LOCUS       NM_001395414            6019 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens mucin 22 (MUC22), transcript variant 4, mRNA.
ACCESSION   NM_001395414
VERSION     NM_001395414.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6019)
  AUTHORS   Castelli,E.C., de Castro,M.V., Naslavsky,M.S., Scliar,M.O.,
            Silva,N.S.B., Pereira,R.N., Ciriaco,V.A.O., Castro,C.F.B.,
            Mendes-Junior,C.T., Silveira,E.S., de Oliveira,I.M., Antonio,E.C.,
            Vieira,G.F., Meyer,D., Nunes,K., Matos,L.R.B., Silva,M.V.R.,
            Wang,J.Y.T., Esposito,J., Coria,V.R., Magawa,J.Y., Santos,K.S.,
            Cunha-Neto,E., Kalil,J., Bortolin,R.H., Hirata,M.H.,
            Dell'Aquila,L.P., Razuk-Filho,A., Batista-Junior,P.B.,
            Duarte-Neto,A.N., Dolhnikoff,M., Saldiva,P.H.N., Passos-Bueno,M.R.
            and Zatz,M.
  TITLE     MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient
            super-agers from Brazil
  JOURNAL   Front Immunol 13, 975918 (2022)
   PUBMED   36389712
  REMARK    GeneRIF: MUC22, HLA-A, and HLA-DOB variants and COVID-19 in
            resilient super-agers from Brazil.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6019)
  AUTHORS   Lin,S., Tian,C., Li,J., Liu,B., Ma,T., Chen,K., Gong,W., Wang,J.M.
            and Huang,J.
  TITLE     Differential MUC22 expression by epigenetic alterations in human
            lung squamous cell carcinoma and adenocarcinoma
  JOURNAL   Oncol Rep 45 (5) (2021)
   PUBMED   33786615
  REMARK    GeneRIF: Differential MUC22 expression by epigenetic alterations in
            human lung squamous cell carcinoma and adenocarcinoma.
REFERENCE   3  (bases 1 to 6019)
  AUTHORS   Chen,J.B., Zhang,J., Hu,H.Z., Xue,M. and Jin,Y.J.
  TITLE     Polymorphisms of TGFB1, TLE4 and MUC22 are associated with
            childhood asthma in Chinese population
  JOURNAL   Allergol Immunopathol (Madr) 45 (5), 432-438 (2017)
   PUBMED   28262390
  REMARK    GeneRIF: Genes TGFB1, TLE4 and MUC22 are associated with the risk
            of childhood asthma in Chinese population.
REFERENCE   4  (bases 1 to 6019)
  AUTHORS   Hijikata,M., Matsushita,I., Tanaka,G., Tsuchiya,T., Ito,H.,
            Tokunaga,K., Ohashi,J., Homma,S., Kobashi,Y., Taguchi,Y., Azuma,A.,
            Kudoh,S. and Keicho,N.
