LOCUS       NM_152793               5761 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens maturin, neural progenitor differentiation regulator
            homolog (MTURN), mRNA.
ACCESSION   NM_152793
VERSION     NM_152793.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5761)
  AUTHORS   Yan,F.J., Wang,Y.J., Wang,S.E. and Hong,H.T.
  TITLE     PKCalpha/ERK/C7ORF41 axis regulates epidermal keratinocyte
            differentiation through the IKKalpha nuclear translocation
  JOURNAL   Biochem J 478 (4), 839-854 (2021)
   PUBMED   33528492
  REMARK    GeneRIF: PKCalpha/ERK/C7ORF41 axis regulates epidermal keratinocyte
            differentiation through the IKKalpha nuclear translocation.
REFERENCE   2  (bases 1 to 5761)
  AUTHORS   Zhou,J., Zhou,Q., Zhang,T. and Fan,J.
  TITLE     C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB Signaling
            Pathway
  JOURNAL   Biomed Res Int 2021, 7413605 (2021)
   PUBMED   33506033
  REMARK    GeneRIF: C7ORF41 Regulates Inflammation by Inhibiting NF-kappaB
            Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5761)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5761)
  AUTHORS   Liu,L., Song,X., Li,X., Xue,L., Ding,S., Niu,L., Xie,L. and Song,X.
  TITLE     A three-platelet mRNA set: MAX, MTURN and HLA-B as biomarker for
            lung cancer
  JOURNAL   J Cancer Res Clin Oncol 145 (11), 2713-2723 (2019)
   PUBMED   31552488
  REMARK    GeneRIF: High MTURN expression is associated with lung cancer.
REFERENCE   5  (bases 1 to 5761)
  AUTHORS   Sun,X., Lu,B., Hu,B., Xiao,W., Li,W. and Huang,Z.
  TITLE     Novel function of the chromosome 7 open reading frame 41 gene to
            promote leukemic megakaryocyte differentiation by modulating
            TPA-induced signaling
  JOURNAL   Blood Cancer J 4 (3), e198 (2014)
   PUBMED   24681962
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5761)
  AUTHORS   Martinez-De Luna,R.I., Ku,R.Y., Lyou,Y. and Zuber,M.E.
  TITLE     Maturin is a novel protein required for differentiation during
            primary neurogenesis
  JOURNAL   Dev Biol 384 (1), 26-40 (2013)
   PUBMED   24095902
REFERENCE   7  (bases 1 to 5761)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI560774.1, DT217816.1, AC007036.3 and AL834391.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152793.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL834391.1, SRR1803617.72211.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324453.13/ ENSP00000324204.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BI560774.1         55-70
            17-713              DT217816.1         2-698
            714-5046            AC007036.3         55649-59981
            5047-5761           AL834391.1         5034-5748
FEATURES             Location/Qualifiers
     source          1..5761
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..5761
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /note="maturin, neural progenitor differentiation
                     regulator homolog"
                     /db_xref="GeneID:222166"
                     /db_xref="HGNC:HGNC:25457"
                     /db_xref="MIM:620491"
     exon            1..313
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..547
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /note="protein Ells1; UPF0452 protein C7orf41; maturin
                     neural progenitor differentiation regulator protein
                     homolog"
                     /codon_start=1
                     /product="maturin"
                     /protein_id="NP_690006.2"
                     /db_xref="CCDS:CCDS5425.2"
                     /db_xref="GeneID:222166"
                     /db_xref="HGNC:HGNC:25457"
                     /db_xref="MIM:620491"
                     /translation="MDFQQLADVAEKWCSNTPFELIATEETERRMDFYADPGVSFYVL
                     CPDNGCGDNFHVWSESEDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDA
