LOCUS       NM_001040105           14352 bp    mRNA    linear   PRI 19-SEP-2023
DEFINITION  Homo sapiens mucin 17, cell surface associated (MUC17), transcript
            variant 1, mRNA.
ACCESSION   NM_001040105 XM_001719956
VERSION     NM_001040105.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14352)
  AUTHORS   Machado GC and Ferrer VP.
  TITLE     MUC17 mutations and methylation are associated with poor prognosis
            in adult-type diffuse glioma patients
  JOURNAL   J Neurol Sci 452, 120762 (2023)
   PUBMED   37562166
  REMARK    GeneRIF: MUC17 mutations and methylation are associated with poor
            prognosis in adult-type diffuse glioma patients.
REFERENCE   2  (bases 1 to 14352)
  AUTHORS   Lin S, Ruan H, Qin L, Zhao C, Gu M, Wang Z, Liu B, Wang H and Wang
            J.
  TITLE     Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic
            downregulation of MUC17 by facilitating NF-kappaB activity via
            UHRF1/DNMT1 complex
  JOURNAL   Int J Biol Sci 19 (3), 832-851 (2023)
   PUBMED   36778111
  REMARK    GeneRIF: Acquired resistance to EGFR-TKIs in NSCLC mediates
            epigenetic downregulation of MUC17 by facilitating NF-kappaB
            activity via UHRF1/DNMT1 complex.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 14352)
  AUTHORS   Schneider H, Berger E, Dolan B, Martinez-Abad B, Arike L, Pelaseyed
            T and Hansson GC.
  TITLE     The human transmembrane mucin MUC17 responds to TNFalpha by
            increased presentation at the plasma membrane
  JOURNAL   Biochem J 476 (16), 2281-2295 (2019)
   PUBMED   31387973
  REMARK    GeneRIF: Overexpression and increased presentation at the plasma
            membrane of wild-type MUC17 and its phosphodeficient variant MUC17
            S-4492A protected Caco-2 cells against adhesion of enteropathogenic
            Escherichia coli, indicating that C-terminal phosphorylation of
            MUC17 may play a functional role in epithelial cell protection.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 14352)
  AUTHORS   Yang B, Wu A, Hu Y, Tao C, Wang JM, Lu Y and Xing R.
  TITLE     Mucin 17 inhibits the progression of human gastric cancer by
            limiting inflammatory responses through a MYH9-p53-RhoA regulatory
            feedback loop
  JOURNAL   J Exp Clin Cancer Res 38 (1), 283 (2019)
   PUBMED   31262330
  REMARK    GeneRIF: MUC17 inactivated NFkappaB to inhibit gastric cancer cell
            proliferation in response to pro-inflammatory cytokines. The MUC17
            function was dependent on its conserved epidermal growth factor
            domain and on downstream sequences to enable its interaction with
            myosin-9, resulting in a regulatory feedback loop between myosin-9,
            p53, and RhoA, and then activation of p38 to negatively regulate
            the NFkappaB pathway in gastric ca...
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 14352)
  AUTHORS   Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR,
            Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME,
            Asara JM, Palumbo A, Roccaro AM, Hynes RO and Ghobrial IM.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   6  (bases 1 to 14352)
  AUTHORS   Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS,
            Noh SM, Kim S, Yoo HS, Kim YS and Kim NS.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 14352)
  AUTHORS   Ho JJ, Jaituni RS, Crawley SC, Yang SC, Gum JR and Kim YS.
  TITLE     N-glycosylation is required for the surface localization of MUC17
            mucin
  JOURNAL   Int J Oncol 23 (3), 585-592 (2003)
   PUBMED   12888891
  REMARK    GeneRIF: surface localization of the smaller subunit of MUC17 is
            dependent on its N-glycosylation status
REFERENCE   8  (bases 1 to 14352)
  AUTHORS   Wang R, Khatri IA and Forstner JF.
  TITLE     C-terminal domain of rodent intestinal mucin Muc3 is
            proteolytically cleaved in the endoplasmic reticulum to generate
            extracellular and membrane components
  JOURNAL   Biochem J 366 (Pt 2), 623-631 (2002)
   PUBMED   12027806
REFERENCE   9  (bases 1 to 14352)
  AUTHORS   Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE and Kim YS.
  TITLE     MUC17, a novel membrane-tethered mucin
  JOURNAL   Biochem Biophys Res Commun 291 (3), 466-475 (2002)
   PUBMED   11855812
  REMARK    GeneRIF: sequence homology & chromosome mapping
REFERENCE   10 (bases 1 to 14352)
  AUTHORS   Van Klinken BJ, Van Dijken TC, Oussoren E, Buller HA, Dekker J and
            Einerhand AW.
  TITLE     Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid
            tandem repeat region
  JOURNAL   Biochem Biophys Res Commun 238 (1), 143-148 (1997)
   PUBMED   9299468
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105446.4, AJ606307.1,
            BM773519.1, BM768498.1 and BM987743.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001040105.1.
