LOCUS       NM_001135091            3387 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens mucin 15, cell surface associated (MUC15), transcript
            variant 1, mRNA.
ACCESSION   NM_001135091
VERSION     NM_001135091.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3387)
  AUTHORS   Nguyen,A., Cannon,P., Kandel,M., Nguyen,T.V., Baird,L., Wong,G.,
            Hannan,N.J., Tong,S., Bartho,L. and Kaitu'u-Lino,T.J.
  TITLE     Cell surface associated protein mucin 15 (MUC15) is elevated in
            preeclampsia
  JOURNAL   Placenta 140, 39-46 (2023)
   PUBMED   37531748
  REMARK    GeneRIF: Cell surface associated protein mucin 15 (MUC15) is
            elevated in preeclampsia.
REFERENCE   2  (bases 1 to 3387)
  AUTHORS   Han,T., Zheng,H., Zhang,J., Yang,P., Li,H., Cheng,Z., Xiang,D. and
            Wang,R.
  TITLE     Downregulation of MUC15 by miR-183-5p.1 promotes liver
            tumor-initiating cells properties and tumorigenesis via regulating
            c-MET/PI3K/AKT/SOX2 axis
  JOURNAL   Cell Death Dis 13 (3), 200 (2022)
   PUBMED   35236826
  REMARK    GeneRIF: Downregulation of MUC15 by miR-183-5p.1 promotes liver
            tumor-initiating cells properties and tumorigenesis via regulating
            c-MET/PI3K/AKT/SOX2 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3387)
  AUTHORS   Wu,S., Yue,Y., Gu,Y., Wang,Q., Liu,T., Li,L., Wang,X., Chang,L.S.,
            He,D. and Wu,K.
  TITLE     MUC15 loss facilitates epithelial-mesenchymal transition and cancer
            stemness for prostate cancer metastasis through
            GSK3beta/beta-catenin signaling
  JOURNAL   Cell Signal 84, 110015 (2021)
   PUBMED   33894313
  REMARK    GeneRIF: MUC15 loss facilitates epithelial-mesenchymal transition
            and cancer stemness for prostate cancer metastasis through
            GSK3beta/beta-catenin signaling.
REFERENCE   4  (bases 1 to 3387)
  AUTHORS   Wang,S., Li,J., You,L., Dai,M. and Zhao,Y.
  TITLE     High Expression of MUC15 Is Correlated with Poor Prognosis of
            Pancreatic Cancer and Promotes Migration, Invasion, and
            Chemo-Resistance In Vitro
  JOURNAL   Med Sci Monit 26, e926432 (2020)
   PUBMED   33051432
  REMARK    GeneRIF: High Expression of MUC15 Is Correlated with Poor Prognosis
            of Pancreatic Cancer and Promotes Migration, Invasion, and
            Chemo-Resistance In Vitro.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3387)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3387)
  AUTHORS   Huang,J., Che,M.I., Huang,Y.T., Shyu,M.K., Huang,Y.M., Wu,Y.M.,
            Lin,W.C., Huang,P.H., Liang,J.T., Lee,P.H. and Huang,M.C.
  TITLE     Overexpression of MUC15 activates extracellular signal-regulated
            kinase 1/2 and promotes the oncogenic potential of human colon
            cancer cells
  JOURNAL   Carcinogenesis 30 (8), 1452-1458 (2009)
   PUBMED   19520792
  REMARK    GeneRIF: Overexpression of MUC15 activates extracellular
            signal-regulated kinase 1/2 and promotes the oncogenic potential of
            colon cancer cells.
REFERENCE   7  (bases 1 to 3387)
  AUTHORS   Samuels,T.L., Handler,E., Syring,M.L., Pajewski,N.M., Blumin,J.H.,
            Kerschner,J.E. and Johnston,N.
  TITLE     Mucin gene expression in human laryngeal epithelia: effect of
            laryngopharyngeal reflux
  JOURNAL   Ann Otol Rhinol Laryngol 117 (9), 688-695 (2008)
   PUBMED   18834073
  REMARK    GeneRIF: Reflux laryngitis is associated with down-regulation of
            mucin gene expression.
REFERENCE   8  (bases 1 to 3387)
  AUTHORS   Shyu,M.K., Lin,M.C., Shih,J.C., Lee,C.N., Huang,J., Liao,C.H.,
            Huang,I.F., Chen,H.Y., Huang,M.C. and Hsieh,F.J.
