LOCUS       NM_014751               4994 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens MTSS I-BAR domain containing 1 (MTSS1), transcript
            variant 2, mRNA.
ACCESSION   NM_014751
VERSION     NM_014751.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4994)
  AUTHORS   Abdullaev,B., Alsaab,H.O., Hjazi,A., Alkhafaji,A.T., Alawadi,A.H.
            and Hamzah,H.F.
  TITLE     The mechanisms behind the dual role of long non-coding RNA (lncRNA)
            metastasis suppressor-1 in human tumors: Shedding light on the
            molecular mechanisms
  JOURNAL   Pathol Res Pract 256, 155189 (2024)
   PUBMED   38452581
  REMARK    GeneRIF: The mechanisms behind the dual role of long non-coding RNA
            (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on
            the molecular mechanisms.
            Review article
REFERENCE   2  (bases 1 to 4994)
  AUTHORS   Aref,S., Sabry,M., Menshawy,N.E., Aref,A., Tantawy,A.E., Ayed,M.
            and El-Sebaie,A.
  TITLE     Prognostic value of MTSS1 gene expression on acute leukemia
            patients outcome
  JOURNAL   Biomark Med 17 (21), 889-898 (2023)
   PUBMED   38230972
  REMARK    GeneRIF: Prognostic value of MTSS1 gene expression on acute
            leukemia patients outcome.
REFERENCE   3  (bases 1 to 4994)
  AUTHORS   Chen,M., Dong,Y., Tian,L., Zhou,J., Zhu,E., Yuan,H., Li,X. and
            Wang,B.
  TITLE     Metastasis suppressor 1 interacts with protein tyrosine phosphatase
            receptor-delta to regulate adipogenesis
  JOURNAL   FASEB J 37 (4), e22857 (2023)
   PUBMED   36906292
  REMARK    GeneRIF: Metastasis suppressor 1 interacts with protein tyrosine
            phosphatase receptor-delta to regulate adipogenesis.
REFERENCE   4  (bases 1 to 4994)
  AUTHORS   Grandits,A.M., Nguyen,C.H., Schlerka,A., Hackl,H., Sill,H.,
            Etzler,J., Heyes,E., Stoiber,D., Grebien,F., Heller,G. and
            Wieser,R.
  TITLE     Downregulation of MTSS1 in acute myeloid leukemia is associated
            with a poor prognosis, chemotherapy resistance, and disease
            aggressiveness
  JOURNAL   Leukemia 35 (10), 2827-2839 (2021)
   PUBMED   33782537
  REMARK    GeneRIF: Downregulation of MTSS1 in acute myeloid leukemia is
            associated with a poor prognosis, chemotherapy resistance, and
            disease aggressiveness.
REFERENCE   5  (bases 1 to 4994)
  AUTHORS   Cong,M., Wang,Y., Yang,Y., Lian,C., Zhuang,X., Li,X., Zhang,P.,
            Liu,Y., Tang,J., Yang,Q., Zhang,X., Xiong,H., Hu,R. and Hu,G.
  TITLE     MTSS1 suppresses mammary tumor-initiating cells by enhancing
            RBCK1-mediated p65 ubiquitination
  JOURNAL   Nat Cancer 1 (2), 222-234 (2020)
   PUBMED   35122005
  REMARK    GeneRIF: MTSS1 suppresses mammary tumor-initiating cells by
            enhancing RBCK1-mediated p65 ubiquitination.
REFERENCE   6  (bases 1 to 4994)
  AUTHORS   Goehler,H., Lalowski,M., Stelzl,U., Waelter,S., Stroedicke,M.,
            Worm,U., Droege,A., Lindenberg,K.S., Knoblich,M., Haenig,C.,
            Herbst,M., Suopanki,J., Scherzinger,E., Abraham,C., Bauer,B.,
            Hasenbank,R., Fritzsche,A., Ludewig,A.H., Bussow,K., Coleman,S.H.,
            Gutekunst,C.A., Landwehrmeyer,B.G., Lehrach,H. and Wanker,E.E.
