LOCUS       NM_001363059            6125 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens microtubule associated scaffold protein 1 (MTUS1),
            transcript variant 10, mRNA.
ACCESSION   NM_001363059 XM_005273579
VERSION     NM_001363059.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6125)
  AUTHORS   Wu,S.Y., Cheng,K.R., Zhou,Y.Y. and Wang,Y.F.
  TITLE     [Microtubule-associated tumor suppressor 1 inhibits hemin-induced
            apoptosis of vascular endothelial cells via hemeoxygenase 1]
  JOURNAL   Sheng Li Xue Bao 76 (2), 215-223 (2024)
   PUBMED   38658371
  REMARK    GeneRIF: [Microtubule-associated tumor suppressor 1 inhibits
            hemin-induced apoptosis of vascular endothelial cells via
            hemeoxygenase 1].
REFERENCE   2  (bases 1 to 6125)
  AUTHORS   Yuan,H., Fang,R., Fu,C., Wang,S., Tong,X., Feng,D., Wei,X., Hu,X.
            and Wang,Y.
  TITLE     ATIP/ATIP1 regulates prostate cancer metastasis through
            mitochondrial dynamic-dependent signaling
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (2), 304-314 (2024)
   PUBMED   38282475
  REMARK    GeneRIF: ATIP/ATIP1 regulates prostate cancer metastasis through
            mitochondrial dynamic-dependent signaling.
REFERENCE   3  (bases 1 to 6125)
  AUTHORS   Chen,F., Zheng,X., Liang,W., Jiang,C., Su,D. and Fu,B.
  TITLE     Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to Prevent
            Pancreatic Cancer Progression Via Mitochondrial Tumor Suppressor
            1-Dependent Suppression of Extracellular Regulated Protein Kinases
            Signaling Pathway
  JOURNAL   Pancreas 51 (10), 1434-1443 (2022)
   PUBMED   37099789
  REMARK    GeneRIF: Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to
            Prevent Pancreatic Cancer Progression Via Mitochondrial Tumor
            Suppressor 1-Dependent Suppression of Extracellular Regulated
            Protein Kinases Signaling Pathway.
REFERENCE   4  (bases 1 to 6125)
  AUTHORS   Cheng,L.Y., Huang,M.S., Zhong,H.G., Ru,H.M., Mo,S.S., Wei,C.Y.,
            Su,Z.J., Mo,X.W., Yan,L.H. and Tang,W.Z.
  TITLE     MTUS1 is a promising diagnostic and prognostic biomarker for
            colorectal cancer
  JOURNAL   World J Surg Oncol 20 (1), 257 (2022)
   PUBMED   35962436
  REMARK    GeneRIF: MTUS1 is a promising diagnostic and prognostic biomarker
            for colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6125)
  AUTHORS   Rozario,L.T., Sharker,T. and Nila,T.A.
  TITLE     In silico analysis of deleterious SNPs of human MTUS1 gene and
            their impacts on subsequent protein structure and function
  JOURNAL   PLoS One 16 (6), e0252932 (2021)
   PUBMED   34125870
  REMARK    GeneRIF: In silico analysis of deleterious SNPs of human MTUS1 gene
            and their impacts on subsequent protein structure and function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6125)
  AUTHORS   Di Benedetto,M., Bieche,I., Deshayes,F., Vacher,S., Nouet,S.,
            Collura,V., Seitz,I., Louis,S., Pineau,P., Amsellem-Ouazana,D.,
            Couraud,P.O., Strosberg,A.D., Stoppa-Lyonnet,D., Lidereau,R. and
            Nahmias,C.
  TITLE     Structural organization and expression of human MTUS1, a candidate
            8p22 tumor suppressor gene encoding a family of angiotensin II AT2
            receptor-interacting proteins, ATIP
  JOURNAL   Gene 380 (2), 127-136 (2006)
   PUBMED   16887298
  REMARK    GeneRIF: MTUS1 encodes a family of proteins(ATIP1, ATIP3 and
            ATIP4), with potential important biological roles in tumor
            suppression and/or brain function.
