LOCUS       NM_001010909            3651 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens mucin 21, cell surface associated (MUC21), transcript
            variant 1, mRNA.
ACCESSION   NM_001010909 XM_371809
VERSION     NM_001010909.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3651)
  AUTHORS   Lee,D.H., Ahn,H., Sim,H.I., Choi,E., Choi,S., Jo,Y., Yun,B.,
            Song,H.K., Oh,S.J., Denda-Nagai,K., Park,C.S., Irimura,T., Park,Y.
            and Jin,H.S.
  TITLE     A CRISPR activation screen identifies MUC-21 as critical for
            resistance to NK and T cell-mediated cytotoxicity
  JOURNAL   J Exp Clin Cancer Res 42 (1), 272 (2023)
   PUBMED   37858248
  REMARK    GeneRIF: A CRISPR activation screen identifies MUC-21 as critical
            for resistance to NK and T cell-mediated cytotoxicity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3651)
  AUTHORS   Liu,X., Xiao,Y., Xiong,X. and Qi,X.
  TITLE     MUC21 controls melanoma progression via regulating SLITRK5 and
            hedgehog signaling pathway
  JOURNAL   Cell Biol Int 46 (9), 1458-1467 (2022)
   PUBMED   35579188
  REMARK    GeneRIF: MUC21 controls melanoma progression via regulating SLITRK5
            and hedgehog signaling pathway.
REFERENCE   3  (bases 1 to 3651)
  AUTHORS   Matsumura,M., Okudela,K., Nakashima,Y., Mitsui,H., Denda-Nagai,K.,
            Suzuki,T., Arai,H., Umeda,S., Tateishi,Y., Koike,C., Kataoka,T.,
            Irimura,T. and Ohashi,K.
  TITLE     Specific expression of MUC21 in micropapillary elements of lung
            adenocarcinomas - Implications for the progression of EGFR-mutated
            lung adenocarcinomas
  JOURNAL   PLoS One 14 (4), e0215237 (2019)
   PUBMED   30973916
  REMARK    GeneRIF: MUC21 proteins with a specific glycosylation status may be
            involved in the progression of EGFR-mutated lung adenocarcinomas,
            particularly at the stage where tumors are transforming from pure
            lepidic to micropapillary through low papillary lepidic lesions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3651)
  AUTHORS   Corfield,A.P.
  TITLE     Mucins: a biologically relevant glycan barrier in mucosal
            protection
  JOURNAL   Biochim Biophys Acta 1850 (1), 236-252 (2015)
   PUBMED   24821013
  REMARK    Review article
REFERENCE   5  (bases 1 to 3651)
  AUTHORS   Jonckheere,N., Skrypek,N., Frenois,F. and Van Seuningen,I.
  TITLE     Membrane-bound mucin modular domains: from structure to function
  JOURNAL   Biochimie 95 (6), 1077-1086 (2013)
   PUBMED   23178705
  REMARK    Review article
REFERENCE   6  (bases 1 to 3651)
  AUTHORS   Tian,Y., Denda-Nagai,K., Kamata-Sakurai,M., Nakamori,S., Tsukui,T.,
            Itoh,Y., Okada,K., Yi,Y. and Irimura,T.
  TITLE     Mucin 21 in esophageal squamous epithelia and carcinomas: analysis
            with glycoform-specific monoclonal antibodies
  JOURNAL   Glycobiology 22 (9), 1218-1226 (2012)
   PUBMED   22611128
REFERENCE   7  (bases 1 to 3651)
  AUTHORS   Hijikata,M., Matsushita,I., Tanaka,G., Tsuchiya,T., Ito,H.,
            Tokunaga,K., Ohashi,J., Homma,S., Kobashi,Y., Taguchi,Y., Azuma,A.,
            Kudoh,S. and Keicho,N.