                     DDDAFEEYSADVEEEEPEADHPQMGVSQQ"
     exon            314..436
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..5761
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5741..5746
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /note="hexamer: ATTAAA"
     polyA_site      5761
                     /gene="MTURN"
                     /gene_synonym="C7orf41; Ells1"
                     /note="major polyA site"
ORIGIN      
        1 actccgcacc gcatgtaaac agtcccagcc ggcccagccc ggccccggag gagcccgcgc
       61 aggccgagcc gagcgccgcg ctgcccgccc gggaggaggg cgcctaggag cgggagggcg
      121 ggcggcggcg ggaggcgggc gcggggccgc gatggatttc cagcagctgg ccgacgttgc
      181 ggagaaatgg tgctccaaca cgcccttcga gctcatcgcc accgaggaga ccgaacgcag
      241 gatggatttc tacgccgacc ccggcgtctc cttctatgtg ctgtgtccgg acaacggctg
      301 cggcgacaat tttcacgtgt ggagtgagag cgaggactgc ctgcctttct tgcagctagc
      361 acaggattac atctcctcct gcggcaagaa gacgctccac gaagtcctgg aaaaagtctt
      421 caagtctttc agacctttac tggggcttcc ggatgcagat gacgatgcgt ttgaagagta
      481 cagtgctgac gtggaagaag aggagccaga ggcggaccac ccccagatgg gggtcagcca
      541 gcagtaaatc tgggggctcc cctgagaagg agagtgagcc ccacagtaac ctaggtgggg
      601 tcactgcccc tcctgggtta gcattttgca ttagcacttc gaaataggac atctggctcc
      661 cagcatccaa attaaaatga aatacctttt taacgaccac aaaatatctg tgatgagctt
      721 tgctcagaag tgacctgaat ttcactcccg cttcagtggg gtttctatgg agttgtcttg
      781 gtagcctttg ccattttgaa tttagagtcc attttgtggc tgactattct cttaagttta
      841 tgttggagaa ttaacattcg ctgactcgaa tgtagagaac tctgaatgta ttaaggatag
      901 gttttgagtc ctcacaggtg accttactga gggaaagcat ggcagagaag aaatgcagtc
      961 tgcacttttt atgtactttt taagtgtccg taagtgaaag gttttgctta taaagcatga
     1021 attttaatat ctagtcatta aactgcacaa gtgcaaatac aagggcagga aaggataatc
     1081 acttagcttt ggactaagag ggtaagagag gcccagaagc ctttaagtgt tttgccatta
     1141 ctgagttacc tgggtatgta gcgactggtt cgtggttagg tgtaaatgtt acttgcttgt
     1201 tcgactgttt caaaacatgc taattccaaa gccacttttg aagtctatag tggaaaatat
     1261 agatggggtg aaagatataa tgtattgatt tttaaagctg tttataagcc gtcccacgta
     1321 taaaatgaaa cattttacct tctctctttc taatgagatg gccgcttgtt aaatcatgaa
     1381 aacatccaga attcaagtgc cgcttaaact ttgaagccat agataaattt gttagaaaag
     1441 taaaccagga ttaaaagttt ttaaaaatat ggtagaatcc ttctttactt tttaagtctt
     1501 ttatttaaaa aaaaaaagtc aaaaaaagga ttccattgtg taatttattt aaaaatttaa
     1561 tcacatgttt cgagggactt aattgtggtg tatttgtaaa gggacacgaa ggtaggaatc
     1621 ttttaatcgt gggttagctt ggttaacagg gaacgtttta ataatcaaga tactcagaca
     1681 actcacagaa acaacttctg taataactgg aaatactgct gttatcgttt agccaacaat
     1741 tacttactgg ggacatcctt tgtaatgcta acatggaatt attcctggac ccttctgcat
     1801 ccctggtttt agttaaccta ggatgcggaa tgcctccttt acaacactag attaaaccta
     1861 gcatctgggg tgggtacgtt taaacagtca cacatgtgcc tgttaggttg tgaaagtttt
     1921 gaattaaaaa caagcagtag cagcagaggc cacagaactt atgggagtct tgtatatctt
     1981 ccaggcatgt cggtgtaaac ctgattgtct cgacattttc tgtttaattg attggtgctg
     2041 tgaggagttc ggctgctcgt ggtaaaacag cgtactccag ttttaagtca tcgggtaaaa
     2101 taataggaca gtgatttcca tctgtgcttc agtacccact ttgtgttctt ttcttgaaaa
     2161 gtcatactaa aggttaattt caagtaaaat gaatttcctt ccaagtagcc tattagtaaa
     2221 acacaactta gtgtttcatc cattggggtg agcatatact gccctttgca gccctgcctg
     2281 tgttctgatt ggctccattc atgagcaaag gtgattgtga gctgtatatt acacaggtgt
     2341 cgcccaggtt tcgtaacctc cactttaatg cagtaagccg caagaatgac ttctgcaagt
     2401 gaaatgagga agcttcacta gcttgctcca ttggaaggta aactgaaatt ttatacgttg
     2461 aagcttaaaa tctaaattta tgtatgtttg gaaatggaat ggacattaac ataaaatgta
     2521 ttttatcaaa aaagtgttta gactttgacc aaatacatgt tggtattatc atgttaatgt
     2581 tctctgttta taaaaattga gtggagatag atagactcgg ccattctgtg ggctgatgag
     2641 aattctgggc tttgttttgc accaggggta ggaaacagag aacatgtctg tatgttactt
