LOCUS       NM_005960              11248 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mucin 3A, cell surface associated (MUC3A), mRNA.
ACCESSION   NM_005960
VERSION     NM_005960.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11248)
  AUTHORS   Sotoudeh,M., Mansouri,V., Shakeri,R., Sharififard,B., Sajadi,N.,
            Haghpanah,V. and Naderi,M.
  TITLE     Decoding the expression pattern of MUC3A in gastric adenocarcinoma:
            unveiling the key to successful immunotherapy
  JOURNAL   Expert Opin Ther Targets 27 (12), 1299-1305 (2023)
   PUBMED   38069509
  REMARK    GeneRIF: Decoding the expression pattern of MUC3A in gastric
            adenocarcinoma: unveiling the key to successful immunotherapy.
REFERENCE   2  (bases 1 to 11248)
  AUTHORS   Su,W., Feng,B., Hu,L., Guo,X. and Yu,M.
  TITLE     MUC3A promotes the progression of colorectal cancer through the
            PI3K/Akt/mTOR pathway
  JOURNAL   BMC Cancer 22 (1), 602 (2022)
   PUBMED   35655161
  REMARK    GeneRIF: MUC3A promotes the progression of colorectal cancer
            through the PI3K/Akt/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 11248)
  AUTHORS   Sun,Y., Sun,X., You,C., Ma,S., Luo,Y., Peng,S., Tang,F., Tian,X.,
            Wang,F., Huang,Z., Yu,H., Xiao,Y., Wang,X., Zhang,J., Gong,Y. and
            Xie,C.
  TITLE     MUC3A promotes non-small cell lung cancer progression via
            activating the NFkappaB pathway and attenuates radiosensitivity
  JOURNAL   Int J Biol Sci 17 (10), 2523-2536 (2021)
   PUBMED   34326691
  REMARK    GeneRIF: MUC3A promotes non-small cell lung cancer progression via
            activating the NFkappaB pathway and attenuates radiosensitivity.
            Erratum:[Int J Biol Sci. 2022 Nov 3;18(16):6226. doi:
            10.7150/ijbs.79140.. PMID: 36439877]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11248)
  AUTHORS   Gum,J.R. Jr., Hicks,J.W., Crawley,S.C., Dahl,C.M., Yang,S.C.,
            Roberton,A.M. and Kim,Y.S.
  TITLE     Initiation of transcription of the MUC3A human intestinal mucin
            from a TATA-less promoter and comparison with the MUC3B amino
            terminus
  JOURNAL   J Biol Chem 278 (49), 49600-49609 (2003)
   PUBMED   12958310
  REMARK    GeneRIF: has highly conserved amino and carboxyl termini,
            suggesting a recent duplication of the entire ancestral gene
REFERENCE   5  (bases 1 to 11248)
  AUTHORS   Pratt,W.S., Crawley,S., Hicks,J., Ho,J., Nash,M., Kim,Y.S.,
            Gum,J.R. and Swallow,D.M.
  TITLE     Multiple transcripts of MUC3: evidence for two genes, MUC3A and
            MUC3B
  JOURNAL   Biochem Biophys Res Commun 275 (3), 916-923 (2000)
   PUBMED   10973822
REFERENCE   6  (bases 1 to 11248)
  AUTHORS   Crawley,S.C., Gum,J.R. Jr., Hicks,J.W., Pratt,W.S., Aubert,J.P.,
            Swallow,D.M. and Kim,Y.S.
  TITLE     Genomic organization and structure of the 3' region of human MUC3:
            alternative splicing predicts membrane-bound and soluble forms of
            the mucin
  JOURNAL   Biochem Biophys Res Commun 263 (3), 728-736 (1999)
   PUBMED   10512748
REFERENCE   7  (bases 1 to 11248)
  AUTHORS   Gum,J.R. Jr., Ho,J.J., Pratt,W.S., Hicks,J.W., Hill,A.S.,
            Vinall,L.E., Roberton,A.M., Swallow,D.M. and Kim,Y.S.
  TITLE     MUC3 human intestinal mucin. Analysis of gene structure, the
            carboxyl terminus, and a novel upstream repetitive region
  JOURNAL   J Biol Chem 272 (42), 26678-26686 (1997)
   PUBMED   9334251
REFERENCE   8  (bases 1 to 11248)
  AUTHORS   Gendler,S.J. and Spicer,A.P.
