LOCUS       NM_018406              16756 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens mucin 4, cell surface associated (MUC4), transcript
            variant 1, mRNA.
ACCESSION   NM_018406
VERSION     NM_018406.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16756)
  AUTHORS   Yamada,Y., Terada,Y., Yamanaka,R., Enoyoshi,M. and Ito,K.
  TITLE     TRPV4 activation in human corneal epithelial cells promotes
            membrane mucin production
  JOURNAL   Biochem Biophys Res Commun 731, 150402 (2024)
   PUBMED   39024979
  REMARK    GeneRIF: TRPV4 activation in human corneal epithelial cells
            promotes membrane mucin production.
REFERENCE   2  (bases 1 to 16756)
  AUTHORS   Zeng,H., Yang,X., Liao,K., Zuo,X., Liang,L., He,D., Ju,R., Wang,B.
            and Yuan,J.
  TITLE     Circadian disruption reduces MUC4 expression via the clock molecule
            BMAL1 during dry eye development
  JOURNAL   Exp Mol Med 56 (7), 1655-1666 (2024)
   PUBMED   38956298
  REMARK    GeneRIF: Circadian disruption reduces MUC4 expression via the clock
            molecule BMAL1 during dry eye development.
REFERENCE   3  (bases 1 to 16756)
  AUTHORS   Li,S., Liu,Z., Chen,Q., Chen,Y. and Ji,S.
  TITLE     A novel fatty acid metabolism-related signature identifies MUC4 as
            a novel therapy target for esophageal squamous cell carcinoma
  JOURNAL   Sci Rep 14 (1), 12476 (2024)
   PUBMED   38816411
  REMARK    GeneRIF: A novel fatty acid metabolism-related signature identifies
            MUC4 as a novel therapy target for esophageal squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 16756)
  AUTHORS   Chen,Y.Y., Liu,H., Li,L.Y., Li,L.J., Wang,H.Q., Song,J., Wu,Y.H.,
            Guan,J., Xing,L.M., Wang,G.J., Qu,W., Liu,H., Wang,X.M., Shao,Z.H.
            and Fu,R.
  TITLE     [Role and clinical significance of MUC4 gene mutations in
            thrombotic events in patients with classic paroxysmal nocturnal
            hemoglobinuria]
  JOURNAL   Zhonghua Xue Ye Xue Za Zhi 44 (7), 561-566 (2023)
   PUBMED   37749036
  REMARK    GeneRIF: [Role and clinical significance of MUC4 gene mutations in
            thrombotic events in patients with classic paroxysmal nocturnal
            hemoglobinuria].
REFERENCE   5  (bases 1 to 16756)
  AUTHORS   Escande,F., Lemaitre,L., Moniaux,N., Batra,S.K., Aubert,J.P. and
            Buisine,M.P.
  TITLE     Genomic organization of MUC4 mucin gene. Towards the
            characterization of splice variants
  JOURNAL   Eur J Biochem 269 (15), 3637-3644 (2002)
   PUBMED   12153560
  REMARK    GeneRIF: the genomic structure of the 3' region of the human MUC4
            gene was determined. Our results show that it spans approximately
            30.8 kb of genomic DNA and is composed of 24 exons, including one
            alternative exon
REFERENCE   6  (bases 1 to 16756)
  AUTHORS   Moniaux,N., Escande,F., Batra,S.K., Porchet,N., Laine,A. and
            Aubert,J.P.
  TITLE     Alternative splicing generates a family of putative secreted and
            membrane-associated MUC4 mucins
  JOURNAL   Eur J Biochem 267 (14), 4536-4544 (2000)
   PUBMED   10880978
REFERENCE   7  (bases 1 to 16756)
  AUTHORS   Moniaux,N., Nollet,S., Porchet,N., Degand,P., Laine,A. and
            Aubert,J.P.
  TITLE     Complete sequence of the human mucin MUC4: a putative cell
            membrane-associated mucin
  JOURNAL   Biochem J 338 (Pt 2) (Pt 2), 325-333 (1999)
   PUBMED   10024507
REFERENCE   8  (bases 1 to 16756)
  AUTHORS   Audie,J.P., Tetaert,D., Pigny,P., Buisine,M.P., Janin,A.,
            Aubert,J.P., Porchet,N. and Boersma,A.
  TITLE     Mucin gene expression in the human endocervix
  JOURNAL   Hum Reprod 10 (1), 98-102 (1995)
   PUBMED   7745080
REFERENCE   9  (bases 1 to 16756)
  AUTHORS   Gross,M.S., Guyonnet-Duperat,V., Porchet,N., Bernheim,A.,
            Aubert,J.P. and Nguyen,V.C.
  TITLE     Mucin 4 (MUC4) gene: regional assignment (3q29) and RFLP analysis
  JOURNAL   Ann Genet 35 (1), 21-26 (1992)
   PUBMED   1351710
REFERENCE   10 (bases 1 to 16756)
  AUTHORS   Porchet,N., Nguyen,V.C., Dufosse,J., Audie,J.P.,
            Guyonnet-Duperat,V., Gross,M.S., Denis,C., Degand,P., Bernheim,A.
            and Aubert,J.P.
  TITLE     Molecular cloning and chromosomal localization of a novel human
            tracheo-bronchial mucin cDNA containing tandemly repeated sequences
            of 48 base pairs
  JOURNAL   Biochem Biophys Res Commun 175 (2), 414-422 (1991)
   PUBMED   1673336
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC069513.28, AC233280.2 and
            AJ242550.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018406.6.
            
            Summary: The major constituents of mucus, the viscous secretion
            that covers epithelial surfaces such as those in the trachea,
            colon, and cervix, are highly glycosylated proteins called mucins.
            These glycoproteins play important roles in the protection of the
            epithelial cells and have been implicated in epithelial renewal and
            differentiation. This gene encodes an integral membrane
            glycoprotein found on the cell surface, although secreted isoforms
            may exist. At least two dozen transcript variants of this gene have
            been found, although for many of them the full-length transcript
            has not been determined or they are found only in tumor tissues.