REFERENCE   7  (bases 1 to 6125)
  AUTHORS   Di Benedetto,M., Pineau,P., Nouet,S., Berhouet,S., Seitz,I.,
            Louis,S., Dejean,A., Couraud,P.O., Strosberg,A.D.,
            Stoppa-Lyonnet,D. and Nahmias,C.
  TITLE     Mutation analysis of the 8p22 candidate tumor suppressor gene
            ATIP/MTUS1 in hepatocellular carcinoma
  JOURNAL   Mol Cell Endocrinol 252 (1-2), 207-215 (2006)
   PUBMED   16650523
  REMARK    GeneRIF: Nucleotide variations result in amino-acid substitution or
            deletion of conserved structural motifs and also exonic splicing
            enhancer motifs and physiological splice sites, suggesting
            deleterious effects on ATIP function and/or expression. [REVIEW]
            Review article
REFERENCE   8  (bases 1 to 6125)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade
REFERENCE   9  (bases 1 to 6125)
  AUTHORS   Seibold,S., Rudroff,C., Weber,M., Galle,J., Wanner,C. and Marx,M.
  TITLE     Identification of a new tumor suppressor gene located at chromosome
            8p21.3-22
  JOURNAL   FASEB J 17 (9), 1180-1182 (2003)
   PUBMED   12692079
  REMARK    GeneRIF: identified a tumor suppressor gene named MTSG1 at
            chromosome 8p21.3-22, encoding a mitochondrial protein, controlling
            cellular proliferation
REFERENCE   10 (bases 1 to 6125)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA214747.1, DB221458.1,
            DA339588.1, AK310871.1, AB033114.1, AL096842.1, BC142971.1 and
            AF121259.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_001363059.1.
            
            Summary: This gene encodes a protein which contains a C-terminal
            domain able to interact with the angiotension II (AT2) receptor and
            a large coiled-coil region allowing dimerization. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. One of the transcript
            variants has been shown to encode a mitochondrial protein that acts
            as a tumor suppressor and partcipates in AT2 signaling pathways.
            Other variants may encode nuclear or transmembrane proteins but it
            has not been determined whether they also participate in AT2
            signaling pathways. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1702295.1,
                                           SRR14038196.2593576.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000693296.1/
                                                  ENSP00000509719.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA214747.1         131-164
            35-47               DB221458.1         322-334
            48-193              DA339588.1         1-146
            194-629             AK310871.1         481-916
            630-658             AB033114.1         368-396
            659-986             AK310871.1         946-1273
            987-1048            AB033114.1         725-786
            1049-1618           AL096842.1         66-635
            1619-4165           AB033114.1         1357-3903
            4166-4866           AL096842.1         3244-3944
            4867-4956           BC142971.1         2466-2555
            4957-6123           AB033114.1         4691-5857
            6124-6125           AF121259.1         3430-3431
FEATURES             Location/Qualifiers
     source          1..6125
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..6125
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="microtubule associated scaffold protein 1"
                     /db_xref="GeneID:57509"
                     /db_xref="HGNC:HGNC:29789"
                     /db_xref="MIM:609589"
     exon            1..34
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..2279
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..4001
