LOCUS       NM_001033602            7439 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens microtubule associated scaffold protein 2 (MTUS2),
            transcript variant 1, mRNA.
ACCESSION   NM_001033602 XM_011535020
VERSION     NM_001033602.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7439)
  AUTHORS   Xicota,L., Cosentino,S., Vardarajan,B., Mayeux,R., Perls,T.T.,
            Andersen,S.L., Zmuda,J.M., Thyagarajan,B., Yashin,A.,
            Wojczynski,M.K., Krinsky-McHale,S., Handen,B.L., Christian,B.T.,
            Head,E., Mapstone,M.E., Schupf,N., Lee,J.H. and Barral,S.
  CONSRTM   Long-Life Family Study (LLFS); Alzheimer's Disease Genetic
            Consortium (ADGC); Alzheimer's Biomarkers Consortium-Down Syndrome
            (ABC-DS)
  TITLE     Whole genome-wide sequence analysis of long-lived families
            (Long-Life Family Study) identifies MTUS2 gene associated with
            late-onset Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (4), 2670-2679 (2024)
   PUBMED   38380866
  REMARK    GeneRIF: Whole genome-wide sequence analysis of long-lived families
            (Long-Life Family Study) identifies MTUS2 gene associated with
            late-onset Alzheimer's disease.
REFERENCE   2  (bases 1 to 7439)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 7439)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7439)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7439)
  AUTHORS   Kovacs,I.A., Luck,K., Spirohn,K., Wang,Y., Pollis,C., Schlabach,S.,
            Bian,W., Kim,D.K., Kishore,N., Hao,T., Calderwood,M.A., Vidal,M.
            and Barabasi,A.L.
  TITLE     Network-based prediction of protein interactions
  JOURNAL   Nat Commun 10 (1), 1240 (2019)
   PUBMED   30886144
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7439)
  AUTHORS   Rodrigues-Ferreira,S. and Nahmias,C.
  TITLE     An ATIPical family of angiotensin II AT2 receptor-interacting
            proteins
  JOURNAL   Trends Endocrinol Metab 21 (11), 684-690 (2010)
   PUBMED   20889352
  REMARK    Review article
REFERENCE   7  (bases 1 to 7439)
  AUTHORS   Trevino,L.R., Shimasaki,N., Yang,W., Panetta,J.C., Cheng,C.,
            Pei,D., Chan,D., Sparreboom,A., Giacomini,K.M., Pui,C.H.,
            Evans,W.E. and Relling,M.V.
  TITLE     Germline genetic variation in an organic anion transporter
            polypeptide associated with methotrexate pharmacokinetics and
            clinical effects
  JOURNAL   J Clin Oncol 27 (35), 5972-5978 (2009)
   PUBMED   19901119
REFERENCE   8  (bases 1 to 7439)
  AUTHORS   Du Puy,L., Beqqali,A., Monshouwer-Kloots,J., Haagsman,H.P.,
            Roelen,B.A. and Passier,R.
  TITLE     CAZIP, a novel protein expressed in the developing heart and
            nervous system
  JOURNAL   Dev Dyn 238 (11), 2903-2911 (2009)
   PUBMED   19806667
  REMARK    GeneRIF: These results suggest a role for CAZIP in development and
            function of the heart and nervous system in vertebrates.
REFERENCE   9  (bases 1 to 7439)
  AUTHORS   Jiang,K., Wang,J., Liu,J., Ward,T., Wordeman,L., Davidson,A.,
            Wang,F. and Yao,X.
  TITLE     TIP150 interacts with and targets MCAK at the microtubule plus ends
  JOURNAL   EMBO Rep 10 (8), 857-865 (2009)
   PUBMED   19543227
  REMARK    GeneRIF: TIP150 facilitates the EB1-dependent loading of MCAK onto
            MT plus ends and orchestrates the dynamics at the plus end of MTs.
REFERENCE   10 (bases 1 to 7439)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359741.9, AL160255.14, AL596092.8, AL607144.5 and AL596114.10.