            This gene contains a region in the coding sequence which has a
            variable number (>100) of 48 nt tandem repeats. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also called sv0, represents
            the reference genome allele and encodes isoform (a). Isoform a is
            thought to be a membrane-bound protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1966682, SAMEA1968189
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000463781.8/ ENSP00000417498.3
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               AC069513.28        15564-15757
            195-12902           AC233280.2         3239-15946
            12903-13055         AC233280.2         16281-16433
            13056-13189         AC233280.2         20431-20564
            13190-13354         AC233280.2         22920-23084
            13355-13510         AC233280.2         24365-24520
            13511-13641         AC233280.2         25584-25714
            13642-13730         AC233280.2         27985-28073
            13731-13910         AC233280.2         29287-29466
            13911-14036         AC233280.2         29614-29739
            14037-14156         AC233280.2         30572-30691
            14157-14365         AC233280.2         31095-31303
            14366-14456         AC233280.2         31791-31881
            14457-14624         AC233280.2         32482-32649
            14625-14726         AC233280.2         33151-33252
            14727-14960         AC233280.2         33619-33852
            14961-15098         AC233280.2         35475-35612
            15099-15280         AC233280.2         37408-37589
            15281-15440         AC233280.2         40364-40523
            15441-15620         AC233280.2         41506-41685
            15621-15694         AC233280.2         42290-42363
            15695-15759         AC233280.2         43465-43529
            15760-15983         AC233280.2         43624-43847
            15984-16146         AC233280.2         45672-45834
            16147-16611         AC233280.2         47356-47820
            16612-16756         AJ242550.1         3674-3818
FEATURES             Location/Qualifiers
     source          1..16756
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..16756
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /note="mucin 4, cell surface associated"
                     /db_xref="GeneID:4585"
                     /db_xref="HGNC:HGNC:7514"
                     /db_xref="MIM:158372"
     exon            1..194
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..16351
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mucin 4, tracheobronchial; mucin-4; testis
                     mucin; tracheobronchial mucin; ascites sialoglycoprotein;
                     pancreatic adenocarcinoma mucin"
                     /codon_start=1
                     /product="mucin-4 isoform a precursor"
                     /protein_id="NP_060876.5"
                     /db_xref="CCDS:CCDS54700.1"
                     /db_xref="GeneID:4585"
                     /db_xref="HGNC:HGNC:7514"
                     /db_xref="MIM:158372"
                     /translation="MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLITGSKTAAPV
                     TSTGSTTATLEGQSTAASSRTSNQDISASSQNHQTKSTETTSKAQTDTLTQMMTSTLF
                     SSPSVHNVMETAPPDEMTTSFPSSVTNTLMMTSKTITMTTSTDSTLGNTEETSTAGTE
                     SSTPVTSAVSITAGQEGQSRTTSWRTSIQDTSASSQNHWTRSTQTTRESQTSTLTHRT
                     TSTPSFSPSVHNVTGTVSQKTSPSGETATSSLCSVTNTSMMTSEKITVTTSTGSTLGN
                     PGETSSVPVTGSLMPVTSAALVTFDPEGQSPATFSRTSTQDTTAFSKNHQTQSVETTR
                     VSQINTLNTLTPVTTSTVLSSPSGFNPSGTVSQETFPSGETTTSSPSSVSNTFLVTSK
                     VFRMPTSRDSTLGNTEETSLSVSGTISAITSKVSTIWWSDTLSTALSPSSLPPKISTA
                     FHTQQSEGAETTGRPHERSSFSPGVSQEIFTLHETTTWPSSFSSKGHTTWSQTELPST
                     STGAATRLVTGNPSTGTAGTIPRVPSKVSAIGEPGEPTTYSSHSTTLPKTTGAGAQTQ
                     WTQETGTTGEALLSSPSYSVTQMIKTATSPSSSPMLDRHTSQQITTAPSTNHSTIHST
                     STSPQESPAVSQRGHTQAPQTTQESQTTRSVSPMTDTKTVTTPGSSFTASGHSPSEIV
                     PQDAPTISAATTFAPAPTGDGHTTQAPTTALQAAPSSHDATLGPSGGTSLSKTGALTL
                     ANSVVSTPGGPEGQWTSASASTSPDTAAAMTHTHQAESTEASGQTQTSEPASSGSRTT
                     SAGTATPSSSGASGTTPSGSEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASHGA
                     IPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTSPSASPQETAAISRMAQTQRTR
                     TSRGSDTISLASQATDTFSTVPPTPPSITSTGLTSPQTETHTLSPSGSGKTFTTALIS
                     NATPLPVTYASSASTGHTTPLHVTDASSVSTGHATPLPVTSPSSVSTGHTTPLPVTDT
                     SSESTGHVTPLPVTSFSSASTGDSTPLPVTDTSSASTGHVTPLPVTSLSSASTGDTTP
                     LPVTDTSSASTGHATSLPVTDTSSVSTGHTTPLPVTDTSSASTGHATSLPVTDTSSVS
                     TGHTTPLHVTDASSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVT
                     DTSSASTGHATPLPVTDASSVSTDHATSLPVTIPSAASTGHTTPLPVTDTSSASTGQA
                     TSLLVTDTSSVSTGDTTPLPVTSTSSASTGHVTPLHVTSPSSASTGHATPLPVTSLSS
                     ASTGDTMPLPVTSPSSASTGDTTPLPVTDASSVSTGHTTPLHVTDASSASTGQATPLP
                     VTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDTSSASTGHATPLPVTDASSVSTD
                     HATSLPVTIPSAASTGHTTPLPVTDTSSASTGQATSLLVTDTSSVSTGDTTPLPVTST
                     SSASTGHVTPLHVTSPSSASTGHATPLPVTSLSSASTGDTMPLPVTSPSSASTGDTTP
                     LPVTDASSVSTGHTTPLPVTSPSSASTGHTTPLPVTDTSSASKGDTTPLPVTSPSSAS
                     TGHTTPLPVTDTSSASTGDTTPLPVTNASSLSTGHATPLHVTSPSSASTGHATPLPVT
                     STSSASTGHATPLPVTGLSSATTDDTTRLPVTDVSSASTGQATPLPVTSLSSVSTGDT
                     TPLPVTSPSSASTGHASPLLVTDASSASTGQATPLPVTDTSSVSTAHATPLPVTGLSS
                     ASTDDTTRLPVTDVSSASTGQAIPLPVTSPSSASTGDTTPLPVTDASSASTGDTTSLP
                     VTIPSSASSGHTTSLPVTDASSVSTGHATSLLVTDASSVSTGDTTPLPVTDTNSASTG
                     DTTPLHVTDASSVSTGHATSLPVTSLSSASTGDTTPLPVTSPSSASSGHTTPLPVTDA
                     SSVPTGHATSLPVTDASSVSTGHATPLPVTDASSVSTGHATPLPVTDTSSVSTGQATP
                     LPVTSLSSASTGDTTPLPVTDTSSASTGQDTPLPVTSLSSVSTGDTTPLPVTNPSSAS
                     TGHATPLLVTDASSISTGHATSLLVTDASSVSTGHATALHDTDASSLSTGDTTPLPVT
                     SPSSTSTGDTTPLPVTETSSVSTGHATSLPVTDTSSASTGHATSLPVTDTSSASTGHA
                     TPLPVTDTSSASTGQATPLPVTSPSSASTGHAIPLLVTDTSSASTGQATPLPVTSLSS
                     ASTGDTTPLPVTDASSVSTGHATSLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLH
                     VTDASSASTGHATPLPVTSLSSASTGDTTPLPVTSPSSASTGHATPLHVTDASSVSTG
                     DTTPLPVTSSSSASSGHTTPLPVTDASSASTGDTTPLPVTDTSSASTGHATHLPVTGL
                     SSASTGDTTRLPVTNVSSASTGHATPLPVTSTSSASTGDTTPLPGTDTSSVSTGHTTP
                     LLVTDASSVSTGDTTRLPVTSPSSASTGHTTPLPVTDTPSASTGDTTPLPVTNASSLS
                     TRHATSLHVTSPSSASTGHATSLPVTDTSAASTGHATPLPVTSTSSASTGDTTPLPVT
                     DTYSASTGQATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATPLLVTDASSASTGQA
                     TPLPVTSLSSVSTGDTTPLPVTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSS
                     AYTGDTTSLPVTDTSSSSTGDTTPLLVTETSSVSTGDTTPLPVTDTSSASTGHATPLP
                     VTNTSSVSTGHATPLHVTSPSSASTGHTTPLPVTDASSVSTGHATSLPVTDASSVFTG
                     HATSLPVTIPSSASSGHTTPLPVTDASSVSTGHATSLPVTDASSVSTGHATPLPVTDA
                     SSVSTGHATPLPLTSLSSVSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTP
                     LPVTDTSSASTGHATSLPVTDTSSASTGHATPLPDTDTSSASTGHATLLPVTDTSSAS
                     IGHATSLPVTDTSSISTGHATPLHVTSPSSASTGHATPLPVTDTSSASTGHANPLHVT
                     SPSSASTGHATPLPVTDTSSASTGHATPLPVTSLSSVSTGDTTPLPVTSPSSASTGHT
                     TPLPVTDTSSASTGQATALPVTSTSSASTGDTTPLPVTDTSSASTGQATPLPVTSLSS
                     VSTGDTTPLPVTSPSSASTGHATPLLVTDASSASTGQATPLPVTSLSSVSTGDTTPLP
                     VTSPSSASTGHATSLPVTDTSSASTGDTTSLPVTDTSSAYTGDTTSLPVTDTSSSSTG
                     DTTPLLVTETSSVSTGHATPLLVTDASSASTGHATPLHVTSPSSASTGDTTPVPVTDT
                     SSVSTGHATPLPVTGLSSASTGDTTRLPVTDISSASTGQATPLPVTNTSSVSTGDTMP
                     LPVTSPSSASTGHATPLPVTSTSSASTGHATPVPVTSTSSASTGHTTPLPVTDTSSAS
                     TGDTTPLPVTSPSSASTGHTTPLHVTIPSSASTGDTSTLPVTGASSASTGHATPLPVT
                     DTSSVSTGHATPLPVTSLSSVSTGDTTPLPVTDASSASTGQATPLPVTSLSSVSTGDT
                     TPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPLPVTSLSS
                     VSTGDTTPLLVTDASSVSTGHATPLPVTDTSSASTGDTTRLPVTDTSSASTGQATPLP
                     VTIPSSSSSGHTTPLPVTSTSSVSTGHVTPLHVTSPSSASTGHVTPLPVTSTSSASTG
                     HATPLLVTDASSVSTGHATPLPVTDASSASTGDTTPLPVTDTSSASTGQATPLPVTSL
                     SSVSTGDTTPLPVTDASSASTGHATPLPVTIPSSVSTGDTMPLPVTSPSSASTGHATP
                     LPVTGLSSASTGDTTPLPVTDTSSASTRHATPLPVTDTSSASTDDTTRLPVTDVSSAS
                     TGHATPLPVTSTSSASTGDTTPLPVTDTSSVSTGHATSLPVTSRSSASTGHATPLPVT
                     DTSSVSTGHATPLPVTSTSSVSTGHATPLPVTSPSSASTGHATPVPVTSTSSASTGDT
                     TPLPVTNASSLSTGHATPLHVTSPSSASRGDTSTLPVTDASSASTGHATPLPLTSLSS
                     VSTGDTTPLPVTDTSSASTGQATPLPVTSLSSVSTGDTTPLPVTIPSSASSGHTTSLP
                     VTDASSVSTGHGTPLPVTSTSSASTGDTTPLPVTDTSSASTGHATPLPVTDTSSASTG
                     HATPLPVTSLSSVSTGHATPLAVSSATSASTVSSDSPLKMETPGMTTPSLKTDGGRRT
                     ATSPPPTTSQTIISTIPSTAMHTRSTAAPIPILPERGVSLFPYGAGAGDLEFVRRTVD
                     FTSPLFKPATGFPLGSSLRDSLYFTDNGQIIFPESDYQIFSYPNPLPTGFTGRDPVAL
                     VAPFWDDADFSTGRGTTFYQEYETFYGEHSLLVQQAESWIRKMTNNGGYKARWALKVT
                     WVNAHAYPAQWTLGSNTYQAILSTDGSRSYALFLYQSGGMQWDVAQRSGNPVLMGFSS
                     GDGYFENSPLMSQPVWERYRPDRFLNSNSGLQGLQFYRLHREERPNYRLECLQWLKSQ
                     PRWPSWGWNQVSCPCSWQQGRRDLRFQPVSIGRWGLGSRQLCSFTSWRGGVCCSYGPW