            
            Summary: The protein encoded by this gene is a membrane-bound mucin
            that provides protection to gut epithelial cells. The encoded
            protein contains about 60 tandem repeats, with each repeat being
            around 60 aa. N-glycosylation enables the encoded protein to
            localize on the cell surface, while the C-terminus interacts with
            the scaffold protein PDZ domain containing 1 (PDZK1). Two
            transcript variants, one protein-coding and the other non-protein
            coding, have been found for this gene. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and is the protein-coding variant.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ606307.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306151.9/ ENSP00000302716.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC105446.4         57319-57320
            3-137               AJ606307.1         1-135
            138-139             AC105446.4         68358-68359
            140-247             AJ606307.1         138-245
            248-449             AC105446.4         68847-69048
            450-13662           AJ606307.1         448-13660
            13663-14189         BM773519.1         176-702
            14190-14214         AJ606307.1         14188-14212
            14215-14343         BM768498.1         212-340
            14344-14352         BM987743.1         19-27               c
FEATURES             Location/Qualifiers
     source          1..14352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..14352
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /note="mucin 17, cell surface associated"
                     /db_xref="GeneID:140453"
                     /db_xref="HGNC:HGNC:16800"
                     /db_xref="MIM:608424"
     exon            1..137
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..13537
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /note="small intestinal mucin MUC3; membrane mucin MUC17;
                     secreted mucin MUC17; small intestinal mucin-3"
                     /codon_start=1
                     /product="mucin-17 precursor"
                     /protein_id="NP_001035194.1"
                     /db_xref="CCDS:CCDS34711.1"
                     /db_xref="GeneID:140453"
                     /db_xref="HGNC:HGNC:16800"
                     /db_xref="MIM:608424"
                     /translation="MPRPGTMALCLLTLVLSLLPPQAAAEQDLSVNRAVWDGGGCISQ
                     GDVLNRQCQQLSQHVRTGSAANTATGTTSTNVVEPRMYLSCSTNPEMTSIESSVTSDT
                     PGVSSTRMTPTESRTTSESTSDSTTLFPSSTEDTSSPTTPEGTDVPMSTPSEESISST
                     MAFVSTAPLPSFEAYTSLTYKVDMSTPLTTSTQASSSPTTPESTTIPKSTNSEGSTPL
                     TSMPASTMKVASSEAITLLTTPVEISTPVTISAQASSSPTTAEGPSLSNSAPSGGSTP
                     LTRMPLSVMLVVSSEASTLSTTPAATNIPVITSTEASSSPTTAEGTSIPTSTYTEGST
                     PLTSTPASTMPVATSEMSTLSITPVDTSTLVTTSTEPSSLPTTAEATSMLTSTLSEGS
                     TPLTNMPVSTILVASSEASTTSTIPVDSKTFVTTASEASSSPTTAEDTSIATSTPSEG
                     STPLTSMPVSTTPVASSEASNLSTTPVDSKTQVTTSTEASSSPPTAEVNSMPTSTPSE
                     GSTPLTSMSVSTMPVASSEASTLSTTPVDTSTPVTTSSEASSSSTTPEGTSIPTSTPS
                     EGSTPLTNMPVSTRLVVSSEASTTSTTPADSNTFVTTSSEASSSSTTAEGTSMPTSTY
                     SERGTTITSMSVSTTLVASSEASTLSTTPVDSNTPVTTSTEATSSSTTAEGTSMPTST
                     YTEGSTPLTSMPVNTTLVASSEASTLSTTPVDTSTPVTTSTEASSSPTTADGASMPTS
                     TPSEGSTPLTSMPVSKTLLTSSEASTLSTTPLDTSTHITTSTEASCSPTTTEGTSMPI
                     STPSEGSPLLTSIPVSITPVTSPEASTLSTTPVDSNSPVTTSTEVSSSPTPAEGTSMP
                     TSTYSEGRTPLTSMPVSTTLVATSAISTLSTTPVDTSTPVTNSTEARSSPTTSEGTSM
                     PTSTPGEGSTPLTSMPDSTTPVVSSEARTLSATPVDTSTPVTTSTEATSSPTTAEGTS
                     IPTSTPSEGTTPLTSTPVSHTLVANSEASTLSTTPVDSNTPLTTSTEASSPPPTAEGT
                     SMPTSTPSEGSTPLTRMPVSTTMVASSETSTLSTTPADTSTPVTTYSQASSSSTTADG
                     TSMPTSTYSEGSTPLTSVPVSTRLVVSSEASTLSTTPVDTSIPVTTSTEASSSPTTAE