  TITLE     A protein interaction network links GIT1, an enhancer of huntingtin
            aggregation, to Huntington's disease
  JOURNAL   Mol Cell 15 (6), 853-865 (2004)
   PUBMED   15383276
  REMARK    Erratum:[Mol Cell. 2005 Jul 22;19(2):287. Buessow, Konrad
            [corrected to Bussow, Konrad]]
REFERENCE   7  (bases 1 to 4994)
  AUTHORS   Yamagishi,A., Masuda,M., Ohki,T., Onishi,H. and Mochizuki,N.
  TITLE     A novel actin bundling/filopodium-forming domain conserved in
            insulin receptor tyrosine kinase substrate p53 and missing in
            metastasis protein
  JOURNAL   J Biol Chem 279 (15), 14929-14936 (2004)
   PUBMED   14752106
  REMARK    GeneRIF: missing in metastasis protein and insulin receptor
            tyrosine kinase substrate p53 have a conserved novel actin
            bundling/filopodium-forming domain
REFERENCE   8  (bases 1 to 4994)
  AUTHORS   Woodings,J.A., Sharp,S.J. and Machesky,L.M.
  TITLE     MIM-B, a putative metastasis suppressor protein, binds to actin and
            to protein tyrosine phosphatase delta
  JOURNAL   Biochem J 371 (Pt 2), 463-471 (2003)
   PUBMED   12570871
REFERENCE   9  (bases 1 to 4994)
  AUTHORS   Mattila,P.K., Salminen,M., Yamashiro,T. and Lappalainen,P.
  TITLE     Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics,
            interacts with ATP-actin monomers through its C-terminal WH2 domain
  JOURNAL   J Biol Chem 278 (10), 8452-8459 (2003)
   PUBMED   12482861
REFERENCE   10 (bases 1 to 4994)
  AUTHORS   Lee,Y.G., Macoska,J.A., Korenchuk,S. and Pienta,K.J.
  TITLE     MIM, a potential metastasis suppressor gene in bladder cancer
  JOURNAL   Neoplasia 4 (4), 291-294 (2002)
   PUBMED   12082544
  REMARK    GeneRIF: a potential metastasis suppressor gene in bladder cancer;
            data suggest that it may be involved in cytoskeletal organization
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA790325.1, AF086645.1, AC090198.7 and AJ710067.1.
            
            On Feb 27, 2020 this sequence version replaced NM_014751.5.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            central coding region compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF086645.1, SRR18074969.3760796.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518547.6/ ENSP00000429064.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                DA790325.1         35-89
            56-2405             AF086645.1         1-2350
            2406-4533           AC090198.7         135384-137511       c
            4534-4994           AJ710067.1         21-481
FEATURES             Location/Qualifiers
     source          1..4994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.13"
     gene            1..4994
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /note="MTSS I-BAR domain containing 1"
                     /db_xref="GeneID:9788"
                     /db_xref="HGNC:HGNC:20443"
                     /db_xref="MIM:608486"
     exon            1..590
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     CDS             519..2786