  TITLE     Epithelial mucin genes
  JOURNAL   Annu Rev Physiol 57, 607-634 (1995)
   PUBMED   7778880
  REMARK    Review article
REFERENCE   9  (bases 1 to 11248)
  AUTHORS   Fox,M.F., Lahbib,F., Pratt,W., Attwood,J., Gum,J., Kim,Y. and
            Swallow,D.M.
  TITLE     Regional localization of the intestinal mucin gene MUC3 to
            chromosome 7q22
  JOURNAL   Ann Hum Genet 56 (4), 281-287 (1992)
   PUBMED   1362870
REFERENCE   10 (bases 1 to 11248)
  AUTHORS   Gum,J.R., Hicks,J.W., Swallow,D.M., Lagace,R.L., Byrd,J.C.,
            Lamport,D.T., Siddiki,B. and Kim,Y.S.
  TITLE     Molecular cloning of cDNAs derived from a novel human intestinal
            mucin gene
  JOURNAL   Biochem Biophys Res Commun 171 (1), 407-415 (1990)
   PUBMED   2393399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC254629.1, BI005786.1 and AB038784.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005960.1.
            
            Summary: The mucin genes encode epithelial glycoproteins, some of
            which are secreted and some membrane bound. Each of the genes
            contains at least one large domain of tandemly repeated sequence
            that encodes the peptide sequence rich in serine and/or threonine
            residues, which carries most of the O-linked glycosylation (Gendler
            and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The genomic coordinates used for
            the transcript record were based on transcript alignments and on
            publication data (PMIDs: 9334251, 10512748, 10973822, 12958310).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA2142348 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000379458.9/ ENSP00000368771.5
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AC254629.1         165989-166133
            146-395             BI005786.1         21-270
            396-8434            AC254629.1         168539-176577
            8435-9633           AB038784.1         1006-2204
            9634-9634           AC254629.1         182253-182253
            9635-10106          AB038784.1         2206-2677
            10107-11248         AC254629.1         183661-184802
FEATURES             Location/Qualifiers
     source          1..11248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..11248
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /note="mucin 3A, cell surface associated"
                     /db_xref="GeneID:4584"
                     /db_xref="HGNC:HGNC:7513"
                     /db_xref="MIM:158371"
     exon            1..152
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..10063
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /note="mucin 3, intestinal; mucin-3A; intestinal mucin"
                     /codon_start=1
                     /product="mucin-3A precursor"
                     /protein_id="NP_005951.1"
                     /db_xref="CCDS:CCDS78262.1"
                     /db_xref="GeneID:4584"
                     /db_xref="HGNC:HGNC:7513"
                     /db_xref="MIM:158371"
                     /translation="MQLLGLLGLLWMLKASPWATGTLSTATSISQVPFPRAEAASAVL
                     SNSPHSRDLAGWPLGVPQLASPAPGHRENAPMTLTTSPHDTLISETLLNSPVSSNTST
                     TPTSKFAFKVETTPPTVLVYSATTECVYPTSFIITISHPTSICVTTTQVAFTSSYTST
