LOCUS       NM_001363058            6183 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens microtubule associated scaffold protein 1 (MTUS1),
            transcript variant 9, mRNA.
ACCESSION   NM_001363058 XM_017013701
VERSION     NM_001363058.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6183)
  AUTHORS   Wu,S.Y., Cheng,K.R., Zhou,Y.Y. and Wang,Y.F.
  TITLE     [Microtubule-associated tumor suppressor 1 inhibits hemin-induced
            apoptosis of vascular endothelial cells via hemeoxygenase 1]
  JOURNAL   Sheng Li Xue Bao 76 (2), 215-223 (2024)
   PUBMED   38658371
  REMARK    GeneRIF: [Microtubule-associated tumor suppressor 1 inhibits
            hemin-induced apoptosis of vascular endothelial cells via
            hemeoxygenase 1].
REFERENCE   2  (bases 1 to 6183)
  AUTHORS   Yuan,H., Fang,R., Fu,C., Wang,S., Tong,X., Feng,D., Wei,X., Hu,X.
            and Wang,Y.
  TITLE     ATIP/ATIP1 regulates prostate cancer metastasis through
            mitochondrial dynamic-dependent signaling
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 56 (2), 304-314 (2024)
   PUBMED   38282475
  REMARK    GeneRIF: ATIP/ATIP1 regulates prostate cancer metastasis through
            mitochondrial dynamic-dependent signaling.
REFERENCE   3  (bases 1 to 6183)
  AUTHORS   Chen,F., Zheng,X., Liang,W., Jiang,C., Su,D. and Fu,B.
  TITLE     Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to Prevent
            Pancreatic Cancer Progression Via Mitochondrial Tumor Suppressor
            1-Dependent Suppression of Extracellular Regulated Protein Kinases
            Signaling Pathway
  JOURNAL   Pancreas 51 (10), 1434-1443 (2022)
   PUBMED   37099789
  REMARK    GeneRIF: Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to
            Prevent Pancreatic Cancer Progression Via Mitochondrial Tumor
            Suppressor 1-Dependent Suppression of Extracellular Regulated
            Protein Kinases Signaling Pathway.
REFERENCE   4  (bases 1 to 6183)
  AUTHORS   Cheng,L.Y., Huang,M.S., Zhong,H.G., Ru,H.M., Mo,S.S., Wei,C.Y.,
            Su,Z.J., Mo,X.W., Yan,L.H. and Tang,W.Z.
  TITLE     MTUS1 is a promising diagnostic and prognostic biomarker for
            colorectal cancer
  JOURNAL   World J Surg Oncol 20 (1), 257 (2022)
   PUBMED   35962436
  REMARK    GeneRIF: MTUS1 is a promising diagnostic and prognostic biomarker
            for colorectal cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6183)
  AUTHORS   Rozario,L.T., Sharker,T. and Nila,T.A.
  TITLE     In silico analysis of deleterious SNPs of human MTUS1 gene and
            their impacts on subsequent protein structure and function
  JOURNAL   PLoS One 16 (6), e0252932 (2021)
   PUBMED   34125870
  REMARK    GeneRIF: In silico analysis of deleterious SNPs of human MTUS1 gene
            and their impacts on subsequent protein structure and function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6183)
  AUTHORS   Di Benedetto,M., Bieche,I., Deshayes,F., Vacher,S., Nouet,S.,
            Collura,V., Seitz,I., Louis,S., Pineau,P., Amsellem-Ouazana,D.,
            Couraud,P.O., Strosberg,A.D., Stoppa-Lyonnet,D., Lidereau,R. and
            Nahmias,C.
  TITLE     Structural organization and expression of human MTUS1, a candidate
            8p22 tumor suppressor gene encoding a family of angiotensin II AT2
            receptor-interacting proteins, ATIP
  JOURNAL   Gene 380 (2), 127-136 (2006)
   PUBMED   16887298
  REMARK    GeneRIF: MTUS1 encodes a family of proteins(ATIP1, ATIP3 and
            ATIP4), with potential important biological roles in tumor
            suppression and/or brain function.
REFERENCE   7  (bases 1 to 6183)
  AUTHORS   Di Benedetto,M., Pineau,P., Nouet,S., Berhouet,S., Seitz,I.,
            Louis,S., Dejean,A., Couraud,P.O., Strosberg,A.D.,
            Stoppa-Lyonnet,D. and Nahmias,C.