            
            On or before Jun 22, 2020 this sequence version replaced
            XM_011535020.3, NM_001033602.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB018317.2 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145743, SAMN03267757 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000612955.6/
                                                ENSP00000483729.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AL359741.9         93482-93754
            274-346             AL359741.9         112921-112993
            347-2793            AL160255.14        8126-10572
            2794-3034           AL160255.14        17554-17794
            3035-3232           AL160255.14        84442-84639
            3233-3394           AL596092.8         94450-94611
            3395-3493           AL596092.8         137359-137457
            3494-3705           AL607144.5         20167-20378
            3706-3772           AL596114.10        9593-9659
            3773-3987           AL596114.10        49760-49974
            3988-4093           AL596114.10        57510-57615
            4094-4167           AL596114.10        62256-62329
            4168-4266           AL596114.10        66848-66946
            4267-4386           AL596114.10        68028-68147
            4387-4484           AL596114.10        70707-70804
            4485-7439           AL596114.10        72603-75557
FEATURES             Location/Qualifiers
     source          1..7439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.3"
     gene            1..7439
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /note="microtubule associated scaffold protein 2"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
     exon            1..273
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            274..346
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            347..2793
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..4698
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /note="isoform a is encoded by transcript variant 1; +TIP
                     of 150 kDa; cardiac zipper protein; tracking protein of
                     150 kDa; microtubule plus-end tracking protein TIP150;
                     microtubule associated tumor suppressor candidate 2"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor
                     candidate 2 isoform a"
                     /protein_id="NP_001028774.3"
                     /db_xref="CCDS:CCDS45022.2"
                     /db_xref="GeneID:23281"
                     /db_xref="HGNC:HGNC:20595"
                     /db_xref="MIM:619358"
                     /translation="MSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTNANQIMLEV
                     SSSHDESKTCDLGDEIGNTNSSEPENRTHFHKEFHQLQGFGKGSQAGSASLKDFRLSS
                     TIQRELNEEHTVERGTDSLQTTRSIQGPSLSSWRNVMSEASLDVLAKRDAEIPRHVPK
                     DKLAKTLDNEELRRHSLERASSSVAAVGSLTPQHPQPLSLDSREARGQIPGGGEGPQK
                     TLPDHAVPAAFPATDSTSEGKSVRHPKPSTSESKQSTPSETQTVGAHVLQVCSEHTSH
                     SAHPEPALNLTLASKEIPSKLEAQLGQGKGEAKLDLKYVPPRRVEQEGKAAQEGYLGC
                     HKEENLSALEGRDPCGEAHPEATDALGHLLNSDLHHLGVGRGNCEEKRGVNPGEQDSL
                     HTTPKQGSASLGGADNQPTGKISPCAGEKLGERTSSSFSPGDSHVAFIPNNLTDSKPL
                     DVIEEERRLGSGNKDSVMVLVFNPSVGENKTEVPEPLDPQSGRSEARESKEVTTSVAE
                     NRNLLENADKIESTSARADSVLNIPAPLHPETTVNMTYQPTTPSSSFQDVSVFGMDAG
                     SPLVVPPPTDSARLLNTSPKVPDKNTCPSGIPKPVFTHSKDTPSSQEGMENYQVEKTE
                     ERTETKPIIMPKPKHVRPKIITYIRRNPQALGQVDASLVPVGLPYAPPTCTMPLPHEE
                     KAAGGDLKPSANLYEKFKPDLQKPRVFSSGLMVSGIKPPGHPFSQMSEKFLQEVTDHP
                     GKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAMSRLPSAKSRILIASQRSSASAIH