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="isoform 1 is encoded by transcript variant 10;
                     transcription factor MTSG1; mitochondrial tumor suppressor
                     gene 1; AT2R binding protein; AT2 receptor-interacting
                     protein; erythroid differentiation-related; AT2
                     receptor-binding protein; angiotensin-II type 2
                     receptor-interacting protein; microtubule associated tumor
                     suppressor 1"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     isoform 1"
                     /protein_id="NP_001349988.1"
                     /db_xref="CCDS:CCDS43717.1"
                     /db_xref="GeneID:57509"
                     /db_xref="HGNC:HGNC:29789"
                     /db_xref="MIM:609589"
                     /translation="MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSV
                     NWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSI
                     CQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQT
                     FDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHA
                     RETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYT
                     DGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMG
                     QNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHT
                     SELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK
                     CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFK
                     NVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKK
                     AEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSA
                     CETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELK
                     QEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNS
                     DNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTG
                     STPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLM
                     KTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCEN
                     QSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTAS
                     TTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYK
                     MQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLL
                     SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV
                     LEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLST
                     EQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSF
                     PSPSISPR"
     exon            2280..2475
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2637
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2772
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2773..2811
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..3026
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3093
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3296
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3402
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3476
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3477..3572
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3689
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3690..3787
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..6125
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6106..6111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="hexamer: AATAAT"
     polyA_site      6125
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgctc ccggagcgct tgaaggagct gcggggaaca acaaatcatt taatcttcag
       61 agcatcttag actgaaaacc tttcaactgt gctgaaaaac ctagaagaca gaccattttg
      121 cccaccctct catttaaaag gaattgaaga agaaataaaa tggcagaggt ttaaggttac