  TITLE     Molecular cloning of two novel mucin-like genes in the
            disease-susceptibility locus for diffuse panbronchiolitis
  JOURNAL   Hum Genet 129 (2), 117-128 (2011)
   PUBMED   20981447
  REMARK    GeneRIF: The mucin-like gene PBMUCL1 is also one of the candidate
            genes of Diffuse panbronchiolitis susceptibility.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669830.9.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2147975,
                              SAMEA2156670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000561890.1/ ENSP00000455906.1
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AL669830.9         104234-104536
            304-4902            AL669830.9         119262-123860
            4903-5288           AL669830.9         125956-126341
            5289-6019           AL669830.9         128432-129162
FEATURES             Location/Qualifiers
     source          1..6019
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..6019
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /note="mucin 22"
                     /db_xref="GeneID:100507679"
                     /db_xref="HGNC:HGNC:39755"
                     /db_xref="MIM:613917"
     exon            1..303
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..5555
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4; panbronchiolitis-related mucin-like protein 1"
                     /codon_start=1
                     /product="mucin-22 isoform 2 precursor"
                     /protein_id="NP_001382343.1"
                     /db_xref="CCDS:CCDS59003.1"
                     /db_xref="GeneID:100507679"
                     /db_xref="HGNC:HGNC:39755"
                     /db_xref="MIM:613917"
                     /translation="MRRGNISPAFWFLWLLLFGLLGPSSENTTAFTKGSDTTTASITG
                     SETTMASTMASTSALTTGSKITTDSTTGSETTSASTMASTAAFTTGSETNTASTTDSG
                     TTIASTRTFTTGSDTTTGSTAGSETIVASTTVSGTTTTFTIASTTVPETTMASSTTST
                     AGSEKTMASSIISETTMASTTGSETATVSTTGSETTTTSTASSEATKVSTTGSETTTA
                     STAGSETTTTSTSMAGSEATTTSTADSKVITASSMSSETTVAPAAGSNTTTASTTGSE
                     TTTILIKASETTTASTAGSETTTPSPTGSQTTIVSISGSEITTTSTAGSENTTVSSAG
                     SGTTTASMAGSETTVSTAGSETTTVSITGTETTMVSAMGSETTTNSTTSSETTVTSTA
                     GSETTTVSTVGSETTTAYTADSETTAASTTGSEMTTVFTAGSETITPSTAGSETTTVS
                     TAGSETTTVSTTGSETTTASTAHSETTAASTMGSETTKVSTAGSETTVSTAGSETTAA
                     STEDSETNTAFTEDSKTTTASTTGFETTAASTTGSEPTMASTMGSETTMASTIGPETT
                     KVSTASSEVTTVFAAGSETIRASTVGSETTTVSTTGSETTTASIMGSETSTDSTTGSE
                     TTTASTEGSETTTASTEGSEATTVSTTGSETTTVSITDSETTTTCTEGSEMTAVSTTV
                     FETTTASTEGSEITIASTSDSETTTASTEGSETTTVTTAGSETKTAYTTGSETTTASN
                     TGLETTTVFTIGSDTTTASTEGSETTAVSATGSEMTTVSTEGSENTTVSTTGSETTTV
                     STTGLETTTTSTEGSEMTTVSTTGAETTTDSTEGSGTTAASTAGSETTTVSTADSENT
                     TASTADSETTSASTTGSETTTASTTSSETTTASTEGSETTTVSTTDSETTMVSTTGSE
