTGPRPTPASTTGPTTPQPG
                     QPTRPTATETTQTRTTTEYTTPQTPHTTHSPPTAGSPVPSTGPVTATSFHATTTYPTP
                     SHPETTLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASNHSAPTGTIPPPTTLKATG
                     STHTAPPITPTTSGTSQAHSSFSTNKTPTSLHSHTSSTHHPEVTPTSTTTITPNPTST
                     RTRTPVAHTNSATSSRPPPPFTTHSPPTGSSPFSSTGPMTATSFKTTTTYPTPSHPQT
                     TLPTHVPPFSTSLVTPSTHTVITPTHAQMATSASIHSMPTGTIPPPTTLKATGSTHTA
                     PTMTLTTSGTSQALSSLNTAKTSTSLHSHTSSTHHAEATSTSTTNITPNPTSTGTPPM
                     TVTTSGTSQSRSSFSTAKTSTSLHSHTSSTHHPEVTSTSTTSITPNHTSTGTRTPVAH
                     TTSATSSRLPTPFTTHSPPTGTTPISSTGPVTATSFQTTTTYPTPSHPHTTLPTHVPS
                     FSTSLVTPSTHTVIIPTHTQMATSASIHSMPTGTIPPPTTIKATGSTHTAPPMTPTTS
                     GTSQSPSSFSTAKTSTSLPYHTSSTHHPEVTPTSTTNITPKHTSTGTRTPVAHTTSAS
                     SSRLPTPFTTHSPPTGSSPFSSTGPMTATSFQTTTTYPTPSHPQTTLPTHVPPFSTSL
                     VTPSTHTVIITTHTQMATSASIHSTPTGTVPPPTTLKATGSTHTAPPMTVTTSGTSQT
                     HSSFSTATASSSFISSSSWLPQNSSSRPPSSPITTQLPHLSSATTPVSTTNQLSSSFS
                     PSPSAPSTVSSYVPSSHSSPQTSSPSVGTSSSFVSAPVHSTTLSSGSHSSLSTHPTTA
                     SVSASPLFPSSPAASTTIRATLPHTISSPFTLSALLPISTVTVSPTPSSHLASSTIAF
                     PSTPRTTASTHTAPAFSSQSTTSRSTSLTTRVPTSGFVSLTSGVTGIPTSPVTNLTTR
                     HPGPTLSPTTRFLTSSLTAHGSTPASAPVSSLGTPTPTSPGVCSVREQQEEITFKGCM
                     ANVTVTRCEGACISAASFNIITQQVDARCSCCRPLHSYEQQLELPCPDPSTPGRRLVL
                     TLQVFSHCVCSSVACGD"
     exon            116..178
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            179..419
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..546
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            547..637
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            638..747
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            748..955
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1078
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1199
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1338
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1443
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1516
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1654
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1816
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1911
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2044
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2294
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2347
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2457
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2609
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2751
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2752..2862
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            2863..3048
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3049..3288
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3289..3445
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3589
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3652
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3653..3703
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3704..3871
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            3872..4093
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..7102
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            7103..7205
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     exon            7206..8016