                     GTSIPTSPPSEGTTPLASMPVSTTLVVSSEANTLSTTPVDSKTQVATSTEASSPPPTA
                     EVTSMPTSTPGERSTPLTSMPVRHTPVASSEASTLSTSPVDTSTPVTTSAETSSSPTT
                     AEGTSLPTSTTSEGSTLLTSIPVSTTLVTSPEASTLLTTPVDTKGPVVTSNEVSSSPT
                     PAEGTSMPTSTYSEGRTPLTSIPVNTTLVASSAISILSTTPVDNSTPVTTSTEACSSP
                     TTSEGTSMPNSNPSEGTTPLTSIPVSTTPVVSSEASTLSATPVDTSTPGTTSAEATSS
                     PTTAEGISIPTSTPSEGKTPLKSIPVSNTPVANSEASTLSTTPVDSNSPVVTSTAVSS
                     SPTPAEGTSIAISTPSEGSTALTSIPVSTTTVASSEINSLSTTPAVTSTPVTTYSQAS
                     SSPTTADGTSMQTSTYSEGSTPLTSLPVSTMLVVSSEANTLSTTPIDSKTQVTASTEA
                     SSSTTAEGSSMTISTPSEGSPLLTSIPVSTTPVASPEASTLSTTPVDSNSPVITSTEV
                     SSSPTPAEGTSMPTSTYTEGRTPLTSITVRTTPVASSAISTLSTTPVDNSTPVTTSTE
                     ARSSPTTSEGTSMPNSTPSEGTTPLTSIPVSTTPVLSSEASTLSATPIDTSTPVTTST
                     EATSSPTTAEGTSIPTSTLSEGMTPLTSTPVSHTLVANSEASTLSTTPVDSNSPVVTS
                     TAVSSSPTPAEGTSIATSTPSEGSTALTSIPVSTTTVASSETNTLSTTPAVTSTPVTT
                     YAQVSSSPTTADGSSMPTSTPREGRPPLTSIPVSTTTVASSEINTLSTTLADTRTPVT
                     TYSQASSSPTTADGTSMPTPAYSEGSTPLTSMPLSTTLVVSSEASTLSTTPVDTSTPA
                     TTSTEGSSSPTTAGGTSIQTSTPSERTTPLAGMPVSTTLVVSSEGNTLSTTPVDSKTQ
                     VTNSTEASSSATAEGSSMTISAPSEGSPLLTSIPLSTTPVASPEASTLSTTPVDSNSP
                     VITSTEVSSSPIPTEGTSMQTSTYSDRRTPLTSMPVSTTVVASSAISTLSTTPVDTST
                     PVTNSTEARSSPTTSEGTSMPTSTPSEGSTPFTSMPVSTMPVVTSEASTLSATPVDTS
                     TPVTTSTEATSSPTTAEGTSIPTSTLSEGTTPLTSIPVSHTLVANSEVSTLSTTPVDS
                     NTPFTTSTEASSPPPTAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFETSTLSTTPAD
                     TSTPVTTYSQAGSSPTTADDTSMPTSTYSEGSTPLTSVPVSTMPVVSSEASTHSTTPV
                     DTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSSEAGTLSTTP
                     VDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPEASTLSTT
                     PVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEASTLST
                     TPVDTSIPVTTSTETSSSPTTAKDTSMPISTPSEVSTSLTSILVSTMPVASSEASTLS
                     TTPVDTRTLVTTSTGTSSSPTTAEGSSMPTSTPGERSTPLTNILVSTTLLANSEASTL
                     STTPVDTSTPVTTSAEASSSPTTAEGTSMRISTPSDGSTPLTSILVSTLPVASSEAST
                     VSTTAVDTSIPVTTSTEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAG
                     TLSTTPVDTSTPVTTSTKASSSPTTAEGIVVPISTASEGSTLLTSIPVSTTPVASSEA
                     STLSTTPVDTSIPVTTSTEGSSSPTTAEGTSMPISTPSEVSTPLTSILVSTVPVAGSE
                     ASTLSTTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASS
                     EASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTPLTSIPVSTTPVAI
                     PEASTLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPVT
                     SSAISTLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEGSTPLTYMPVSTMLV
                     VSSEDSTLSATPVDTSTPVTTSTEATSSTTAEGTSIPTSTPSEGMTPLTSVPVSNTPV
                     ASSEASILSTTPVDSNTPLTTSTEASSSPPTAEGTSMPTSTPSEGSTPLTSMPVSTTT
                     VASSETSTLSTTPADTSTPVTTYSQASSSPPIADGTSMPTSTYSEGSTPLTNMSFSTT
                     PVVSSEASTLSTTPVDTSTPVTTSTEASLSPTTAEGTSIPTSSPSEGTTPLASMPVST
                     TPVVSSEVNTLSTTPVDSNTLVTTSTEASSSPTIAEGTSLPTSTTSEGSTPLSIMPLS
                     TTPVASSEASTLSTTPVDTSTPVTTSSPTNSSPTTAEVTSMPTSTAGEGSTPLTNMPV
                     STTPVASSEASTLSTTPVDSNTFVTSSSQASSSPATLQVTTMRMSTPSEGSSSLTTML
                     LSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNSTPTPPEVITLPMSTPSEVSTPLTIM
                     PVSTTSVTISEAGTASTLPVDTSTPVITSTQVSSSPVTPEGTTMPIWTPSEGSTPLTT
                     MPVSTTRVTSSEGSTLSTPSVVTSTPVTTSTEAISSSATLDSTTMSVSMPMEISTLGT
                     TILVSTTPVTRFPESSTPSIPSVYTSMSMTTASEGSSSPTTLEGTTTMPMSTTSERST
                     LLTTVLISPISVMSPSEASTLSTPPGDTSTPLLTSTKAGSFSIPAEVTTIRISITSER
                     STPLTTLLVSTTLPTSFPGASIASTPPLDTSTTFTPSTDTASTPTIPVATTISVSVIT