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /note="isoform 2 is encoded by transcript variant 2;
                     metastasis suppressor protein 1; metastasis suppressor
                     YGL-1; missing in metastasis protein; metastasis
                     suppressor 1; MTSS1, I-BAR domain containing; protein MTSS
                     1"
                     /codon_start=1
                     /product="protein MTSS 1 isoform 2"
                     /protein_id="NP_055566.3"
                     /db_xref="CCDS:CCDS6353.1"
                     /db_xref="GeneID:9788"
                     /db_xref="HGNC:HGNC:20443"
                     /db_xref="MIM:608486"
                     /translation="MEAVIEKECSALGGLFQTIISDMKGSYPVWEDFINKAGKLQSQL
                     RTTVVAAAAFLDAFQKVADMATNTRGGTREIGSALTRMCMRHRSIEAKLRQFSSALID
                     CLINPLQEQMEEWKKVANQLDKDHAKEYKKARQEIKKKSSDTLKLQKKAKKGRGDIQP
                     QLDSALQDVNDKYLLLEETEKQAVRKALIEERGRFCTFISMLRPVIEEEISMLGEITH
                     LQTISEDLKSLTMDPHKLPSSSEQVILDLKGSDYSWSYQTPPSSPSTTMSRKSSVCSS
                     LNSVNSSDSRSSGSHSHSPSSHYRYRSSNLAQQAPVRLSSVSSHDSGFISQDAFQSKS
                     PSPMPPEAPNQLSNGFSHYSLSSESHVGPTGAGLFPHCLPASRLLPRVTSVHLPDYAH
                     YYTIGPGMFPSSQIPSWKDWAKPGPYDQPLVNTLQRRKEKREPDPNGGGPTTASGPPA
                     AAEEAQRPRSMTVSAATRPGEEMEACEELALALSRGLQLDTQRSSRDSLQCSSGYSTQ
                     TTTPCCSEDTIPSQVSDYDYFSVSGDQEADQQEFDKSSTIPRNSDISQSYRRMFQAKR
                     PASTAGLPTTLGPAMVTPGVATIRRTPSTKPSVRRGTIGAGPIPIKTPVIPVKTPTVP
                     DLPGVLPAPPDGPEERGEHSPESPSVGEGPQGVTSMPSSMWSGQASVNPPLPGPKPSI
                     PEEHRQAIPESEAEDQEREPPSATVSPGQIPESDPADLSPRDTPQGEDMLNAIRRGVK
                     LKKTTTNDRSAPRFS"
     exon            591..652
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            653..726
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            727..811
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            812..903
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            904..978
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1136
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1244
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1342
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1553
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1748
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1922
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2085
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..4994
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4970..4975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /note="hexamer: AATAAA"
     polyA_site      4994
                     /gene="MTSS1"
                     /gene_synonym="MIM; MIMA; MIMB"
                     /note="major polyA site"
ORIGIN      
        1 agagcgagcg ccggggccgg gcgcgcagga gtgaaaagga ggcggcggcc gcagctgcga
       61 gcaacagatc cggacgccgc gagctgaccc gctctgctgt tgggcgattt ttttttaatt
      121 gcagaaaaat ttattaaatt ggaaaatctt gcgtttttca atggcgctgg ccccgggtca