                     PVTQKPVTTVTSTYSMTTTEKGTSAMTSSPSTTTARETPIVTVTPSSVSATDTTFHTT
                     ISSTTRTTERTPLPTGSIHTTTSPTPVFTTLKTAVTSTSPITSSITSTNTVTSMTTTA
                     SQPTATNTLSSPTRTILSSTPVLSTETITSGITNTTPLSTLVTTLPTTISRSTPTSET
                     TYTTSPTSTVTDSTTKIAYSTSMTGTLSTETSLPPTSSSLPTTETATTPMTNLVTTTT
                     EISSHSTPSFSSSTIYSTVSTSTTAISSLPPTSGTMVTSTTMTPSSLSTDIPFTTPTT
                     ITHHSVGSTGFLTTATDLTSTFTVSSSSAMSTSVIPSSPSIQNTETSSLVSMTSATTP
                     NVRPTFVSTLSTPTSSLLTTFPATYSFSSSMSASSAGTTHTESISSPPASTSTLHTTA
                     ESTLAPTTTTSFTTSTTMEPPSTTAATTGTGQTTFTSSTATFPETTTPTPTTDMSTES
                     LTTAMTSPPITSSVTSTNTVTSMTTTTSPPTTTNSFTSLTSMPLSSTPVPSTEVVTSG
                     TINTIPPSILVTTLPTPNASSMTTSETTYPNSPTGPGTNSTTEITYPTTMTETSSTAT
                     SLPPTSPLVSTAKTAKTPTTNLVTTTTKTTSHSTTSFTSSTVYSTASTYTTAITSVPT
                     TLGTMVTSTSMISSTVSTGIPTSQPTTITPSSVGISGSLPMMTDLTSVYTVSNMSARP
                     TTVIPSSPTVQNTEISISVSMTSATTPSGGPTFTSTENTPTRSLLTSFPMTHSFSSSM
                     SESSAGTTHTESISSPRGTTSTLHTTVESTPSPTTTTSFTTSTMMEPPSSTVSTTGRG
                     QTTFPSSTATFPETTTLTPTTDISTVSLTTAMTSPPPVSSSITPTNTMTSMRTTTYWP
                     TATNTLSPLTSSILSSTPVPSTEMITSHTTNTTPLSTLVTTLLTTITRSTPTSETTYP
                     TSPTSIVSDSTTEITYSTSITGTLSTATTLPPTSSSLPTTETATMTPTTTLITTTPNT
                     TSLSTPSFTSSTIYSTVSTSTTAISSASPTSGTMVTSTTMTPSSLSTDTPSTTPTTIT
                     YPSVGSTGFLTTATDLTSTFTVSSSSAMSTSVIPSSPSIQNTETSSLVSMTSATTPSL
                     RPTITSTDSTLTSSLLTTFPSTYSFSSSMSASSAGTTHTETISSLPASTNTIHTTAES
                     ALAPTTTTSFTTSPTMEPPSTTVATTGTGQTTFPSSTATFLETTTLTPTTDFSTESLT
                     TAMTSTPPITSSITPTDTMTSMRTTTSWPTATNTLSPLTSSILSSTPVPSTEVTTSHT
                     TNTNPVSTLVTTLPITITRSTLTSETAYPSSPTSTVTESTTEITYPTTMTETSSTATS
                     LPPTSSLVSTAETAKTPTTNLVTTTTKTTSHSTTSFTSSTIYSTASTPTTAITSVPTT
                     LGTMVTSTSMIPSTVSTGIPTSQPTTITPSSVGISGSLPMMTDLTSVYTVSSMSARPT
                     SVIPSSPTVQNTETSIFVSMMSATTPSGGPTFTSTENTPTRSLLTSFPVTHSFSSSMS
                     ASSVGTTHTQSISSPPAITSTLHTTAESTPSPTTTMSFTTFTKMETPSSTVATTGTGQ
                     TTFTSSTATSPKTTTLTPTSDISTGSFKTAVSSTPPITSSITSTYTVTSMTTTTPLGP
                     TATNTLPSFTSSVSSSTPVPSTEAITSGTTNTTPLSTLVTTFSNSDTSSTPTSETTYP
                     TSLTSALTDSTTRTTYSTNMTGTLSTVTSLRPTSSSLLTTVTATVPTTNLVTTTTKIT
                     SHSTPSFTSSIATTETPSHSTPRFTSSITTTETPSHSTPRFTSSITNTKTTSHSSPSF
                     TSSITTTETTSHNTPSLTSSITTTKTTSHSTPSYTSLITTTTTTSHSTPSFTSSITTT
                     ETTSHNTPSLTSSITTTETTSHSTPSFTSSITTETTSHSTPSFTSLITITEITSHSTL
                     SYTTSITTTETPSHSTLSFTSSITTTETTSHSTPSFTSSITTSEMPSHSTPSFTSSIT
                     TTENATHSTPNFTSSITTTETTSHSTPSFTSLITTTETTSHRWGTTETTSYSTPSFTS
                     SNTITETTSHSTPSYITSITTTETPSSSTPSFSSSITTTETTSHSTPGFTSSITTTET
                     TSHSTPSFTSSITTTETTSHDTPSFTSSITTSETPSHSTPSSTSLITTTKTTSHSTPS
                     FTSSITTTETTSHSAHSFTSSITTTETTSHNTRSFTSSITTTETNSHSTTSFTSSITT
                     TETTSHSTPSFSSSITTTETPLHSTPGLTSWVTTTKTTSHITPGLTSSITTTETTSHS
                     TPGFTSSITTTETTSESTPSLSSSTIYSTVSTSTTAITSHFTTSETAVTPTPVTPSSL
                     STDIPTTSLRTLTPSSVGTSTSLTTTTDFPSIPTDISTLPTRTHIISSSPSIQSTETS