                     EGSTPGTTIFIPSTPVTSSTADVFPATTGAVSTPVITSTELNTPSTSSSSTTTSFSTT
                     KEFTTPAMTTAAPLTYVTMSTAPSTPRTTSRGCTTSASTLSATSTPHTSTSVTTRPVT
                     PSSESSRPSTITSHTIPPTFPPAHSSTPPTTSASSTTVNPEAVTTMTTRTKPSTRTTS
                     FPTVTTTAVPTNTTIKSNPTSTPTVPRTTTCFGDGCQNTASRCKNGGTWDGLKCQCPN
                     LYYGELCEEVVSSIDIGPPETISAQMELTVTVTSVKFTEELKNHSSQEFQEFKQTFTE
                     QMNIVYSGIPEYVGVNITKLRLGSVVVEHDVLLRTKYTPEYKTVLDNATEVVKEKITK
                     VTTQQIMINDICSDMMCFNTTGTQVQNITVTQYDPEEDCRKMAKEYGDYFVVEYRDQK
                     PYCISPCEPGFSVSKNCNLGKCQMSLSGPQCLCVTTETHWYSGETCNQGTQKSLVYGL
                     VGAGVVLMLIILVALLMLVFRSKREVKRQKYRLSQLYKWQEEDSGPAPGTFQNIGFDI
                     CQDDDSIHLESIYSNFQPSLRHIDPETKIRIQRPQVMTTSF"
     exon            138..239
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            240..12458
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12459..12590
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12591..12718
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12719..12777
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12778..12929
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12930..12998
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            12999..13158
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            13159..13320
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            13321..13418
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            13419..13495
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
     exon            13496..14352
                     /gene="MUC17"
                     /gene_synonym="MUC-17; MUC-3; MUC3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catttcgcca gctcctctgg gggtgacagg caagtgagac gtgctcagag ctccgatgcc
       61 aaggccaggg accatggcgc tgtgtctgct gaccttggtc ctctcgctct tgcccccaca
      121 agctgctgca gaacaggacc tcagtgtgaa cagggctgtg tgggatggag gagggtgcat
      181 ctcccaaggg gacgtcttga accgtcagtg ccagcagctg tctcagcacg ttaggacagg
      241 ttctgcggca aacaccgcca caggtacaac atctacaaat gtcgtggagc caagaatgta
      301 tttgagttgc agcaccaacc ctgagatgac ctcgattgag tccagtgtga cttcagacac
      361 tcctggtgtc tccagtacca ggatgacacc aacagaatcc agaacaactt cagaatctac
      421 cagtgacagc accacacttt tccccagttc tactgaagac acttcatctc ctacaactcc
      481 tgaaggcacc gacgtgccca tgtcaacacc aagtgaagaa agcatttcat caacaatggc
      541 ttttgtcagc actgcacctc ttcccagttt tgaggcctac acatctttaa catataaggt
      601 tgatatgagc acacctctga ccacttctac tcaggcaagt tcatctccta ctactcctga
      661 aagcaccacc atacccaaat caactaacag tgaaggaagc actccattaa caagtatgcc
      721 tgccagcacc atgaaggtgg ccagttcaga ggctatcacc cttttgacaa ctcctgttga
      781 aatcagcaca cctgtgacca tttctgctca agccagttca tctcctacaa ctgctgaagg
      841 tcccagcctg tcaaactcag ctcctagtgg aggaagcact ccattaacaa gaatgcctct
      901 cagcgtgatg ctggtggtca gttctgaggc tagcaccctt tcaacaactc ctgctgccac
      961 caacattcct gtgatcactt ctactgaagc cagttcatct cctacaacgg ctgaaggcac
     1021 cagcatacca acctcaactt atactgaagg aagcactcca ttaacaagta cgcctgccag
     1081 caccatgccg gttgccactt ctgaaatgag cacactttca ataactcctg ttgacaccag
     1141 cacacttgtg accacttcta ctgaacccag ttcacttcct acaactgctg aagctaccag
     1201 catgctaacc tcaactctta gtgaaggaag cactccatta acaaatatgc ctgtcagcac
     1261 catattggtg gccagttctg aggctagcac cacttcaaca attcctgttg actccaaaac
     1321 ttttgtgacc actgctagtg aagccagctc atctcccaca actgctgaag ataccagcat
     1381 tgcaacctca actcctagtg aaggaagcac tccattaaca agtatgcctg tcagcaccac
     1441 tccagtggcc agttctgagg ctagcaacct ttcaacaact cctgttgact ccaaaactca
     1501 ggtgaccact tctactgaag ccagttcatc tcctccaact gctgaagtta acagcatgcc
     1561 aacctcaact cctagtgaag gaagcactcc attaacaagt atgtctgtca gcaccatgcc
     1621 ggtggccagt tctgaggcta gcaccctttc aacaactcct gttgacacca gcacacctgt
     1681 gaccacttct agtgaagcca gttcatcttc tacaactcct gaaggtacca gcataccaac