  TITLE     Mutation analysis of the 8p22 candidate tumor suppressor gene
            ATIP/MTUS1 in hepatocellular carcinoma
  JOURNAL   Mol Cell Endocrinol 252 (1-2), 207-215 (2006)
   PUBMED   16650523
  REMARK    GeneRIF: Nucleotide variations result in amino-acid substitution or
            deletion of conserved structural motifs and also exonic splicing
            enhancer motifs and physiological splice sites, suggesting
            deleterious effects on ATIP function and/or expression. [REVIEW]
            Review article
REFERENCE   8  (bases 1 to 6183)
  AUTHORS   Nouet,S., Amzallag,N., Li,J.M., Louis,S., Seitz,I., Cui,T.X.,
            Alleaume,A.M., Di Benedetto,M., Boden,C., Masson,M.,
            Strosberg,A.D., Horiuchi,M., Couraud,P.O. and Nahmias,C.
  TITLE     Trans-inactivation of receptor tyrosine kinases by novel
            angiotensin II AT2 receptor-interacting protein, ATIP
  JOURNAL   J Biol Chem 279 (28), 28989-28997 (2004)
   PUBMED   15123706
  REMARK    GeneRIF: Results identify ATIP1 (angiotensin II AT2
            receptor-interacting protein) as a novel early component of growth
            inhibitory signaling cascade
REFERENCE   9  (bases 1 to 6183)
  AUTHORS   Seibold,S., Rudroff,C., Weber,M., Galle,J., Wanner,C. and Marx,M.
  TITLE     Identification of a new tumor suppressor gene located at chromosome
            8p21.3-22
  JOURNAL   FASEB J 17 (9), 1180-1182 (2003)
   PUBMED   12692079
  REMARK    GeneRIF: identified a tumor suppressor gene named MTSG1 at
            chromosome 8p21.3-22, encoding a mitochondrial protein, controlling
            cellular proliferation
REFERENCE   10 (bases 1 to 6183)
  AUTHORS   Adams,M.D., Soares,M.B., Kerlavage,A.R., Fields,C. and Venter,J.C.
  TITLE     Rapid cDNA sequencing (expressed sequence tags) from a
            directionally cloned human infant brain cDNA library
  JOURNAL   Nat Genet 4 (4), 373-380 (1993)
   PUBMED   8401585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA214747.1, AC027117.6,
            DB221458.1, DA339588.1, AK310871.1, AB033114.1, AL096842.1,
            BC142971.1 and AF121259.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001363058.1.
            
            Summary: This gene encodes a protein which contains a C-terminal
            domain able to interact with the angiotension II (AT2) receptor and
            a large coiled-coil region allowing dimerization. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. One of the transcript
            variants has been shown to encode a mitochondrial protein that acts
            as a tumor suppressor and partcipates in AT2 signaling pathways.
            Other variants may encode nuclear or transmembrane proteins but it
            has not been determined whether they also participate in AT2
            signaling pathways. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3140337.1,
                                           SRR1660803.94050.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                DA214747.1         131-164
            35-92               AC027117.6         54620-54677
            93-105              DB221458.1         322-334
            106-251             DA339588.1         1-146
            252-687             AK310871.1         481-916
            688-716             AB033114.1         368-396
            717-1044            AK310871.1         946-1273
            1045-1106           AB033114.1         725-786
            1107-1676           AL096842.1         66-635
            1677-4223           AB033114.1         1357-3903
            4224-4924           AL096842.1         3244-3944
            4925-5014           BC142971.1         2466-2555
            5015-6181           AB033114.1         4691-5857
            6182-6183           AF121259.1         3430-3431
FEATURES             Location/Qualifiers
     source          1..6183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p22"
     gene            1..6183
