LOCUS       NM_033049               2879 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mucin 13, cell surface associated (MUC13), mRNA.
ACCESSION   NM_033049 NM_017648
VERSION     NM_033049.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Kang,Q., Tingting,W., Bingzi,D., Hao,Z., Yuwei,X., Chuandong,S. and
            Chengzhan,Z.
  TITLE     GCNT3 regulated MUC13 to promote the development of hepatocellular
            carcinoma through the GSK3beta/beta-catenin pathway
  JOURNAL   Dig Liver Dis 56 (9), 1572-1581 (2024)
   PUBMED   38369410
  REMARK    GeneRIF: GCNT3 regulated MUC13 to promote the development of
            hepatocellular carcinoma through the GSK3beta/beta-catenin pathway.
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Segui-Perez,C., Stapels,D.A.C., Ma,Z., Su,J., Passchier,E.,
            Westendorp,B., Wubbolts,R.W., Wu,W., van Putten,J.P.M. and
            Strijbis,K.
  TITLE     MUC13 negatively regulates tight junction proteins and intestinal
            epithelial barrier integrity via protein kinase C
  JOURNAL   J Cell Sci 137 (5) (2024)
   PUBMED   38345099
  REMARK    GeneRIF: MUC13 negatively regulates tight junction proteins and
            intestinal epithelial barrier integrity via protein kinase C.
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Doxtater,K., Tripathi,M.K., Sekhri,R., Hafeez,B.B., Khan,S.,
            Zafar,N., Behrman,S.W., Yallapu,M.M., Jaggi,M. and Chauhan,S.C.
  TITLE     MUC13 drives cancer aggressiveness and metastasis through the
            YAP1-dependent pathway
  JOURNAL   Life Sci Alliance 6 (12), e202301975 (2023)
   PUBMED   37793774
  REMARK    GeneRIF: MUC13 drives cancer aggressiveness and metastasis through
            the YAP1-dependent pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Cai,T., Peng,B., Hu,J. and He,Y.
  TITLE     Long noncoding RNA BBOX1-AS1 promotes the progression of gastric
            cancer by regulating the miR-361-3p/Mucin 13 signaling axis
  JOURNAL   Bioengineered 13 (5), 13407-13421 (2022)
   PUBMED   36700475
  REMARK    GeneRIF: Long noncoding RNA BBOX1-AS1 promotes the progression of
            gastric cancer by regulating the miR-361-3p/Mucin 13 signaling
            axis.
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Gupta,B.K., Maher,D.M., Ebeling,M.C., Sundram,V., Koch,M.D.,
            Lynch,D.W., Bohlmeyer,T., Watanabe,A., Aburatani,H., Puumala,S.E.,
            Jaggi,M. and Chauhan,S.C.
  TITLE     Increased expression and aberrant localization of mucin 13 in
            metastatic colon cancer
  JOURNAL   J Histochem Cytochem 60 (11), 822-831 (2012)
   PUBMED   22914648
  REMARK    GeneRIF: Metastatic colon cancer and liver metastasis tissue
            samples demonstrated significantly (p<0.05) higher cytoplasmic and
            nuclear MUC13 expression compared with non-metastatic colon cancer
            and adjacent normal colon samples.
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Chauhan,S.C., Ebeling,M.C., Maher,D.M., Koch,M.D., Watanabe,A.,
            Aburatani,H., Lio,Y. and Jaggi,M.
  TITLE     MUC13 mucin augments pancreatic tumorigenesis
  JOURNAL   Mol Cancer Ther 11 (1), 24-33 (2012)
   PUBMED   22027689
  REMARK    GeneRIF: MUC13 overexpression caused a significant increase in cell
            motility, invasion, proliferation, and anchorage-dependent or
            -independent clonogenicity while decreasing cell-cell and
            cell-substratum adhesion in pancreatic cancer.
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Maher,D.M., Gupta,B.K., Nagata,S., Jaggi,M. and Chauhan,S.C.
  TITLE     Mucin 13: structure, function, and potential roles in cancer
            pathogenesis
  JOURNAL   Mol Cancer Res 9 (5), 531-537 (2011)
   PUBMED   21450906
  REMARK    GeneRIF: The various functional domains of MUC13 may confer
            oncogenic potential to MUC13
            Review article
REFERENCE   8  (bases 1 to 2879)
  AUTHORS   Samuels,T.L., Handler,E., Syring,M.L., Pajewski,N.M., Blumin,J.H.,
            Kerschner,J.E. and Johnston,N.
  TITLE     Mucin gene expression in human laryngeal epithelia: effect of
            laryngopharyngeal reflux
  JOURNAL   Ann Otol Rhinol Laryngol 117 (9), 688-695 (2008)
   PUBMED   18834073
  REMARK    GeneRIF: Reflux laryngitis is associated with down-regulation of
            mucin gene expression.