                     GEFREGWHVQRPWQLAQELEPQSWCCRWNDKPYLCALYQQRRPHVGCATYRPPQPAWM
                     FGDPHITTLDGVSYTFNGLGDFLLVGAQDGNSSFLLQGRTAQTGSAQATNFIAFAAQY
                     RSSSLGPVTVQWLLEPHDAIRVLLDNQTVTFQPDHEDGGGQETFNATGVLLSRNGSEV
                     SASFDGWATVSVIALSNILHASASLPPEYQNRTEGLLGVWNNNPEDDFRMPNGSTIPP
                     GSPEEMLFHFGMTWQINGTGLLGKRNDQLPSNFTPVFYSQLQKNSSWAEHLISNCDGD
                     SSCIYDTLALRNASIGLHTREVSKNYEQANATLNQYPPSINGGRVIEAYKGQTTLIQY
                     TSNAEDANFTLRDSCTDLELFENGTLLWTPKSLEPFTLEILARSAKIGLASALQPRTV
                     VCHCNAESQCLYNQTSRVGNSSLEVAGCKCDGGTFGRYCEGSEDACEEPCFPSVHCVP
                     GKGCEACPPNLTGDGRHCAALGSSFLCQNQSCPVNYCYNQGHCYISQTLGCQPMCTCP
                     PAFTDSRCFLAGNNFSPTVNLELPLRVIQLLLSEEENASMAEVNASVAYRLGTLDMRA
                     FLRNSQVERIDSAAPASGSPIQHWMVISEFQYRPRGPVIDFLNNQLLAAVVEAFLYHV
                     PRRSEEPRNDVVFQPISGEDVRDVTALNVSTLKAYFRCDGYKGYDLVYSPQSGFTCVS
                     PCSRGYCDHGGQCQHLPSGPRCSCVSFSIYTAWGEHCEHLSMKLDAFFGIFFGALGGL
                     LLLGVGTFVVLRFWGCSGARFSYFLNSAEALP"
     exon            195..12902
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            12903..13055
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13056..13189
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13190..13354
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13355..13510
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13511..13641
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13642..13730
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13731..13910
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            13911..14036
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14037..14156
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14157..14365
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14366..14456
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14457..14624
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14625..14726
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14727..14960
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            14961..15098
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15099..15280
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15281..15440
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15441..15620
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15621..15694
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15695..15759
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15760..15983
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            15984..16146
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     exon            16147..16756
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      16729..16734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /note="hexamer: AATAAA"
     polyA_site      16756
                     /gene="MUC4"
                     /gene_synonym="ASGP; HSA276359; MUC-4"
                     /note="major polyA site"
ORIGIN      
        1 gcacttggtt cgggccagcc gcctgagggg acgggctcac gtctgctcct cacactgcag
       61 ctgctgggcc gtggagcttc cccagggagc cagggggact tttgccgcag ccatgaaggg
      121 ggcacgctgg aggagggtcc cctgggtgtc cctgagctgc ctgtgtctct gcctccttcc
      181 gcatgtggtc ccaggaacca cagaggacac attaataact ggaagtaaaa ctgctgcccc
      241 agtcacctca acaggctcaa caacagcgac actagaggga caatcaactg cagcttcttc
      301 aaggacctct aatcaggaca tatcagcttc atctcagaac caccagacta agagcacgga
      361 gaccaccagc aaagctcaaa ccgacaccct cacgcagatg atgacatcaa ctcttttttc
      421 ttccccaagt gtacacaatg tgatggagac agctcctcca gatgaaatga ccacatcatt
      481 tccctccagt gtcaccaaca cactcatgat gacatcaaag actataacaa tgacaacctc
      541 cacagactcc actcttggaa acacagaaga gacatcaaca gcaggaactg aaagttctac
      601 cccagtgacc tcagcagtct caataacagc tggacaggaa ggacaatcac gaacaacttc
      661 ctggaggacc tctatccaag acacatcagc ttcttctcag aaccactgga ctcggagcac
      721 gcagaccacc agggaatctc aaaccagcac cctaacacac agaaccactt caactccttc
      781 tttctctcca agtgtacaca atgtgacagg gactgtttct cagaagacat ctccttcagg
      841 tgaaacagct acctcatccc tctgtagtgt cacaaacaca tccatgatga catcagagaa
      901 gataacagtg acaacctcca caggctccac tcttggaaac ccaggggaga catcatcagt
      961 acctgttact ggaagtctta tgccagtcac ctcagcagcc ttagtaacat ttgatccaga
     1021 aggacaatca ccagcaactt tctcaaggac ttctactcag gacacaacag ctttttctaa
     1081 gaaccaccag actcagagcg tggagaccac cagagtatct caaatcaaca ccctcaacac
     1141 cctcacaccg gttacaacat caactgtttt atcctcacca agtggattca acccaagtgg
     1201 aacagtttct caggagacat tcccttctgg tgaaacaacc acctcatccc cttccagtgt
     1261 cagcaataca ttcctggtaa catcaaaggt gttcagaatg ccaacctcca gagactctac
     1321 tcttggaaac acagaggaga catcactatc tgtaagtgga accatttctg caatcacttc
