LOCUS       NM_002458              17911 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens mucin 5B, oligomeric mucus/gel-forming (MUC5B), mRNA.
ACCESSION   NM_002458 XM_001126093 XM_001129427
VERSION     NM_002458.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 17911)
  AUTHORS   Li,T.A., Gonzalez-Gil,A., Awol,A.K., Ackerman,S.J., Orsburn,B.C.
            and Schnaar,R.L.
  TITLE     Sialylated keratan sulfates on MUC5B are Siglec-8 ligands in the
            human esophagus
  JOURNAL   Glycobiology 34 (10) (2024)
   PUBMED   39173029
  REMARK    GeneRIF: Sialylated keratan sulfates on MUC5B are Siglec-8 ligands
            in the human esophagus.
REFERENCE   2  (bases 1 to 17911)
  AUTHORS   Ueda,Y., Mogami,H., Chigusa,Y., Kawamura,Y., Inohaya,A.,
            Takakura,M., Yasuda,E., Matsuzaka,Y., Shimada,M., Ito,S.,
            Morita,S., Mandai,M. and Kondoh,E.
  TITLE     Hyposecretion of cervical MUC5B is related to preterm birth in
            pregnant women after cervical excisional surgery
  JOURNAL   Am J Reprod Immunol 91 (3), e13832 (2024)
   PUBMED   38462543
  REMARK    GeneRIF: Hyposecretion of cervical MUC5B is related to preterm
            birth in pregnant women after cervical excisional surgery.
REFERENCE   3  (bases 1 to 17911)
  AUTHORS   Dhooria,S., Bal,A., Sharma,R., Prabhakar,N., Arora,S., Sehgal,I.S.,
            Kashyap,D., Garg,M., Bhalla,A., Aggarwal,A.N. and Agarwal,R.
  TITLE     Association of MUC5B promoter polymorphism with interstitial lung
            changes after COVID-19: A preliminary observation
  JOURNAL   Indian J Med Res 159 (1), 109-113 (2024)
   PUBMED   38344913
  REMARK    GeneRIF: Association of MUC5B promoter polymorphism with
            interstitial lung changes after COVID-19: A preliminary
            observation.
REFERENCE   4  (bases 1 to 17911)
  AUTHORS   Chen,Y., Zhao,Y.H., Di,Y.P. and Wu,R.
  TITLE     Characterization of human mucin 5B gene expression in airway
            epithelium and the genomic clone of the amino-terminal and
            5'-flanking region
  JOURNAL   Am J Respir Cell Mol Biol 25 (5), 542-553 (2001)
   PUBMED   11713095
REFERENCE   5  (bases 1 to 17911)
  AUTHORS   Desseyn,J.L., Buisine,M.P., Porchet,N., Aubert,J.P. and Laine,A.
  TITLE     Genomic organization of the human mucin gene MUC5B. cDNA and
            genomic sequences upstream of the large central exon
  JOURNAL   J Biol Chem 273 (46), 30157-30164 (1998)
   PUBMED   9804771
REFERENCE   6  (bases 1 to 17911)
  AUTHORS   Desseyn,J.L., Guyonnet-Duperat,V., Porchet,N., Aubert,J.P. and
            Laine,A.
  TITLE     Human mucin gene MUC5B, the 10.7-kb large central exon encodes
            various alternate subdomains resulting in a super-repeat.
            Structural evidence for a 11p15.5 gene family
  JOURNAL   J Biol Chem 272 (6), 3168-3178 (1997)
   PUBMED   9013550
REFERENCE   7  (bases 1 to 17911)
  AUTHORS   Troxler,R.F., Offner,G.D., Zhang,F., Iontcheva,I. and
            Oppenheim,F.G.
  TITLE     Molecular cloning of a novel high molecular weight mucin (MG1) from
            human sublingual gland
  JOURNAL   Biochem Biophys Res Commun 217 (3), 1112-1119 (1995)
   PUBMED   8554565
REFERENCE   8  (bases 1 to 17911)
  AUTHORS   Meezaman,D., Charles,P., Daskal,E., Polymeropoulos,M.H.,
            Martin,B.M. and Rose,M.C.
  TITLE     Cloning and analysis of cDNA encoding a major airway glycoprotein,
            human tracheobronchial mucin (MUC5)
  JOURNAL   J Biol Chem 269 (17), 12932-12939 (1994)
   PUBMED   7513696
REFERENCE   9  (bases 1 to 17911)
  AUTHORS   Dufosse,J., Porchet,N., Audie,J.P., Guyonnet Duperat,V., Laine,A.,
            Van-Seuningen,I., Marrakchi,S., Degand,P. and Aubert,J.P.
  TITLE     Degenerate 87-base-pair tandem repeats create
            hydrophilic/hydrophobic alternating domains in human mucin peptides
            mapped to 11p15
  JOURNAL   Biochem J 293 (Pt 2) (Pt 2), 329-337 (1993)
   PUBMED   7916618
REFERENCE   10 (bases 1 to 17911)
  AUTHORS   Douglas,W.H., Reeh,E.S., Ramasubbu,N., Raj,P.A., Bhandary,K.K. and
            Levine,M.J.
  TITLE     Statherin: a major boundary lubricant of human saliva
  JOURNAL   Biochem Biophys Res Commun 180 (1), 91-97 (1991)
   PUBMED   1718282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC061979.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002458.2.