                     PPGPITTATSLYSSDPSADLKKASSSNAAKSNLPKSGLRPPGYSRLPAAKLAAFGFVR
                     SSSVSSVSSTQSGDSAQPEQGRPATRSTFGNEEQPVLKASLPSKDTPKGAGRVAPPAS
                     SSVTAPRRSLLPAPKSTSTPAGTKKDAQKDQDTNKPAVSSPKRVAASTTKLHSPGYPK
                     QRTAAARNGFPPKPDPQAREAERQLVLRLKERCEQQTRQLGVAQGELKRAICGFDALA
                     VATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELERRFEDEVKR
                     LGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTASHDAALL
                     EMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLTFQSQ
                     SLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKILE
                     LEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKK
                     RLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR"
     exon            2794..3034
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3035..3232
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3394
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3395..3493
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3705
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3772
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3987
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            3988..4093
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            4094..4167
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            4168..4266
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4386
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            4387..4484
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     exon            4485..7439
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7415..7420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /note="hexamer: AATAAA"
     polyA_site      7439
                     /gene="MTUS2"
                     /gene_synonym="CAZIP; ICIS; KIAA0774; TIP150"
                     /note="major polyA site"
ORIGIN      
        1 agaggtgata gcgagcgccg gcggctccag gtgcgggggc gcccctcgcg ctccacctgc
       61 gccgccgccg ccggctctca gggcaagttt atctcccccc ttctgcggaa acccttgacc
      121 gcttagcgga gtacagacct gtcggtaaat agaaaactcg agctggagag gaggaggaag
      181 cagcgtggcg gaacccggcc cgagatgagc gtctccgtga gggcagtggt ggcctcttgg
      241 acattacatc tttcttggct ctttttgacc caggtttcca cagctggatt gtttactagg
      301 gccaattgtc accaatggca gtaaaactca ttttctgggg aatagggtct catggactga
      361 ttggctctca ttcagcagga acctaacaga taagtcttcc tgctgtatat caagacaatg
      421 cttggttttc aagctgttct gagaatgatt aaagcagtgt cgcaaggtga cattgtcagg
      481 ggagaacaag cagcttgaga atttcctctt aatctgattg cagcttgaag gcagcccatt
      541 tccattaagt aggactgcat ggcaagcagc cccaccaaag ggttgacaat gagcgtccca
      601 gtggctccta agaaatcatg ttacactcag ttgcgggaca acagaaatgc agcaagaaat
      661 aataatgaaa gcatcttaag tctgggagat acgaatgcca atcaaatcat gttggaggtc
      721 agctcctctc atgacgagtc caagacatgt gacctgggag atgaaattgg aaatacaaat
      781 tcaagtgagc cagaaaaccg tacccatttc cataaggaat ttcaccaact tcagggcttt
      841 gggaaaggct ctcaggctgg ctctgccagc ctgaaagatt ttagactttc ttcaaccatt
      901 cagagggaac tcaatgaaga gcacacagtg gagagaggca cagatagcct gcagaccacg
      961 cggagtattc agggaccaag tctgtcgagt tggaggaatg tgatgagtga ggccagtcta
     1021 gacgttttgg ctaaaaggga tgctgaaatt ccccggcatg ttcccaagga taaactggca
     1081 aagacccttg acaatgagga actgaggagg cattctttgg aaagagcaag cagctctgta
     1141 gctgcagtcg ggagcctgac tccgcagcat ccacagcctc tatccctcga ctcccgggaa
     1201 gcacggggtc agatacctgg gggtggggag gggccacaga agacattgcc agaccacgct
     1261 gtcccggcag ctttccctgc aactgacagt acctcagagg gaaagagtgt gcgtcatcct
     1321 aaaccatcta cctcagaaag caagcagagc actccctcag agacccaaac agtgggggca
     1381 catgtactgc aggtgtgcag tgagcacaca tcacattccg cccatccaga gcctgctctg
