LOCUS       NM_001363818            7931 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens metaxin 3 (MTX3), transcript variant 3, mRNA.
ACCESSION   NM_001363818 XM_005248495
VERSION     NM_001363818.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7931)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 7931)
  AUTHORS   Huynen,M.A., Muhlmeister,M., Gotthardt,K., Guerrero-Castillo,S. and
            Brandt,U.
  TITLE     Evolution and structural organization of the mitochondrial contact
            site (MICOS) complex and the mitochondrial intermembrane space
            bridging (MIB) complex
  JOURNAL   Biochim Biophys Acta 1863 (1), 91-101 (2016)
   PUBMED   26477565
REFERENCE   3  (bases 1 to 7931)
  AUTHORS   Adolph,K.W.
  TITLE     The zebrafish metaxin 3 gene (mtx3): cDNA and protein structure,
            and comparison to zebrafish metaxins 1 and 2
  JOURNAL   Gene 330, 67-73 (2004)
   PUBMED   15087125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112184.2.
            
            On Aug 29, 2019 this sequence version replaced NM_001363818.1.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2899168.1,
                                           SRR11853567.24247.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512528.3/ ENSP00000424798.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC112184.2         112131-112235       c
            106-175             AC112184.2         111567-111636       c
            176-252             AC112184.2         111133-111209       c
            253-345             AC112184.2         110125-110217       c
            346-528             AC112184.2         109435-109617       c
            529-605             AC112184.2         109212-109288       c
            606-763             AC112184.2         107923-108080       c
            764-852             AC112184.2         106544-106632       c
            853-7931            AC112184.2         97689-104767        c
FEATURES             Location/Qualifiers
     source          1..7931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.1"
     gene            1..7931
                     /gene="MTX3"
                     /note="metaxin 3"
                     /db_xref="GeneID:345778"
                     /db_xref="HGNC:HGNC:24812"
                     /db_xref="MIM:619336"
     exon            1..105
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..963
                     /gene="MTX3"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="metaxin-3 isoform 3"
                     /protein_id="NP_001350747.1"
                     /db_xref="CCDS:CCDS87308.1"
                     /db_xref="GeneID:345778"
                     /db_xref="HGNC:HGNC:24812"
                     /db_xref="MIM:619336"
                     /translation="MAAPLELSCWGGGWGLPSVHSESLVVMAYAKFSGAPLKVNVIDN
                     TWRGSRGDVPILTTEDDMVSQPAKILNFLRKQKYNADYELSAKQGADTLAYIALLEEK
                     LLPAVLHTFWVESDNYFTVTKPWFASQIPFPLSLILPGRMSKGALNRILLTRGQPPLY
                     HLREVEAQIYRDAKECLNLLSNRLGTSQFFFGDTPSTLDAYVFGFLAPLYKVRFPKVQ
                     LQEHLKQLSNLCRFCDDILSSYFRLSLGGISPAGQETVDANLQKLTQLVNKESNLIEK
                     MDDNLRQSPQLPPRKLPTLKLTPAEEENNSFQRLSP"
     exon            106..175
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            176..252
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            253..345
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            346..528
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..605