            
            Summary: This gene encodes a member of the mucin family of
            proteins, which are highly glycosylated macromolecular components
            of mucus secretions. This family member is the major gel-forming
            mucin in mucus. It is a major contributor to the lubricating and
            viscoelastic properties of whole saliva, normal lung mucus and
            cervical mucus. This gene has been found to be up-regulated in some
            human diseases, including sinus mucosa of chronic rhinosinusitis
            (CRS), CRS with nasal polyposis, chronic obstructive pulmonary
            disease (COPD) and H. pylori-associated gastric disease, and it may
            be involved in the pathogenesis of these diseases. [provided by
            RefSeq, Jul 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on partial transcript alignments that tile across
            this locus.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000529681.5/ ENSP00000436812.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC061979.17        11008-11135
            129-185             AC061979.17        13623-13679
            186-257             AC061979.17        14147-14218
            258-519             AC061979.17        14557-14818
            520-634             AC061979.17        14973-15087
            635-725             AC061979.17        15250-15340
            726-832             AC061979.17        15617-15723
            833-1034            AC061979.17        16506-16707
            1035-1160           AC061979.17        17112-17237
            1161-1278           AC061979.17        17632-17749
            1279-1417           AC061979.17        17947-18085
            1418-1528           AC061979.17        18432-18542
            1529-1598           AC061979.17        18878-18947
            1599-1736           AC061979.17        19365-19502
            1737-1901           AC061979.17        19938-20102
            1902-1996           AC061979.17        20392-20486
            1997-2123           AC061979.17        20586-20712
            2124-2379           AC061979.17        20955-21210
            2380-2435           AC061979.17        21735-21790
            2436-2536           AC061979.17        22147-22247
            2537-2688           AC061979.17        22471-22622
            2689-2827           AC061979.17        23027-23165
            2828-2938           AC061979.17        23245-23355
            2939-3115           AC061979.17        24328-24504
            3116-3355           AC061979.17        24867-25106
            3356-3512           AC061979.17        26813-26969
            3513-3641           AC061979.17        27380-27508
            3642-3786           AC061979.17        27741-27885
            3787-3830           AC061979.17        27987-28030
            3831-4028           AC061979.17        28120-28317
            4029-14921          AC061979.17        28793-39685
            14922-15103         AC061979.17        40285-40466
            15104-15275         AC061979.17        40751-40922
            15276-15535         AC061979.17        42034-42293
            15536-15722         AC061979.17        42636-42822
            15723-15948         AC061979.17        42983-43208
            15949-16124         AC061979.17        43325-43500
            16125-16194         AC061979.17        44098-44167
            16195-16295         AC061979.17        44613-44713
            16296-16327         AC061979.17        45182-45213
            16328-16508         AC061979.17        45472-45652
            16509-16613         AC061979.17        46041-46145
            16614-16651         AC061979.17        46272-46309
            16652-16771         AC061979.17        46884-47003
            16772-16858         AC061979.17        47698-47784
            16859-16981         AC061979.17        47905-48027
            16982-17024         AC061979.17        48293-48335
            17025-17127         AC061979.17        48568-48670
            17128-17911         AC061979.17        49331-50114
FEATURES             Location/Qualifiers
     source          1..17911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..17911
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /note="mucin 5B, oligomeric mucus/gel-forming"
                     /db_xref="GeneID:727897"
                     /db_xref="HGNC:HGNC:7516"
                     /db_xref="MIM:600770"
     exon            1..128
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..17347
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /note="mucin 5, subtype B, tracheobronchial; cervical
                     mucin MUC5B; sublingual gland mucin; high molecular weight
                     salivary mucin MG1"
                     /codon_start=1
                     /product="mucin-5B precursor"
                     /protein_id="NP_002449.2"
                     /db_xref="CCDS:CCDS44515.2"
                     /db_xref="GeneID:727897"
                     /db_xref="HGNC:HGNC:7516"
                     /db_xref="MIM:600770"
                     /translation="MGAPSACRTLVLALAAMLVVPQAETQGPVEPSWENAGHTMDGGA
                     PTSSPTRRVSFVPPVTVFPSLSPLNPAHNGRVCSTWGDFHYKTFDGDVFRFPGLCNYV
                     FSEHCRAAYEDFNVQLRRGLVGSRPVVTRVVIKAQGLVLEASNGSVLINGQREELPYS
                     RTGLLVEQSGDYIKVSIRLVLTFLWNGEDSALLELDPKYANQTCGLCGDFNGLPAFNE
                     FYAHNARLTPLQFGNLQKLDGPTEQCPDPLPLPAGNCTDEEGICHRTLLGPAFAECHA
                     LVDSTAYLAACAQDLCRCPTCPCATFVEYSRQCAHAGGQPRNWRCPELCPRTCPLNMQ
                     HQECGSPCTDTCSNPQRAQLCEDHCVDGCFCPPGTVLDDITHSGCLPLGQCPCTHGGR