     1441 aatttgactt tggcatcgaa ggaaatccca agtaaactgg aagcacaatt aggtcaggga
     1501 aagggagagg ccaagctgga tctgaaatat gttcctccca ggagagttga acaggaggga
     1561 aaggcagccc aggaagggta tctgggatgc cacaaggaag agaatctgtc agccttggag
     1621 ggaagggatc catgtgggga agcacacccg gaagccaccg atgcacttgg ccatctgctg
     1681 aacagtgacc tccaccacct tggggtggga agaggcaact gtgaagagaa gagaggagtc
     1741 aacccagggg agcaggattc tctccacacc acccccaaac agggctctgc ttccttagga
     1801 ggggctgata atcagcccac tggcaaaatt tcaccatgtg caggtgagaa gttgggtgaa
     1861 aggacatcca gcagcttttc accaggtgac agtcatgtgg cttttattcc taataatctg
     1921 actgacagca agcccttgga tgtcattgag gaggaaaggc ggttgggcag tgggaataag
     1981 gacagtgtta tggttttggt gttcaatcct tctgttggag agaacaagac ggaggtgcct
     2041 gagcccctgg accctcaaag tggccgctca gaagcacggg aaagcaaaga ggtcaccaca
     2101 tctgttgctg aaaacaggaa ccttctagag aatgcagata agattgaaag cacctcagca
     2161 agagcagatt cagttctcaa tattccagca cccctccacc cagagacaac tgtgaacatg
     2221 acctaccagc ctacaacacc cagtagcagt tttcaggatg ttagcgtgtt cggtatggat
     2281 gcggggtccc ccttggtagt tccaccccct actgatagtg cacgcttgtt gaacacgtcc
     2341 cccaaagtgc ctgacaagaa cacttgcccc agtgggatcc ccaagcctgt cttcacacat
     2401 tccaaggaca caccttcctc gcaggaggga atggagaact atcaggttga aaaaacagag
     2461 gagaggacag aaactaagcc catcattatg cccaagccca agcatgtgag gcccaagatc
     2521 atcacctaca tcaggaggaa tccccaggcc ctgggccagg tggacgcctc gctggttcca
     2581 gtggggcttc catatgcccc gcccacatgt accatgcctc ttccccacga agagaaggca
     2641 gcaggtggtg acctgaagcc atctgccaac ctctatgaga aattcaagcc agacctgcag
     2701 aagccaaggg tcttcagttc cggattgatg gtgtctggaa tcaagccccc gggacatcct
     2761 ttcagtcaaa tgagtgaaaa gtttttgcag gaggttacag accaccctgg aaaagaagag
     2821 ttttgttctc ctccctatgc tcattatgaa gtccctccaa ctttctatcg gtcagccatg
     2881 ctccttaagc cccagctagg attgggtgca atgtcccgtt taccatctgc aaagagcagg
     2941 attctgattg caagtcagag gtcttcagcg agcgccatcc acccaccagg acccataaca
     3001 acagccacca gtctctacag ttccgatcct tcagcagatt taaagaaagc ttccagttca
     3061 aatgctgcaa aatccaatct cccgaaatct ggtctccgtc ctcccggata ctcacgtctc
     3121 ccggcagcca aactggcggc atttggcttt gtccggagct ccagcgtctc ctcagtctcc
     3181 agcacccagt ccggggacag tgcacagcca gagcagggcc ggccagccac ccgttcaacc
     3241 tttgggaatg aagaacagcc agttctgaag gcatctctgc cttctaagga cacacccaag
     3301 ggggccggcc gggtggcccc tccagcatcc tccagtgtga cagcaccccg caggagttta
     3361 cttccagcgc caaaatccac ttccacaccc gctggaacaa agaaagatgc tcagaaagat
     3421 caagatacga ataaacctgc tgtttcatct cctaagagag tagcagcttc aaccaccaag
     3481 cttcattcac caggataccc aaagcagagg actgcggcag ctcgaaatgg gtttccgccc
     3541 aagccggacc cgcaggcccg tgaggctgag cggcagctgg tgctgcggct gaaggagcgg
     3601 tgtgagcagc agaccagaca gctgggcgtt gcgcaagggg agctgaagag ggccatctgc
     3661 ggctttgatg ccctcgccgt ggccacgcag catttcttta gaaagaatga aagtgccctt
     3721 gtgaaagaaa aagagctgtc aatcgaactt gcaaacatca gggatgaagt tgccttccat
     3781 acagcaaagt gcgagaaact acaaaaggag aaggaggagc tggagaggcg gttcgaggac
     3841 gaggtgaaga ggctgggctg gcagcagcag gccgagctcc aggagctgga ggagcggctg
     3901 cagctgcaat tcgaggcgga aatggcgcgc ctgcaggagg agcacggtga ccagctgctg
     3961 agcatccggt gtcaacacca ggagcaggtg gaagatctca ccgccagcca tgatgctgct
     4021 ctcctagaga tggaaaataa ccacacagtt gccatcacaa tcctgcagga tgaccacgac
     4081 cacaaagtcc aagaattgat gtccactcat gagcttgaaa agaaagaatt ggaagaaaat
     4141 tttgaaaaac tgcggctgtc attgcaggac caggtggaca cgctgacctt ccagagccag
     4201 tctctgcggg acagagcccg ccgcttcgaa gaggccttga ggaagaacac agaggagcag
     4261 ctggagattg cattggctcc ttatcagcac ttggaagaag acatgaagag tctgaagcag
     4321 gtattagaaa tgaagaatca gcaaatacac gagcaagaaa agaagattct tgagctggaa
     4381 aagctggcag aaaagaacat tatcctagaa gaaaagatcc aggttctcca acagcagaac