      181 tattcaggat gactgatgat aattcagatg ataaaataga agatgaattg caaaccttct
      241 ttaccagtga taaagatgga aatacacatg catacaaccc gaaatcacca cctacacaaa
      301 actcttcagc cagcagtgtg aactggaatt ctgccaaccc agatgacatg gtggttgatt
      361 atgaaactga ccctgctgta gttactggtg aaaatatttc tttaagcctt cagggtgttg
      421 aagtatttgg tcatgaaaag tcttctagtg atttcattag taagcaggtg ttagatatgc
      481 ataaagattc tatttgtcag tgtcctgcac ttgtaggtac tgagaagccc aaatatctgc
      541 aacacagttg tcattcccta gaagcagttg agggccagag tgttgagcca tctttgcctt
      601 ttgtgtggaa gcctaatgac aatttgaact gtgcaggcta ctgtgatgcc ttggagctaa
      661 accaaacatt tgacatgaca gtggataaag ttaactgcac ctttatatca catcatgcca
      721 tcggaaagag tcagtccttc catactgctg gaagcctgcc accaactggt aggagaagtg
      781 gaagtacatc ttctttatcc tattccactt ggacatcttc ccattctgat aagacgcatg
      841 caagagaaac tacttatgat agagaaagct ttgaaaaccc tcaagtcaca ccatcagaag
      901 cccaagacat gacttacaca gcattttctg atgtggtgat gcaaagtgag gtttttgttt
      961 cagatattgg aaatcagtgt gcatgttctt caggaaaggt caccagtgag tacacagatg
     1021 gatcacaaca aagactagtt ggagaaaagg agacacaagc actaacacca gtttctgatg
     1081 gcatggaagt ccccaatgat tctgcattac aagagttctt ttgtttatcc catgatgaat
     1141 ccaatagcga accacattca cagagctcat acaggcacaa ggaaatgggc caaaatctga
     1201 gagagacagt gtcctattgt cttattgatg atgaatgccc tttaatggtg ccagcttttg
     1261 ataagagcga agctcaagtg ctgaacccag agcataaagt cactgagact gaagacacac
     1321 aaatggtctc caaaggaaag gatttgggaa cccaaaatca tacctcagaa ttgattctaa
     1381 gtagcccgcc aggacaaaag gtgggctcgt catttggact gacttgggat gcaaatgata
     1441 tggtcattag cacagacaaa acgatgtgca tgtcaacacc agtcctagaa cccacaaaag
     1501 taaccttttc tgtttcaccg attgaagcga cggagaaatg taagaaagtg gagaagggta
     1561 atcgagggct taaaaacata ccagactcga aggaggcacc tgtgaacctg tgtaaaccca
     1621 gtttaggaaa atcaacaatc aaaacgaata ccccaatagg ctgcaaagtt agaaaaactg
     1681 aaattataag ttacccaaga ccaaacttca agaatgtcaa agcaaaagtt atgtctagag
     1741 cagtgttgca gcccaaagat gctgctttat caaaggtcac gcccagacct cagcagacca
     1801 gtgcctcatc accctcatca gtgaattcaa gacaacaaac agtcttgagc agaacaccga
     1861 gatctgactt gaatgcagac aaaaaagcag aaattctaat taacaagaca cataagcagc
     1921 agtttaataa actcattact agccaggctg tgcatgttac aactcattct aaaaatgctt
     1981 cacacagggt tccaagaaca acatctgccg tgaaatcgaa tcaggaagat gttgacaaag
     2041 ccagttcttc taactcagca tgcgagaccg ggtccgtttc tgcgttgttt cagaagatca
     2101 aaggcatact ccctgttaaa atggaaagtg cagaatgttt ggaaatgacc tatgttccca
     2161 acattgatag gattagccct gaaaagaagg gtgaaaaaga aaatgggaca tctatggaaa
     2221 aacaagagct gaaacaagag attatgaatg agacttttga atatggttct ctgtttttgg
     2281 gctctgcttc aaaaacaacg accacctcag gtaggaatat atccaagcct gactcctgcg
     2341 gtttgaggca aatagctgct ccaaaagcca aagtggggcc ccctgtttcc tgtttgaggc
     2401 ggaacagtga caatagaaat cccagtgctg atcgagccgt atctcctcag aggatcaggc
     2461 gtgtgtccag ttctggaaag cctacatcct tgaaaactgc acagtcgtca tgggtgaatt
     2521 tgcctagacc acttcctaaa tccaaagcat ctttgaaaag tcctgcgctg cggaggacag
     2581 gaagcacccc ctcaatagcc agcacccaca gtgagctgag cacttacagc aacaattctg
     2641 gtaatgccgc tgtcatcaaa tatgaggaga aacctccaaa accagcattt cagaatggtt
     2701 cctcaggatc cttttatttg aagcctttgg tatccagggc tcatgttcac ttgatgaaaa
     2761 ctcctccaaa aggtccttcg agaaaaaatt tatttacagc tcttaatgca gttgaaaaga
     2821 gcaggcaaaa gaatcctcga agcttatgta tccagccaca gacagctccc gatgcgctgc
     2881 cccctgagaa aacacttgaa ttgacgcaat ataaaacaaa atgtgaaaac caaagtggat
     2941 ttatcctgca gctcaagcag cttcttgcct gtggtaatac caagtttgag gcattgacag
     3001 ttgtgattca gcacctgctg tctgagcggg aggaagcact gaaacaacac aaaaccctat
     3061 ctcaagaact tgttaacctc cggggagagc tagtcactgc ttcaaccacc tgtgagaaat
     3121 tagaaaaagc caggaatgag ttacaaacag tgtatgaagc attcgtccag cagcaccagg