  TITLE     Mucin 15 is expressed in human placenta and suppresses invasion of
            trophoblast-like cells in vitro
  JOURNAL   Hum Reprod 22 (10), 2723-2732 (2007)
   PUBMED   17720698
  REMARK    GeneRIF: MUC15 was expressed most highly in human placenta. MUC15
            mRNA & protein increased with gestational age (P < 0.05, 1st versus
            3rd trimester). Differential expression of MUC15 in human placentas
            may play critical role in regulation of trophoblast invasion.
REFERENCE   9  (bases 1 to 3387)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 3387)
  AUTHORS   Pallesen,L.T., Berglund,L., Rasmussen,L.K., Petersen,T.E. and
            Rasmussen,J.T.
  TITLE     Isolation and characterization of MUC15, a novel cell
            membrane-associated mucin
  JOURNAL   Eur J Biochem 269 (11), 2755-2763 (2002)
   PUBMED   12047385
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA842986.1, AY358668.1, AC036114.7 and BU676338.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135091.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.3103646.1, AY358668.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968832 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000529533.6/
                                                ENSP00000431983.1
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                DA842986.1         6-35
            31-2114             AY358668.1         1-2084
            2115-3328           AC036114.7         95881-97094         c
            3329-3387           BU676338.1         18-76               c
FEATURES             Location/Qualifiers
     source          1..3387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p14.2"
     gene            1..3387
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="mucin 15, cell surface associated"
                     /db_xref="GeneID:143662"
                     /db_xref="HGNC:HGNC:14956"
                     /db_xref="MIM:608566"
     exon            1..223
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:2.1.0"
     exon            224..311
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:2.1.0"
     CDS             269..1354
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="isoform a is encoded by transcript variant 1;
                     mucin-15"
                     /codon_start=1
                     /product="mucin-15 isoform a"
                     /protein_id="NP_001128563.1"
                     /db_xref="CCDS:CCDS44557.1"
                     /db_xref="GeneID:143662"
                     /db_xref="HGNC:HGNC:14956"
                     /db_xref="MIM:608566"
                     /translation="MGIIQSILATSRDCYSFKKKPIPKKPTMLALAKILLISTLFYSL
                     LSGSHGKENQDINTTQNIAEVFKTMENKPISLESEANLNSDKENITTSNLKASHSPPL
                     NLPNNSHGITDFSSNSSAEHSLGSLKPTSTISTSPPLIHSFVSKVPWNAPIADEDLLP
                     ISAHPNATPALSSENFTWSLVNDTVKTPDNSSITVSILSSEPTSPSVTPLIVEPSGWL
                     TTNSDSFTGFTPYQEKTTLQPTLKFTNNSKLFPNTSDPQKENRNTGIVFGAILGAILG
                     VSLLTLVGYLLCGKRKTDSFSHRRLYDDRNEPVLRLDNAPEPYDVSFGNSSYYNPTLN
                     DSAMPESEENARDGIPMDDIPPLRTSV"
     exon            312..1043
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1193
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..3387
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="hexamer: AATAAA"
     polyA_site      1697
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="major polyA site"
     regulatory      3366..3371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="hexamer: AATAAA"
     polyA_site      3387
                     /gene="MUC15"
                     /gene_synonym="MUC-15; PAS3; PASIII"
                     /note="major polyA site"
ORIGIN      
        1 aatgcttaca gctgagaagc aggtcagtca ggttcctggg cgctctgtta cacaagcaag
       61 atacagccag ccccacctaa ttttgtttcc ctggcaccct cctgctcagt gcgacattgt
      121 cacacttaac ccatctgttt tctctaatgc acgacagatt cctttcagac aggacaactg