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7993..7998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /note="hexamer: AATAAA"
     polyA_site      8016
                     /gene="MUC6"
                     /gene_synonym="MUC-6"
                     /note="major polyA site"
ORIGIN      
        1 agccgcatgg atggcagcag caggcctgcc gggcccagcg cgagctcctc tccactgtgc
       61 accatggtcc agcggtggct gctgctgtcc tgctgcggag ccctgctcag cgctggtctg
      121 gctaacacct cctacaccag cccaggcctc cagaggctga aggactctcc acagacagcc
      181 ccggacaaag gccagtgctc cacgtggggg gctggtcact tctccacctt cgaccaccac
      241 gtgtacgact tctcggggac gtgcaactac atcttcgcgg ccacctgcaa ggacgccttc
      301 cccaccttca gtgtccagct gcggcgaggc ccagacggga gcatctcgcg gatcatcgtg
      361 gagctggggg cctccgtcgt cactgtgagc gaagccatca tctcagtcaa ggacatcggg
      421 gtcatcagcc tgccctatac cagcaatgga ctccagatca cacccttcgg ccagagcgtg
      481 cggctggtgg ccaagcagct ggagctggag ctggaagtcg tgtggggtcc tgacagccac
      541 ctcatggttc tggtggagcg gaagtacatg ggtcagatgt gcgggctctg cgggaacttt
      601 gacgggaagg tgaccaacga gtttgtcagt gaggagggca agttcctgga accccacaag
      661 tttgctgccc tccagaagct ggacgacccc ggcgagatct gcaccttcca ggacatcccc
      721 agcacccacg tccggcaggc ccagcacgcc cggatctgca cccagctgct gaccctggtg
      781 gcccctgagt gcagcgtgtc caaggagccc ttcgtgctaa gctgccaggc ggacgtggcc
      841 gcagcccccc agccaggccc acagaacagc agttgtgcca ccctgtcgga gtactcccgc
      901 cagtgcagca tggtgggcca gccggtccgc cgctggcgga gccccggcct gtgctccgtg
      961 ggtcagtgcc cggccaacca ggtgtaccag gagtgcggct cggcctgcgt gaagacctgc
     1021 tccaacccgc agcacagctg ctccagctcc tgcaccttcg ggtgcttctg cccggaaggt
     1081 acggtcctga atgacctctc caataaccac acctgcgtgc ccgtcaccca gtgcccctgt
     1141 gtgctccacg gcgccatgta tgcccccggg gaggtcacaa tagctgcctg ccaaacctgc
     1201 cggtgcaccc tgggccgctg ggtgtgcacg gagcggccgt gccccggaca ctgctccctg
     1261 gaaggtggct cctttgttac cacatttgac gccaggccct accgcttcca cggcacctgc
     1321 acctacatcc tcctccagag cccccagctt cccgaggacg gtgccctcat ggctgtgtac
     1381 gacaagtccg gcgtctcaca ctccgagacc tccctggtgg ctgtggtcta cctctccagg
     1441 caggacaaaa ttgtgatctc tcaggacgag gtggtcacca acaacggaga agccaagtgg
     1501 ctgccataca agactcgcaa catcacggtc ttcaggcaga cgtccaccca cctccagatg
     1561 gccaccagct tcgggctgga gctcgtggtc cagctgcgcc ccatcttcca ggcctatgtc
     1621 actgttgggc cccagttcag aggtcagacc agagggctct gcggcaactt caacggggac
     1681 acaacggatg acttcaccac tagcatgggt atcgccgagg gcaccgcctc gctgtttgtg
     1741 gactcctggc gggcggggaa ctgtccggcc gctctggagc gtgagactga cccctgctcc
     1801 atgagccagc tcaacaaggt gtgtgcagag acccactgct ccatgctgct gaggacaggc
     1861 acggtgttcg agaggtgcca cgccacagtg aaccctgcac ccttctacaa gaggtgcgtg
     1921 taccaggcct gcaactacga ggagaccttt ccccacatct gtgccgccct gggcgactac
     1981 gtacacgcct gctccttgcg gggcgtcctg ctctggggct ggagaagcag tgtggacaac
     2041 tgcaccatcc cctgcacggg taacaccacc ttcagctaca acagccaagc ctgtgagcgc
     2101 acctgcctgt cgctgtcgga ccgtgccacc gagtgccacc acagcgccgt gcccgtggac
     2161 ggttgcaact gccccgatgg cacctacctg aaccaaaagg gcgagtgtgt gcgcaaggcc
     2221 cagtgcccgt gcatactgga gggttacaag ttcatcctgg ccgagcagtc cactgtcatc
     2281 aacggcatca cctgccactg catcaacggg cggctgagtt gcccgcagcg gccacagatg
     2341 ttcctggcct cctgccaggc ccctaagacc ttcaagtcct gcagccagtc ctccgagaac
     2401 aagtttgggg cagcctgtgc ccccacatgc cagatgctgg ccaccggtgt tgcctgcgtg
     2461 cccaccaagt gtgagcctgg ctgtgtctgc gccgagggcc tctacgagaa tgccgacggg