                     SLVGTTSPTMSTVRMTLRITENTPISSFSTSIVVIPETPTQTPPVLTSATGTQTSPAP
                     TTVTFGSTDSSTSTLHTLTPSTALSTIVSTSQVPIPSTHSSTLQTTPSTPSLQTSLTS
                     TSEFTTESFTRGSTSTNAILTSFSTIIWSSTPTIIMSSSPSSASITPVFSTTIHSVPS
                     SPYIFSTENVGSASITGFPSLSSSATTSTSSTSSSLTTALTEITPFSYISLPSTTPCP
                     GTITITIVPASPTDPCVEMDPSTEATSPPTTPLTVFPFTTEMVTCPTSISIQTTLTTY
                     MDTSSMMPESESSISPNASSSTGTGTVPTNTVFTSTRLPTSETWLSNSSVIPLPLPGV
                     STIPLTMKPSSSLPTILRTSSKSTHPSPPTTRTSETPVATTQTPTTLTSRRTTRITSQ
                     MTTQSTLTTTAGTCDNGGTWEQGQCACLPGFSGDRCQLQTRCQNGGQWDGLKCQCPST
                     FYGSSCEFAVEQVDLDVVETEVGMEVSVDQQFSPDLNDNTSQAYRDFNKTFWNQMQKI
                     FADMQGFTFKGVEILSLRNGSIVVDYLVLLEMPFSPQLESEYEQVKTTLKEGLQNASQ
                     DVNSCQDSQTLCFKPDSIKVNNNSKTELTPAAICRRAAPTGYEEFYFPLVEATRLRCV
                     TKCTSGVDNAIDCHQGQCVLETSGPTCRCYSTDTHWFSGPRCEVAVHWRALVGGLTAG
                     AALLVLLLLALGVRAVRSGWWGGQRRGRSWDQDRKWFETWDEEVVGTFSNWGFEDDGT
                     DKDTNFYVALENVDTTMKVHIKRPEMTSSSV"
     exon            153..8957
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            8958..9143
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9144..9259
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9260..9324
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9325..9473
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9474..9539
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9540..9702
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9703..9876
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9877..9968
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            9969..10021
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            10022..11248
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11224..11229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /note="hexamer: AATACA"
     polyA_site      11248
                     /gene="MUC3A"
                     /gene_synonym="MUC-3A; MUC3"
                     /note="major polyA site"
ORIGIN      
        1 actttcatta cgtgcacgcc ccagggccac gtccctgccg ctgtcttggt cctgaagcct
       61 gttctgcccc agccccctgc ccgctgggcc catgcagctg ttggggctcc tcggcctcct
      121 ctggatgctc aaggcctccc cgtgggccac aggaacttta tccacggcca catccatctc
      181 tcaagtgcct ttccccagag cagaagcagc cagcgctgtg ctcagcaatt ctccacactc
      241 cagagacctg gctgggtggc cacttggtgt cccccagctc gcctctcctg ctcctggcca
      301 cagggaaaat gcacctatga cactcactac ctccccccat gacacactca tctctgaaac
      361 attgctcaac tctccagtca gttccaacac ctcaaccacc ccgacgtcca agtttgcctt
      421 caaggttgaa accactccac ccaccgtgtt ggtctattca gccaccactg agtgcgtgta
      481 tccaacgagc tttataatca ccatctccca ccccacctcc atctgtgtga ccacgacgca
      541 ggtggccttc accagctctt acacctcgac tcccgtgaca cagaagccag tgaccaccgt
      601 caccagtact tactctatga ccactactga gaaaggaacg tcagccatga catcttctcc
      661 ctctaccacc actgcaaggg aaactcccat agtgacagtg acaccctcct ctgtgtcagc
      721 cacagacaca accttccaca ctacaatctc gtctacaact agaaccacag aaaggactcc
      781 cctgcccact ggaagcatcc atacaaccac gtccccaacc ccagtattta ctactctcaa
      841 aacagcagtg acttccactt cccccatcac ttcttcaatc acttccacaa atacagtgac