     1381 caaagtttca accatatggt ggtcagacac tctgtcaaca gcactctccc ccagttctct
     1441 acctccaaaa atatccacag ctttccacac ccagcagagt gaaggtgcag agaccacagg
     1501 acggcctcat gagaggagct cattctctcc aggtgtgtct caagaaatat ttactctaca
     1561 tgaaacaaca acatggcctt cctcattctc cagcaaaggc cacacaactt ggtcacaaac
     1621 agaactgccc tcaacatcaa caggtgctgc cactaggctt gtcacaggaa atccatctac
     1681 agggacagct ggcactattc caagggtccc ctctaaggtc tcagcaatag gggaaccagg
     1741 agagcccacc acatactcct cccacagcac aactctccca aaaacaacag gggcaggcgc
     1801 ccagacacaa tggacacaag aaacggggac cactggagag gctcttctca gcagcccaag
     1861 ctacagtgtg actcagatga taaaaacggc cacatcccca tcttcttcac ctatgctgga
     1921 tagacacaca tcccaacaaa ttacaacggc accatcaaca aatcattcaa caatacattc
     1981 cacaagcacc tctcctcagg aatcaccagc tgtttcccaa aggggtcaca ctcaagcccc
     2041 gcagaccaca caagaatcac aaaccacgag gtccgtctcc cccatgactg acaccaagac
     2101 agtcaccacc ccaggttctt ccttcacagc cagtgggcac tcgccctcag aaattgttcc
     2161 tcaggacgca cccaccataa gtgcagcaac aacctttgcc ccagctccca ccggggatgg
     2221 tcacacaacc caggccccga ccacagcact gcaggcagca cccagcagcc atgatgccac
     2281 cctggggccc tcaggaggca cgtcactttc caaaacaggt gcccttactc tggccaactc
     2341 tgtagtgtca acaccagggg gcccagaagg acaatggaca tcagcctctg ccagcacctc
     2401 acctgacaca gcagcagcca tgacccatac ccaccaggct gagagcacag aggcctctgg
     2461 acaaacacag accagcgaac cggcctcctc agggtcacga accacctcag cgggcacagc
     2521 taccccttcc tcatccgggg cgagtggcac aacaccttca ggaagcgaag gaatatccac
     2581 ctcaggagag acgacaaggt tttcatcaaa cccctccagg gacagtcaca caacccagtc
     2641 aacaaccgaa ttgctgtccg cctcagccag tcatggtgcc atcccagtaa gcacaggaat
     2701 ggcgtcttcg atcgtccccg gcacctttca tcccaccctc tctgaggcct ccactgcagg
     2761 gagaccgaca ggacagtcaa gcccaacttc tcccagtgcc tctcctcagg agacagccgc
     2821 catttcccgg atggcccaga ctcagaggac aagaaccagc agagggtctg acactatcag
     2881 cctggcgtcc caggcaaccg acaccttctc aacagtccca cccacacctc catcgatcac
     2941 atccactggg cttacatctc cacaaaccga gacccacact ctgtcacctt cagggtctgg
     3001 taaaaccttc accacggccc tcatcagcaa cgccacccct cttcctgtca cctacgcttc
     3061 ctcggcatcc acaggtcaca ccacccctct tcatgtcacc gatgcttcct cagtatccac
     3121 aggtcacgcc acccctcttc ctgtcaccag cccttcctca gtatccacag gtcacaccac
     3181 ccctcttcct gtcaccgaca cttcctcaga atccacaggt cacgtcaccc ctcttcctgt
     3241 caccagcttt tcctcagcat ccacaggtga cagcacccct cttcctgtca ctgacacttc
     3301 ctcagcatcc acaggtcacg tcacccctct tcctgtcacc agcctttcct cagcatccac
     3361 aggtgacacc acccctcttc ctgtcactga cacttcctca gcatccacag gtcacgccac
     3421 ctctcttcct gtcaccgaca cttcctcagt atccacaggt cacaccaccc ctcttcctgt
     3481 caccgacact tcctcagcat ccacaggtca cgccacctct cttcctgtca ccgacacttc
     3541 ctcagtatcc acaggtcaca ccacccctct tcatgtcact gatgcttcct cagcatccac
     3601 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     3661 gcctcttcct gtcactagcc cttcctcagc atccacaggt cacgccaccc ctcttcttgt
     3721 caccgacact tcctcagcat ccacaggaca cgccacccct cttcctgtca ccgacgcttc
     3781 ctcagtgtcc acagatcacg ccacctctct tcctgtaacc atcccttccg cagcatccac
     3841 aggtcacacc acccctcttc ctgtcaccga cacttcctca gcatccacag gtcaggccac
     3901 ctctcttctt gtcaccgaca cttcctcagt atccacaggt gacaccacgc ctcttcctgt
     3961 cactagcact tcctcagcat ccacaggtca cgtcactcct cttcatgtca ccagcccttc
     4021 ctcagcatcc acaggtcacg ccacccctct tcctgtcacc agcctttcct cagcatccac
     4081 aggtgacacc atgcctcttc ctgtcactag cccttcctca gcatccacag gtgacaccac
     4141 ccctcttcct gtcaccgacg cttcctcagt atccacaggt cacaccaccc ctcttcatgt
     4201 cactgatgct tcctcagcat ccacaggtca ggccacccct cttcctgtca ccagcctttc
     4261 ctcagtatcc acaggtgaca ccacgcctct tcctgtcact agcccttcct cagcatccac
     4321 aggtcacgcc acccctcttc ttgtcaccga cacttcctca gcatccacag gacacgccac
     4381 ccctcttcct gtcaccgacg cttcctcagt gtccacagat cacgccacct ctcttcctgt
     4441 aaccatccct tccgcagcat ccacaggtca caccacccct cttcctgtca ccgacacttc
     4501 ctcagcatcc acaggtcagg ccacctctct tcttgtcacc gacacttcct cagtatccac
     4561 aggtgacacc acgcctcttc ctgtcactag cacttcctca gcatccacag gtcacgtcac
     4621 tcctcttcat gtcaccagcc cttcctcagc atccacaggt cacgccaccc ctcttcctgt
     4681 caccagcctt tcctcagcat ccacaggtga caccatgcct cttcctgtca ctagcccttc
     4741 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacgcttcct cagtatccac
     4801 aggtcacacc acccctcttc ctgtcaccag cccttcctca gcatctacag gtcacaccac
     4861 ccctcttcct gtcaccgaca cttcctcagc atccaaaggt gacaccaccc ctcttcctgt
     4921 caccagccct tcctcagcat ctacaggtca caccacccct cttcctgtca ccgacacttc
     4981 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc aatgcttcct cattatccac
     5041 aggtcacgcc acccctcttc atgtcaccag cccttcctca gcatccacag gtcacgccac
     5101 ccctcttcct gtcaccagca cttcctcagc atccaccggt cacgccaccc ctcttcctgt
     5161 caccggcctt tcctcagcta ccacagatga caccacccgt cttcctgtca ccgacgtttc