                     TYSPGTSFNTTCSSCTCSGGLWQCQDLPCPGTCSVQGGAHISTYDEKLYDLHGDCSYV
                     LSKKCADSSFTVLAELRKCGLTDNENCLKAVTLSLDGGDTAIRVQADGGVFLNSIYTQ
                     LPLSAANITLFTPSSFFIVVQTGLGLQLLVQLVPLMQVFVRLDPAHQGQMCGLCGNFN
                     QNQADDFTALSGVVEATGAAFANTWKAQAACANARNSFEDPCSLSVENENYARHWCSR
                     LTDPNSAFSRCHSIINPKPFHSNCMFDTCNCERSEDCLCAALSSYVHACAAKGVQLSD
                     WRDGVCTKYMQNCPKSQRYAYVVDACQPTCRGLSEADVTCSVSFVPVDGCTCPAGTFL
                     NDAGACVPAQECPCYAHGTVLAPGEVVHDEGAVCSCTGGKLSCLGASLQKSTGCAAPM
                     VYLDCSNSSAGTPGAECLRSCHTLDVGCFSTHCVSGCVCPPGLVSDGSGGCIAEEDCP
                     CVHNEATYKPGETIRVDCNTCTCRNRRWECSHRLCLGTCVAYGDGHFITFDGDRYSFE
                     GSCEYILAQDYCGDNTTHGTFRIVTENIPCGTTGTTCSKAIKLFVESYELILQEGTFK
                     AVARGPGGDPPYKIRYMGIFLVIETHGMAVSWDRKTSVFIRLHQDYKGRVCGLCGNFD
                     DNAINDFATRSRSVVGDALEFGNSWKLSPSCPDALAPKDPCTANPFRKSWAQKQCSIL
                     HGPTFAACRSQVDSTKYYEACVNDACACDSGGDCECFCTAVAAYAQACHDAGLCVSWR
                     TPDTCPLFCDFYNPHGGCEWHYQPCGAPCLKTCRNPSGHCLVDLPGLEGCYPKCPPSQ
                     PFFNEDQMKCVAQCGCYDKDGNYYDVGARVPTAENCQSCNCTPSGIQCAHSLEACTCT
                     YEDRTYSYQDVIYNTTDGLGACLIAICGSNGTIIRKAVACPGTPATTPFTFTTAWVPH
                     STTSPALPVSTVCVREVCRWSSWYNGHRPEPGLGGGDFETFENLRQRGYQVCPVLADI
                     ECRAAQLPDMPLEELGQQVDCDRMRGLMCANSQQSPPLCHDYELRVLCCEYVPCGPSP
                     APGTSPQPSLSASTEPAVPTPTQTTATEKTTLWVTPSIRSTAALTSQTGSSSGPVTVT
                     PSAPGTTTCQPRCQWTEWFDEDYPKSEQLGGDVESYDKIRAAGGHLCQQPKDIECQAE
                     SFPNWTLAQVGQKVHCDVHFGLVCRNWEQEGVFKMCYNYRIRVLCCSDDHCRGRATTP
                     PPTTELETATTTTTQALFSTPQPTSSPGLTRAPPASTTAVPTLSEGLTSPRYTSTLGT
                     ATTGGPTTPAGSTEPTVPGVATSTLPTRSALPGTTGSLGTWRPSQPPTLAPTTMATSR
                     ARPTGTASTASKEPLTTSLAPTLTSELSTSQAETSTPRTETTMSPLTNTTTSQGTTRC
                     QPKCEWTEWFDVDFPTSGVAGGDMETFENIRAAGGKMCWAPKSIECRAENYPEVSIDQ
                     VGQVLTCSLETGLTCKNEDQTGRFNMCFNYNVRVLCCDDYSHCPSTPATSSTATPSST
                     PGTTWILTKPTTTATTTASTGSTATPTSTLRTAPPPKVLTTTATTPTVTSSKATPSSS
                     PGTATALPALRSTATTPTATSVTPIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPET
                     AHTSTVLTATATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPP
                     VWISTTTTPTTRGSTVTPSSIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPS
                     LTTTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSNTVTPSSALGTTHTPPV
                     PNTMATTHGRSLPPSSPHTVRTAWTSATSGILGTTHITEPSTVTSHTLAATTGTTQHS
                     TPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSKTRTSTLLPSSPTSAPI
                     TTVVTMGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQA
                     QPGVPLRELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSS
                     TAMPSSTPGTTWILTELTTTATTTESTGSTATPSSTPGTTWILTEPSTTATVTVPTGS
                     TATASSTQATAGTPHVSTTATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFT
                     AIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTATTTGATGSVATP
                     SSTPGTAHTTKVLTTTTTGFTATPSSSPGTARTLPVWISTTTTPTTRGSTVTPSSIPG
                     TTHTPTVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSSTPGT
                     TPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNTTATTHGRSLSPSSPHTVRTA
                     WTSATSGTLGTTHITEPSTGTSHTPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTT
                     TPGHTRATSRTTATATPSKTRTSTLLPSSPTSAPITTVVTMGCEPQCAWSEWLDYSYP
                     MPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDFGLVC
                     RNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTEQTTAATT
                     TATTGSTAIPSSTPGTAPPPKVLTSTATTPTATSSKATSSSSPRTATTLPVLTSTATK
                     STATSFTPIPSFTLGTTGTLPEQTTTPMATMSTIHPSSTPETTHTSTVLTTKATTTRA
                     TSSMSTPSSTPGTTWILTELTTAATTTAATGPTATPSSTPGTTWILTEPSTTATVTVP
                     TGSTATASSTRATAGTLKVLTSTATTPTVISSRATPSSSPGTATALPALRSTATTPTA
                     TSVTAIPSSSLGTAWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTTTTTTTRATGS
                     VATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPTTRGSTVTPS
                     SIPGTTHTATVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTATTITATGSTTNPSS
                     TPGTTPIPPVLTTTATTPAATSSTVTPSSALGTTHTPPVPNTTATTHGRSLPPSSPHT
                     VRTAWTSATSGILGTTHITEPSTVTSHTPAATTSTTQHSTPALSSPHPSSRTTESPPS
                     PGTTTPGHTRGTSRTTATATPSKTRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLD
                     YSYPMPGPSGGDFDTYSNIRAAGGAVCEQPLGLECRAQAQPGVPLRELGQVVECSLDF
                     GLVCRNREQVGKFKMCFNYEIRVFCCNYGHCPSTPATSSTATPSSTPGTTWILTKLTT
                     TATTTESTGSTATPSSTPGTTWILTEPSTTATVTVPTGSTATASSTQATAGTPHVSTT
                     ATTPTVTSSKATPFSSPGTATALPALRSTATTPTATSFTAIPSSSLGTTWTRLSQTTT
                     PTATMSTATPSSTPETAHTSTVLTTTATTTRATGSVATPSSTPGTAHTTKVPTTTTTG
                     FTVTPSSSPGTARTPPVWISTTTTPTTSGSTVTPSSVPGTTHTPTVLTTTTTTVATGS
                     MATPSSSTQTSGTPPSLITTATTITATGSTTNPSSTPGTTPIPPVLTTTATTPAATSS
                     TVTPSSALGTTHTPPVPNTTATTHGRSLSPSSPHTVRTAWTSATSGTLGTTHITEPST
                     GTSHTPAATTGTTQHSTPALSSPHPSSRTTESPPSPGTTTPGHTTATSRTTATATPSK
                     TRTSTLLPSSPTSAPITTVVTTGCEPQCAWSEWLDYSYPMPGPSGGDFDTYSNIRAAG
                     GAVCEQPLGLECRAQAQPGVPLGELGQVVECSLDFGLVCRNREQVGKFKMCFNYEIRV
                     FCCNYGHCPSTPATSSTAMPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTAPP
                     PKVLTSPATTPTATSSKATSSSSPRTATTLPVLTSTATKSTATSVTPIPSSTLGTTGT
                     LPEQTTTPVATMSTIHPSSTPETTHTSTVLTTKATTTRATSSTSTPSSTPGTTWILTE
                     LTTAATTTAATGPTATPSSTPGTTWILTELTTTATTTASTGSTATPSSTPGTTWILTE
                     PSTTATVTVPTGSTATASSTQATAGTPHVSTTATTPTVTSSKATPSSSPGTATALPAL
                     RSTATTPTATSFTAIPSSSLGTTWTRLSQTTTPTATMSTATPSSTPETVHTSTVLTAT
                     ATTTGATGSVATPSSTPGTAHTTKVPTTTTTGFTATPSSSPGTALTPPVWISTTTTPT
                     TTTPTTSGSTVTPSSIPGTTHTARVLTTTTTTVATGSMATPSSSTQTSGTPPSLTTTA
                     TTITATGSTTNPSSTPGTTPITPVLTSTATTPAATSSKATSSSSPRTATTLPVLTSTA
                     TKSTATSFTPIPSSTLWTTWTVPAQTTTPMSTMSTIHTSSTPETTHTSTVLTTTATMT
                     RATNSTATPSSTLGTTRILTELTTTATTTAATGSTATLSSTPGTTWILTEPSTIATVM
                     VPTGSTATASSTLGTAHTPKVVTTMATMPTATASTVPSSSTVGTTRTPAVLPSSLPTF
                     SVSTVSSSVLTTLRPTGFPSSHFSTPCFCRAFGQFFSPGEVIYNKTDRAGCHFYAVCN
                     QHCDIDRFQGACPTSPPPVSSAPLSSPSPAPGCDNAIPLRQVNETWTLENCTVARCVG
                     DNRVVLLDPKPVANVTCVNKHLPIKVSDPSQPCDFHYECECICSMWGGSHYSTFDGTS
                     YTFRGNCTYVLMREIHARFGNLSLYLDNHYCTASATAAAARCPRALSIHYKSMDIVLT
                     VTMVHGKEEGLILFDQIPVSSGFSKNGVLVSVLGTTTMRVDIPALGVSVTFNGQVFQA
                     RLPYSLFHNNTEGQCGTCTNNQRDDCLQRDGTTAASCKDMAKTWLVPDSRKDGCWAPT
                     GTPPTASPAAPVSSTPTPTPCPPQPLCDLMLSQVFAECHNLVPPGPFFNACISDHCRG
                     RLEVPCQSLEAYAELCRARGVCSDWRGATGGLCDLTCPPTKVYKPCGPIQPATCNSRN
                     QSPQLEGMAEGCFCPEDQILFNAHMGICVQACPCVGPDGFPKFPGERWVSNCQSCVCD
                     EGSVSVQCKPLPCDAQGQPPPCNRPGFVTVTRPRAENPCCPETVCVCNTTTCPQSLPV
                     CPPGQESICTQEEGDCCPTFRCRPQLCSYNGTFYGVGATFPGALPCHMCTCLSGDTQD
                     PTVQCQEDACNNTTCPQGFEYKRVAGQCCGECVQTACLTPDGQPVQLNETWVNSHVDN
                     CTVYLCEAEGGVHLLTPQPASCPDVSSCRGSLRKTGCCYSCEEDSCQVRINTTILWHQ
                     GCETEVNITFCEGSCPGASKYSAEAQAMQHQCTCCQERRVHEETVPLHCPNGSAILHT
                     YTHVDECGCTPFCVPAPMAPPHTRGFPAQEATAV"
     exon            129..185
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            186..257
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            258..519
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            520..634
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            635..725
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            726..832
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1034
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1160
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1278
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1417
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1528
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1598
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1736
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1901
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1996
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2123
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2379
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2435
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2536
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2688
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..2827
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2828..2938
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3115
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3355
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3512
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..3641
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3786
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3830
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            3831..4028
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..14921
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            14922..15103
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            15104..15275
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            15276..15535
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            15536..15722
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            15723..15948
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            15949..16124
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16125..16194
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16195..16295
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16296..16327
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16328..16508
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16509..16613
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16614..16651
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16652..16771
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16772..16858
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16859..16981
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            16982..17024
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            17025..17127
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     exon            17128..17911
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      17890..17895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /note="hexamer: AATAAA"
     polyA_site      17911
                     /gene="MUC5B"
                     /gene_synonym="MG1; MUC-5B; MUC5; MUC9"
                     /note="major polyA site"
ORIGIN      
        1 acccggcccg gctccctccc tgcccgtccc cgtcccccca cccgtgccag cccccaggat