      901 ttctatgaca acgaccgcct cccagcccac agccactaat acattgtcat cacccactag
      961 gaccatttta tcttccacac ctgtcctgag cacagaaaca atcaccagtg gtatcacaaa
     1021 caccaccccc ctatccacct tggtgaccac actccccact accatcagca ggtctacacc
     1081 tacatctgag accacctaca ctacttctcc caccagcact gtcacagact ccactaccaa
     1141 aatcgcctac tccacaagta tgacaggtac attgtccaca gagacttctc tcccacccac
     1201 ctcttcctct ctcccaacca cagaaacagc cacgactcct atgacaaact tggtaaccac
     1261 caccactgag atctcctccc acagtactcc cagcttctct tcatcaacca tctactccac
     1321 agtcagcaca tccacaactg ccatctcctc acttccccct acctcaggta ctatggtgac
     1381 ttccacaacc atgaccccat cttctctgag tacagacatc cctttcacaa caccaacaac
     1441 tatcacccac cattctgtgg gctctaccgg tttcctgact acagcaacag acctcacatc
     1501 aacattcacg gtttccagtt cctcagcaat gtccacgagt gtcattccat cttcccccag
     1561 cattcagaat acagaaacct catcccttgt cagcatgacc tctgccacta ctcccaatgt
     1621 gagaccaact tttgtaagta cactcagcac tcctacaagt tccctcctga cgaccttccc
     1681 agcaacatat tcattttcat cttccatgtc tgccagcagt gctgggacca ctcacacaga
     1741 gagtatctcc tcacctccag ccagcaccag tacactccac acaacagctg aatccaccct
     1801 ggcacccact accaccacct cattcacaac ttccacaact atggaaccac cttcaaccac
     1861 tgcagcaact acaggaacag gtcagaccac cttcaccagc tctacagcca catttcctga
     1921 gaccaccaca ccgactccta caactgacat gtccacagaa tctctcacaa cagccatgac
     1981 ttctcctccc atcacttcat cagtcacttc cacaaataca gtgacttcta tgacaactac
     2041 gacctctcct cccacaacca ccaattcttt tacatcactg accagtatgc ctctgtcttc
     2101 tacacctgtc ccaagcacag aagtagtcac cagtggcacc ataaacacaa tccctccatc
     2161 tatcttggtg accacactcc ccactccaaa tgcttcatct atgactacat ctgagaccac
     2221 ctatcctaat tctccgactg gtcctggtac aaactccacg acggaaatca cctatcccac
     2281 cactatgaca gagacatcat ccactgccac ctctcttcca cccacctctc ccttggtctc
     2341 aactgcaaaa acagccaaaa ctcctaccac aaacttggta accaccacca ccaagaccac
     2401 ctcacatagt accaccagct tcacttcttc aaccgtctac tccacagcca gcacatacac
     2461 aactgccatc acctcagttc ccactacgtt gggtaccatg gtaacttcta catccatgat
     2521 ctcatctact gtgagtacag gtatccctac ctcacaacca acaaccatca ctccctcatc
     2581 cgtgggcatc agtggttcat tacctatgat gacagacctc acctcagtgt acacagtctc
     2641 taacatgtct gcaaggccaa caactgtcat tccctcatct cccactgtcc agaatacaga
     2701 aatctcaatc tctgttagca tgacgtctgc taccactccc agtggaggac caactttcac
     2761 aagtactgag aacactccaa caaggtccct cctgacaagc tttccaatga cacattcatt
     2821 ctcttcttct atgtctgaaa gtagtgctgg gaccactcac acagagagta tctcctcacc
     2881 tcgaggcacc accagtacac tccacacaac agttgaatcc accccatcac ccactaccac
     2941 cacctcattt accacatcca caatgatgga accaccttca tccactgtat caactacagg
     3001 cagaggtcag accacctttc ccagctctac agccacattc cctgagacca ctacactgac
     3061 tcctacaact gacatttcta cagtatctct cacaacagcc atgacttctc ctccccccgt
     3121 cagttcttca atcactccca ccaatacaat gacttctatg agaactacaa cctattggcc
     3181 cacagccact aatacattat caccactcac cagtagcatt ttatcttcta cacctgtccc
     3241 aagcacagaa atgatcacca gtcataccac aaacaccacc cctctatcca ccttggtgac
     3301 tacactcctc actaccatca ccagatctac acctacatct gagaccacct accctacttc
     3361 tcccaccagc attgtctcag actccacgac tgaaatcacc tattccacaa gtataacagg
     3421 tacattgtcc actgccacta ctctcccacc cacctcttcc tctctcccaa ccacagaaac