  TITLE     Molecular cloning of two novel mucin-like genes in the
            disease-susceptibility locus for diffuse panbronchiolitis
  JOURNAL   Hum Genet 129 (2), 117-128 (2011)
   PUBMED   20981447
REFERENCE   8  (bases 1 to 3651)
  AUTHORS   Yi,Y., Kamata-Sakurai,M., Denda-Nagai,K., Itoh,T., Okada,K.,
            Ishii-Schrade,K., Iguchi,A., Sugiura,D. and Irimura,T.
  TITLE     Mucin 21/epiglycanin modulates cell adhesion
  JOURNAL   J Biol Chem 285 (28), 21233-21240 (2010)
   PUBMED   20388707
  REMARK    GeneRIF: Mucin 21/epiglycanin modulates cell adhesion
REFERENCE   9  (bases 1 to 3651)
  AUTHORS   Bafna,S., Kaur,S. and Batra,S.K.
  TITLE     Membrane-bound mucins: the mechanistic basis for alterations in the
            growth and survival of cancer cells
  JOURNAL   Oncogene 29 (20), 2893-2904 (2010)
   PUBMED   20348949
  REMARK    Review article
REFERENCE   10 (bases 1 to 3651)
  AUTHORS   Itoh,Y., Kamata-Sakurai,M., Denda-Nagai,K., Nagai,S., Tsuiji,M.,
            Ishii-Schrade,K., Okada,K., Goto,A., Fukayama,M. and Irimura,T.
  TITLE     Identification and expression of human epiglycanin/MUC21: a novel
            transmembrane mucin
  JOURNAL   Glycobiology 18 (1), 74-83 (2008)
   PUBMED   17977904
  REMARK    GeneRIF: Identification and expression of human epiglycanin/MUC21:
            a novel transmembrane mucin
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA763771.1, BC105737.1,
            DC373882.1, AK298642.1, BC105735.1 and AL669830.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001010909.4.
            
            Summary: This gene encodes a large membrane-bound glycoprotein
            which is a member of the mucin family. Mucins are O-glycosylated
            proteins that play an essential role in forming protective mucous
            barriers on epithelial surfaces. These proteins also play a role in
            intracellular signaling. The encoded protein contains an N-terminal
            signal sequence, an extracellular mucin domain, a stem domain, a
            transmembrane domain, and a C-terminal cytoplasmic tail domain. The
            mucin domain contains O-glycosylation sites and is polymorphic with
            isoforms containing a variable number of nonidentical proline-,
            threonine-, and serine-rich tandem repeats of 15 amino acids each.
            The aberrent expression of this gene is associated with lung
            adenocarcinoma. [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK316363.1, BC105735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376296.3/ ENSP00000365473.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DA763771.1         11-65
            56-533              BC105737.1         1-478
            534-534             DC373882.1         534-534
            535-2295            AK298642.1         533-2293
            2296-2385           BC105735.1         2241-2330
            2386-3651           AL669830.9         82398-83663
FEATURES             Location/Qualifiers
     source          1..3651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3651
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="mucin 21, cell surface associated"
                     /db_xref="GeneID:394263"