                     RTITSTEGSETTTVSATGSETTVSTEGSGTTTVSITGSETTKVSTTGSETTTTSTEGS
                     EITTASITGSETTTASTEGSETTTASTEGSETTSASTTGSETTTASTTSSETTMASIM
                     GSETTMASTIGSETTKVSTASSKMTTVFTENSETTIASTTASETTTVSTAGSETIPAS
                     TAGSETTTTTSTEGSETTTASTEGSETTTASTESSETTTATTIGSETTTASTEGSETT
                     TTSTEGSETTTASTEGSEITTVSTTGSETTTASTEGSETTTASTEGSELTTVSTTGSE
                     TITVSAEGSETTTVTTMGSETTTASTAGSETTTVSTAGSETTTASIEGSETTTVSSTG
                     SETTTVSTTGTETTITSTEGSETTTVTTAGSETTAVYTTGSETTTTSTEGSETTTVST
                     TGSETTTASTADLETTTVSTSGSGTTTASTAGSETTTVYITGSKTTTASTEGSEATTV
                     STTSSETTTASTTGSEMTTVFTTVSETTTVSTIGSEATTSSAAGSEATTTSTEGSETT
                     TASTAGSETTTASTAGSETTTASTSGSETNTACTTGSETSTPSSAGSETNTAFIIGSE
                     STIASTASLEPTATSLTGSETTTVSITASGATAASTTVSSTTFVLTKATDVSIQPITN
                     TPMSGTRTTGTRLTASSSVTMAPGMDFTASAASHTVPGIVLNTSGLGTSTMGASSTTS
                     AHGVRTTTGSTREPTSSTFQETGPVSMGTNTVSMSHTPTNVIKPSGYLQPWAIILISL
                     AAVVAAVGLSVGLSFCLRNLFFPLRYCGIYYPHGHSHSLGLDLNLGLGSGTFHSLGNA
                     LVHGGELEMGHGGTHGFGYGVGHGLSHIHGDGYGVNHGGHYGHGGGH"
     exon            304..4902
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            4903..5288
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /inference="alignment:Splign:2.1.0"
     exon            5289..6019
                     /gene="MUC22"
                     /gene_synonym="PBMUCL1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaaaagaag aaaaataaga agccaaactg tggagcaatt tgggggctcc ccccaaccat
       61 gccatctgcc tacaaggctt accctggcac tggctggcct ttgggtcttt ttgtgcaact
      121 ttattttcta tcaaggccca gggggtttgc cccttgtctc tctgcctctt tgacctatcc
      181 ttcctttgga acccaggcat ctaaatgaca acttctatgt gcatcattta gagatgagaa
      241 gaggaaatat ctctcctgct ttctggttcc tgtggctgct tctctttgga cttctgggac
      301 ccagctctga gaataccaca gccttcacaa aaggctccga caccaccaca gcctccatca
      361 caggctctga gaccaccatg gcctccacca tggcctctac ttcggcctta actacaggct
      421 ctaagatcac cacagactct accacaggct ctgagacaac ctcagcctcc accatggctt
      481 ctactgcagc cttcaccaca ggctctgaga ccaacacggc ctccaccaca gactcaggga
      541 ctactatagc ctccactagg accttcacca caggctctga cacaaccaca ggctccactg
      601 caggctctga aactatcgtg gcctccacca cagtctctgg gaccacaaca acctttacta
      661 tagcctccac tacagtccct gagactacca tggcctccag cacaacctcc actgcaggct
      721 ctgagaaaac gatggcctcc tccataattt ctgagaccac catggcctcc accacaggct
      781 ctgagactgc cacagtctct accacaggct ctgagaccac caccacctcc actgcaagct
      841 ctgaggccac taaagtctct accacaggct ctgaaaccac cacagcatct actgcaggtt
      901 ctgagaccac cactacctcc acctccatgg caggctctga ggccaccaca acctcaactg
      961 cagactccaa ggtgatcacg gcatccagca tgagctctga gaccactgtg gcccccgctg
     1021 caggctctaa caccaccaca gcctctacca caggctctga gaccactaca atcctgatta
     1081 aagcctctga gaccaccaca gcctctacag caggttctga gaccaccacc ccctccccca
     1141 caggctctca gaccaccata gtctctattt caggttctga gatcaccacc acctctacgg