     3481 agccacgatg actcctacca caaccttgat aaccaccacc cctaatacca cctcccttag
     3541 tacccccagc ttcacttctt caaccatcta ctccacagtc agcacatcca caactgccat
     3601 ctcctcagct tcccctacct caggtaccat ggtaacttcc acaaccatga ccccatcttc
     3661 tctgagtaca gacacccctt ccacaacacc aacaactatc acctaccctt ctgtgggctc
     3721 taccggtttc ctgactacag caacagacct cacatcaaca ttcactgttt ccagttcctc
     3781 agcaatgtcc acaagtgtca ttccatcttc ccccagcatc cagaatacag aaacctcatc
     3841 ccttgtcagc atgacctctg ccaccactcc cagtttgaga ccaactatca caagtactga
     3901 cagcactcta acaagttccc tcctgacgac cttcccaagt acatattcat tttcatcttc
     3961 catgtctgcc agcagtgcag ggaccactca cacagagact atttcctcac ttccagccag
     4021 caccaataca atccacacaa cagctgaatc cgccctggca cccactacca ccacctcatt
     4081 caccacatcc ccaacgatgg aaccaccttc aaccactgta gcgactacag gcacaggtca
     4141 gaccaccttc cccagctcta cagccacatt ccttgagacc accacactga ctcctacaac
     4201 tgacttttct acagaatctc tcacaacagc catgacttct actcccccca tcacttcttc
     4261 aatcactccc accgatacaa tgacttctat gagaactacg acctcttggc ccacagccac
     4321 taatacgtta tcaccactca ccagtagcat tttatcttct acacctgtcc caagcacaga
     4381 ggtgaccacc agtcatacca caaacaccaa tcctgtatcc acgttggtga ctacactccc
     4441 cattaccatc accaggtcta cacttacatc tgagaccgcc taccctagtt ctcccacaag
     4501 cactgtcaca gagtccacaa ctgaaatcac ctatcccacc actatgacag agacatcatc
     4561 tactgccacc tctcttccac ccacctcttc cttggtctca accgcagaaa cagccaaaac
     4621 tcctaccaca aacttggtaa ccaccaccac caagaccacc tcacatagta ccaccagctt
     4681 cacttcttca accatctact ccacagccag cacacccacc actgccatca cctcagttcc
     4741 cactaccttg ggtaccatgg tgacttctac atccatgatc ccatctactg tgagtacagg
     4801 tatccctacc tcacaaccaa caactattac tccctcatcc gtgggcatca gtggttcatt
     4861 acctatgatg acagacctca cctcagtgta cacagtctcc agcatgtctg caaggccaac
     4921 aagtgtcatt ccttcatctc ccactgtcca gaatacagaa acctcaatct ttgttagcat
     4981 gatgtctgct accactccca gtggaggacc aactttcaca agtactgaga acactccaac
     5041 aaggtccctc ctgacaagct ttccagtgac acattcattt tcctcttcca tgtctgccag
     5101 cagtgtaggg accactcaca cccagagtat ctcctcaccc ccagccatca ccagtacact
     5161 ccacacaaca gctgaatcca ccccatcacc tacaaccacc atgtcattca caacatttac
     5221 aaagatggaa acaccttcat ccactgtagc aactacaggc acaggtcaga ctacattcac
     5281 cagttcaaca gccacatccc ctaagaccac cacactgact cctacctctg acatttccac
     5341 aggatctttc aaaacagccg tgagttctac tccccccatc acttcttcaa tcacctccac
     5401 atatacggtg acttcgatga caactaccac ccctctaggg cccacagcca ctaatacgtt
     5461 accatcattt accagtagcg tttcatcttc tacgcctgtc ccaagtacag aagcgatcac
     5521 cagtggtacc acaaacacca cccctctatc tacattggtg accacattct ccaattccga
     5581 caccagttct acacctacat ctgagaccac ctaccctact tctcttacta gtgctctcac
     5641 agattccacg accagaacca cctattccac caatatgaca ggtacattgt ccactgtgac
     5701 ctctcttcga cccacctctt cctctctcct caccacagta acagccacag ttccaacaac
     5761 aaacttggta accacgacca ccaagatcac ctcacacagt actcctagct tcacttcttc
     5821 aatcgcaacc accgagaccc cctcacacag tactcccaga ttcacttctt caatcaccac
     5881 taccgagacc ccctcacaca gtactcccag attcacttct tcaatcacca ataccaagac
     5941 cacctcacac agctctccca gcttcacttc ttcgatcacc accaccgaga ccacatccca
     6001 caatactccc agcctcactt cttcaatcac caccaccaag accacctcac acagtactcc