     2701 aatctccata gcaaaatccc aaacagcatt agcagatcga attgtttctt ctaagacttc
     2761 ctttttctga atgtgtgcac atcccttctc gtgctcacac acttgcccac acactcactt
     2821 cttcctgcgc tgtggctgct ctaagcaggg ctgtgcatgg tgcaaagctg cagtcagtga
     2881 gcctggcagc ctgtggtttc tgttatggaa atggttccat ggtgaaacac atccctgacc
     2941 cttcacagac ttacacattt actcaccagg aggtggcagc ggtgtgggag gaggagtgtt
     3001 gaccttggac gcaggagaga cacctgggtt ctagttcaag tcggccaagg actgtgtgac
     3061 cttgacaagt ctaactggtc tgtgaacaag gggcatttgc ccttccagct gtaaacactg
     3121 cccttctgtg cctgccttat gtgtgtgtgt gagtaaggag caacagtcaa ggaaactttt
     3181 agggattcga gaagaaaata catgtgggat cttgccaagg tgctgccttt aggatgctga
     3241 cccctgcact accttagaac atgttgatct gtgagtgccc aagcccctga gggctcgatc
     3301 tcatggggca gatgaaattc tcttccttag aggaaaggga aaggtgaggc cccagaggac
     3361 ttatctcagc tgtacatgct ctgcctgtgg agacatggct tttctttgtg ctgtggcaga
     3421 ctggggcttt ggaagtggtg tatgtttaac ttacctgaga gtgagagatg tgtaggaaga
     3481 atagctggaa gaaagtgaaa gatgagtgcc agtacttttg gcctgttatc cagtagagag
     3541 aaagtgacag tgaaagtaac gtgagagaga aagagtgtgt gtgtatatgt gagagagaga
     3601 aagaaagaga aaggaatgct tgattgcttg ttgttcactg ggccagctct gaaatccaaa
     3661 atcatgcctt gataacatta caaaaccgtg atcctgggtt tgagtgaatc ctagagacat
     3721 tgttcttatg gccgcctggt ttccgcagcc tgatcaccat atcgagcaga cgtcaaggaa
     3781 tcagagtgaa gtacggagcc agggagggag gtgaggcccc gtgtagtgcc tgtcaccact
     3841 gtggattcac ctgcactcag gtgtccactc ctgtctccca ggcccaaagc agcacatggt
     3901 gcaatggaaa agtctcttat gtagggatcc tccttgtgtc ctggtgccag aattagattt
     3961 ccagtgtact tcaacgaaaa cctctctcct ttatagttgc tgtcatcttt catgtataaa
     4021 cagaaaccgt ctctagcaca atatatttct gaatattgtt tctgtttcat aagagcacaa
     4081 tgtacatgga cctaggggag ctgtggtccc aagtgtcatt ggaatttata ttttaggaat
     4141 aggctttgca tgttaaaatt cacaagttgg gaaactggta tgaacagatc tgatttctta
     4201 cagagaggca tgaaggaata ggcaggactt aacttggggt gggaggagat gaataaggga
     4261 gaatgggaga gttggggtct gacagttacc acctgagccc caggaaaact gttttcattt
     4321 tcacggctgt ctcactgggg gcctgctttc ctcaaaggaa ctgactgtat gttgagaggc
     4381 aatgccttgt gttggcatgg ctttgccact ttaaaagtgc cccccagcca aggagaccaa
     4441 caggaaccct gctcatctgg tagggctctt tccttcagta aaaccagctg ccagcctgag
     4501 aagcctgtct ttcccaaatg caggcagatc tgagaggggc tccaggcacc cggcaggtaa
     4561 atcacaaagc aaacttgggt gtccttggca gcggggagga agcaggagtg ccccctcagg
     4621 ccagagggca gggccaacct cctcactgtg cttcaaggtt gtagaaagag cacaattaat
     4681 gcttaagcga tcacagaccc ctctcccctg cagtgggtgt tagctccaaa gagatgccat
     4741 tgctgatcac ccagtcttcg gagaagccta aaatttcttt gaattaaaaa ctgatccttt
     4801 ttcataaaga cccagtcact tctcccagtt tagtgataac aggtatgaca caagaagctg
     4861 aagtctttta gattttatag agagtaattc tgaaacctgc cagaatgctg gtagcctgtg
     4921 gtgtccatgg caatgggtgt ccatggtaaa atatctatag cttctgctca ctgggcaaat
     4981 ataaaagaca acatattatt taacataata tgttgtcttt tatattttta tttaaatctg
     5041 gattacgaaa atatagtacc catgagcatt tcatgttaga aaccccattt aaagcactat
     5101 aaggctgaat aggcacaagc gattaaaagt agatgccagg ccacataaaa ataaatgttt
     5161 taatttactt agagctgtat tcaagttgtt tgataccaga cagaaagctg acagtctgtt
     5221 ctttgtaaac tgcctttccc tgtttttctg ttttgttttg tttctcaagt ttcatttttt
     5281 actaagcccc ttctgacacc taggcagata aagataagag tagtgcgcag tacaaatgtc
     5341 agctctgaag aggaggaagt aaatcttcaa tgctagggca gatcttcact atccgtgatc
     5401 cagtcttaat ttgagcatga gagcaaaatt tagtcatcta cacaagaagc aaaagcaagg
     5461 aatagttgtt gggtttttgt tttttggttg ttgttttttt ttttttttag gcaagaagtg
     5521 ttgccggtag ggtatgtgtg ctttctttgc cttcctattt cctttcaaag aaatctcttg
     5581 taaattacaa aactgtgaat tgggttgcca aaaactgttg cccttcgtta gatgcttcaa
     5641 acagtgtaaa tcctatactg caccctgtcc acctctgctc cctcctccct cccctgagag
     5701 tgaggacctc atccgaccat gtaattacca ttcgcttgct attaaagagc ctttcaaact
     5761 c
//