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            606..763
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            764..852
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..7931
                     /gene="MTX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7898..7903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTX3"
                     /note="hexamer: AATAAA"
     polyA_site      7931
                     /gene="MTX3"
                     /note="major polyA site"
ORIGIN      
        1 atagtaaagg tcggcccgcg caagatggcg gcccccttgg aactcagttg ctggggaggc
       61 ggctggggac tcccatcggt tcacagcgag tccctggtgg tgatggctta tgccaaattt
      121 tctggtgcac ccttgaaagt caatgtgata gataacacct ggagaggttc aagaggcgat
      181 gtaccaattt tgacaactga agacgacatg gtttctcagc cagcaaaaat actaaacttt
      241 ttaagaaaac agaaatataa tgctgattat gaactctcag caaaacaagg ggcagataca
      301 ttggcttata ttgctctcct cgaagagaag cttctccctg cagtgcttca cacattctgg
      361 gttgagagtg acaattactt tactgtgaca aagccatggt ttgcttcaca aattcctttt
      421 cctttgagtt tgatcctgcc tggaagaatg tctaagggag cactgaatag gattctcctg
      481 accagaggac agcctcccct ctaccacctc cgagaagtgg aagcacagat atacagagat
      541 gccaaggagt gcctaaatct tctatcaaac agattgggaa catctcagtt tttctttgga
      601 gatacgcctt ctaccttgga tgcctatgtt tttggttttc ttgcacctct ttacaaagta
      661 cggtttccta aagttcagct acaagaacat ctgaaacagc tctccaacct ctgtcgcttt
      721 tgtgatgaca tcctgagcag ttattttagg cttagtcttg gaggcatctc tccagctgga
      781 caagaaacgg tagatgcaaa tctgcagaaa ctcacacaac ttgtaaataa ggaatccaac
      841 ttgattgaaa agatggatga caatcttcgc caaagccctc agcttcctcc tcggaaactg
      901 ccaacactta aattgactcc agcagaagaa gaaaataatt ccttccaacg gctttcgccc
      961 tgagagtagt catggtttgt ggccaaagtc aaacgattgt tgcagtaatc tcttacacca
     1021 agtgtgtgaa ggcaaaaaga agataccata ataggtatta aggaagactc taaaccaaaa
     1081 ggaactttct atgccatcta tttttactat tattattagg aagcttgtat tctagcttgg
     1141 cactgcattt ttaataacaa agagaatgct aaatgaactt ggttgggggg gcggggaaga
     1201 aaaacacatc gtactgtata caaagaactg ccttaatcat ggcagatttt tgcctttggt
     1261 tcacatgttg ctgaccaaag gctacaattc tgttctgaat gtgcactcct aatttatttg
     1321 atttaattta ttcaatttat taacttagtt ttcttagacc aggctgaata cctaatatgt
     1381 ggctttttgg ctgaggcttt ttacttctgt ttagaaattt gatgcctatt ttaggaacca
     1441 gaaaaagata aattgcttca gtagaagaga ccatatttaa ctttaaaaag tgaggaggaa
     1501 tgtgcttttt aattatgctc tcataagtct aatcttttgg gggtttagta gcacatagat
     1561 aaatattaaa ggtggttaca tataataaca tctgataata ctcatttcag tataacattg
     1621 gtctttgctg atgtgttcga tataggttag gaagagttct tttagtttac ttgggcaaat
     1681 gtggcagttt tagacctatg tctttgtagt acatcttcag ttgtctttct tgtattaatt
     1741 ccagaagaag tgaatgtact ggttatcgtt actatgctag gctgtaaaat tcttactgaa
     1801 attgcccact tgttagacac tactcaggag gagcccatgg ccagggtagt agaaatactg
     1861 tgcatctggt ccaagttttc tatgcttggc tcatattctt tcataagatg catattcttt
     1921 cataagatgc atatcatgta gtcaaaagct ttctgacaac caattatttt tcatatgttt
     1981 cacttatagt cgaagaatac aaaggaacaa tcagaaatag cagcttttaa tgaatatttt
     2041 ctatttattg gttgctgaac tgttaaggga tttgctgtgt ggtaatttta cttataatag
     2101 aaacttgctt attttagtgg ttgaggtgct tctgttgtcc taaaactact tctgaggttt
     2161 ttaaaatgta gaaccatgtt tttgattagt gtcttaaaag attactgtgg tgctcagcaa
     2221 atcttatcaa gtcgtgcagg aacccatatg ttaagaaaat gagctttgta gtcaaaagac
     2281 tcatctaatt tgagctgagt ggagctcagc tgtgtttgac ccacatcctc ccaatttgtt