       61 gggtgccccg agcgcgtgcc ggacgctggt gttggctctg gcggccatgc tcgtggtgcc
      121 gcaggcagag acccagggcc ctgtggagcc gagctgggag aatgcagggc acaccatgga
      181 tggcggtgcc ccgacgtcct cgcccacccg gcgcgtgagc tttgttccac ccgtcactgt
      241 cttccccagc ctgagccccc tgaacccggc gcacaatggg cgggtgtgca gcacctgggg
      301 tgacttccac tacaagacct tcgacggcga cgtcttccgc ttccctggcc tttgcaacta
      361 cgtgttctct gagcactgcc gcgccgccta cgaggacttc aacgtccagc tacgccgagg
      421 cctagtgggc tccaggcctg tggtcacccg tgttgtcatc aaggcccagg ggctggtgct
      481 ggaggcgtcc aacggctccg tcctcatcaa tgggcagcgg gaggagctgc cttacagccg
      541 cactggcctc ctggtggagc agagcgggga ctacatcaag gtcagcatcc ggctggtgct
      601 gacattcctg tggaacggag aggacagtgc cctgctggag ctggatccca aatacgccaa
      661 ccagacctgt ggcctgtgtg gggacttcaa cggcctcccg gccttcaacg agttctatgc
      721 ccacaacgcc aggctgaccc cgctccagtt tgggaacctg cagaagttgg atgggcccac
      781 ggagcagtgc ccggacccgc tgcccttgcc ggccggcaac tgcacggacg aggagggcat
      841 ctgccaccgc accctgctgg ggccggcctt tgcggagtgc cacgcactgg tggacagcac
      901 tgcgtacctg gccgcctgcg cccaggacct gtgccgctgc cccacctgcc cgtgtgccac
      961 ctttgtggaa tactcacgcc agtgcgccca cgcggggggc cagccgcgga actggaggtg
     1021 ccctgagctc tgcccccgga cctgccccct caacatgcag caccaggagt gtggctcacc
     1081 ctgcacggac acctgctcca acccccagcg cgcgcagctc tgcgaggacc actgtgtgga
     1141 cggctgcttc tgccccccag gcacggtgct ggatgacatc acgcactctg gctgcctgcc
     1201 cctcgggcag tgcccctgca cccacggcgg ccgcacctac agcccgggca cctccttcaa
     1261 caccacctgc agctcctgca cctgctccgg ggggctatgg cagtgccagg acctgccgtg
     1321 ccctggcacc tgctctgtgc agggcggggc ccacatctcc acctatgatg agaaactcta
     1381 cgacctgcat ggtgactgca gctacgttct gtccaagaaa tgtgccgaca gcagcttcac
     1441 cgtgctggct gagctgcgga agtgcggcct gacggacaac gagaactgcc tgaaagcggt
     1501 gacgctcagc ctggacggcg gggacacggc catccgggtc caagcggacg gcggcgtgtt
     1561 cctcaactcc atctacacgc agctgcccct gtcggcagcc aacatcaccc tgttcacacc
     1621 ctcgagcttc ttcatcgtgg tgcagacagg cctggggctg cagctgctgg tgcagctggt
     1681 gccactcatg caggtgtttg tcaggctgga ccccgcccac cagggccaga tgtgcggcct
     1741 gtgtgggaac ttcaaccaga accaggctga cgacttcacg gccctcagcg gggtggtgga
     1801 ggccacgggc gcagccttcg ccaacacctg gaaggcccag gctgcctgtg ccaatgccag
     1861 gaacagcttt gaggacccct gctccctcag tgtggagaat gagaactacg cccggcactg
     1921 gtgctcgcgc ctgaccgatc ccaacagtgc cttctcgcgc tgccactcca tcatcaaccc
     1981 caagcccttc cactcgaact gcatgtttga cacctgcaac tgtgagcgga gcgaggactg
     2041 cctgtgcgcc gcgctgtcct cctatgtgca cgcctgtgcc gccaagggcg tacagctcag
     2101 cgactggagg gacggcgtct gcaccaagta catgcagaac tgccccaagt cccagcgcta
     2161 cgcctacgtg gtggatgcct gccagcccac ttgccgcggc ctgagtgagg ccgacgtcac
     2221 ctgcagcgtt tccttcgtgc ctgtggacgg ctgcacctgc cccgcgggca ccttcctcaa
     2281 tgacgcgggc gcctgtgtgc ccgcccagga gtgcccctgc tacgctcacg gcaccgtgct
     2341 ggctcctgga gaggtggtgc acgacgaggg cgccgtgtgt tcatgtacgg gtgggaagct
     2401 aagctgcctg ggagcctctc tgcagaaaag cacagggtgt gcagccccca tggtgtacct
     2461 ggactgcagc aacagctcgg cgggcacccc tggggccgag tgcctccgga gctgccacac
     2521 gctggacgtg ggctgtttca gcacacactg cgtgtccggc tgtgtctgtc ccccggggct
     2581 ggtgtcggat gggagtgggg gctgcattgc cgaggaggac tgcccctgtg tgcacaacga
     2641 ggccacctac aagcctggag agaccatcag ggtcgactgc aacacctgca cctgcaggaa
     2701 ccggaggtgg gagtgcagcc accggctctg cctgggcacc tgcgtggcct acggggatgg
     2761 ccacttcatc acctttgatg gcgatcgcta cagctttgaa ggcagctgcg agtacatctt
     2821 ggcccaggac tactgtgggg acaacaccac ccacgggacc ttccgcatcg tcaccgagaa
     2881 catcccctgt gggaccaccg gcaccacctg ctccaaggcc atcaagctct tcgtggagag
     2941 ctacgagctg atcctccaag aggggacctt taaggcggtg gcgagagggc cgggtgggga
     3001 cccaccctac aagatacgct acatggggat cttcctggtc atcgagaccc acgggatggc
     3061 cgtgtcctgg gaccggaaga ccagcgtgtt catccgactg caccaggact acaagggcag
     3121 ggtctgcggc ctgtgcggga acttcgacga caatgccatc aatgactttg ccacgcgtag
     3181 ccggtccgtg gtgggggacg cactggagtt tgggaacagc tggaagctct ccccctcctg
     3241 cccggacgcc ctggcaccca aggacccctg cacggccaac cccttccgca agtcctgggc
     3301 ccagaagcag tgcagcatcc tccacggccc caccttcgcc gcctgccgct cccaggttga
     3361 ctccaccaag tactacgagg cctgcgtgaa cgacgcgtgt gcctgcgact cgggtggcga
     3421 ctgcgagtgt ttctgcacgg ctgtggctgc ctacgcccag gcctgccacg acgcgggcct
     3481 gtgtgtgtcc tggcggactc cggacacctg ccccttgttc tgtgacttct acaacccaca
     3541 tgggggctgt gagtggcact accagccctg cggggcaccc tgcctaaaaa cctgccggaa
     3601 ccccagtggg cactgcctgg tggacctgcc tggcctggaa ggctgctacc cgaagtgccc
     3661 acccagccag cccttcttca atgaggacca gatgaagtgc gtggcccagt gtggctgcta
     3721 cgacaaggac ggaaactact atgacgtcgg tgcaagggtc cccacagcgg agaactgcca
     3781 gagctgtaac tgcacaccca gtggcatcca gtgcgctcac agccttgagg cctgcacctg
     3841 cacctatgag gacaggacct acagctacca ggacgtcatc tacaacacca ccgatgggct
     3901 tggcgcctgc ttgatcgcca tctgcggaag caacggcacc atcatcagga aggctgtggc
     3961 atgtcctgga actccagcca caacgccatt caccttcacc accgcctggg tcccccactc
     4021 cacgacaagc ccggccctcc cggtctccac cgtgtgtgtc cgcgaggtct gccgctggtc
     4081 cagctggtac aatgggcacc gcccagagcc cggcctggga ggcggagact ttgagacgtt
     4141 tgaaaacctg aggcagagag ggtaccaggt atgccctgtg ctggctgaca tcgagtgccg
     4201 ggcggcgcag cttcccgaca tgccgctgga ggagctgggc cagcaggtgg actgtgaccg
     4261 catgcggggg ctgatgtgcg ccaacagcca acagagtccc ccgctctgtc acgactacga
     4321 gctgcgggtt ctctgctgcg aatacgtgcc ctgtggcccc tccccggccc caggcaccag
     4381 ccctcagccc tccctcagtg ccagcacgga gcctgctgtg cctaccccaa cccagaccac
     4441 agcaaccgaa aagaccaccc tatgggtgac cccgagcatc cggtcgacgg cggccctcac
     4501 ctcgcagact gggtccagct caggccccgt gacggtcacc ccctcggccc caggtaccac