                     /db_xref="HGNC:HGNC:21661"
                     /db_xref="MIM:616991"
     exon            1..302
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1942
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epiglycanin; mucin-21"
                     /codon_start=1
                     /product="mucin-21 isoform 1 precursor"
                     /protein_id="NP_001010909.2"
                     /db_xref="CCDS:CCDS34388.1"
                     /db_xref="GeneID:394263"
                     /db_xref="HGNC:HGNC:21661"
                     /db_xref="MIM:616991"
                     /translation="MKMQKGNVLLMFGLLLHLEAATNSNETSTSANTGSSVISSGAST
                     ATNSGSSVTSSGVSTATISGSSVTSNGVSIVTNSEFHTTSSGISTATNSEFSTVSSGI
                     SIATNSESSTTSSGASTATNSESSTPSSGASTATNSDSSTTSSGASTATNSDSSTTSS
                     EASTATNSESSTTSSGASTATNSESSTVSSRASTATNSESSTTSSGASTATNSESRTT
                     SNGAGTATNSESSTTSSGASTATNSESSTPSSGAGTATNSESSTTSSGAGTATNSESS
                     TVSSGISTVTNSESSTPSSGANTATNSESSTTSSGANTATNSDSSTTSSGASTATNSE
                     SSTTSSGASTATNSESSTTSSGASTATNSGSSTTSSGTSTATNSESSTVSSGASTATT
                     SESSTTSSGASTATNSESSTVSSGASTATNSESSTTSSGANTATNSGSSVTSAGSGTA
                     ALTGMHTTSHSASTAVSEAKPGGSLVPWEIFLITLVSVVAAVGLFAGLFFCVRNSLSL
                     RNTFNTAVYHPHGLNHGLGPGPGGNHGAPHRPRWSPNWFWRRPVSSIAMEMSGRNSGP
                     "
     exon            303..1747
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..3651
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="hexamer: AGTAAA"
     polyA_site      2296
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="major polyA site"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="hexamer: ATTAAA"
     polyA_site      3651
                     /gene="MUC21"
                     /gene_synonym="C6orf205; KMQK697; MUC-21"
                     /note="major polyA site"
ORIGIN      
        1 agagaaagag gcaactacat tgcctggagg aagcctaagg aacccaggca tccagctgcc
       61 cacgcctgag tccaagattc ttcccaggaa cacaaacgta ggagacccac gctcctggaa
      121 gcaccagcct ttatctcttc accttcaagt cccctttctc aagaatcctc tgttctttgc
      181 cctctaaagt cttggtacat ctaggaccca ggcatcttgc tttccagcca caaagagaca
      241 gatgaagatg cagaaaggaa atgttctcct tatgtttggt ctactattgc atttagaagc
      301 tgcaacaaat tccaatgaga ctagcacctc tgccaacact ggatccagtg tgatctccag
      361 tggagccagc acagccacca actctgggtc cagtgtgacc tccagtgggg tcagcacagc
      421 caccatctca gggtccagcg tgacctccaa tggggtcagc atagtcacca actctgagtt
      481 ccatacaacc tccagtggga tcagcacagc caccaactct gagttcagca cagtgtccag
      541 tgggatcagc atagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc
      601 caccaactct gagtccagca caccctccag tggggccagc acagccacca actctgactc
      661 cagcacaacc tccagtgggg ctagcacagc caccaactct gactccagca caacctccag
      721 tgaggccagc acagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc
      781 caccaactct gagtccagca cagtgtccag tagggccagc actgccacca actctgagtc
      841 cagcacaacc tccagtgggg ccagcacagc caccaactct gagtccagaa cgacctccaa
      901 tggggctggc acagccacca actctgagtc cagcacgacc tccagtgggg ccagcacagc
      961 caccaactct gagtccagca caccctccag tggggccggc acagccacca actctgagtc
     1021 cagcacgacc tccagtgggg ccggcacagc caccaactct gagtccagca cagtgtccag