     2341 ctgtatttag gtagttattt atacaagagt ctttaagtca ttctaaatat tttttcttga
     2401 aagttttaac taagtgagaa ataaggtagt cttcaaaatc ttggtcatct gtttggatga
     2461 gggaaagtac ctcatgagtt gcacattact tctacaacag ggtgtgtgtg tgtgtgtttg
     2521 tgtgtgtcag tcatcttcaa aggcagatta ttagattcca gcaatctgaa atctattatt
     2581 ccagcagtct gaaacctaaa tatgttatat tggaaatcat gactgtgaga ctttattgtc
     2641 ctctaggatg gatgtatatt ggagaagggt ggttagcaca ttcatcagac atctgcttat
     2701 gctgtggtca aggccagtca tttttaattt atatcagatt tatatcagac cctccaaaaa
     2761 gtatttgaaa tatattacag ttataacgta caagtacatt acatgtatat tacaagtata
     2821 ttacatgtaa aacaggacaa tttaaaaatt ttaaatttta aagaattaaa aattttaaaa
     2881 atttaaatta aaaaaattaa aaatttatag aaccatatca acactgacag attctaaaat
     2941 taagtagtaa atttaactcc aagtttctcc atgggcaaag tcaaaagata atgctaggtt
     3001 atgtcaattt ttcttttcaa caaaactgct aatgtctatt aggaagaaaa atgtgtttaa
     3061 agttttacag gaacgtggag ctcatgttct tctgatatgt agactttgat aaagaagcat
     3121 actgtaatgt tttatgaact gaaattttaa tcaaaagagg tcattttaga ataacaagta
     3181 ttattctttt ttagtagagg gaatgactgt caatatgatt tatttgtttt tgtgtcatcc
     3241 ctactttgaa ctgctgttag ccttacattc tcactatagt ccataatgct tccagatcac
     3301 cttttctaag atgcaacatg tgagtttagt gagagtttat atgttgggtt acttagttga
     3361 gctatttatg tataagtaaa tgagatgaca ggaagctgta actgagcaca aagtacttta
     3421 gggagcagcc acacatacag gaagctctta gaaaagaact tttttttttt tttgagacag
     3481 agtttcactc ttgttgccca ggctggagtg cagtagcgca gtctcggctc actgcaacct
     3541 ctacctcctg ggttcaagca agtctcctgt ctcagcctcc caagtagctg ggattacagg
     3601 catgtgccac catgcccagc taattttgtt ttttttttag tcgagacggg gtttcaccat
     3661 gttgctcagg ctggtcttga actcctgacc tcaagtgatt cacctgcctc ggcctcccaa
     3721 agtgctggga ttacaggcgt gagccactgc gcccggccaa aaagaacatt ttgtcaatct
     3781 gaacagagca cagaacattt tttcagactg aacagactgt tggaccagcc tgtcatgata
     3841 tgttttagat aaagtttgag tgagttcatt gggataaatg gtccacaatc ttaaacagaa
     3901 tactgtgagc caatgccttt tggaagtaat ggtggaggat aatatgatta aagggaacat
     3961 gcttgtgttt atttttgttg gtagtatatg attagaaaaa ctagataatt cccataagat
     4021 gaagatcttc catgaacaaa ctaccatcaa tcatccatca gattgatttt tttttttttt
     4081 ttaagtaaca ctaaagaagc tgtaaagaac attgaaggtg gtcattcctt caaaactgtg
     4141 ttttgaccac acaaggtggg cattaacaaa ccaaatttca acttaagttt gtttgtatta
     4201 tattgggggt gctgcgagac tggagatttt ataaaagcaa gcatttttat ttccatttat
     4261 aatttctatt caatattgct agatatatta acatgaagga atggggaagc ttatttcaat
     4321 caaagctaaa attttcagaa gtctgtaaaa atggaaaaac accattgaaa gaggcagaaa
     4381 caggtaaggg ggatagtatc ttagaaaacc tgttggttaa ggcagctgca tgtgataaaa
     4441 gtggtacttg aacttggtag tgtttcctta gaacctcctc caaaaatatg catttaccag
     4501 gcttgttaca attttttgac agtttttcat caactgtcaa aaacttcaac ccttttaaaa
     4561 cctagatata aatgcttaca tgtaaagaaa ggaagctaag cagtgggtac ctgggatctc
     4621 tctgaactat ttttataact tcttgtgagt cttaagtatt tcaaaataaa agtggtttta
     4681 aagtaaattc atagattaaa tgtatcatta tctatatata aaccatgatt taaaacttta
     4741 attttctaaa catagtattc aacttagttg aataaatata tgatagaagt taaatagaat
     4801 ttttatttca ttcttaagaa aaactcatgt ttgtaacaaa tgatatctaa agatctattt
     4861 tgccttacca gaaaagaaaa aaaaaaccct aaaaccaaaa actccttttc cctaggaagt
     4921 caaaaatgct gtgatttaaa atatctaatt atattttttt ctttctatgg tagtggggtt
     4981 tacttctgag gataaaatat tttgaaaaag ctctgtccct tgacatggta gttctcccgt
     5041 gccttgtact tgttctctct ccatatgcac agtgtgacaa gatgctcacc tttaatgaag
     5101 aaggtgtagc ttttcgtttt aagctgtaat tgtctttgtc ttgatttggc tatttttata