     4561 cacctgccag ccccggtgtc agtggacaga gtggtttgat gaggactacc ccaagtctga
     4621 acaacttgga ggggacgttg agtcctacga taagatcagg gccgctggag ggcacttatg
     4681 ccagcagcct aaggacatag agtgccaggc cgagagcttc cccaactgga ccctggcaca
     4741 ggtggggcag aaggtgcact gtgacgtcca cttcggcctg gtgtgcagga actgggagca
     4801 ggagggcgtc ttcaagatgt gctacaacta caggatccgg gtcctctgct gcagtgacga
     4861 ccactgcagg ggacgtgcca caaccccgcc accgaccaca gagctggaga cggccaccac
     4921 caccaccacc caggccctgt tctcaacgcc gcagcctacg agtagcccgg ggctgaccag
     4981 ggctcccccg gccagcacca cagcagtccc caccctctca gaaggactga catcccccag
     5041 atacacaagc acccttggta cagccaccac gggaggcccc acgacgcctg caggctccac
     5101 agaacccact gtcccagggg tggccacatc cacccttcca acacgctcag cccttccagg
     5161 gacgacgggg agcttgggca catggcgccc ctcacagcca cccacgctgg ccccaacaac
     5221 aatggcaacc tccagagctc gcccgacagg cacagccagc accgcttcca aagagccgct
     5281 gaccacgagc ctggcgccaa cactcacgag cgagctgtcc acctctcagg ccgagaccag
     5341 cacgcccagg acagagacga caatgagccc cttgactaac accaccacca gccagggcac
     5401 gacccgctgt caaccgaagt gtgagtggac agagtggttt gacgtggact tcccaacctc
     5461 aggggttgca ggcggggaca tggaaacttt tgaaaacatc agggctgctg ggggcaagat
     5521 gtgctgggca ccaaagagca tagagtgccg ggcggagaac taccccgagg taagcatcga
     5581 ccaggtcggg caggtgctga cctgcagcct ggagacgggg ctgacctgca agaacgaaga
     5641 ccagacaggc aggttcaaca tgtgcttcaa ctacaacgtg cgtgtgcttt gctgtgacga
     5701 ctacagccac tgccccagta ccccagccac cagctccacg gccacgccct cctcaactcc
     5761 ggggacgacc tggatcctca caaagccgac cacaacagcc actacgactg cgtccactgg
     5821 atccacggcc accccgacct ccaccctgag aacagctccc cctcccaaag tgctgaccac
     5881 cacggccacc acacccacag tcaccagctc caaagccact ccctcctcca gtccagggac
     5941 tgcaaccgcc cttccagcac tgagaagcac agccaccaca cccacagcta ccagcgttac
     6001 acccatcccc tcttcctccc tgggcaccac ctggacccgc ctatcacaga ccaccacacc
     6061 cacggccacc atgtccacag ccacaccctc ctccactcca gagactgccc acacctccac
     6121 agtgcttacc gccacggcca ccacaactgg ggccaccggc tctgtggcca ccccctcctc
     6181 caccccagga acagctcaca ctaccaaagt gccaactacc acaaccacgg gcttcacagc
     6241 caccccctcc tccagcccag ggacggcact cacgcctcca gtgtggatca gcacaaccac
     6301 cacacccaca accagaggct ccacggtgac cccctcctcc atcccgggga ccacccacac
     6361 cgccacagtg ctgaccacca ccaccacaac tgtggccact ggttctatgg caacaccctc
     6421 ctctagcaca cagaccagtg gtactccccc atcactgacc accacggcca ctacgatcac
     6481 ggccaccggc tccaccacca acccctcctc aactcctggg acaactccca tccccccagt
     6541 gctgaccacc accgccacca cacctgcagc caccagcaac acagtgactc cctcctctgc
     6601 cctagggacc acccacacac ccccagtgcc gaacaccatg gccaccacac acgggcgatc
     6661 cctgcccccc agcagtcccc acacggtgcg cacagcctgg acttcggcca cctcgggcat
     6721 cttgggcacc acccacatca cagagccttc cacggtgact tcccacaccc tagcagcaac
     6781 caccggtacc acccagcact cgactccagc cctttccagc cctcacccta gcagcagaac
     6841 caccgagtca cccccttctc cagggacgac caccccgggc cacaccacgg ccacctccag
     6901 gaccacagcc acggccacac ccagcaagac ccgcacctcg accctgctgc ccagcagccc
     6961 cacatcggcc cccataacca cggtggtgac catgggctgt gagccccagt gtgcctggtc
     7021 agagtggctg gactacagct accccatgcc ggggccctct ggcggggact ttgacaccta
     7081 ctccaacatc cgtgcggccg gaggggccgt ctgtgagcag cccctgggcc tcgagtgccg
     7141 tgcccaggcc cagcctggtg tccccctgcg ggagttgggc caggtcgtgg aatgcagcct
     7201 ggactttggc ctggtctgca ggaaccgtga gcaggtgggg aagttcaaga tgtgcttcaa
     7261 ctatgaaatc cgtgtgttct gctgcaacta cggccactgc cccagcaccc cggccaccag
     7321 ctctacggcc atgccctcct ccactccggg gacgacctgg atcctcacag agctgaccac
     7381 aacagccact acgactgagt ccactggatc cacggccacc ccgtcctcca ccccagggac
     7441 cacctggatc ctcacagagc cgagcactac agccaccgtg acggtgccca ccggatccac
     7501 ggccaccgcc tcctccaccc aggcaactgc tggcacccca catgtgagca ccacggccac
     7561 gacacccaca gtcaccagct ccaaagccac tcccttctcc agtccaggga ctgcaaccgc
     7621 ccttccagca ctgagaagca cagccaccac acccacagct accagcttta cagccatccc
     7681 ctcctcctcc ctgggcacca cctggacccg cctatcacag accaccacac ccacggccac
     7741 catgtccaca gccacaccct cctccactcc agagactgtc cacacctcca cagtgcttac
     7801 caccacggcc accacaaccg gggccaccgg ctctgtggcc accccctcct ccaccccagg
     7861 aacagctcac actaccaaag tgctgactac cacaaccacg ggcttcacag ccaccccctc
     7921 ctccagccca gggacggcac gcacgcttcc agtgtggatc agcacaacca ccacacccac
     7981 aaccagaggt tccacggtga ccccctcctc catcccgggg accacccaca cccccacagt
     8041 gctgaccacc accaccacaa ctgtggccac tggttctatg gcaacaccct cctctagcac
     8101 acagaccagt ggtactcccc catcactgac caccacggcc actacgatca cggccaccgg
     8161 ctccaccacc aacccctcct caactccagg gacaacacct atccccccag tgctgaccac
     8221 caccgccacc acacctgcag ccaccagcag cacagtgact ccctcctctg ccctagggac
     8281 cacccacaca cccccagtgc cgaacaccac ggccaccaca cacgggcgat ccctgtcccc
     8341 cagcagtccc cacacggtgc gcacagcctg gacttcggcc acctcaggca ccttgggcac
     8401 cacccacatc acagagcctt ccacggggac ttcccacacc ccagcagcaa ccaccggtac
     8461 cacccagcac tcgactccag ccctgtccag ccctcaccct agcagcagga ccaccgagtc
     8521 acccccttct ccagggacga ccaccccggg ccacaccagg gccacctcca ggaccacggc
     8581 cacggccaca cccagcaaga cccgcacctc gaccctgctg cccagcagcc ccacatcggc
     8641 cccaataacc acggtggtga ccatgggctg tgagccccag tgtgcctggt cagagtggct
     8701 ggactacagc taccccatgc cggggccctc tggcggggac tttgacacct actccaacat
     8761 ccgtgcggcc ggaggggccg tctgtgagca gcccctgggc ctcgagtgcc gtgcccaggc
     8821 ccagcctggt gtccccctgc gggagttggg ccaggtcgtg gaatgcagcc tggactttgg
     8881 cctggtctgc aggaaccgtg agcaggtggg gaagttcaag atgtgcttca actatgaaat
     8941 ccgtgtgttc tgctgcaact acggccactg ccccagcacc ccggccacca gctctacggc