     1201 caggatccga gaacaccaca gtctctagtg caggctctgg gaccaccaca gcttctatgg
     1261 caggctctga gaccaccgtc tccactgcag gctctgagac cactacagtc tctatcacag
     1321 gcactgagac caccatggtc tctgccatgg gctcagagac caccacaaac tctactacaa
     1381 gctctgagac caccgtcacc tctactgcag gctctgagac caccacagtc tccaccgtgg
     1441 gctctgagac caccacagcc tatactgcag attctgagac cactgcagcc tctaccacag
     1501 gctctgagat gaccacagtc ttcactgcag gctcggaaac catcacaccc tctactgcag
     1561 gctcagagac caccacagtc tctactgcag gctctgagac cactacagtc tccaccacag
     1621 gctctgagac cacaacagcc tctactgcac attctgagac gactgcagcc tccaccatgg
     1681 gctctgagac caccaaagtc tcaactgcag gctctgagac cacagtctcc actgcaggct
     1741 ctgagaccac tgcagcctct actgaagatt ctgaaaccaa cacagcattt actgaagatt
     1801 ctaagactac cacagcctct actacagggt ttgagacaac cgcagcctct actacaggct
     1861 ctgagcctac catggcatcc accatgggct ctgagaccac tatggcctct accataggcc
     1921 ctgagaccac caaggtctcc actgcaagct ctgaggtgac cacagtcttt gctgcaggct
     1981 ctgagacaat cagagcctct accgtaggct ctgagaccac cacagtctct accacaggct
     2041 ctgagaccac cacagcctcc atcatgggct ctgagaccag cacagattct accacaggct
     2101 ctgagaccac cacagcctct actgaaggct ctgagaccac cacagcttcc actgaaggct
     2161 ctgaggccac tacagtctcc accacaggct ctgagaccac tacagtttct atcacagact
     2221 cagagaccac caccacctgt actgaaggct ctgagatgac tgcagtctcc accacagtct
     2281 ttgagaccac tacagcctct actgaaggct ctgagatcac aatagcctct acttcagact
     2341 ctgagaccac cacagcttct actgaaggtt ctgagaccac tacagtcact accgcaggct
     2401 ctgagaccaa aacagcctat actacaggct ctgagaccac cacagcctct aatacaggct
     2461 tggagaccac cacagtcttt accataggct ctgacaccac cacagcctct actgaaggct
     2521 ctgagaccac tgcagtctct gccacaggct ctgagatgac cacagtctct actgaaggct
     2581 ctgagaacac tacagtctcc accacaggct ctgagaccac tacagtttcc accacaggct
     2641 tggagaccac caccacttcc actgaaggct ctgagatgac tacagtctcc accacaggtg
     2701 ctgagaccac cacagactct actgaaggct ctgggaccac tgcagcctcc actgcaggct
     2761 ctgagaccac cacagtctct actgcagatt ctgagaacac cacagcatct actgcagatt
     2821 ctgagaccac ctcagcctct actacaggct ctgagaccac cacagcctct actacaagct
     2881 ctgagaccac cacagcctct actgaaggct ctgagaccac tacagtctcc accacagact
     2941 ctgagaccac catggtctct accacaggct ctgagaggac catcacctct actgaaggct
     3001 ctgagaccac tacagtatct gccacaggct ctgagaccac agtctctact gaaggctctg
     3061 ggaccactac agtctccatc acaggctctg agaccactaa agtttctacc acaggttcag
     3121 agaccaccac cacttctact gaaggctctg agattactac agcctccatc acaggctctg
     3181 agaccaccac agcctctact gaaggctccg agaccaccac agcctctact gaaggctccg
     3241 agaccacctc agcctctact acaggctctg agaccaccac agcctctact acaagctctg
     3301 agaccaccat ggcatccatc atgggctctg agaccactat ggcctctacc ataggctctg
     3361 agaccaccaa ggtctccact gcaagctcta aaatgaccac agtcttcact gaaaactctg
     3421 agaccaccat agcctctacc acagcctctg agaccaccac agtctccact gcaggctctg
     3481 agaccatccc agcctctaca gcaggctctg agaccaccac caccacctct actgaaggct
     3541 ctgagaccac tacagcctct actgaaggct ctgagaccac cacagcctct actgaaagct