     5221 ctcggcatcc acaggtcagg ccacccctct tcctgtcacc agcctttcct cagtatccac
     5281 aggtgacacc acgcctcttc ctgtcactag cccttcctca gcatccacag gtcacgccag
     5341 ccctcttctt gtcactgacg cttcctcagc atccacaggt caggccaccc ctcttcctgt
     5401 caccgacact tcctcagtat ccacagctca cgccacccca cttcctgtca ccggcctttc
     5461 ttcagcttcc acagatgaca ccacccgtct tcctgtcacc gacgtttcct cggcatccac
     5521 aggtcaggcc atccctcttc ctgtcaccag cccttcctca gcatccacag gtgacaccac
     5581 ccctcttcct gtcaccgacg cttcctcagc atccacaggt gacaccacct ctcttcctgt
     5641 caccatccct tcctcagcat cttcaggtca caccacctct cttcctgtca ccgacgcttc
     5701 ctcagtgtcc acaggtcacg ccacctctct tcttgtcacc gacgcttcct cagtatccac
     5761 aggtgacacc acccctcttc ctgtcaccga cactaactca gcatccacag gtgacaccac
     5821 ccctcttcat gtcaccgacg cttcctcagt atccacaggt cacgccacct ctcttcctgt
     5881 caccagcctt tcctcagcat ccacaggtga caccacgcct cttcctgtca ctagcccttc
     5941 ctcagcatcc tcaggtcaca ccacccctct tcctgtcacc gacgcttcct cagtacccac
     6001 aggtcacgcc acctctcttc ctgtcaccga cgcttcctca gtgtccacag gtcacgccac
     6061 ccctcttcct gtcaccgacg cttcctcagt gtccacaggt catgccaccc ctcttccggt
     6121 caccgacact tcctcagtat ctacaggaca ggccacccct cttcctgtca ccagcctttc
     6181 ctcagcatcc actggtgaca ccacgccgct tcctgtcacc gatacttcct cagcatccac
     6241 aggtcaggac acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     6301 gcctcttcct gtcactaacc cttcctcagc atccacaggt cacgccaccc ctcttcttgt
     6361 caccgacgct tcctcaatat ccacaggtca cgccacctct cttcttgtca ccgacgcttc
     6421 ctcagtatcc acaggtcacg ccaccgctct tcatgacacc gatgcttcct cattatccac
     6481 aggggacacc acccctcttc ctgtcaccag cccttcctca acatccacag gtgacaccac
     6541 ccctcttcct gtcaccgaaa cttcctcagt atccacaggt cacgccacct ctcttcctgt
     6601 caccgacact tcctcagcat ccacaggtca cgccacctct cttcctgtca ccgacacttc
     6661 ctcagcatcc acaggtcacg ccacccctct tcctgtcacc gacacttcct cagcatccac
     6721 aggtcaggcc acccctcttc ctgtcaccag cccttcctca gcatccacag gtcacgccat
     6781 ccctcttctt gtcaccgaca cttcctcagc atccacagga caggccaccc ctcttcctgt
     6841 caccagcctt tcctcagcat ccacaggtga caccacccct cttcctgtca ccgacgcttc
     6901 ctcagtgtcc acaggtcacg ccacctctct tcctgtcacc agcctttcct cagtatccac
     6961 aggtgacacc actcctcttc ctgtcactag cccttcctca gcatccacag gtcacgccac
     7021 ccctcttcat gtcaccgacg cttcctcagc atccacaggt cacgccaccc ctcttcctgt
     7081 caccagcctt tcctcagcat ccacaggtga caccacgcct cttcctgtca ctagcccttc
     7141 ctcagcatcc acaggtcacg ccacccctct tcatgtcacc gacgcttcct cagtatccac
     7201 aggtgacacc acccctcttc ctgtcaccag ctcttcctca gcatcctcag gtcacaccac
     7261 ccctcttcct gtcaccgacg cttcctcagc atccacaggt gacaccaccc ctcttcctgt
     7321 caccgacact tcctcagcat ccacaggtca cgccacccat cttcctgtca ccggcctttc
     7381 ctcagcttcc acaggtgaca ccacccgtct tcctgtcacc aacgtttcct cggcatccac
     7441 aggtcatgcc acccctcttc ctgtcaccag cacttcctca gcatccacag gtgacaccac
     7501 ccctcttcct ggcaccgaca cttcctcagt atccacaggt cacaccaccc ctcttcttgt
     7561 caccgacgct tcgtcagtat ccacaggtga caccacccgt cttcctgtca ccagcccttc
     7621 ctcagcatct acaggtcaca ccacccctct acctgtcacc gacactccct cagcatccac
     7681 aggtgacacc acccctcttc ctgtcaccaa tgcttcctca ttatccacac gtcacgccac
     7741 ctctcttcat gtcaccagcc cttcctcagc atccacaggt cacgccacct ctcttcctgt
     7801 caccgacact tccgcagcat ccacaggtca cgccacccct cttcctgtca ccagcacttc
     7861 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacacttact cagcatccac
     7921 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     7981 gcctcttcct gtcactagcc cttcctcagc atccacaggt cacgccactc ctcttcttgt
     8041 caccgacgct tcctcagcat ccacaggtca ggccacccct cttcctgtca ccagcctttc
     8101 ctcagtatcc acaggtgaca ccacgcctct tcctgtcact agcccttcct cagcatccac
     8161 cggtcatgcc acctctcttc ctgtcaccga cacttcctca gcatccacag gtgacaccac
     8221 ctctcttcct gtcaccgaca cttcctcagc atacacaggt gacaccacct ctcttcctgt
     8281 caccgacact tcctcatcat ccacaggtga caccacccct cttcttgtca ccgagacttc
     8341 ctcagtatcc acaggtgaca ccacccctct tcctgtcacc gacacttcct cagcatccac
     8401 aggtcacgcc acccctcttc ctgtcaccaa cacttcctca gtatccacag gtcacgccac
     8461 ccctcttcat gtcaccagcc cttcctcagc atccacaggt cacaccaccc ctcttcctgt
     8521 caccgacgct tcgtcagtgt ccacaggtca cgccacctct cttcctgtca ccgacgcttc
     8581 ctcagtgttc acaggtcatg ccacctctct tcctgtcacc atcccttcct cagcatcctc
     8641 aggtcacacc acccctcttc ctgtcaccga cgcttcctca gtgtccacag gtcacgccac
     8701 ctctcttcct gtcaccgacg cttcctcagt gtccacaggt catgccaccc ctcttcctgt
     8761 caccgacgct tcctcagtgt ccacaggtca cgctacccct cttcctctca ccagcctttc
     8821 ctcagtatcc acaggtgaca ccacgcctct tcctgtcacc gacacttcct cagcatccac
     8881 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     8941 ccctcttcct gtcaccgaca cttcctcagc atccacaggt cacgccacct ctcttcctgt
     9001 caccgacact tcctcagcat ccacaggtca cgccacccct cttcctgaca ccgacacttc