     1741 ctcaactcct agtgaaggaa gcactccatt aacaaacatg cctgtcagca ccaggctggt
     1801 ggtcagttct gaggctagca ccacttcaac aactcctgct gactccaaca cttttgtgac
     1861 cacttctagt gaagctagtt catcttctac aactgctgaa ggtaccagca tgccaacctc
     1921 aacttacagt gaaagaggca ctacaataac aagtatgtct gtcagcacca cactggtggc
     1981 cagttctgag gctagcaccc tttcaacaac tcctgttgac tccaacactc ctgtgaccac
     2041 ttcaactgaa gccacttcat cttctacaac tgcggaaggt accagcatgc caacctcaac
     2101 ttatactgaa ggaagcactc cattaacaag tatgcctgtc aacaccacac tggtggccag
     2161 ttctgaggct agcacccttt caacaactcc tgttgacacc agcacacctg tgaccacttc
     2221 aactgaagcc agttcctctc ctacaactgc tgatggtgcc agtatgccaa cctcaactcc
     2281 tagtgaagga agcactccat taacaagtat gcctgtcagc aaaacgctgt tgaccagttc
     2341 tgaggctagc accctttcaa caactcctct tgacacaagc acacatatca ccacttctac
     2401 tgaagccagt tgctctccta caaccactga aggtaccagc atgccaatct caactcctag
     2461 tgaaggaagt cctttattaa caagtatacc tgtcagcatc acaccggtga ccagtcctga
     2521 ggctagcacc ctttcaacaa ctcctgttga ctccaacagt cctgtgacca cttctactga
     2581 agtcagttca tctcctacac ctgctgaagg taccagcatg ccaacctcaa cttatagtga
     2641 aggaagaact cctttaacaa gtatgcctgt cagcaccaca ctggtggcca cttctgcaat
     2701 cagcaccctt tcaacaactc ctgttgacac cagcacacct gtgaccaatt ctactgaagc
     2761 ccgttcgtct cctacaactt ctgaaggtac cagcatgcca acctcaactc ctggggaagg
     2821 aagcactcca ttaacaagta tgcctgacag caccacgccg gtagtcagtt ctgaggctag
     2881 aacactttca gcaactcctg ttgacaccag cacacctgtg accacttcta ctgaagccac
     2941 ttcatctcct acaactgctg aaggtaccag cataccaacc tcgactccta gtgaaggaac
     3001 gactccatta acaagcacac ctgtcagcca cacgctggtg gccaattctg aggctagcac
     3061 cctttcaaca actcctgttg actccaacac tcctttgacc acttctactg aagccagttc
     3121 acctcctccc actgctgaag gtaccagcat gccaacctca actcctagtg aaggaagcac
     3181 tccattaaca cgtatgcctg tcagcaccac aatggtggcc agttctgaaa cgagcacact
     3241 ttcaacaact cctgctgaca ccagcacacc tgtgaccact tattctcaag ccagttcatc
     3301 ttctacaact gctgacggta ccagcatgcc aacctcaact tatagtgaag gaagcactcc
     3361 actaacaagt gtgcctgtca gcaccaggct ggtggtcagt tctgaggcta gcaccctttc
     3421 cacaactcct gtcgacacca gcatacctgt caccacttct actgaagcca gttcatctcc
     3481 tacaactgct gaaggtacca gcataccaac ctcacctccc agtgaaggaa ccactccgtt
     3541 agcaagtatg cctgtcagca ccacgctggt ggtcagttct gaggctaaca ccctttcaac
     3601 aactcctgtg gactccaaaa ctcaggtggc cacttctact gaagccagtt cacctcctcc
     3661 aactgctgaa gttaccagca tgccaacctc aactcctgga gaaagaagca ctccattaac
     3721 aagtatgcct gtcagacaca cgccagtggc cagttctgag gctagcaccc tttcaacatc
     3781 tcccgttgac accagcacac ctgtgaccac ttctgctgaa accagttcct ctcctacaac
     3841 cgctgaaggt accagcttgc caacctcaac tactagtgaa ggaagtactc tattaacaag
     3901 tatacctgtc agcaccacgc tggtgaccag tcctgaggct agcacccttt taacaactcc
     3961 tgttgacact aaaggtcctg tggtcacttc taatgaagtc agttcatctc ctacacctgc
     4021 tgaaggtacc agcatgccaa cctcaactta tagtgaagga agaactcctt taacaagtat
     4081 acctgtcaac accacactgg tggccagttc tgcaatcagc atcctttcaa caactcctgt
     4141 tgacaacagc acacctgtga ccacttctac tgaagcctgt tcatctccta caacttctga
     4201 aggtaccagc atgccaaact caaatcctag tgaaggaacc actccgttaa caagtatacc
     4261 tgtcagcacc acgccggtag tcagttctga ggctagcacc ctttcagcaa ctcctgttga
     4321 caccagcacc cctgggacca cttctgctga agccacttca tctcctacaa ctgctgaagg
     4381 tatcagcata ccaacctcaa ctcctagtga aggaaagact ccattaaaaa gtatacctgt
     4441 cagcaacacg ccggtggcca attctgaggc tagcaccctt tcaacaactc ctgttgactc
     4501 taacagtcct gtggtcactt ctacagcagt cagttcatct cctacacctg ctgaaggtac
     4561 cagcatagca atctcaacgc ctagtgaagg aagcactgca ttaacaagta tacctgtcag
     4621 caccacaaca gtggccagtt ctgaaatcaa cagcctttca acaactcctg ctgtcaccag
     4681 cacacctgtg accacttatt ctcaagccag ttcatctcct acaactgctg acggtaccag
     4741 catgcaaacc tcaacttata gtgaaggaag cactccacta acaagtttgc ctgtcagcac
     4801 catgctggtg gtcagttctg aggctaacac cctttcaaca acccctattg actccaaaac
     4861 tcaggtgacc gcttctactg aagccagttc atctacaacc gctgaaggta gcagcatgac