     4441 gaagacctca aagcaaggat tgaccaaaac acagttgtca ccagacagct gtcggaggaa
     4501 aatgctaacc tccaggaata tgttgagaag gaaacccagg agaagaagag attgagccga
     4561 accaatgaag agctgctttg gaagctccaa actggggacc cgaccagtcc gattaaactc
     4621 tcgcccacat ctcccgttta ccgcggctcc tcctcggggc cctcctctcc ggccagagtc
     4681 agcacaacac ccagatgacg ccactacacg gcctgcggga gctccggctt ctcgtcctcc
     4741 ggtctccacc ctgagggagc accgacccgg tgccgccgga gctggccctg tgcgcatgct
     4801 cagtagctgc gaatgcatcc taggcgcgtc ctcctctgat ccccgtgtaa gactgccctg
     4861 gtgtcggcac ttaggaatgt gtaaatggta aagtctgatg tgcaaacgtt ttaccatagt
     4921 tagagccaaa agaaagacac ttgcaattgt tcttgagcaa tgaactttca ctgcagaatt
     4981 tcaggttagt tacaaaaagc tcagttttca atatacattg aataatcatt gtgtactgca
     5041 ccgatatgtg tgtatattta gatatacgta tatacacatg ctgcggttct gaatttcatt
     5101 ttttataaca tgaagtgctg acatatttta gtgaaggtca gcagttttct aacttgtgcc
     5161 taagaattat tgggaaatga aaatgcattt ctatctagct tcccaggaat atttctaccc
     5221 aaaatagaaa aaggaaaaaa aaaaagatac agagaagaag cgcctttcaa ctcaccacca
     5281 agtggtactc tctttaacac gaacaccagc tatttgtgaa cggtaactgc ctttggaaca
     5341 atcagcttct cagtcaacat gatgtgagat cactattatt ccattcgcaa gttttaatta
     5401 ttgatactcc tgtcatgagc ggataaggga gagcagtggg aaaccctaag ggggtttagc
     5461 agttttgcag atgttaccca tgacagtgac tcatctctga tagtcttgta aacacaagtt
     5521 ttgctttttt cctaaatggc atctcagact cggtcattaa gctattgttg caccctccgg
     5581 aaaacatggc agagcatgac ctttgagtaa gagtgaggat gaccttgcag atgactgtgc
     5641 ccattcgcgc tccatcctca tgaaggaaat tgctgccaag gtctgtattt tgaccaggca
     5701 cagaggggga acatcactcc agctttccat gtggttcact ctgatgcgat gctgtaaatg
     5761 atcaactctt tgaaatagga ccctcaggcc cccatttcct agcagccccc cttcagtttg
     5821 gttctacaac tcaacccctt cactgcacat tgagatggct caggggttct agcaggggct
     5881 tccagaaaaa aaaaacacca tttctgtccc gggggaccag ttctgagctg tgctagatca
     5941 tcacacgacc acccagaaac ccacttgcac ttcctgctgg atgatcaggc aacgctgctg
     6001 ctgaccgtgc tcccatctta gacccagaag gttctcccaa acagaggagc ccagtgaaac
     6061 agccagccag ggggcaccag ctcctggact ggcatctgtc tctaaaatgg tagaattagg
     6121 atatgaacag tactcatgta gtggtgtgga agattaggag catgatacac aaaaggaaga
     6181 agtagtttta acagatatgg tgatgatgat gatgcccttg tttcctgtat gtgacaaaga
     6241 ccctgcactt tctccctgag acccccccaa aattgtcctg agcacaggcc tgtctttgag
     6301 cgtgcccaag gcgagaagaa ccatgagggg gtcctgcagg ggccggagcc atggaacggg
     6361 gaagaaaaca gcccgcggac ggggtcggct tgtccagggc acgcctgctc ggcacacgtg
     6421 ttgccaacgt gaaggcagac atggtccctg gccctaggat gagtccacgc tgggcttccg
     6481 ggcctcaggt gcatctccag ccaacctcca agggtcttgc tccttctggg gacgtacaca
     6541 gtaaatccac atggaaacac caccatttct ctttgcttta gtggctctgc atgatactgt
     6601 gatattgagt tgggcattcc attagagtag atcttgccac attgactaaa tacacaagta
     6661 tttattctag tagcaggcac aacctgcaaa cacaaattca gttacagctt agctgtccga
     6721 attaggaacc gcttacatag ccgcacctgc taaatgcagt tacacagcaa tactgacttc
     6781 cgtgtgatgc tagaacgtgg tacagtgtat taggctgctg tggtcagagt tgtagcatcg
     6841 ttagcactaa gtaattcctc attaggtgga cttcggtgag agctttgccc taacctgccc
     6901 tgaccttggg tacttgagct aatttccacg tggccctggc ttcgtggttt gtttgttttt
     6961 tttcttttgt tacggacacc catcatgtat ggctcctcat ctgagccatc accgctcccg
     7021 aaacacatgg ggcggcagct gctgtgcctc cttctcaatt cttccacccc cccacaccat
     7081 cagaattcgg atttctctcc acgtggcgtc tgcctctgtc cccttccagg ctggagcgac
     7141 gtttccacgt tcggatgctg cagcctctgc acctgcctca gacagaccca ccagatacca
     7201 cctgtctctt cgtggcattt gggagatgcg tgggcggcct gccccccgac cgccgcccct
     7261 gcccaccaca tgctgggaca aggttctggc tggatgtcag aatggatggg ggtgggggca
     7321 gccctggccg tgattagttg aatgaatggg gtcacaacat cccttttcct gcccctacag
     7381 tttgtgttgc atatttgtgt ttaaagccta ttaaaataaa cttgagggac tttctgcga
//