     9061 ctcagcatcc acaggtcacg ccacccttct tcctgtcacc gacacttcct cagcatccat
     9121 aggtcacgcc acctctcttc ctgtcaccga cacttcctca atatccacag gtcacgccac
     9181 ccctcttcat gtcaccagcc cttcctcagc atccaccggt cacgccaccc cgcttcctgt
     9241 caccgacact tcctcagcat ccacaggtca cgccaaccct cttcatgtca ccagcccttc
     9301 ctcagcatcc accggtcacg ccaccccgct tcctgtcacc gacacttcct cagcatccac
     9361 aggtcacgcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     9421 gcctcttcct gtcactagcc cttcctcagc atccacaggt cacaccaccc ctcttcctgt
     9481 caccgacact tcctcagcat ccacaggtca ggccaccgct cttcctgtca ccagcacttc
     9541 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacacttcct cagcatccac
     9601 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
     9661 gcctcttcct gtcactagcc cttcctcagc atccacaggt cacgccactc ctcttcttgt
     9721 caccgacgct tcctcagcat ccacaggtca ggccacccct cttcctgtca ccagcctttc
     9781 ctcagtatcc acaggtgaca ccacgcctct tcctgtcact agcccttcct cagcatccac
     9841 cggtcatgcc acctctcttc ctgtcaccga cacttcctca gcatccacag gtgacaccac
     9901 ctctcttcct gtcaccgaca cttcctcagc atacacaggt gacaccacct ctcttcctgt
     9961 caccgacact tcctcatcat ccacaggtga caccacccct cttcttgtca ccgagacttc
    10021 ctcagtatcc acaggtcacg ccactcctct tcttgtcacc gacgcttcct cagcatccac
    10081 aggtcacgcc acccctcttc atgtcaccag cccttcctca gcatccacag gtgacaccac
    10141 ccctgtgcct gtcaccgaca cttcctcagt atccacaggt cacgccaccc ctcttcctgt
    10201 caccggcctt tcctcagctt ccacaggtga caccacccgt cttcctgtca ccgacatttc
    10261 ctcggcatcc acaggtcagg ccacccctct tcctgtcacc aacacttcct cagtatccac
    10321 aggtgacacc atgcctcttc ctgtcactag cccttcctca gcatccacag gtcacgccac
    10381 ccctcttcct gtcaccagca cttcctcagc atccaccggt cacgccaccc ctgttcctgt
    10441 caccagcact tcctcagcat ctacaggtca caccacccct cttcctgtca ccgacacttc
    10501 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc agcccttcct cagcatctac
    10561 aggtcacacc acccctcttc atgtcaccat cccttcctca gcatccacag gtgacaccag
    10621 cactcttcct gtcaccggcg cttcctcagc atccaccggt cacgccaccc ctcttcctgt
    10681 caccgacact tcctcagtat ccaccggtca cgccacgcct cttcctgtca ccagcctttc
    10741 ctcagtatcc acaggtgaca ccacccctct tcctgtcacc gacgcttcct cggcatccac
    10801 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
    10861 ccctcttctt gtcaccgacg cttcctcagt atccacaggt cacgccaccc ctcttcctgt
    10921 caccgacact tcctcagcat ccacaggtga caccacccgt cttcctgtca cggacacttc
    10981 ctcagcatcc acaggtcagg ccacccctct tcctgtcacc agcctttcct cagtatccac
    11041 aggtgacacc acccctcttc ttgtcaccga cgcttcctca gtatccacag gtcacgccac
    11101 ccctcttcct gtcaccgaca cttcctcagc atccacaggt gacaccaccc gtcttcctgt
    11161 cacggacact tcctcagcat ccacaggtca ggccacccct cttcctgtca ccatcccttc
    11221 ctcatcatcc tcaggtcaca ccacccctct tcctgtcacc agcacttcct cagtatctac
    11281 aggtcacgtc acccctcttc atgtcaccag cccttcctca gcatccacag gtcacgtcac
    11341 ccctcttcct gtcaccagca cttcctcagc atccacaggt cacgccaccc ctcttcttgt
    11401 caccgacgct tcctcagtgt ccacaggtca cgccacgcct cttcctgtca ccgacgcttc
    11461 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacacttcct cagcatccac
    11521 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
    11581 ccctcttcct gtcaccgacg cttcctcagc atccacaggt cacgccaccc ctcttcctgt
    11641 caccatccct tcctcagtat ccacaggtga caccatgcct cttcctgtca ctagcccttc
    11701 ctcagcatcc acaggtcacg ccacccctct tcctgttacc ggcctttcct cagcttccac
    11761 aggtgacacc acccctcttc ctgtcaccga cacttcctca gcatccacac gtcacgccac
    11821 ccctcttcct gtcaccgaca cttcctcagc ttccacagat gacaccaccc gtcttcctgt
    11881 caccgacgtt tcctcggcat ccacaggaca tgccacccct cttcctgtca ccagcacttc
    11941 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacacttcct cagtatccac
    12001 aggtcacgcc acctctcttc ctgtcaccag ccgttcctca gcatccacag gtcacgccac
    12061 cccccttcct gtcaccgaca cttcctcagt atccacaggt cacgccaccc ctcttcctgt
    12121 caccagcact tcctcagtat ctacaggtca cgccacccct cttcctgtca ccagcccttc
    12181 ctcagcatcc acaggtcacg ccacccctgt tcctgtcacc agcacttcct cagcatccac
    12241 aggtgacacc acccctcttc ctgtcaccaa tgcttcctca ttatccacag gtcacgccac
    12301 ccctcttcat gtcaccagcc cttcctcagc atccagaggt gacaccagca ctcttcctgt
    12361 caccgatgct tcctcagcat ccaccggtca cgccacccct cttcctctca ccagcctttc
    12421 ctcagtatcc acaggtgaca ccacgcctct tcctgtcacc gacacttcct ctgcatccac
    12481 aggtcaggcc acccctcttc ctgtcaccag cctttcctca gtatccacag gtgacaccac
    12541 gcctcttcct gtcaccatcc cttcctcagc atcctcaggt cacaccacct ctcttcctgt
    12601 caccgacgct tcctcagtgt ccacaggtca cggcacccct cttcctgtca ccagcacttc
    12661 ctcagcatcc acaggtgaca ccacccctct tcctgtcacc gacacttcct cagcatccac
    12721 aggtcacgcc acccctcttc ctgtcaccga cacttcctca gcatccacag gtcacgccac
    12781 ccctcttcct gtcaccagcc tttcctcagt atccacaggt cacgccaccc ctcttgctgt
    12841 cagcagtgct acctcagctt ccacagtatc ctcggactcc cctctgaaga tggaaacacc