     9001 cacgccctcc tccactccag ggacgacctg gatcctcaca gagcagacca cagcagccac
     9061 tacgaccgca accactggat ccacggccat cccgtcctcc accccgggaa cagctccccc
     9121 tcccaaagtg ctgaccagca cggccaccac acccacagcc accagttcca aagccacttc
     9181 ctcctccagt ccaaggactg caaccaccct tccagtgctg acaagcacag ccaccaaatc
     9241 cacagctacc agctttacac ccatcccctc cttcaccctt gggaccaccg ggaccctccc
     9301 agaacagacc accacaccca tggccaccat gtccacaatc cacccctcct ccactccgga
     9361 gaccacccac acctccacag tgctgaccac gaaggccacc acgacaaggg ccaccagttc
     9421 catgtccacc ccctcctcca ctccggggac gacctggatc ctcacagagc tgaccacagc
     9481 agccactaca actgcagcca ctggccccac ggccaccccg tcctccaccc cagggaccac
     9541 ctggatcctc acagagccca gcactacagc caccgtgacg gtgcccaccg gatccacggc
     9601 caccgcctcc tccacccggg caactgctgg caccctcaaa gtgctgacca gcacggccac
     9661 cacacccaca gtcatcagct ccagagccac tccctcctcc agtccaggga ctgcaaccgc
     9721 ccttccagca ctgagaagca cagccaccac acccacagct accagcgtta cagccatccc
     9781 ctcttcctcc ctgggcaccg cctggacccg cctatcacag accaccacac ccacggccac
     9841 catgtccaca gccacaccct cctctactcc agagactgtc cacacctcca cagtgcttac
     9901 caccacgacc accacaacca gggccaccgg ctctgtggcc accccctcct ccaccccagg
     9961 aacagctcac actaccaaag tgccgactac cacaaccacg ggcttcacag ccaccccctc
    10021 ctccagccca gggacggcac tcacgcctcc agtgtggatc agcacaacca ccacacccac
    10081 aaccagaggc tccacggtga ccccctcctc catcccgggg accacccaca ccgccacagt
    10141 gctgaccacc accaccacaa ctgtggccac tggttctatg gcaacaccct cctctagcac
    10201 acagaccagt ggtactcccc catcactgac caccacggcc actacgatca cagccaccgg
    10261 ctccaccacc aacccctcct caactccagg gacaactccc atccccccag tgctgaccac
    10321 caccgccacc acacctgcag ccaccagcag cacagtgact ccctcctctg ccctagggac
    10381 cacccacaca cccccagtgc cgaacaccac ggccaccaca cacgggcggt ccctgccccc
    10441 cagcagtccc cacacggtgc gcacagcctg gacttcggcc acctcgggca tcttgggcac
    10501 cacccacatc acagagcctt ccacggtgac ttcccacacc ccagcagcaa ccaccagtac
    10561 cacccagcac tcgactccag ccctgtccag ccctcaccct agcagcagga ccaccgagtc
    10621 acccccttct ccagggacga ccaccccggg ccacaccagg ggcacctcca ggaccacagc
    10681 cacagccaca cccagcaaga cccgcacctc gaccctgctg cccagcagcc ccacatcggc
    10741 ccccataacc acggtggtga ccacgggctg tgagccccag tgtgcctggt cagagtggct
    10801 ggactacagc taccccatgc cggggccctc tggcggggac tttgacacct actccaacat
    10861 ccgtgcggcc ggaggggcag tctgtgagca gcccctgggc ctcgagtgcc gtgcccaggc
    10921 ccagcctggt gtccccctgc gggagttggg ccaggtcgtg gaatgcagcc tggactttgg
    10981 cctggtctgc aggaaccgtg agcaggtggg gaagttcaag atgtgcttca actatgaaat
    11041 ccgtgtgttc tgctgcaact acggccactg ccccagcacc ccggccacca gctctacggc
    11101 cacgccctcc tcaactccgg ggacgacctg gatcctcaca aagctgacca caacagccac
    11161 tacgactgag tccactggat ccacggccac cccgtcctcc accccaggga ccacctggat
    11221 cctcacagag ccgagcacta cagccaccgt gacggtgccc accggatcca cggccaccgc
    11281 ctcctccacc caggcaactg ctggcacccc acatgtgagc accacggcca cgacacccac
    11341 agtcaccagc tccaaagcca ctcccttctc cagtccaggg actgcaaccg cccttccagc
    11401 actgagaagc acagccacca cacccacagc taccagcttt acagccatcc cctcctcctc
    11461 cctgggcacc acctggaccc gcctatcaca gaccaccaca cccacggcca ccatgtccac
    11521 agccacaccc tcctccactc cagagactgc ccacacctcc acagtgctta ccaccacggc
    11581 caccacaacc agggccaccg gctctgtggc caccccctct tccaccccag gaacagctca
    11641 cactaccaaa gtgccgacta ccacaaccac gggcttcaca gtcaccccct cctccagccc
    11701 agggacggca cgcacgcctc cagtgtggat cagcacaacc accacaccca caaccagtgg
    11761 ctccacggtg accccctcct ccgtcccggg gaccacccac acccccacag tgctgaccac
    11821 caccaccaca actgtggcca ctggttctat ggcaacaccc tcctctagca cacagaccag
    11881 tggtactccc ccatcactga tcaccacggc cactacgatc acggccaccg gctccaccac
    11941 caacccctcc tcaactccag ggacaacacc tatcccccca gtgctgacca ccaccgccac
    12001 cacacctgca gccaccagca gcacagtgac tccctcctct gccctaggga ccacccacac
    12061 acccccagtg ccgaacacca cggccaccac acacgggcga tccctgtccc ccagcagtcc
    12121 ccacacggtg cgcacagcct ggacttcggc cacctcaggc accttgggca ccacccacat
    12181 cacagagcct tccacgggga cttcccacac cccagcagca accaccggta ccacccagca
    12241 ctcgactcca gccctgtcca gccctcaccc tagcagcagg accaccgagt cacccccttc
    12301 cccagggacg accaccccgg gccacaccac ggccacctcc aggaccacgg ccacggccac
    12361 acccagcaag acccgcacct cgaccctgct gcccagcagc cccacatcgg cccccataac
    12421 cacggtggtg accacgggct gtgagcccca gtgtgcctgg tcagagtggc tggactacag
    12481 ctaccccatg ccggggccct ctggcgggga ctttgacacc tactccaaca tccgtgcggc
    12541 cggaggggcc gtctgtgagc agcccctggg cctcgagtgc cgtgcccagg cccagcctgg
    12601 tgtccccctg ggggagttgg gccaggtcgt ggaatgcagc ctggactttg gcctggtctg
    12661 caggaaccgt gagcaggtgg ggaagttcaa gatgtgcttc aactatgaaa tccgtgtgtt
    12721 ctgctgcaac tacggccact gccccagcac cccggccacc agctctacgg ccatgccctc
    12781 ctccactccg gggacgacct ggatcctcac agagctgacc acaacagcca ctacgactgc
    12841 atccactgga tccacggcca ccccgtcctc caccccggga acagctcccc ctcccaaagt
    12901 gctgaccagc ccggccacca cacccacagc caccagttcc aaagccactt cctcctccag
    12961 tccaaggact gcaaccaccc ttccagtgct gacaagcaca gccaccaaat ccacagctac
    13021 cagcgttaca cccatcccct cctccaccct tgggaccacc gggaccctcc cagaacagac
    13081 caccacaccc gtggccacca tgtccacaat ccacccctcc tccactccgg agaccaccca
    13141 cacctccaca gtgctgacca cgaaggccac cacgacaagg gccaccagtt ccacgtccac
    13201 cccctcctcc actccgggga cgacctggat cctcacagag ctgaccacag cagccactac
    13261 aactgcagcc actggcccca cggccacccc gtcctccacc ccagggacca cctggatcct
    13321 cacagagctg accacaacag ccactacgac tgcgtccact ggatccacgg ccaccccgtc
    13381 ctccacccca gggaccacct ggatcctcac agagccgagc actacagcca ccgtgacggt