     2521 cagtgtgtgc cccccgagga gtgcccatgt gagttctcgg gggtctccta ccctggagga
     2581 gctgagctcc acactgactg caggacctgc tcctgctcaa gggggaggtg ggcctgtcag
     2641 cagggcaccc actgcccatc cacctgcacc ctctacgggg agggccacgt catcaccttc
     2701 gacggccagc gcttcgtatt cgacggcaac tgcgagtaca tcctggccac ggacgtctgt
     2761 ggtgtcaacg actcacagcc caccttcaag atcctgacag agaacgtcat ctgtgggaac
     2821 tccggggtca catgctcacg ggccatcaag atcttcctgg ggggcctgtc cgtggtgctg
     2881 gcggacagaa actacacggt caccggggag gagccccacg tgcagctcgg ggtgacgccg
     2941 ggtgcgctga gccttgtcgt ggacatcagc atccccggga ggtacaacct gacgctcatc
     3001 tggaacaggc acatgaccat cctcatcagg atcgcccgtg cctcccagga tcccctctgc
     3061 ggcttgtgtg gcaacttcaa cgggaacatg aaggacgact tcgagacgcg cagcaggtac
     3121 gtggcatcca gcgagctgga gttggtgaac tcgtggaagg agagcccgct gtgcggggac
     3181 gtgagcttcg tgacagaccc ctgcagtctc aatgccttcc ggcgctcctg ggccgagcgc
     3241 aagtgcagcg tcatcaacag ccagaccttt gccacctgcc acagcaaggt ataccacctg
     3301 ccctactacg aggcctgcgt gcgcgacgca tgtgggtgtg acagtggcgg ggactgtgag
     3361 tgtctgtgcg atgccgtggc tgcctacgcc caagcctgtc tggacaaggg tgtgtgcgtg
     3421 gactggagga ccccggcctt ctgccccatc tactgcggct tctacaacac gcacacgcag
     3481 gacggccatg gcgagtacca gtacacacag gaggccaact gcacgtggca ctaccagccc
     3541 tgcctctgcc ccagccagcc acagagcgtc ccaggcagca acatcgaagg ctgctacaac
     3601 tgctcccagg atgagtactt cgaccacgag gagggggtgt gcgtgccctg catgccgccc
     3661 accacgccgc agccacccac cacgccgcag ctgcccacca caggctcacg gcccacgcaa
     3721 gtctggccca tgacgggaac ctccaccacc atcgggcttc tcagctccac cggaccctca
     3781 cccagctcta atcacacccc tgccagcccc acccagacac ccctccttcc agccacgctc
     3841 acatcctcca agcccacagc ctcctcggga gaaccaccta gaccaaccac ggccgtcacc
     3901 ccacaagcca catcagggct gcctcccaca gccacactga gatcgacagc cacaaaaccc
     3961 acagtgaccc aggccacaac cagggccacg gcgtcgaccg ccagcccagc cacgacgtcc
     4021 acagctcagt ccacaacacg gaccacaatg acactaccaa ccccagccac atcagggaca
     4081 agccccacgc tgccaaaatc gaccaatcag gaactgccag gaacaacggc cacccagacg
     4141 acaggcccac gtccaacccc agcaagcacc acaggcccaa ccaccccaca gccaggacaa
     4201 cccacgaggc ccacagccac agagaccact caaacaagaa cgactactga atacacaacg
     4261 ccccaaaccc cacacaccac acactccccg cctacggcgg ggagtcccgt cccttccaca
     4321 ggtcctgtca ctgcaacatc tttccatgcc accactacct atccaacccc atcacaccct
     4381 gagaccacac ttcccactca cgttccacct ttctccacct ccttggtgac tccaagtact
     4441 cacacagtca tcacccctac ccacgcacag atggccacat ctgcctccaa ccactcagcg
     4501 ccaacaggta ccattcctcc accaacaacg ctcaaggcca cagggtccac ccacacagcc
     4561 ccaccaataa cgccgaccac cagtgggacc agccaagccc acagctcatt cagcacaaac
     4621 aaaacaccta cctcgctaca ttcacacact tcctccacac accatcctga agtcacccca
     4681 acttctacta ccacgattac tcccaacccc actagtacac gcaccagaac ccctgtggcc
     4741 cacaccaact cagccaccag cagcaggcca ccaccaccct tcaccacaca ctccccacct
     4801 acagggagca gtcccttctc ttccacaggt cccatgacgg caacatcctt caagaccacc
     4861 actacctatc caaccccatc acaccctcag accacacttc ccactcacgt tccacctttc
     4921 tccacctctt tggtgactcc aagtactcac acagtcatca cccctaccca tgcacagatg
     4981 gccacttctg cctccatcca ctcaatgcca acaggcacga ttcctccacc gacaacgctc
     5041 aaggccacag ggtccaccca cacagcgcca acaatgacgc tgaccaccag cgggaccagc
     5101 caagccctga gctcattaaa cacagccaaa acctctacat ccctacattc acacacttcc
     5161 tccacacacc atgctgaagc cacctcaact tctaccacca acatcacccc caaccccacc
     5221 agtacaggaa ccccaccaat gacagtgacc accagtggga ccagccaatc ccgaagctca