     4921 aatctcaact cctagtgaag gaagtcctct attaacaagt atacctgtca gcaccacgcc
     4981 ggtggccagt cctgaggcta gcaccctttc aacaactcct gttgactcca acagtcctgt
     5041 gatcacttct actgaagtca gttcatctcc tacacctgct gaaggtacca gcatgccaac
     5101 ctcaacttat actgaaggaa gaactccttt aacaagtata actgtcagaa caacaccggt
     5161 ggccagctct gcaatcagca ccctttcaac aactcccgtt gacaacagca cacctgtgac
     5221 cacttctact gaagcccgtt catctcctac aacttctgaa ggtaccagca tgccaaactc
     5281 aactcctagt gaaggaacca ctccattaac aagtatacct gtcagcacca cgccggtact
     5341 cagttctgag gctagcaccc tttcagcaac tcctattgac accagcaccc ctgtgaccac
     5401 ttctactgaa gccacttcgt ctcctacaac tgctgaaggt accagcatac caacctcgac
     5461 tcttagtgaa ggaatgactc cattaacaag cacacctgtc agccacacgc tggtggccaa
     5521 ttctgaggct agcacccttt caacaactcc tgttgactct aacagtcctg tggtcacttc
     5581 tacagcagtc agttcatctc ctacacctgc tgaaggtacc agcatagcaa cctcaacgcc
     5641 tagtgaagga agcactgcat taacaagtat acctgtcagc accacaacag tggccagttc
     5701 tgaaaccaac accctttcaa caactcccgc tgtcaccagc acacctgtga ccacttatgc
     5761 tcaagtcagt tcatctccta caactgctga cggtagcagc atgccaacct caactcctag
     5821 ggaaggaagg cctccattaa caagtatacc tgtcagcacc acaacagtgg ccagttctga
     5881 aatcaacacc ctttcaacaa ctcttgctga caccaggaca cctgtgacca cttattctca
     5941 agccagttca tctcctacaa ctgctgatgg taccagcatg ccaaccccag cttatagtga
     6001 aggaagcact ccactaacaa gtatgcctct cagcaccacg ctggtggtca gttctgaggc
     6061 tagcactctt tccacaactc ctgttgacac cagcactcct gccaccactt ctactgaagg
     6121 cagttcatct cctacaactg caggaggtac cagcatacaa acctcaactc ctagtgaacg
     6181 gaccactcca ttagcaggta tgcctgtcag cactacgctt gtggtcagtt ctgagggtaa
     6241 caccctttca acaactcctg ttgactccaa aactcaggtg accaattcta ctgaagccag
     6301 ttcatctgca accgctgaag gtagcagcat gacaatctca gctcctagtg aaggaagtcc
     6361 tctactaaca agtatacctc tcagcaccac gccggtggcc agtcctgagg ctagcaccct
     6421 ttcaacaact cctgttgact ccaacagtcc tgtgatcact tctactgaag tcagttcatc
     6481 tcctatacct actgaaggta ccagcatgca aacctcaact tatagtgaca gaagaactcc
     6541 tttaacaagt atgcctgtca gcaccacagt ggtggccagt tctgcaatca gcaccctttc
     6601 aacaactcct gttgacacca gcacacctgt gaccaattct actgaagccc gttcatctcc
     6661 tacaacttct gaaggtacca gcatgccaac ctcaactcct agtgaaggaa gcactccatt
     6721 cacaagtatg cctgtcagca ccatgccggt agttacttct gaggctagca ccctttcagc
     6781 aactcctgtt gacaccagca cacctgtgac cacttctact gaagccactt catctcctac
     6841 aactgctgaa ggtaccagca taccaacttc aactcttagt gaaggaacga ctccattaac
     6901 aagtatacct gtcagccaca cgctggtggc caattctgag gttagcaccc tttcaacaac
     6961 tcctgttgac tccaacactc ctttcactac ttctactgaa gccagttcac ctcctcccac
     7021 tgctgaaggt accagcatgc caacctcaac ttctagtgaa ggaaacactc cattaacacg
     7081 tatgcctgtc agcaccacaa tggtggccag ttttgaaaca agcacacttt ctacaactcc
     7141 tgctgacacc agcacacctg tgactactta ttctcaagcc ggttcatctc ctacaactgc
     7201 tgacgatact agcatgccaa cctcaactta tagtgaagga agcactccac taacaagtgt
     7261 gcctgtcagc accatgccgg tggtcagttc tgaggctagc acccattcca caactcctgt
     7321 tgacaccagc acacctgtca ccacttctac tgaagccagt tcatctccta caactgctga
     7381 aggtaccagc ataccaacct cacctcctag tgaaggaacc actccgttag caagtatgcc
     7441 tgtcagcacc acgccggtgg tcagttctga ggctggcacc ctttccacaa ctcctgttga
     7501 caccagcaca cctatgacca cttctactga agccagttca tctcctacaa ctgctgaaga
     7561 tatcgtcgtg ccaatctcaa ctgctagtga aggaagtact ctattaacaa gtatacctgt
     7621 cagcaccacg ccagtggcca gtcctgaggc tagcaccctt tcaacaactc ctgttgactc
     7681 caacagtcct gtggtcactt ctactgaaat cagttcatct gctacatccg ctgaaggtac
     7741 cagcatgcct acctcaactt atagtgaagg aagcactcca ttaagaagta tgcctgtcag
     7801 caccaagccg ttggccagtt ctgaggctag cactctttca acaactcctg ttgacaccag
     7861 catacctgtc accacttcta ctgaaaccag ttcatctcct acaactgcaa aagataccag
     7921 catgccaatc tcaactccta gtgaagtaag tacttcatta acaagtatac ttgtcagcac
     7981 catgccagtg gccagttctg aggctagcac cctttcaaca actcctgttg acaccaggac