     1081 tgggatcagc acagtcacca attctgagtc cagcacaccc tccagtgggg ccaacacagc
     1141 caccaactct gagtccagta cgacctccag tggggccaac acagccacca actctgactc
     1201 cagcacaacc tccagtgggg ccagcacagc caccaactct gagtccagca cgacctccag
     1261 tggggccagc acagccacca actctgagtc cagcacaacc tccagtgggg ccagcacagc
     1321 caccaactct gggtccagca cgacctccag tgggaccagc acagccacca actctgagtc
     1381 cagcacagtg tccagtgggg ccagcacagc caccacctct gagtccagca cgacctccag
     1441 tggggccagc acagccacca actctgagtc cagcacagtg tccagtgggg ccagcactgc
     1501 caccaattct gagtccagca caacctccag tggggccaac acagccacca actctgggtc
     1561 cagtgtgacc tctgcaggct ctggaacagc agctctgact ggaatgcaca caacttccca
     1621 tagtgcatct actgcagtga gtgaggcgaa gcctggtggg tccctggtgc cgtgggaaat
     1681 cttcctcatc accctggtct cggttgtggc ggccgtgggg ctctttgctg ggctcttctt
     1741 ctgtgtgaga aacagcctgt ccctgagaaa cacctttaac acagctgtct accaccctca
     1801 tggcctcaac catggccttg gtccaggccc tggagggaat catggagccc cccacaggcc
     1861 caggtggagt cctaactggt tctggaggag accagtatcc tcgatagcca tggagatgag
     1921 cgggaggaac agcgggccct gagcagcccc ggaagcaagt gccgcattct tcaggaagga
     1981 agagacctgg gcacccaaga cctggtttcc tttcattcat cccaggagac ccctcccagc
     2041 tttgtttgag atcctgaaaa tcttgaagaa ggtattcctc acctttcttg cctttaccag
     2101 acactggaaa gagaatacta tattgctcat ttagctaaga aataaataca tctcatctaa
     2161 cacacacgac aaagagaagc tgtgcgtgcc ccggggtggg tatctagctc tgagatgaac
     2221 tcagttatag gagaaaacct ccatgctgga ctccatctgg cattcaaaat ctccacagta
     2281 aaatccaaag acctcattct tatctgtgtg tctgcatttt ctaatccttt ttgccccagg
     2341 caaggtccct gtatctctga gacaccccga ttggctggag aattgacttg ggagagataa
     2401 ggagggaggg cgggtgccag catgctatgg gctcctgcgt gaggcctgtg gtacacagag
     2461 attaggttgt gatacatgaa gagccaagag caggatgagg tggaggcgtt acaactacct
     2521 gctctgtgtg tgggggggga ggggggaggg gggtacgcat attcacttga agtcgaggtt
     2581 cccagggcat ttccatgtgc tccaggcctg actacccatc agggtggagg agctggtgac
     2641 actcatctcc ctgagtgctc cctggtttcc caagggaaag actttctggc ctgctgaggt
     2701 cgaatcttcc aagaggctct tgcaaagacc cgagattctc ataaatcccc gcccagaaga
     2761 gctgcacgta tccctttcat gagtccaggg aagagggtcc tccaggtctt ggaagacaga
     2821 ggggagctgc tttagaggct aagttgcttt gagcccacaa ggtaatggag ggctcctact
     2881 tgggacagag ccctcagcag agaattagca gtctgttggt gggttcaccc caactcacag
     2941 cagtagaaac tgctccatct tccaccactt attgggtttc tccagtgtca gcaaaccaaa
     3001 gaattggatc ttaccaatgc ggctatagga aaacagcctg ttgcatggta agagtgatac
     3061 catcttgaag tgaaaccacc acaatggcca tttttttttt agatggagtt ttgcagtggt
     3121 gcaatcatag ctcattgcag ccttcaattc ctgggctcag gcaatcctcc tgcctcagcc
     3181 tcctgagtag ctgggactac agtttcgtgt gccaccatgc ctggctaatt tttagaattt
     3241 tttgtaggga cagggcctca ctctgttgca caagctggtc ttgaactcct ggcctccttg
     3301 aactcctcct gccttggcct cccaaaatgc tgagattaca ggtgtgagcc actgcacctc
     3361 gccagatgtc caatgtctga ctcctgcata ccaaggtgtt ctgtatcaag ggctttaaaa
     3421 caatgcctgt agcgtaatta acctctcaca aagatgctta tctaacctcc ccagcagtca
     3481 tgggtttcag caagaaagtc tgtgatgtga ccagttgcac atgttttccc ctaaaagctt
     3541 actctagaaa ggatattttt tggagaggga gtgtgggaat ccaccatctt gtggccacct
     3601 cagacatcac ttctctttgg aagactccat taaatatttc tctgtgagaa a
//