    13441 gcccaccgga tccacggcca ccgcctcctc cacccaggca actgctggca ccccacatgt
    13501 gagcaccacg gccacgacac ccacagtcac cagctccaaa gccactccct cctccagtcc
    13561 agggactgca actgcccttc cagcactgag aagcacagcc accacaccca cagctaccag
    13621 ctttacagcc atcccctcct cctccctggg caccacctgg acccgcctat cacagaccac
    13681 cacacccacg gccaccatgt ccacagccac accctcctcc actccagaga ctgtccacac
    13741 ctccacagtg cttaccgcca cggccaccac aaccggggcc accggctctg tggccacccc
    13801 ctcctccacc ccaggaacag ctcacactac caaagtgccg actaccacaa ccacgggctt
    13861 cacagccacc ccctcctcca gcccagggac ggcactcacg cctccagtgt ggatcagcac
    13921 aaccaccaca cccacaacca ccacacccac aaccagtggc tccacggtga ccccctcctc
    13981 catcccgggg accacccaca ccgccagagt gctgaccacc accaccacaa ctgtggccac
    14041 tggttctatg gcaacaccct cctctagcac acagaccagt ggtactcccc catcactgac
    14101 caccacggcc actacgatca cggccaccgg ctccaccacc aacccctcct caactccagg
    14161 gacaacaccc atcaccccag tgctgaccag cacggccacc acacccgcag ccaccagctc
    14221 caaagccact tcctcctcca gtccaaggac tgcaaccacc cttccagtgc tgacaagcac
    14281 agccacaaaa tccacagcta ccagctttac acccatcccc tcctccaccc tgtggaccac
    14341 gtggaccgtc ccagcacaga ccaccacacc catgtccacc atgtccacaa tccacacctc
    14401 ctctactcca gagaccaccc acacctccac agtgctgacc accacagcca ccatgacaag
    14461 ggccaccaat tccacggcca caccctcctc cactctgggg acgacccgga tcctcactga
    14521 gctgaccaca acagccacta caactgcagc cactggatcc acggccaccc tgtcctccac
    14581 cccagggacc acctggatcc tcacagagcc gagcactata gccaccgtga tggtgcccac
    14641 cggttccacg gccaccgcct cctccactct gggaacagct cacaccccca aagtggtgac
    14701 caccatggcc actatgccca cagccactgc ctccacggtt cccagctcgt ccaccgtggg
    14761 gaccacccgc acccctgcag tgctccccag cagcctgcca accttcagcg tgtccactgt
    14821 gtcctcctca gtcctcacca ccctgagacc cactggcttc cccagctccc acttctctac
    14881 tccctgcttc tgcagggcat ttggacagtt tttctcgccc ggggaagtca tctacaataa
    14941 gaccgaccga gccggctgcc atttctacgc agtgtgcaat cagcactgtg acattgaccg
    15001 cttccagggc gcctgtccca cctccccacc gccagtgtcc tccgccccgc tgtcctcgcc
    15061 ctcccctgcc cctggctgtg acaatgccat ccctctccgg caggtgaatg agacctggac
    15121 cctggagaac tgcacggtgg ccaggtgcgt gggtgacaac cgtgtcgtcc tgctggaccc
    15181 aaagcctgtg gccaacgtca cctgcgtgaa caagcacctg cccatcaaag tgtcggaccc
    15241 gagccagccc tgtgacttcc actatgagtg cgagtgcatc tgcagcatgt ggggcggctc
    15301 ccactattcc acctttgacg gcacctctta caccttccgg ggcaactgca cctatgtcct
    15361 catgagagag atccatgcac gctttgggaa tctcagcctc tacctggaca accactactg
    15421 cacggcctct gccactgccg ctgccgcccg ctgcccccgc gccctcagca tccactacaa
    15481 gtccatggat atcgtcctca ctgtcaccat ggtgcatggg aaggaggagg gcctgatcct
    15541 gtttgaccaa attccggtga gcagcggttt cagcaagaac ggcgtgcttg tgtctgtgct
    15601 ggggaccacc accatgcgtg tggacattcc tgccctgggc gtgagcgtca ccttcaatgg
    15661 ccaagtcttc caggcccggc tgccctacag cctcttccac aacaacaccg agggccagtg
    15721 cggcacctgc accaacaacc agagggacga ctgtctccag cgggacggaa ccactgccgc
    15781 cagttgcaag gacatggcca agacgtggct ggtccccgac agcagaaagg atggctgctg
    15841 ggccccgact ggcacacccc ccactgccag ccccgcagcc ccggtgtcta gcacacccac
    15901 ccccacccca tgcccaccac agccgctctg tgatctgatg ctgagccagg tctttgctga
    15961 gtgccacaac cttgtgcccc cgggcccatt cttcaacgcc tgcatcagcg accactgcag
    16021 gggccgcctt gaggtgccct gccagagcct ggaggcttac gcagagctct gccgcgcccg
    16081 gggagtgtgc agtgactggc gaggtgcaac cggtggcctg tgcgacctca cctgcccacc
    16141 caccaaagtg tacaagccat gcggccccat acagcctgcc acctgcaact ctaggaacca
    16201 gagcccacag ctggagggga tggcggaggg ctgcttctgc cctgaggacc agatcctctt
    16261 caacgcacac atgggcatct gcgtgcaggc ctgcccctgc gtgggacccg atgggtttcc
    16321 taaatttccc ggggagcggt gggtcagcaa ctgccagtcc tgcgtgtgtg acgagggttc
    16381 agtgtcggtg cagtgcaagc ccctgccctg tgacgcccag ggtcagcccc cgccgtgcaa
    16441 ccgtcccggc ttcgtaaccg tgaccaggcc ccgggccgag aacccctgct gccccgagac
    16501 ggtgtgcgtg tgcaacacaa ccacctgccc ccagagcctg cctgtgtgcc cgccagggca
    16561 ggagtccatc tgcacccagg aggagggcga ctgctgtccc accttccgct gcagacctca
    16621 gctgtgttcg tacaatggca ccttctacgg ggttggtgca accttcccag gcgcccttcc
    16681 ctgccacatg tgtacctgcc tctctgggga cacccaggac ccaacggtgc aatgtcagga
    16741 ggatgcctgc aacaatacta cctgtcccca gggctttgag tacaagagag tggccgggca
    16801 gtgctgtggg gagtgcgtcc agaccgcctg cctcacgccc gatggccagc cagtccagct
    16861 gaatgaaacc tgggtcaaca gccatgtgga caactgcacc gtgtacctct gtgaggctga
    16921 gggtggagtc catttgctga ccccacagcc tgcatcctgc ccagatgtgt ccagctgcag
    16981 ggggagcctc aggaaaaccg gctgctgcta ctcctgtgag gaggactcct gtcaagtccg
    17041 catcaacacg accatcctgt ggcaccaggg ctgcgagacc gaggtcaaca tcaccttctg
    17101 cgagggctcc tgccccggag cgtccaagta ctcagcagag gcccaggcca tgcagcacca
    17161 gtgcacctgc tgccaggaga ggcgggtcca cgaggagacg gtgcccttgc actgtcctaa
    17221 cggctcagcc atcctgcaca cctacaccca cgtggatgag tgtggctgca cgcccttctg
    17281 tgtccctgcg cccatggctc ccccacacac ccgtggcttc ccggcccagg aggccactgc
    17341 tgtctgagaa cgttctgcct ccatccccat gctctgtcca cctggagcca ggatgtgcat
    17401 tgtctgatca tgaaaacctt gggcctcctc tgcggagccc cccggcctgt gtgtggcacc
    17461 ccgcgctccg tgctcctgct gcccaccccg tgggtgaaac cggccccaga agggtgaggg
    17521 gccagcagga cccctttcgg gagggcgcca ctcaggagtc ctaccctggg agagcctgtg
    17581 gcccaccttg gccttgcccc tccctgatgt cactgggacg ccctggaaca aactaagcat
    17641 gtgcgggcct atgtgtccct gccacggccg gagcgcccgc gcagcacgga ttccagctgg
    17701 ccacgtccgg ccgctggggc agacaggctg gtccaggcaa ggccagctgc tgccaggaag
    17761 ctgcgacagg caaggcggcc gcctgtccat gcctgctgca gggtaactca gggctgaggt
    17821 cgcaacggcc aggtcagaga ggggtcagca tcccaaagcc ccctctgctc aacccagccc
    17881 agttttgcaa ataaaccctg agcattgagt a
//