     8041 acttgtgacc acttccactg gaaccagttc atctcctaca actgctgaag gtagcagcat
     8101 gccaacctca actcctggtg aaagaagcac tccattaaca aatatacttg tcagcaccac
     8161 gctgttggcc aattctgagg ctagcaccct ttcaacaact cctgttgaca ccagcacacc
     8221 tgtcaccact tctgctgaag ccagttcttc tcctacaact gctgaaggta ccagcatgcg
     8281 aatctcaact cctagtgatg gaagtactcc attaacaagt atacttgtca gcaccctgcc
     8341 agtggccagt tctgaggcta gcaccgtttc aacaactgct gttgacacca gcatacctgt
     8401 caccacttct actgaagcca gttcctctcc tacaactgct gaagttacca gcatgccaac
     8461 ctcaactcct agtgaaacaa gtactccatt aactagtatg cctgtcaacc acacgccagt
     8521 ggccagttct gaggctggca ccctttcaac aactcctgtt gacaccagca cacctgtgac
     8581 cacttctact aaagccagtt catctcctac aactgctgaa ggtatcgtcg tgccaatctc
     8641 aactgctagt gaaggaagta ctctattaac aagtatacct gtcagcacca cgccggtggc
     8701 cagttctgag gctagcaccc tttcaacaac tcctgttgat accagcatac ctgtcaccac
     8761 ttctactgaa ggcagttctt ctcctacaac tgctgaaggt accagcatgc caatctcaac
     8821 tcctagtgaa gtaagtactc cattaacaag tatacttgtc agcaccgtgc cagtggccgg
     8881 ttctgaggct agcacccttt caacaactcc tgttgacacc aggacacctg tcaccacttc
     8941 tgctgaagct agttcttctc ctacaactgc tgaaggtacc agcatgccaa tctcaactcc
     9001 tggcgaaaga agaactccat taacaagtat gtctgtcagc accatgccgg tggccagttc
     9061 tgaggctagc accctttcaa gaactcctgc tgacaccagc acacctgtga ccacttctac
     9121 tgaagccagt tcctctccta caactgctga aggtaccggc ataccaatct caactcctag
     9181 tgaaggaagt actccattaa caagtatacc tgtcagcacc acgccagtgg ccattcctga
     9241 ggctagcacc ctttcaacaa ctcctgttga ctccaacagt cctgtggtca cttctactga
     9301 agtcagttca tctcctacac ctgctgaagg taccagcatg ccaatctcaa cttatagtga
     9361 aggaagcact ccattaacag gtgtgcctgt cagcaccaca ccggtgacca gttctgcaat
     9421 cagcaccctt tcaacaactc ctgttgacac cagcacacct gtgaccactt ctactgaagc
     9481 ccattcatct cctacaactt ctgaaggtac cagcatgcca acctcaactc ctagtgaagg
     9541 aagtactcca ttaacatata tgcctgtcag caccatgctg gtagtcagtt ctgaggatag
     9601 caccctttca gcaactcctg ttgacaccag cacacctgtg accacttcta ctgaagccac
     9661 ttcatctaca actgctgaag gtaccagcat tccaacctca actcctagtg aaggaatgac
     9721 tccattaact agtgtacctg tcagcaacac gccggtggcc agttctgagg ctagcatcct
     9781 ttcaacaact cctgttgact ccaacactcc tttgaccact tctactgaag ccagttcatc
     9841 tcctcccact gctgaaggta ccagcatgcc aacctcaact cctagtgaag gaagcactcc
     9901 attaacaagt atgcctgtca gcaccacaac ggtggccagt tctgaaacga gcaccctttc
     9961 aacaactcct gctgacacca gcacacctgt gaccacttat tctcaagcca gttcatctcc
    10021 tccaattgct gacggtacta gcatgccaac ctcaacttat agtgaaggaa gcactccact
    10081 aacaaatatg tctttcagca ccacgccagt ggtcagttct gaggctagca ccctttccac
    10141 aactcctgtt gacaccagca cacctgtcac cacttctact gaagccagtt tatctcctac
    10201 aactgctgaa ggtaccagca taccaacctc aagtcctagt gaaggaacca ctccattagc
    10261 aagtatgcct gtcagcacca cgccggtggt cagttctgag gttaacaccc tttcaacaac
    10321 tcctgtggac tccaacactc tggtgaccac ttctactgaa gccagttcat ctcctacaat
    10381 cgctgaaggt accagcttgc caacctcaac tactagtgaa ggaagcactc cattatcaat
    10441 tatgcctctc agtaccacgc cggtggccag ttctgaggct agcacccttt caacaactcc
    10501 tgttgacacc agcacacctg tgaccacttc ttctccaacc aattcatctc ctacaactgc
    10561 tgaagttacc agcatgccaa catcaactgc tggtgaagga agcactccat taacaaatat
    10621 gcctgtcagc accacaccgg tggccagttc tgaggctagc accctttcaa caactcctgt
    10681 tgactccaac acttttgtta ccagttctag tcaagccagt tcatctccag caactcttca
    10741 ggtcaccact atgcgtatgt ctactccaag tgaaggaagc tcttcattaa caactatgct
    10801 cctcagcagc acatatgtga ccagttctga ggctagcaca ccttccactc cttctgttga
    10861 cagaagcaca cctgtgacca cttctactca gagcaattct actcctacac ctcctgaagt
    10921 tatcaccctg ccaatgtcaa ctcctagtga agtaagcact ccattaacca ttatgcctgt
    10981 cagcaccaca tcggtgacca tttctgaggc tggcacagct tcaacacttc ctgttgacac
    11041 cagcacacct gtgatcactt ctacccaagt cagttcatct cctgtgactc ctgaaggtac
    11101 caccatgcca atctggacgc ctagtgaagg aagcactcca ttaacaacta tgcctgtcag
    11161 caccacacgt gtgaccagct ctgagggtag caccctttca acaccttctg ttgtcaccag