     3601 ctgagaccac tacagccact accataggct ctgagaccac cacagcctct actgaaggct
     3661 ctgagactac caccacctct actgaaggct ctgagaccac cacagcctct actgaaggct
     3721 ctgagatcac tacagtttct accacaggct ctgagaccac cacagcctct actgaaggct
     3781 ctgagaccac cacagcctct actgaaggct ctgagctcac tacagtttct accacaggct
     3841 ctgagaccat cacagtctct gctgaaggct ctgagaccac tacagtcact actatgggct
     3901 ctgagaccac cacggcctct actgcaggct cagagaccac cacagtctct actgcaggct
     3961 ctgagaccac cacagcctct attgaaggct ctgagaccac tacagtctcc tccacaggct
     4021 ctgagaccac cacagtctct accacaggca ctgagactac catcacctct actgaaggtt
     4081 cagagaccac tacagtcact actgcaggtt ctgagaccac agcagtctat accacaggct
     4141 ctgagactac caccacctct actgaaggct ctgagacaac cacagtctct accacgggct
     4201 ctgagaccac cacagcctct accgcagatt tggagaccac cacagtctcc acctcaggct
     4261 ctgggaccac cacagcctct accgcaggct ctgagaccac aacagtctat atcacaggct
     4321 ctaagactac caccgcctct actgaaggct ctgaggccac tacagtttct accactagct
     4381 ctgagaccac cacagcctct accacaggct ctgagatgac tacagtcttt accacagtct
     4441 ctgagaccac cacagtctct accataggct ctgaggccac cacatcctct gctgcaggct
     4501 ctgaggccac caccacctct actgaaggct ctgagaccac cacagcctcc actgcaggct
     4561 ctgagaccac cacagcctcc actgcaggct ctgagaccac cacagcctcc acttcaggct
     4621 ctgagaccaa cacagcctgt accacaggtt ctgagacctc cacaccctcc agtgcaggct
     4681 ctgagaccaa cactgccttc atcataggct ctgagagcac catagcttcc actgcaagct
     4741 tggagcccac tgcaacttcc ctcacaggct ctgagaccac cacagtctct atcacagctt
     4801 ctggggccac tgcagcctcc accactgtct cttccaccac gtttgtactc accaaggcca
     4861 ctgacgtttc tatccagccc atcaccaaca cacctatgtc aggcaccaga accactggaa
     4921 ccagactcac tgcctccagc tctgtcacca tggcccctgg aatggacttc acggcctctg
     4981 ctgccagcca tactgtgcca ggaatagtct taaacacctc tggcctgggt acatccacta
     5041 tgggagcatc atctaccacc tcagcccacg gcgtcaggac caccacagga tccacccgtg
     5101 agccaaccag cagcaccttc caggaaacag gcccggtgtc catgggcaca aacacagtta
     5161 gcatgagcca cacacccaca aacgtgatca aaccaagtgg atatttacag ccctgggcta
     5221 tcatcctcat ttccctggct gcagttgtgg ctgctgttgg attgtcagta ggactgagtt
     5281 tttgtctgag aaaccttttc ttccccctga gatattgtgg tatttattac ccccatggcc
     5341 acagccacag ccttggtctg gacctgaact tgggcctggg ctctgggaca ttccacagcc
     5401 tgggaaatgc actggttcat ggaggagaac ttgaaatggg acatggagga acacacggct
     5461 ttggatatgg agtgggccat ggactgagcc acatccatgg agatggctac ggagtgaatc
     5521 atggcgggca ttatggacat ggaggaggcc actgaggaca ccatggagtg gatcacagag
     5581 ggagccacca aggaggccac ggcaggacaa gatggctgtg gccatagatt gggtatcaaa
     5641 acatattatg ggtgggaggg ggtcatggag gagaaaaaaa taatgatcat gaaataatta
     5701 aaatggagca taggaagctt cccaggatgt gatccatgga gatggacatg gactaggtca
     5761 agaaaagaac cagcaaaagg acctcagaga ctttgactgg cttggagggg acttcaagtc
     5821 aaagcttctg tgagtttttc ctgagtctca gcctctgttg tggggagtca cgacaaccac
     5881 cctcaggaca tcttctctcc catttcccgc cacatcaggg tcaacgtttc tcatccctgt
     5941 gtttcctcat ggtgctataa atattaccaa gacatgtcta agaaacaaaa gcacataatg
     6001 aatgtattat cagggccac
//