     5161 actgaaatcc tgagcaacag agataatttg ggtggtaatg atcatctttt gtatatgttc
     5221 ttgatgttaa gaaatatttt ttgctgccat tcagctttgt ggaatttatg tttacttttc
     5281 aatattttca tatttcttaa ccagatttta aagaaatttg ttgttagtta cgtgaaatca
     5341 aaggtcaggt cagtaagccc attatcctca aacttgaagt ttcgttggat gttcaaaatg
     5401 ctaatttttg cagagatata aggataaatt agttttagtt tgtgttctta agggtttgca
     5461 aaataatttg gctcccaaac tcttgttggg gtgtagtgtt tgctaggagc ccaggatacc
     5521 tgccctggac ttaaattgtg attgaagtgg agaggtactc taggaattta aaaagacaca
     5581 aaattatttt tttccagact agtgtgccat ggatttctga taagaattaa cattcttgaa
     5641 caaaggtatc agaaagggta actcgagttg aaggtttgtg aatagaaggg gaaatgtgat
     5701 agaagattat tcagaacaaa ataagtagac aaaataacaa aagacaggaa aataagtctc
     5761 tttgtatcct tattaatcat ttgaaattat gctataatat tttttaaaac tcacctgttt
     5821 ggttctgggt gaagcagttc ctgaaggagt gttttgtcag aatatattgt taggagaata
     5881 gagggttctg tggccaagta agtttgggaa atagtgggtt agacaaagtt gagttactgt
     5941 tggcctttca gacctttgat acgctaatgt gcattttaaa tctccaagaa gcacctctat
     6001 tttatacatc atttccctaa tttattttaa tatggatttc ttgtttttgt tttcttgaga
     6061 cggagtcttg gtcttgtcac ccaggctgga gtgcagtggc acgatctcgg ctcactacaa
     6121 cctccgcctc ccaggttcaa gcgattctcc tgcctcagcc tcccaattta ctgggattac
     6181 aggcacctgc caccacgccc agctaatttt tgtattttta gtagagatgg ggtttcacca
     6241 tgttgaccag gctgattttg aactcctgac ctcaggtgat tctgcccgcc tcaccctccc
     6301 acagtgctgg aattataggt atgagccact gtccccggcc agattttttt aaaagtaggt
     6361 atcttgtggg atttatgttc tgagagatac acctaaggaa atgctgccct acagtgtttt
     6421 tgctagttca tactcattac aaaggtttct tgttgttggg tgcccctcta gccagtggta
     6481 gtaaaatggg aagagacagg tcaagactcc cttggaccat ggcattgaga gagggatggc
     6541 tgtcggcata gatatgttgg ttatttaggc atttgtgagg gaggcccctg gctcttccag
     6601 cctgtttcct taggatccca gttggccggg aacagctgta caagggtctg ctgaactggt
     6661 ggtttcagca gactacccag ttcctaagca tccatgagac agagggaacc aacttgtatt
     6721 tccagaacaa ttttccaaac cttttctggc tgtactttaa aagtgccaaa aaggcaatgg
     6781 gtgtttatga cactaaagtc acatacaagc tagtatgata catacatcat agaaagctta
     6841 tagttgctca gtgacaaagc aaaggaagtt taatattttc cagttttgtt cattaccgaa
     6901 gacagtctac ggttcatagt tttcactaaa ttctaagcag attctatatc ctaaaacatt
     6961 taaacctcac taggcctgca attttgagag ggttagctaa atatgtttgg tatcacttca
     7021 gagtctaaaa ccagattact aatcgtgtgt aaggaggcat tttgtgtgtc tttgcaatgt
     7081 atacaattgg attatttgga acaccatttt gaatgtgtat ttgagagaaa gctcgcctgt
     7141 gggttttgag ttgtggtgta atggtgaaca tgtagccacg tgaaaggccg ttggatcttt
     7201 gttctgattc ttcagtcgtc ttcttgcaaa ttcagagaaa tgtcttttaa tcatttcgtt
     7261 tacatatccc agatccttgg aaatcatgaa aaataacttg ccagagtttg catcagccct
     7321 cagtaagtca tgaaccatag agaaggtcat ggggccattt attctttgga ccactggcta
     7381 cttctgaagt tctggcttcc ttctctctag gaggagtcgt gtattcaagc ttttaagtta
     7441 aatgcataaa aatgagtttt acttctcttc tgacttgatt tttaatttta tgaaatggga
     7501 aataatgttt ttccattttt ctgttcattt tgaagtggga atttgaggtg tttgtaatgt
     7561 catgttactg ttctgaaaga ttgacagtaa agaagacaag aaatatatgt atgtagtatg
     7621 catattagtt ttgtcccacc aagcctatct ttgaatggca aacattttaa aaacatctgt
     7681 tctagttgca caactactct agcttcttta taaagtaaac aatcttaaag taagcaatgt
     7741 tggccataat ttcaatattc tagccttgcc gagtgtgaat atattttact cagagactat
     7801 gtacaaatac actaaagtgg tgatggtgat caatattgta aagaatttat tctgataaat
     7861 gagaaactgg atataatgtc aaaatagcta ttttctcaat aaaaatctca aatctcctga
     7921 ctgcttatga a
//