      181 gcgggcgatt ttctctgcat caagatgggc tttgccgttt ccgtagtggg caccagtggt
      241 ggcctgattg tcagtcttct cccggcattt ttaaggccag gagccgagcg ctgcttgtag
      301 gcgaataccc tacagagcgg tttggctttt taaattactg ttattatttt gggcagagaa
      361 cagtcggtct ggtgcacccc gtcctcgctg cagaagaggc tgcgagtccg aggtgggtct
      421 ctcggaaggt gaaattcctt ctggggtgag cgagccccgg ccccgcgcgc agtccagcgg
      481 ccccgcgtgt gtgccctcgc cctgccggag ccgggaaaat ggaggctgtg attgagaagg
      541 aatgcagcgc gctcggaggc ctcttccaga ccatcatcag cgacatgaag gggagctatc
      601 cagtttggga agatttcata aacaaagcag gaaagctgca gtcccagctt cggacaacag
      661 tagtagcagc agctgccttc ttggacgcct ttcagaaagt ggctgacatg gccaccaaca
      721 cacgtggtgg gaccagggag attggatctg ctctcaccag gatgtgcatg aggcacagaa
      781 gcattgaagc caagctgagg cagttttcga gcgctttaat tgattgtctg ataaacccac
      841 ttcaagaaca gatggaagaa tggaagaaag tggccaacca gctggataaa gaccacgcaa
      901 aagaatataa gaaagcccgc caagagataa aaaagaagtc ctcggatacg ctgaaactgc
      961 agaagaaagc aaaaaaaggg agaggtgata tccagcctca gttggacagt gctctccaag
     1021 atgtcaatga taagtatctc ttattggaag aaacagaaaa gcaggctgtc cggaaggctt
     1081 tgattgaaga acgtggccga ttctgtacct tcatctctat gctgcggcca gtgattgaag
     1141 aagaaatctc aatgctaggg gaaataaccc accttcagac catctcggaa gatctaaaaa
     1201 gcctgaccat ggaccctcac aaactgccct cctcaagtga acaggtgatt ctggacttga
     1261 aaggttctga ttacagctgg tcgtatcaga cgccaccctc ttcccccagc accaccatgt
     1321 ccagaaagtc cagtgtctgc agcagcctga acagtgtcaa cagcagtgac tcccggtcca
     1381 gcggctccca ctcgcattcc cccagctcac attaccgcta ccgcagctcc aacctggccc
     1441 agcaggctcc tgtgaggctg tccagcgtgt cctcccatga ctcaggattc atatcccagg
     1501 atgccttcca gtccaagtca ccatccccca tgccgccaga ggcccccaac cagttgtcta
     1561 acgggttttc tcactatagt ttatcaagtg agtcccacgt ggggcccacg ggtgcaggcc
     1621 ttttccctca ttgcctgcct gcctcccgcc tgctccctcg ggtcacctct gtccaccttc
     1681 cagactacgc tcattattac accattgggc ccggcatgtt cccgtcatct cagatcccta
     1741 gctggaagga ctgggctaag cctgggccct atgaccagcc tctggtgaac accctgcagc
     1801 gccgcaaaga gaagcgagaa ccggacccca acgggggagg acccactacc gccagcggcc
     1861 cacctgcagc agctgaggag gctcagagac cacggagcat gactgtatcg gctgccacca
     1921 ggcctggtga ggagatggag gcttgtgagg agctggccct ggccctgtct cggggcctgc
     1981 agctggacac ccagaggagc agccgggact cgcttcagtg ctccagcggc tacagcaccc
     2041 agacaaccac cccctgctgc tctgaggaca ccatcccttc ccaagtttca gattatgatt
     2101 atttctctgt aagtggtgac caggaggcag atcagcagga gttcgacaag tcctccacca
     2161 ttccaagaaa cagcgacatc agccagtcct accgacggat gttccaagcc aagcgtccag
     2221 cctcaactgc tggcctcccc accaccctgg gacctgctat ggtcactcca ggggttgcaa
     2281 ctatccgacg gaccccttcc accaagcctt ctgtccgccg gggaaccatt ggagctggtc
     2341 ccatccccat caagacaccc gtgatccctg tcaagacccc aaccgtccca gacctcccag
     2401 gggtgttgcc agcccctcca gatgggccag aagagcgggg ggagcacagc cctgagtcgc
     2461 catctgtggg tgagggcccc caaggtgtca ccagcatgcc ctcctcaatg tggagcggcc
     2521 aagcttccgt taaccctcca cttccaggcc cgaagcccag tatccctgag gagcacagac