     6061 cagctacact tctttgatca ccacaaccac caccacctca cacagtactc ccagcttcac
     6121 ttcttccatc accaccactg agaccacatc ccacaatact cccagcttga cttcttcgat
     6181 cacaaccacc gagaccacat cccatagtac tcccagcttc acttcttcga tcaccaccga
     6241 gaccacatcc cacagtactc ccagcttcac ttcattgatc accatcaccg agatcacctc
     6301 acacagtact ctcagctaca ctacctcaat caccaccacc gagaccccct cacacagtac
     6361 tctcagcttc acttcttcaa tcaccaccac tgagaccacc tcacacagta ctcccagctt
     6421 cacttcctca atcaccacct ctgagatgcc ctcacacagt actcccagct tcacttcttc
     6481 gatcaccacc actgagaacg ccacacacag tactcccaac ttcacttctt caatcaccac
     6541 caccgagacc acatcccaca gtactcccag cttcacttct ttgatcacca ccacggagac
     6601 cacctcacac aggtggggga ccaccgagac cacatcctac agtactccca gcttcacttc
     6661 ttcaaatacc atcactgaga ccacctcaca cagtactccc agctacatta cctcaatcac
     6721 caccaccgag accccctcaa gcagtactcc cagcttcagt tcttcgatca ccaccactga
     6781 gaccacatcc cacagtactc ccggcttcac ttcttcaatc accaccactg agactacatc
     6841 ccacagtact cccagcttca cttcttcgat caccaccact gagaccacct cacatgatac
     6901 tcccagcttc acttcttcaa tcaccaccag tgagaccccc tcacacagta ctcccagctc
     6961 cacttcttta atcaccacca ccaagaccac ctcacacagt actcccagct tcacttcttc
     7021 gatcaccacc acggagacca cctcacacag tgctcacagc ttcacttctt cgatcaccac
     7081 caccgagacc acctcacaca atactcgcag cttcacttct tcgatcacca ccaccgagac
     7141 caactctcac agtactacca gcttcacttc ttcgatcacc accaccgaga ccacctcaca
     7201 cagtactccc agcttcagtt cttcaatcac caccactgag acccccttac acagtactcc
     7261 tggcctcact tcgtgggtca ccaccaccaa gaccacctca cacattactc ctggcctcac
     7321 ttcttcaatc accaccactg agactacctc acacagtact cctggcttca cttcttcaat
     7381 caccaccact gagaccacct cagagagtac tcccagcctc agttcttcaa ccatctactc
     7441 cacagtcagc acatccacaa ctgccatcac ctcacatttt actacctcag agactgcggt
     7501 gactcccaca cctgtaaccc catcttctct gagtacagac atcccgacca caagcctacg
     7561 aactctcacc ccttcgtctg tgggcaccag cacttcattg actacaacca cagactttcc
     7621 ctctataccc actgatatca gtaccttacc aactcgaaca cacatcattt catcttctcc
     7681 ctccatccaa agtacagaaa cctcatccct tgtgggcacc acctctccca ccatgtccac
     7741 tgtgagaatg accctcagaa ttactgagaa caccccaatc agttccttta gcacaagtat
     7801 tgttgttata cctgaaaccc caacacagac ccctcctgta ctgacgtcag ccactgggac
     7861 ccaaacatct cctgcaccta ctactgtcac ctttggaagt acggattcct ccacgtccac
     7921 tcttcatact cttactccat caacagcctt gagcacgatc gtgtcaacat cacaggttcc
     7981 tattcctagc acacattcct ccacccttca aacaactcct tctactccct cattgcaaac
     8041 ttcactcaca tctacaagtg agttcactac agaatctttc actaggggaa gtacgtctac
     8101 aaatgcaatc ttgacttctt ttagtaccat catctggtcc tcaacaccca ctattatcat
     8161 gtcctcttct ccatcttctg ccagcataac tccagtgttt tccactacca ttcattctgt
     8221 tccttcttca ccatacattt tcagtacaga aaatgtgggc tccgcttcta tcacaggctt
     8281 tcctagtctc tcttcctctg caactaccag cacttcttca accagctcct ctctgaccac
     8341 agctctcact gaaataaccc ccttttctta tatttccctt ccctccacca caccctgtcc
     8401 aggaactata acaattacca tagtccctgc ctcccccact gatccatgtg ttgaaatgga
     8461 tcccagcact gaagctactt ctcctcccac caccccatta acagtctttc cctttactac
     8521 cgaaatggtc acctgtccta cctccatcag tatccaaact actcttacta catatatgga
     8581 cacttcttcc atgatgccag aaagtgagtc cagcatctca cccaatgctt ccagttccac