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="microtubule associated scaffold protein 1"
                     /db_xref="GeneID:57509"
                     /db_xref="HGNC:HGNC:29789"
                     /db_xref="MIM:609589"
     exon            1..34
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            35..92
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..2337
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..4059
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="isoform 1 is encoded by transcript variant 9;
                     transcription factor MTSG1; mitochondrial tumor suppressor
                     gene 1; AT2R binding protein; AT2 receptor-interacting
                     protein; erythroid differentiation-related; AT2
                     receptor-binding protein; angiotensin-II type 2
                     receptor-interacting protein; microtubule associated tumor
                     suppressor 1"
                     /codon_start=1
                     /product="microtubule-associated tumor suppressor 1
                     isoform 1"
                     /protein_id="NP_001349987.1"
                     /db_xref="CCDS:CCDS43717.1"
                     /db_xref="GeneID:57509"
                     /db_xref="HGNC:HGNC:29789"
                     /db_xref="MIM:609589"
                     /translation="MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSV
                     NWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSI
                     CQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQT
                     FDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHA
                     RETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYT
                     DGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMG
                     QNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHT
                     SELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEK
                     CKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFK
                     NVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKK
                     AEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSA
                     CETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELK
                     QEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNS
                     DNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTG
                     STPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLM
                     KTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCEN
                     QSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTAS
                     TTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYK
                     MQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLL
                     SEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAV
                     LEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLST
                     EQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSF
                     PSPSISPR"
     exon            2338..2533
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2695
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2696..2830
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2869
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2870..3084
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3151
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3354
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3355..3460
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3534
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3630
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3631..3747
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3748..3845
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     exon            3846..6183
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6164..6169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="hexamer: AATAAT"