    12901 aggaatgaca acaccgtcac tgaagacaga cggtgggaga cgcacagcca catcaccacc
    12961 ccccacaacc tcccagacca tcatttccac cattcccagc actgccatgc acacccgctc
    13021 cacagctgcc cccatcccca tcctgcctga gagaggagtt tccctcttcc cctatggggc
    13081 aggcgccggg gacctggagt tcgtcaggag gaccgtggac ttcacctccc cactcttcaa
    13141 gccggcgact ggcttccccc ttggctcctc tctccgtgat tccctctact tcacagacaa
    13201 tggccagatc atcttcccag agtcagacta ccagattttc tcctacccca acccactccc
    13261 aacaggcttc acaggccggg accctgtggc cctggtggct ccgttctggg acgatgctga
    13321 cttctccact ggtcggggga ccacatttta tcaggaatac gagacgttct atggtgaaca
    13381 cagcctgcta gtccagcagg ccgagtcttg gattagaaag atgacaaaca acgggggcta
    13441 caaggccagg tgggccctaa aggtcacgtg ggtcaatgcc cacgcctatc ctgcccagtg
    13501 gaccctcggg agcaacacct accaagccat cctctccacg gacgggagca ggtcctatgc
    13561 cctgtttctc taccagagcg gtgggatgca gtgggacgtg gcccagcgct caggcaaccc
    13621 ggtgctcatg ggcttctcta gtggagatgg ctatttcgaa aacagcccac tgatgtccca
    13681 gccagtgtgg gagaggtatc gccctgatag attcctgaat tccaactcag gcctccaagg
    13741 gctgcagttc tacaggctac accgggaaga aaggcccaac taccgtctcg agtgcctgca
    13801 gtggctgaag agccagcctc ggtggcccag ctggggctgg aaccaggtct cctgcccttg
    13861 ttcctggcag cagggacgac gggacttacg attccaaccc gtcagcatag gtcgctgggg
    13921 cctcggcagt aggcagctgt gcagcttcac ctcttggcga ggaggcgtgt gctgcagcta
    13981 cgggccctgg ggagagtttc gtgaaggctg gcacgtgcag cgtccttggc agttggccca
    14041 ggaactggag ccacagagct ggtgctgccg ctggaatgac aagccctacc tctgtgccct
    14101 gtaccagcag aggcggcccc acgtgggctg tgctacatac aggcccccac agcccgcctg
    14161 gatgttcggg gacccccaca tcaccacctt ggatggtgtc agttacacct tcaatgggct
    14221 gggggacttc ctgctggtcg gggcccaaga cgggaactcc tccttcctgc ttcagggccg
    14281 caccgcccag actggctcag cccaggccac caacttcatc gcctttgcgg ctcagtaccg
    14341 ctccagcagc ctgggccccg tcacggtcca atggctcctt gagcctcacg acgcaatccg
    14401 tgtcctgctg gataaccaga ctgtgacatt tcagcctgac catgaagacg gcggaggcca
    14461 ggagacgttc aacgccaccg gagtcctcct gagccgcaac ggctctgagg tctcggccag
    14521 cttcgacggc tgggccaccg tctcggtgat cgcgctctcc aacatcctcc acgcctccgc
    14581 cagcctcccg cccgagtacc agaaccgcac ggaggggctc ctgggggtct ggaataacaa
    14641 tccagaggac gacttcagga tgcccaatgg ctccaccatt cccccaggga gccctgagga
    14701 gatgcttttc cactttggaa tgacctggca gatcaacggg acaggcctcc ttggcaagag
    14761 gaatgaccag ctgccttcca acttcacccc tgttttctac tcacaactgc aaaaaaacag
    14821 ctcctgggct gaacatttga tctccaactg tgacggagat agctcatgca tctatgacac
    14881 cctggccctg cgcaacgcaa gcatcggact tcacacgagg gaagtcagta aaaactacga
    14941 gcaggcgaac gccaccctca atcagtaccc gccctccatc aatggtggtc gtgtgattga
    15001 agcctacaag gggcagacca cgctgattca gtacaccagc aatgctgagg atgccaactt
    15061 cacgctcaga gacagctgca ccgacttgga gctctttgag aatgggacgt tgctgtggac
    15121 acccaagtcg ctggagccat tcactctgga gattctagca agaagtgcca agattggctt
    15181 ggcatctgca ctccagccca ggactgtggt ctgccattgc aatgcagaga gccagtgttt
    15241 gtacaatcag accagcaggg tgggcaactc ctccctggag gtggctggct gcaagtgtga
    15301 cgggggcacc ttcggccgct actgcgaggg ctccgaggat gcctgtgagg agccgtgctt
    15361 cccgagtgtc cactgcgttc ctgggaaggg ctgcgaggcc tgccctccaa acctgactgg
    15421 ggatgggcgg cactgtgcgg ctctggggag ctctttcctg tgtcagaacc agtcctgccc
    15481 tgtgaattac tgctacaatc aaggccactg ctacatctcc cagactctgg gctgtcagcc
    15541 catgtgcacc tgccccccag ccttcactga cagccgctgc ttcctggctg ggaacaactt
    15601 cagtccaact gtcaacctag aacttccctt aagagtcatc cagctcttgc tcagtgaaga
    15661 ggaaaatgcc tccatggcag aagtcaacgc ctcggtggca tacagactgg ggaccctgga
    15721 catgcgggcc tttctccgca acagccaagt ggaacgaatc gattctgcag caccggcctc
    15781 gggaagcccc atccaacact ggatggtcat ctcggagttc cagtaccgcc ctcggggccc
    15841 ggtcattgac ttcctgaaca accagctgct ggccgcggtg gtggaggcgt tcttatacca
    15901 cgttccacgg aggagtgagg agcccaggaa cgacgtggtc ttccagccca tctccgggga
    15961 agacgtgcgc gatgtgacag ccctgaacgt gagcacgctg aaggcttact tcagatgcga
    16021 tggctacaag ggctacgacc tggtctacag cccccagagc ggcttcacct gcgtgtcccc
    16081 gtgcagtagg ggctactgtg accatggagg ccagtgccag cacctgccca gtgggccccg
    16141 ctgcagctgt gtgtccttct ccatctacac ggcctggggc gagcactgtg agcacctgag
    16201 catgaaactc gacgcgttct tcggcatctt ctttggggcc ctgggcggcc tcttgctgct
    16261 gggggtcggg acgttcgtgg tcctgcgctt ctggggttgc tccggggcca ggttctccta
    16321 tttcctgaac tcagctgagg ccttgccttg aaggggcagc tgtggcctag gctacctcaa
    16381 gactcacctc atccttaccg cacatttaag gcgccattgc ttttgggaga ctggaaaagg
    16441 gaaggtgact gaaggctgtc aggattcttc aaggagaatg aatactggga atcaagacaa
    16501 gactatacct tatccatagg cgcaggtgca cagggggagg ccataaagat caaacatgca
    16561 tggatgggtc ctcacgcaga cacacccaca gaaggacact agcctgtgca cgcgcgcgtg
    16621 cacacacaca cacacacaca cgagttcata atgtggtgat ggccctaagt taagcaaaat
    16681 gcttctgcac acaaaactct ctggtttact tcaaattaac tctatttaaa taaagtctct
    16741 ctgacttttt gtgtct
//