REFERENCE   9  (bases 1 to 2879)
  AUTHORS   Shimamura,T., Ito,H., Shibahara,J., Watanabe,A., Hippo,Y.,
            Taniguchi,H., Chen,Y., Kashima,T., Ohtomo,T., Tanioka,F.,
            Iwanari,H., Kodama,T., Kazui,T., Sugimura,H., Fukayama,M. and
            Aburatani,H.
  TITLE     Overexpression of MUC13 is associated with intestinal-type gastric
            cancer
  JOURNAL   Cancer Sci 96 (5), 265-273 (2005)
   PUBMED   15904467
  REMARK    GeneRIF: MUC13 is a good differentiation marker for
            gastrointestinal mucosa
REFERENCE   10 (bases 1 to 2879)
  AUTHORS   Williams,S.J., Wreschner,D.H., Tran,M., Eyre,H.J., Sutherland,G.R.
            and McGuckin,M.A.
  TITLE     Muc13, a novel human cell surface mucin expressed by epithelial and
            hemopoietic cells
  JOURNAL   J Biol Chem 276 (21), 18327-18336 (2001)
   PUBMED   11278439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA428072.1, AB035807.1, AK000070.1 and AF286113.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033049.3.
            
            Summary: Epithelial mucins, such as MUC13, are a family of secreted
            and cell surface glycoproteins expressed by ductal and glandular
            epithelial tissues (Williams et al., 2001 [PubMed
            11278439]).[supplied by OMIM, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB035807.1, AY358831.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2161836
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616727.4/ ENSP00000485028.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DA428072.1         1-15
            16-2047             AB035807.1         1-2032
            2048-2872           AK000070.1         1424-2248
            2873-2879           AF286113.1         2861-2867
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.2"
     gene            1..2879
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /note="mucin 13, cell surface associated"
                     /db_xref="GeneID:56667"
                     /db_xref="HGNC:HGNC:7511"
                     /db_xref="MIM:612181"
     exon            1..91
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1578
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /note="down-regulated in colon cancer 1; mucin 13,
                     epithelial transmembrane; mucin-13"
                     /codon_start=1
                     /product="mucin-13 precursor"
                     /protein_id="NP_149038.3"
                     /db_xref="CCDS:CCDS33839.2"
                     /db_xref="GeneID:56667"
                     /db_xref="HGNC:HGNC:7511"
                     /db_xref="MIM:612181"
                     /translation="MKAIIHLTLLALLSVNTATNQGNSADAVTTTETATSGPTVAAAD
                     TTETNFPETASTTANTPSFPTATSPAPPIISTHSSSTIPTPAPPIISTHSSSTIPIPT
                     AADSESTTNVNSLATSDIITASSPNDGLITMVPSETQSNNEMSPTTEDNQSSGPPTGT
                     ALLETSTLNSTGPSNPCQDDPCADNSLCVKLHNTSFCLCLEGYYYNSSTCKKGKVFPG
                     KISVTVSETFDPEEKHSMAYQDLHSEITSLFKDVFGTSVYGQTVILTVSTSLSPRSEM
                     RADDKFVNVTIVTILAETTSDNEKTVTEKINKAIRSSSSNFLNYDLTLRCDYYGCNQT
                     ADDCLNGLACDCKSDLQRPNPQSPFCVASSLKCPDACNAQHKQCLIKKSGGAPECACV
                     PGYQEDANGNCQKCAFGYSGLDCKDKFQLILTIVGTIAGIVILSMIIALIVTARSNNK
                     TKHIEEENLIDEDFQNLKLRSTGFTNLGAEGSVFPKVRITASRDSQMQNPYSRHSSMP
                     RPDY"
     exon            92..553
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            554..676
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            677..783
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            784..839
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1003
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1123
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1253
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1291
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1376
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1578