     polyA_site      6183
                     /gene="MTUS1"
                     /gene_synonym="ATBP; ATIP; ATIP3; ICIS; MP44; MTSG1"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgctc ccggagcgct tgaaggagct gcgggacaca gtgtgaactc atctaaaggg
       61 aagaacagac taggaatgga tcagtctttc agggaacaac aaatcattta atcttcagag
      121 catcttagac tgaaaacctt tcaactgtgc tgaaaaacct agaagacaga ccattttgcc
      181 caccctctca tttaaaagga attgaagaag aaataaaatg gcagaggttt aaggttacta
      241 ttcaggatga ctgatgataa ttcagatgat aaaatagaag atgaattgca aaccttcttt
      301 accagtgata aagatggaaa tacacatgca tacaacccga aatcaccacc tacacaaaac
      361 tcttcagcca gcagtgtgaa ctggaattct gccaacccag atgacatggt ggttgattat
      421 gaaactgacc ctgctgtagt tactggtgaa aatatttctt taagccttca gggtgttgaa
      481 gtatttggtc atgaaaagtc ttctagtgat ttcattagta agcaggtgtt agatatgcat
      541 aaagattcta tttgtcagtg tcctgcactt gtaggtactg agaagcccaa atatctgcaa
      601 cacagttgtc attccctaga agcagttgag ggccagagtg ttgagccatc tttgcctttt
      661 gtgtggaagc ctaatgacaa tttgaactgt gcaggctact gtgatgcctt ggagctaaac
      721 caaacatttg acatgacagt ggataaagtt aactgcacct ttatatcaca tcatgccatc
      781 ggaaagagtc agtccttcca tactgctgga agcctgccac caactggtag gagaagtgga
      841 agtacatctt ctttatccta ttccacttgg acatcttccc attctgataa gacgcatgca
      901 agagaaacta cttatgatag agaaagcttt gaaaaccctc aagtcacacc atcagaagcc
      961 caagacatga cttacacagc attttctgat gtggtgatgc aaagtgaggt ttttgtttca
     1021 gatattggaa atcagtgtgc atgttcttca ggaaaggtca ccagtgagta cacagatgga
     1081 tcacaacaaa gactagttgg agaaaaggag acacaagcac taacaccagt ttctgatggc
     1141 atggaagtcc ccaatgattc tgcattacaa gagttctttt gtttatccca tgatgaatcc
     1201 aatagcgaac cacattcaca gagctcatac aggcacaagg aaatgggcca aaatctgaga
     1261 gagacagtgt cctattgtct tattgatgat gaatgccctt taatggtgcc agcttttgat
     1321 aagagcgaag ctcaagtgct gaacccagag cataaagtca ctgagactga agacacacaa
     1381 atggtctcca aaggaaagga tttgggaacc caaaatcata cctcagaatt gattctaagt
     1441 agcccgccag gacaaaaggt gggctcgtca tttggactga cttgggatgc aaatgatatg
     1501 gtcattagca cagacaaaac gatgtgcatg tcaacaccag tcctagaacc cacaaaagta
     1561 accttttctg tttcaccgat tgaagcgacg gagaaatgta agaaagtgga gaagggtaat
     1621 cgagggctta aaaacatacc agactcgaag gaggcacctg tgaacctgtg taaacccagt
     1681 ttaggaaaat caacaatcaa aacgaatacc ccaataggct gcaaagttag aaaaactgaa
     1741 attataagtt acccaagacc aaacttcaag aatgtcaaag caaaagttat gtctagagca
     1801 gtgttgcagc ccaaagatgc tgctttatca aaggtcacgc ccagacctca gcagaccagt
     1861 gcctcatcac cctcatcagt gaattcaaga caacaaacag tcttgagcag aacaccgaga
     1921 tctgacttga atgcagacaa aaaagcagaa attctaatta acaagacaca taagcagcag
     1981 tttaataaac tcattactag ccaggctgtg catgttacaa ctcattctaa aaatgcttca
     2041 cacagggttc caagaacaac atctgccgtg aaatcgaatc aggaagatgt tgacaaagcc
     2101 agttcttcta actcagcatg cgagaccggg tccgtttctg cgttgtttca gaagatcaaa
     2161 ggcatactcc ctgttaaaat ggaaagtgca gaatgtttgg aaatgaccta tgttcccaac
     2221 attgatagga ttagccctga aaagaagggt gaaaaagaaa atgggacatc tatggaaaaa
     2281 caagagctga aacaagagat tatgaatgag acttttgaat atggttctct gtttttgggc
     2341 tctgcttcaa aaacaacgac cacctcaggt aggaatatat ccaagcctga ctcctgcggt
     2401 ttgaggcaaa tagctgctcc aaaagccaaa gtggggcccc ctgtttcctg tttgaggcgg
     2461 aacagtgaca atagaaatcc cagtgctgat cgagccgtat ctcctcagag gatcaggcgt
     2521 gtgtccagtt ctggaaagcc tacatccttg aaaactgcac agtcgtcatg ggtgaatttg
     2581 cctagaccac ttcctaaatc caaagcatct ttgaaaagtc ctgcgctgcg gaggacagga
     2641 agcaccccct caatagccag cacccacagt gagctgagca cttacagcaa caattctggt
     2701 aatgccgctg tcatcaaata tgaggagaaa cctccaaaac cagcatttca gaatggttcc
     2761 tcaggatcct tttatttgaa gcctttggta tccagggctc atgttcactt gatgaaaact
     2821 cctccaaaag gtccttcgag aaaaaattta tttacagctc ttaatgcagt tgaaaagagc
     2881 aggcaaaaga atcctcgaag cttatgtatc cagccacaga cagctcccga tgcgctgccc
     2941 cctgagaaaa cacttgaatt gacgcaatat aaaacaaaat gtgaaaacca aagtggattt