     5281 tttagcacgg ccaaaacctc tacatcccta cattcacaca cttcctccac acaccatcct
     5341 gaagtcacct caacttctac caccagcatc acccccaacc acaccagtac aggcaccaga
     5401 acccctgtgg cccacaccac gtcggccacc agcagcaggc tacccacacc cttcaccaca
     5461 cactccccac ctacagggac cactcccatc tcttccacag gtcctgtcac tgcaacatcc
     5521 ttccagacca ccactaccta tccaacccca tcacaccctc acaccacact tcccactcac
     5581 gttccatctt tctccacctc cttggtgact ccaagtactc acacggtcat catccctacc
     5641 cacacacaga tggccacttc tgcctccatc cactcaatgc caacaggcac cattcctcca
     5701 ccgaccacga tcaaggccac agggtccacc cacacagccc caccaatgac accgaccacc
     5761 agtgggacca gccaatcccc aagctcattt agcacggcca aaacttctac atccctacct
     5821 taccacactt cctcaacaca ccatcctgaa gtcaccccaa cttctaccac caacatcacc
     5881 cccaaacaca ccagtacagg caccagaacc cctgtggccc acaccacctc ggccagcagc
     5941 agcaggctac ccacaccctt caccacacac tccccaccta cagggagcag tcccttctct
     6001 tccacaggtc ctatgactgc aacatccttc cagaccacca ctacctatcc aaccccatca
     6061 caccctcaga ccacacttcc cactcacgtt ccacctttct ccacctcctt ggtgactcca
     6121 agtactcaca cagtcatcat cactacccac acacagatgg ccacttctgc ctccatccac
     6181 tcaacgccaa caggcaccgt tcctccacca acaacgctca aggccacagg gtccacccac
     6241 acagccccac caatgacagt gaccaccagt gggaccagcc aaacccacag ctcattcagc
     6301 acagctacag cctcttcttc cttcatatcc tcctcgtctt ggctgcctca gaactctagc
     6361 tcaaggccac cgtcatcacc tatcaccaca caactccccc acttgagttc tgcaaccact
     6421 cctgtttcca caactaatca gctgtcctcc tcattttctc ccagtccttc tgccccctct
     6481 actgtttctt cttatgtgcc ctcctcccac tcctctcccc agacttcatc gccttctgtt
     6541 ggcacatctt cctctttcgt gtccgccccc gtgcactcca caaccctgag ctcggggtca
     6601 cactcctcat tgtccactca tcccacgact gcatcagtgt ctgcatctcc tctttttcct
     6661 tcttctccag ctgcctctac taccattagg gccactctcc cccacactat ctcctctcct
     6721 ttcaccctct ctgctctact ccccatatcc actgttaccg tgtctcccac cccatccagc
     6781 cacctagcct ccagcaccat tgcatttccg tccacgccca ggaccacggc cagcacccac
     6841 accgcccctg ccttctcctc tcagtccacc acctcgcggt ccacttctct caccacccga
     6901 gttcccacat caggctttgt gtcactcacc tcgggggtga cgggtatccc cacctctcca
     6961 gtcaccaacc ttaccaccag gcaccctggt cccaccttgt cgcctaccac acggttcctg
     7021 accagctccc tcactgccca tggaagcacc cctgcttctg ccccggtatc ttctctcggg
     7081 acacctacgc ccacctcacc cggggtctgc agtgtgcggg agcagcagga ggagatcacg
     7141 ttcaaggggt gcatggcgaa cgtgacggta acccgctgtg agggcgcctg catttccgct
     7201 gccagcttca acatcatcac ccagcaggtg gatgcccgct gcagctgctg ccgccccctc
     7261 cactcctatg agcagcagct ggagctgccc tgccccgatc ccagcacgcc tggccggcgg
     7321 ctcgtactca ccctgcaggt gttcagccac tgcgtgtgca gctctgtggc ctgtggagac
     7381 tagcagggtc gctgcctgct ctcctggggc tgaaggactg cagatgacag acaggaaaac
     7441 acccaccagc ccccttcccg cttgtgccag cagctgcttt cctggtcacc aggcctggcc
     7501 cccaagtgcc ctgggccgtg gctccctggg gcaccggttg gagaggggct gccaagcagg
     7561 ggctcagact accacactcc tgcagaccct gagccagcag agagggactg aggcggacag
     7621 tggtcacgga cctcccaggc acacagggca ctcccgacca cccctgccca ccgtccaaca
     7681 cctcccagcc cctgaacttg gccccagccc tgctgggccc agaaccctgc agatgaagcc
     7741 acagagcagg cgctcgacca gacccatcag gggcgaggag ggcacggaaa cctgtgccga
     7801 gatgggggca agaggcccag gcagccacca gcacagagaa gaggagatcc ccagagtcag
     7861 ggagggcaga gggtggcagc gagggcaggg cagccgcccc cgctcccagc caggcagaag
     7921 gcccccacca gcaccacacc catccccagc agcctgtcct tgggagaggg cgtcacccgg
     7981 tcagagactc caaataaacc ggttcttgtc aaggca
//