      181 tgatatttca gttcctgatt gtaaatacct cctaagcctg aagcttctgt tactagccat
      241 tgtgagcttc agtttcttca tctgcaaaat gggcataata caatctattc ttgccacatc
      301 aagggattgt tattccttta aaaaaaaacc aataccaaag aagcctacaa tgttggcctt
      361 agccaaaatt ctgttgattt caacgttgtt ttattcactt ctatcgggga gccatggaaa
      421 agaaaatcaa gacataaaca caacacagaa cattgcagaa gtttttaaaa caatggaaaa
      481 taaacctatt tctttggaaa gtgaagcaaa cttaaactca gataaagaaa atataaccac
      541 ctcaaatctc aaggcgagtc attcccctcc tttgaatcta cccaacaaca gccacggaat
      601 aacagatttc tccagtaact catcagcaga gcattctttg ggcagtctaa aacccacatc
      661 taccatttcc acaagccctc ccttgatcca tagctttgtt tctaaagtgc cttggaatgc
      721 acctatagca gatgaagatc ttttgcccat ctcagcacat cccaatgcta cacctgctct
      781 gtcttcagaa aacttcactt ggtctttggt caatgacacc gtgaaaactc ctgataacag
      841 ttccattaca gttagcatcc tctcttcaga accaacttct ccatctgtga cccccttgat
      901 agtggaacca agtggatggc ttaccacaaa cagtgatagc ttcactgggt ttacccctta
      961 tcaagaaaaa acaactctac agcctacctt aaaattcacc aataattcaa aactctttcc
     1021 aaatacgtca gatccccaaa aagaaaatag aaatacagga atagtattcg gggccatttt
     1081 aggtgctatt ctgggtgtct cattgcttac tcttgtgggc tacttgttgt gtggaaaaag
     1141 gaaaacggat tcattttccc atcggcgact ttatgacgac agaaatgaac cagttctgcg
     1201 attagacaat gcaccggaac cttatgatgt gagttttggg aattctagct actacaatcc
     1261 aactttgaat gattcagcca tgccagaaag tgaagaaaat gcacgtgatg gcattcctat
     1321 ggatgacata cctccacttc gtacttctgt atagaactaa cagcaaaaag gcgttaaaca
     1381 gcaagtgtca tctacatcct agccttttga caaattcatc tttcaaaagg ttacacaaaa
     1441 ttactgtcac gtggattttg tcaaggagaa tcataaaagc aggagaccag tagcagaaat
     1501 gtagacagga tgtatcatcc aaaggttttc tttcttacaa tttttggcca tcctgaggca
     1561 tttactaagt agccttaatt tgtattttag tagtattttc ttagtagaaa atatttgtgg
     1621 aatcagataa aactaaaaga tttcaccatt acagccctgc ctcataacta aataataaaa
     1681 attattccac caaaaaattc taaaacaatg aagatgactc tttactgctc tgcctgaagc
     1741 cctagtacca taattcaaga ttgcattttc ttaaatgaaa attgaaaggg tgctttttaa
     1801 agaaaatttg acttaaagct aaaaagagga catagcccag agtttctgtt attgggaaat
     1861 tgaggcaata gaaatgacag acctgtattc tagtacgtta taattttcta gatcagcaca
     1921 cacatgatca gcccactgag ttatgaagct gacaatgact gcattcaacg gggccatggc
     1981 aggaaagctg accctaccca ggaaagtaat agcttcttta aaagtcttca aaggttttgg
     2041 gaattttaac ttgtcttaat atatcttagg cttcaattat ttgggtgcct taaaaactca
     2101 atgagaatca tggtaaaaaa aaaaagttaa ccaaagaata tacctgtaca taatttgtac
     2161 agttttaagt tgttagatag gaactggatt tcttatgtat tagacattat tgctcaatca
     2221 taatggaata gattctgcat ccctaaatgt atgaaccata aggttaaaaa agatgaatgg
     2281 aaatatcaaa caacttttta ctgagcatca gtttcataat caataatata agaagattaa
     2341 tttggattct agtatgtttc agtttgtttt taattaccac cttcctttgg tagaaaaaat
     2401 atgttccttg atgtaggaaa gtctaggttt tagagattag aggatgagat caagagttaa
     2461 attcctaaag aagcactgaa tatatgaaga gagcaaacaa atcaagtacc aacctagagg
     2521 ctttattttt gaattgattc atggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2581 tgtaacacag aaacagcttc agaaaataag ggatagaaag taatgaagaa agtacttacc
     2641 ccatattgcc ataaaaatag caaagaagac tgtccctcca ttatcgaaca aatatgtcac
     2701 ctgagtagaa aacaaacaga aatattagtc atgcaaattg attataataa gccagtgaat
     2761 actgtttgca ctcaggtact atgatttttt ctcaaataga atcatattat tttatagtac
     2821 agaaatatta tatatgaatt cctttcatgg gtcttgcaac aatttcacat gatttttctc
     2881 atggggagag gtgaagaaac aacattagcc ctcttctctc ctctcttgat tccctttata
     2941 ccccaccatc atttctgatt ataaataatt ctaccattct atggaagtat ttgtgggtca
     3001 cagattgtca aactacttaa tgaaagttgt atgaaattag tttttcaggt gaggcattcc
     3061 tagttgcaat tcctgttagc aaaacttcta ggagtgggga agttggaaaa tgcaggattc
     3121 ttccagtgag ccagcatttc ccatagctaa ccctattctc ttagtctttc aaaatgtaga
     3181 atgggtccaa taatggctat aagatgtaat aaatcccatc ttaatttgtt ttaaaagttt
     3241 cataaatcac tgaacactta tgaaacaaag tgttttttaa tcagatatca actgaaactt
     3301 cataaaggat gcatagtttt ataatgttat tgaatcaaat tttaaggctt gtattgtttg
     3361 attttaataa agtataaatt caattta
//