     3181 ctgaaaaaac agaacgagag aatcggctta aagagtttta caccagggag tatgaaaagc
     3241 ttcgggacac ttacattgaa gaagcagaga agtacaaaat gcaattgcaa gagcagtttg
     3301 acaacttaaa tgctgcgcat gaaacctcta agttggaaat tgaagctagc cactcagaga
     3361 aacttgaatt gctaaagaag gcctatgaag cctccctttc agaaattaag aaaggccatg
     3421 aaatagaaaa gaaatcgctt gaagatttac tttctgagaa gcaggaatcg ctagagaagc
     3481 aaatcaatga tctgaagagt gaaaatgatg ctttaaatga aaaattgaaa tcagaagaac
     3541 aaaaaagaag agcaagagaa aaagcaaatt tgaaaaatcc tcagatcatg tatctagaac
     3601 aggagttaga aagcctgaaa gctgtgttag agatcaagaa tgagaaactg catcaacagg
     3661 acatcaagtt aatgaaaatg gagaaactgg tggacaacaa cacagcattg gttgacaaat
     3721 tgaagcgttt ccagcaggag aatgaagaat tgaaagctcg gatggacaag cacatggcaa
     3781 tctcaaggca gctttccacg gagcaggctg ttctgcaaga gtcgctggag aaggagtcga
     3841 aagtcaacaa gcgactctct atggaaaacg aggagcttct gtggaaactg cacaatgggg
     3901 acctgtgtag ccccaagaga tcccccacat cctccgccat ccctttgcag tcaccaagga
     3961 attcgggctc cttccctagc cccagcattt cacccagatg acacctcccc aaagtccaca
     4021 gactctctga aagcattttg atgcaggtct gcaggactga ccccaaggag gaacgtgggc
     4081 acaagaggta tatcagcaca cgtgtgatca ccgtagggta actggagcgt caccaccggc
     4141 ggaatcgcag cttctgagac tggaactctg gaggaagact tttgcctccg tccaaaagat
     4201 tcctccaaaa aaagatttaa aaaaagattt cggcatcgac acggacgttg ttgcacaaag
     4261 cacttaaaga acgagagcat cttgttcatt gcctttttca cctaagcata gggggaaaaa
     4321 ctctcagggc cctattaaga tttataacct ttgtaatgtt cttcaccaca gacaccttct
     4381 tgtgagtttt cagtctgact gtgggggtgg ggggtgtgaa tgaaatggat gtcacagagt
     4441 gtcatgtgtc tgatgcagcc tcctctgctg tgtattaaat gtcaaaatct gaatatatct
     4501 ggatatgtac taatcaaata ataatcaatc aatcagcata tacatttcag ccaaagccat
     4561 agaagaaaaa gcaatagttg cttgaattat gatcatctac caccaactct gctcagccct
     4621 gtaacagggt agggagaggg tataacagga agagctttga cttgtccctg tctatacatt
     4681 ctctgtatct tttgggggta acttcttggc agtttttcag tgttcagcca tgtcagttga
     4741 aactagattt ttctgtagat tttttactta cccatgtgag cctaacacta tcctgtaatt
     4801 cattttctca ggctatgtgt aaatgtagaa ccctaatttt tctataaaaa aacaaactaa
     4861 ctaactaact gtgtaaagaa agaaaaaggg aagtaccaat gggtttttcc accttatttt
     4921 tacctttgat ctacccttgc agatttaacc tgtcttcttc cctcccatta ttctcatttt
     4981 ccttttacct ttctccacca tccagagcca caaaagcaaa ccttctacct cctacctact
     5041 tttctctggg acaaggataa aggaatatga ttttccagag ccccagagcc agctcatctt
     5101 ccaggtgctg aaaccacttt ccaaataaac taaagcctgg atttgatatt acaaattttg
     5161 ggaaatctta gaataaagaa cgagaacaag gaagtcattg gctagtataa ttaagaaagg
     5221 taggattcag tgcttaccga tgatgcagta cttgatagaa gaaaacagtc tgggaggata
     5281 gcgctcattt ttcagttacc ctttaaggag tccctttgtc tttgggaaag tagcagaatg
     5341 gtccgcttct ttcccatgag tggaaaatgt ggcttgtcca actctcctcc aggttgcatt
     5401 tcagtttctt tccaaaactt attacctccc ctaatcctga gactttggaa aaggtggaag
     5461 gaagaactgt tgctttatct ccccctccct gcatgtgtca acattgtgat gtcagtattt
     5521 actaatctac attcagtggc tgtacaaata acagctgtag taagaagaga ttcaggatgc
     5581 tagaggtgaa tatttgggtc atttacatgt acactacata gcaagttgat actcatgttg
     5641 catgttcttt taaattagtg attttgtgtc ttaagtcttt aacttccaat acttcatcat
     5701 gtatgtaacc ttccatgttt gcttctgata aatggaaatg taggttcact gccacttcat
     5761 gagatatctc tgctcacgct tccaagttgt tctcaatgac attagccaaa gttgggtttg
     5821 ccattcatcc cctaggcatg gtaaatcttg tgttgttccc tgctgtcctc cgtattacgt
     5881 gaccggcaaa taaatctcat agcagttaat ataaaacatc tttggaggat gggagagaac
     5941 aggagggaag atgggaaaca aaatagagaa ttcttaagat tttgtttaaa ccaaatgttt
     6001 catgtagaat gcaaaatgtt ggcacgtcaa aaatatgaat gtgtagacaa ctgtagttgt
     6061 gctcagtttg tagtgatggg aagtgtattt tactctgatc aaataaataa tgctggaata
     6121 ctcaa
//