     8641 tggcactggg actgtaccca caaacacagt tttcacaagt actcgactgc ccaccagtga
     8701 gacctggctg agcaacagtt ctgtgatccc cctacctctt cctggcgtct ctaccatccc
     8761 gctcaccatg aaaccaagca gtagcctccc gaccatcctg aggacttcaa gcaagtcaac
     8821 acacccctcc ccacccacca ctaggacttc agagacacca gtggccacta cccagactcc
     8881 taccaccctt acatcacgca ggacaactcg catcacttct cagatgacca cacagtccac
     8941 gttgaccacc actgcaggca cctgtgacaa tggtggcacc tgggaacagg gccagtgtgc
     9001 ttgccttccg gggttttctg gggaccgctg tcagctccag accagatgcc agaatggggg
     9061 tcagtgggat ggcctcaaat gccagtgccc cagcaccttc tatggttcca gttgtgagtt
     9121 tgctgtggaa caggtggatc tagatgtagt ggagaccgag gtgggcatgg aagtgtctgt
     9181 ggatcagcag ttctcgccgg acctcaatga caacacttcc caggcctaca gggatttcaa
     9241 caagaccttc tggaatcaga tgcagaagat ttttgcagac atgcagggct tcaccttcaa
     9301 gggtgtggag atcctgtccc tgaggaatgg cagcatcgtg gtggactacc tggtcctgct
     9361 ggagatgccc ttcagccccc agctggagag cgagtatgag caggtgaaga ccacgctgaa
     9421 ggaggggctg cagaacgcca gccaggatgt gaacagctgc caggactccc agaccctgtg
     9481 ttttaagcct gactccatca aggtgaacaa caacagcaag acagagctga ccccggcagc
     9541 catctgccgc cgcgccgctc ccacgggcta tgaagagttc tacttcccct tggtggaggc
     9601 cacccggctc cgctgtgtca ccaaatgcac gtcgggggtg gacaacgcca tcgactgtca
     9661 ccagggccag tgcgttctgg agacgagcgg tcccacgtgt cgctgctact ccaccgacac
     9721 gcactggttc tctggcccgc gctgcgaggt ggccgtccac tggagggcgc tggtcggggg
     9781 cctgacggcc ggcgccgcgc tgctggtgct gctgctgctg gcgctgggcg tccgggcggt
     9841 gcgctccgga tggtggggcg gccagcgccg aggccggtcc tgggaccagg acaggaaatg
     9901 gttcgagacc tgggatgagg aagtcgtggg cactttttca aactggggtt tcgaggacga
     9961 cggaacagac aaggatacaa atttctatgt ggccttggag aacgtggaca ccactatgaa
    10021 ggtgcacatc aagagacccg agatgacctc gtcctcagtg tgagccctgc ggggcccctt
    10081 caccaccccc tccgccctgc cccggacaca agggtctgca ttgcgtccat ttcaagaggt
    10141 ggccccagga cgcgggcagc ccaggctcct gctgttcttg ggcaagatga gactgttccc
    10201 ccaaatccca tccttctcct tccaacttgg ctgaaaccca cctggagacg cagttcacgt
    10261 ccaggctctt ccactgtgga atcttgggca agtcagtaac gagcctcagt ttcctcacct
    10321 gcaaaacggg tacagcattc ctgtatgata gctcacgccg ttgttgtgaa aaccacatag
    10381 acttggtcaa ttctcggtcc tactctgccc tcccgtctca gccctcgtgt tgccattgcc
    10441 tctctcggat cctccaatcc tcacgtcctt cacctggtct ctggccctgg ttcttatttt
    10501 ctctcaattc cctactgcct gtttcttact ttgaacctgg aggcagcctg cagccccatc
    10561 ccatctcctg ccctctcctg atctaactcc ctgctgcatc tcttgctctc attccttaga
    10621 cgtcctcccc ttttgacccc gttccttcat ccatcctgca ccccagtccc ccagccctaa
    10681 atcctccctc ctctcctcac atcctggtcc ctagcaaggt atagatagcc tctgtgtctt
    10741 aggataccca ggtgctgttc tccccgtcac cccgttgccc agttccccgt ttctcttgct
    10801 ctcattcctt gtatcttctc ccttctgagc ccgtccattc atcggttctg cccccgactc
    10861 cccctgacct aaatacccca gctgctgttc cccccatcac cctgctgccc aattctttat
    10921 tctccacccc tttctctcac ccctggagcc ctgcgggtgg gggcagggca tgagttcccc
    10981 agtccccaag gaaaggcagc cccctcagtc tccctcctcc tcatttcctt cgatccccct
    11041 cccttcttgc ctcccctctg ccttttaaac ccatcccctc cgattcccct cctccccctt
    11101 ctcttcctgg tgtcacctgg attcctgcag taactctgag cccttgaaat cctcagtcgc
    11161 cttggcgggg aagattggct ttggggacag gaagtcggca catctccagg tcttcatgtg
    11221 cacaatacag agtttattgt aaaaagca
//