     2581 aggcaattcc agaaagtgaa gctgaagacc aggaacggga acccccaagt gccactgtct
     2641 ccccaggcca gattccagag agtgaccctg cagacctgag cccaagggat actccacaag
     2701 gagaagacat gctgaacgcc atccgaaggg gcgtgaaact gaagaagacc acgacaaacg
     2761 atcgctcagc ccctcgcttt tcttaggttc acaagaaatg cgccggtggg gaatgaactg
     2821 tttcattaat aaaacctaat ttgtcttgat ccattccact ctataataaa acaaaagatt
     2881 ttgtaggcaa ctcggaatat agctcttttg aaagtactcg acacctttag ataagaatta
     2941 aaaccaacct atgtaactga cataatcttg atcttttaat ttgtaaatat tgacaatttt
     3001 ctttctgcac attttaatct tagtttccct tttgattttt ctgaaggtgc caaattccat
     3061 ttaacttttt tacaagtctt tgtaaaattt taaatgcata aagggggttg gggcagggga
     3121 accacgaagt agttaatttt agaaaaggat ttactatact tcactcttct ttttttttcc
     3181 ccacaagctt ttgtagatgc attgtagtag tctagcttag aagcaaatgc aagttatttt
     3241 aatgtacaaa ctaaatgggt aagaggtaaa atcttcattt aaatatacta tgttctggat
     3301 gaaaagagca ggagtaacaa ttgatgagca atattcagag tgaagtaaat ctggaaatgg
     3361 tagactgtgt tgggattggg gggagggcca tgggaggggt acatcgtcaa catagccgat
     3421 cctgttacat ttaagagtag cctcgtaggt tgaatttctt ctggtagctt catggtaaat
     3481 gcatccgaat aagccatact ggattgcagt gtttgtttct gtagggtgtt taaggacttg
     3541 acttcctttc tcccatgatt cctctggact gcacacagca cccacaacca gccccatgca
     3601 tgctgctgcc tctgggcagt cgtagaatct cccacttcag tttctcgttg attgtactca
     3661 cctttatgga atccaaatac atccaaaagg gtaaggcagt tttaaaaatg tgaaaacatt
     3721 taaaaatgat aatagcaggg aattcttaga ttatagtaaa tgccttttac ttaactgtgc
     3781 ccagcaggct gggtgcgtta aaaagcccaa gtattttgaa aaaactcgaa cagatttgac
     3841 aagggtagcc agcttggagt ctagcaactt gccaatgtgt ttaccaatct gggggcttgt
     3901 ttttcttttc ttctttcaaa taaatggcag ttaactggct ttacagtaaa cattgaagag
     3961 aggaggattt gtttattgtc actgggaatc tgaccactat actgtccttt ttttgtattc
     4021 tgggtaaatg ttttttggaa aagatttgtc ttttctaagt ggaagttaaa tttgttatac
     4081 tgcccatccc ctaaagccaa cagagatttg tagatttaaa gggatcacat ttgaagacaa
     4141 tagtgtttaa gaaagcaagc aagtccctta gcagtcaggt cataacaggg cacatttctg
     4201 accgaaccct ctcaaggcag aggaggagtt tggtgggttt catacaccct gcagattcct
     4261 gttggctcta accctcaatt acctaatctt atgctttaac acataactgc attggatgtg
     4321 agagtaacgt accgtatggt cattgttcta tatattaaca ttgaacactg ctgcgattgc
     4381 tcaaggacat tttatgttac ggctttaaag caaaggcatg attattagaa actatttaag
     4441 cttttttctt tgaaaaacaa gctcctttta cagaatataa acaacagtag tgcctgtggt
     4501 ttagcccacc aatcttgatg actaaaagta gctgatgcat tgtgcatatg atgcttgaga
     4561 tggtttttgc aaaagcagaa atcgctgcaa ggtaatcaca atagataaaa gtggtatttt
     4621 aaacctttga aataaatgga tgtaactgta ccttggtaca gcttttcact tgtttagttt
     4681 ttaaacgtta gtataatctg aataaataaa atgttgccaa attcaatgta gaaagaatgt
     4741 gacaacacac cttgggtagt tctgcttgtg tttttgcata ttgtaaaagc agtgtcacag
     4801 ctaaaaagaa agaaatcgtt tctaacagta aattattgtg ctttagttgc tagtttgtac
     4861 tgagagttga cctctccctg tgcagttttt tgttctaaac ttgtataaat aacaattgtg
     4921 taatgtgtct ccctcctaca ttgtaacaat tgcttcagcc tacgttataa ataaagaacc
     4981 actagattaa aaaa
//