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..2879
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2855..2860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /note="hexamer: AATAAA"
     polyA_site      2879
                     /gene="MUC13"
                     /gene_synonym="DRCC1; MUC-13"
                     /note="major polyA site"
ORIGIN      
        1 atcatttcct cctcagatta ccaagcaaga acagctaaaa tgaaagccat cattcatctt
       61 actcttcttg ctctcctttc tgtaaacaca gccaccaacc aaggcaactc agctgatgct
      121 gtaacaacca cagaaactgc gactagtggt cctacagtag ctgcagctga taccactgaa
      181 actaatttcc ctgaaactgc tagcaccaca gcaaatacac cttctttccc aacagctact
      241 tcacctgctc cccccataat tagtacacat agttcctcca caattcctac acctgctccc
      301 cccataatta gtacacatag ttcctccaca attcctatac ctactgctgc agacagtgag
      361 tcaaccacaa atgtaaattc attagctacc tctgacataa tcaccgcttc atctccaaat
      421 gatggattaa tcacaatggt tccttctgaa acacaaagta acaatgaaat gtcccccacc
      481 acagaagaca atcaatcatc agggcctccc actggcaccg ctttattgga gaccagcacc
      541 ctaaacagca caggtcccag caatccttgc caagatgatc cctgtgcaga taattcgtta
      601 tgtgttaagc tgcataatac aagtttttgc ctgtgtttag aagggtatta ctacaactct
      661 tctacatgta agaaaggaaa ggtattccct gggaagattt cagtgacagt atcagaaaca
      721 tttgacccag aagagaaaca ttccatggcc tatcaagact tgcatagtga aattactagc
      781 ttgtttaaag atgtatttgg cacatctgtt tatggacaga ctgtaattct tactgtaagc
      841 acatctctgt caccaagatc tgaaatgcgt gctgatgaca agtttgttaa tgtaacaata
      901 gtaacaattt tggcagaaac cacaagtgac aatgagaaga ctgtgactga gaaaattaat
      961 aaagcaatta gaagtagctc aagcaacttt ctaaactatg atttgaccct tcggtgtgat
     1021 tattatggct gtaaccagac tgcggatgac tgcctcaatg gtttagcatg cgattgcaaa
     1081 tctgacctgc aaaggcctaa cccacagagc cctttctgcg ttgcttccag tctcaagtgt
     1141 cctgatgcct gcaacgcaca gcacaagcaa tgcttaataa agaagagtgg tggggcccct
     1201 gagtgtgcgt gcgtgcccgg ctaccaggaa gatgctaatg ggaactgcca aaagtgtgca
     1261 tttggctaca gtggactcga ctgtaaggac aaatttcagc tgatcctcac tattgtgggc
     1321 accatcgctg gcattgtcat tctcagcatg ataattgcat tgattgtcac agcaagatca
     1381 aataacaaaa cgaagcatat tgaagaagag aacttgattg acgaagactt tcaaaatcta
     1441 aaactgcggt cgacaggctt caccaatctt ggagcagaag ggagcgtctt tcctaaggtc
     1501 aggataacgg cctccagaga cagccagatg caaaatccct attcaagaca cagcagcatg
     1561 ccccgccctg actattagaa tcataagaat gtggaacccg ccatggcccc caaccaatgt
     1621 acaagctatt atttagagtg tttagaaaga ctgatggaga agtgagcacc agtaaagatc
     1681 tggcctccgg ggtttttctt ccatctgaca tctgccagcc tctctgaatg gaagttgtga
     1741 atgtttgcaa cgaatccagc tcacttgcta aataagaatc tatgacatta aatgtagtag
     1801 atgctattag cgcttgtcag agaggtggtt ttcttcaatc agtacaaagt actgagacaa
     1861 tggttagggt tgttttctta attcttttcc tggtagggca acaagaacca tttccaatct
     1921 agaggaaagc tccccagcat tgcttgctcc tgggcaaaca ttgctcttga gttaagtgac
     1981 ctaattcccc tgggagacat acgcatcaac tgtggaggtc cgaggggatg agaagggata
     2041 cccaccatct ttcaagggtc acaagctcac tctctgacaa gtcagaatag ggacactgct
     2101 tctatccctc caatggagag attctggcaa cctttgaaca gcccagagct tgcaacctag
     2161 cctcacccaa gaagactgga aagagacata tctctcagct ttttcaggag gcgtgcctgg
     2221 gaatccagga actttttgat gctaattaga aggcctggac taaaaatgtc cactatgggg
     2281 tgcactctac agtttttgaa atgctaggag gcagaagggg cagagagtaa aaaacatgac
     2341 ctggtagaag gaagagaggc aaaggaaact gggtggggag gatcaattag agaggaggca
     2401 cctgggatcc accttcttcc ttaggtcccc tcctccatca gcaaaggagc acttctctaa
     2461 tcatgccctc ccgaagactg gctgggagaa ggtttaaaaa caaaaaatcc aggagtaaga
     2521 gccttaggtc agtttgaaat tggagacaaa ctgtctggca aagggtgcga gagggagctt
     2581 gtgctcagga gtccagccgt ccagcctcgg ggtgtaggtt tctgaggtgt gccattgggg
     2641 cctcagcctt ctctggtgac agaggctcag ctgtggccac caacacacaa ccacacacac
     2701 acaaccacac acacaaatgg gggcaaccac atccagtaca agcttttaca aatgttatta
     2761 gtgtcctttt ttatttctaa tgccttgtcc tcttaaaagt tattttattt gttattatta
     2821 tttgttcttg actgttaatt gtgaatggta atgcaataaa gtgcctttgt tagatggtg
//