    11221 cacacctgtg accacttcta ctgaagccat ttcatcttct gcaactcttg acagcaccac
    11281 catgtctgtg tcaatgccca tggaaataag cacccttggg accactattc ttgtcagtac
    11341 cacacctgtt acgaggtttc ctgagagtag caccccttcc ataccatctg tttacaccag
    11401 catgtctatg accactgcct ctgaaggcag ttcatctcct acaactcttg aaggcaccac
    11461 caccatgcct atgtcaacta cgagtgaaag aagcacttta ttgacaactg tcctcatcag
    11521 ccctatatct gtgatgagtc cttctgaggc cagcacactt tcaacacctc ctggtgatac
    11581 cagcacacct ttgctcacct ctaccaaagc cggttcattc tccatacctg ctgaagtcac
    11641 taccatacgt atttcaatta ccagtgaaag aagcactcca ttaacaactc tccttgtcag
    11701 caccacactt ccaactagct ttcctggggc cagcatagct tcgacacctc ctcttgacac
    11761 aagcacaact tttacccctt ctactgacac tgcctcaact cccacaattc ctgtagccac
    11821 caccatatct gtatcagtga tcacagaagg aagcacacct gggacaacca tttttattcc
    11881 cagcactcct gtcaccagtt ctactgctga tgtctttcct gcaacaactg gtgctgtatc
    11941 tacccctgtg ataacttcca ctgaactaaa cacaccatca acctccagta gtagtaccac
    12001 cacatctttt tcaactacta aggaatttac aacacccgca atgactactg cagctcccct
    12061 cacatatgtg accatgtcta ctgcccccag cacacccaga acaaccagca gaggctgcac
    12121 tacttctgca tcaacgcttt ctgcaaccag tacacctcac acctctactt ctgtcaccac
    12181 ccgtcctgtg accccttcat cagaatccag caggccgtca acaattactt ctcacaccat
    12241 cccacctaca tttcctcctg ctcactccag tacacctcca acaacctctg cctcctccac
    12301 gactgtgaac cctgaggctg tcaccaccat gaccaccagg acaaaaccca gcacacggac
    12361 cacttccttc cccacggtga ccaccaccgc tgtccccacg aatactacaa ttaagagcaa
    12421 ccccacctca actcctactg tgccaagaac cacaacatgc tttggagatg ggtgccagaa
    12481 tacggcctct cgctgcaaga atggaggcac ctgggatggg ctcaagtgcc agtgtcccaa
    12541 cctctattat ggggagttgt gtgaggaggt ggtcagcagc attgacatag ggccaccgga
    12601 gactatctct gcccaaatgg aactgactgt gacagtgacc agtgtgaagt tcaccgaaga
    12661 gctaaaaaac cactcttccc aggaattcca ggagttcaaa cagacattca cggaacagat
    12721 gaatattgtg tattccggga tccctgagta tgtcggggtg aacatcacaa agctacgtct
    12781 tggcagtgtg gtggtggagc atgacgtcct cctaagaacc aagtacacac cagaatacaa
    12841 gacagtattg gacaatgcca ccgaagtagt gaaagagaaa atcacaaaag tgaccacaca
    12901 gcaaataatg attaatgata tttgctcaga catgatgtgt ttcaacacca ctggcaccca
    12961 agtgcaaaac attacggtga cccagtacga ccctgaagag gactgccgga agatggccaa
    13021 ggaatatgga gactacttcg tagtggagta ccgggaccag aagccatact gcatcagccc
    13081 ctgtgagcct ggcttcagtg tctccaagaa ctgtaacctc ggcaagtgcc agatgtctct
    13141 aagtggacct cagtgcctct gcgtgaccac ggaaactcac tggtacagtg gggagacctg
    13201 taaccagggc acccagaaga gtctggtgta cggcctcgtg ggggcagggg tcgtgctgat
    13261 gctgatcatc ctggtagctc tcctgatgct cgttttccgc tccaagagag aggtgaaacg
    13321 gcaaaagtac agattgtctc agttatacaa gtggcaagaa gaggacagtg gaccagctcc
    13381 tgggaccttc caaaacattg gctttgacat ctgccaagat gatgattcca tccacctgga
    13441 gtccatctat agtaatttcc agccctcctt gagacacata gaccctgaaa caaagatccg
    13501 aattcagagg cctcaggtaa tgacgacatc attttaaggc atggagctga gaagtctggg
    13561 agtgaggaga tcccagtccg gctaagcttg gtggagcatt ttcccattga gagccttcca
    13621 tgggaactca atgttcccat tgtaagtaca ggaaacaagc cctgtactta ccaaggagaa
    13681 agaggagaga cagcagtgct gggagattct caaatagaaa cccgtggacg ctccaatggg
    13741 cttgtcatga tatcaggcta ggctttcctg ctcatttttc aaagacgctc cagatttgag
    13801 ggtactctga ctgcaacatc tttcacccca ttgatcgcca ggattgattt ggttgatctg
    13861 gctgagcagg cgggtgtccc cgtcctccct cactgcccca tatgtgtccc tcctaaagct
    13921 gcatgctcag ttgaagagga cgagaggacg accttctctg atagaggagg accacgcttc
    13981 agtcaaaggc atacaagtat ctatctggac ttccctgcta gcacttccaa acaagctcag
    14041 agatgttcct cccctcatct gcccgggttc agtaccatgg acagcgccct cgacccgctg
    14101 tttacaacca tgaccccttg gacactggac tgcatgcact ttacatatca caaaatgctc
    14161 tcataagaat tattgcatac catcttcatg aaaaacacct gtatttaaat atagagcatt
    14221 taccttttgg tatataagat tgtgggtatt ttttaagttc ttattgttat gagttctgat
    14281 tttttcctta gtaaatatta taatatatat ttgtagtaac taaaaataat aaagcaattt
    14341 tattacaatt tt
//