     3001 atcctgcagc tcaagcagct tcttgcctgt ggtaatacca agtttgaggc attgacagtt
     3061 gtgattcagc acctgctgtc tgagcgggag gaagcactga aacaacacaa aaccctatct
     3121 caagaacttg ttaacctccg gggagagcta gtcactgctt caaccacctg tgagaaatta
     3181 gaaaaagcca ggaatgagtt acaaacagtg tatgaagcat tcgtccagca gcaccaggct
     3241 gaaaaaacag aacgagagaa tcggcttaaa gagttttaca ccagggagta tgaaaagctt
     3301 cgggacactt acattgaaga agcagagaag tacaaaatgc aattgcaaga gcagtttgac
     3361 aacttaaatg ctgcgcatga aacctctaag ttggaaattg aagctagcca ctcagagaaa
     3421 cttgaattgc taaagaaggc ctatgaagcc tccctttcag aaattaagaa aggccatgaa
     3481 atagaaaaga aatcgcttga agatttactt tctgagaagc aggaatcgct agagaagcaa
     3541 atcaatgatc tgaagagtga aaatgatgct ttaaatgaaa aattgaaatc agaagaacaa
     3601 aaaagaagag caagagaaaa agcaaatttg aaaaatcctc agatcatgta tctagaacag
     3661 gagttagaaa gcctgaaagc tgtgttagag atcaagaatg agaaactgca tcaacaggac
     3721 atcaagttaa tgaaaatgga gaaactggtg gacaacaaca cagcattggt tgacaaattg
     3781 aagcgtttcc agcaggagaa tgaagaattg aaagctcgga tggacaagca catggcaatc
     3841 tcaaggcagc tttccacgga gcaggctgtt ctgcaagagt cgctggagaa ggagtcgaaa
     3901 gtcaacaagc gactctctat ggaaaacgag gagcttctgt ggaaactgca caatggggac
     3961 ctgtgtagcc ccaagagatc ccccacatcc tccgccatcc ctttgcagtc accaaggaat
     4021 tcgggctcct tccctagccc cagcatttca cccagatgac acctccccaa agtccacaga
     4081 ctctctgaaa gcattttgat gcaggtctgc aggactgacc ccaaggagga acgtgggcac
     4141 aagaggtata tcagcacacg tgtgatcacc gtagggtaac tggagcgtca ccaccggcgg
     4201 aatcgcagct tctgagactg gaactctgga ggaagacttt tgcctccgtc caaaagattc
     4261 ctccaaaaaa agatttaaaa aaagatttcg gcatcgacac ggacgttgtt gcacaaagca
     4321 cttaaagaac gagagcatct tgttcattgc ctttttcacc taagcatagg gggaaaaact
     4381 ctcagggccc tattaagatt tataaccttt gtaatgttct tcaccacaga caccttcttg
     4441 tgagttttca gtctgactgt gggggtgggg ggtgtgaatg aaatggatgt cacagagtgt
     4501 catgtgtctg atgcagcctc ctctgctgtg tattaaatgt caaaatctga atatatctgg
     4561 atatgtacta atcaaataat aatcaatcaa tcagcatata catttcagcc aaagccatag
     4621 aagaaaaagc aatagttgct tgaattatga tcatctacca ccaactctgc tcagccctgt
     4681 aacagggtag ggagagggta taacaggaag agctttgact tgtccctgtc tatacattct
     4741 ctgtatcttt tgggggtaac ttcttggcag tttttcagtg ttcagccatg tcagttgaaa
     4801 ctagattttt ctgtagattt tttacttacc catgtgagcc taacactatc ctgtaattca
     4861 ttttctcagg ctatgtgtaa atgtagaacc ctaatttttc tataaaaaaa caaactaact
     4921 aactaactgt gtaaagaaag aaaaagggaa gtaccaatgg gtttttccac cttattttta
     4981 cctttgatct acccttgcag atttaacctg tcttcttccc tcccattatt ctcattttcc
     5041 ttttaccttt ctccaccatc cagagccaca aaagcaaacc ttctacctcc tacctacttt
     5101 tctctgggac aaggataaag gaatatgatt ttccagagcc ccagagccag ctcatcttcc
     5161 aggtgctgaa accactttcc aaataaacta aagcctggat ttgatattac aaattttggg
     5221 aaatcttaga ataaagaacg agaacaagga agtcattggc tagtataatt aagaaaggta
     5281 ggattcagtg cttaccgatg atgcagtact tgatagaaga aaacagtctg ggaggatagc
     5341 gctcattttt cagttaccct ttaaggagtc cctttgtctt tgggaaagta gcagaatggt
     5401 ccgcttcttt cccatgagtg gaaaatgtgg cttgtccaac tctcctccag gttgcatttc
     5461 agtttctttc caaaacttat tacctcccct aatcctgaga ctttggaaaa ggtggaagga
     5521 agaactgttg ctttatctcc ccctccctgc atgtgtcaac attgtgatgt cagtatttac
     5581 taatctacat tcagtggctg tacaaataac agctgtagta agaagagatt caggatgcta
     5641 gaggtgaata tttgggtcat ttacatgtac actacatagc aagttgatac tcatgttgca
     5701 tgttctttta aattagtgat tttgtgtctt aagtctttaa cttccaatac ttcatcatgt
     5761 atgtaacctt ccatgtttgc ttctgataaa tggaaatgta ggttcactgc cacttcatga
     5821 gatatctctg ctcacgcttc caagttgttc tcaatgacat tagccaaagt tgggtttgcc
     5881 attcatcccc taggcatggt aaatcttgtg ttgttccctg ctgtcctccg tattacgtga
     5941 ccggcaaata aatctcatag cagttaatat aaaacatctt tggaggatgg gagagaacag
     6001 gagggaagat gggaaacaaa atagagaatt cttaagattt tgtttaaacc aaatgtttca
     6061 tgtagaatgc aaaatgttgg cacgtcaaaa atatgaatgt gtagacaact gtagttgtgc
     6121 tcagtttgta gtgatgggaa gtgtatttta ctctgatcaa ataaataatg ctggaatact
     6181 caa
//
