LOCUS       XM_047417236            1540 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens 5-methyltetrahydrofolate-homocysteine
            methyltransferase reductase (MTRR), transcript variant X5, mRNA.
ACCESSION   XM_047417236
VERSION     XM_047417236.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000005.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
     gene            1..1540
                     /gene="MTRR"
                     /gene_synonym="cblE; MSR"
                     /note="5-methyltetrahydrofolate-homocysteine
                     methyltransferase reductase; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 17 ESTs, 66 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     74 samples with support for all annotated introns"
                     /db_xref="GeneID:4552"
                     /db_xref="HGNC:HGNC:7473"
                     /db_xref="MIM:602568"
     CDS             68..1429
                     /gene="MTRR"
                     /gene_synonym="cblE; MSR"
                     /codon_start=1
                     /product="methionine synthase reductase isoform X3"
                     /protein_id="XP_047273192.1"
                     /db_xref="GeneID:4552"
                     /db_xref="HGNC:HGNC:7473"
                     /db_xref="MIM:602568"
                     /translation="MRRFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKY
                     DLKTETAPLVVVVSTTGTGDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYT
                     YFCNGGKIIDKRLQELGARHFYDTGHADDCVGLELVVEPWIAGLWPALRKHFRSSRGQ
                     EEISGALPVASPASSRTDLVKSELLHIESQVELLRFDDSGRKDSEVLKQNAVNSNQSN
                     VVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQESLGQEESQVSVTSADPVFQV
                     PISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDSEVQSLLQRLQLE
                     DKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRALVDYT
                     SDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLVFFPLRTS
                     PKC"
ORIGIN      
        1 agtgcgcgct ggcgcaaggt tggtggaagt cgcgttgtgc agtttcactg ttacatgcct
       61 tgaagtgatg aggaggtttc tgttactata tgctacacag cagggacagg caaaggccat
      121 cgcagaagaa atatgtgagc aagctgtggt acatggattt tctgcagatc ttcactgtat
      181 tagtgaatcc gataagtatg acctaaaaac cgaaacagct cctcttgttg ttgtggtttc
      241 taccacgggc accggagacc cacccgacac agcccgcaag tttgttaagg aaatacagaa
      301 ccaaacactg ccggttgatt tctttgctca cctgcggtat gggttactgg gtctcggtga
      361 ttcagaatac acctactttt gcaatggggg gaagataatt gataaacgac ttcaagagct
      421 tggagcccgg catttctatg acactggaca tgcagatgac tgtgtaggtt tagaacttgt
      481 ggttgagccg tggattgctg gactctggcc agccctcaga aagcatttta ggtcaagcag
      541 aggacaagag gagataagtg gcgcactccc ggtggcatca cctgcatcct cgaggacaga
      601 ccttgtgaag tcagagctgc tacacattga atctcaagtc gagcttctga gattcgatga
      661 ttcaggaaga aaggattctg aggttttgaa gcaaaatgca gtgaacagca accaatccaa
      721 tgttgtaatt gaagactttg agtcctcact tacccgttcg gtacccccac tctcacaagc
      781 ctctctgaat attcctggtt tacccccaga atatttacag gtacatctgc aggagtctct
      841 tggccaggag gaaagccaag tatctgtgac ttcagcagat ccagtttttc aagtgccaat
      901 ttcaaaggca gttcaactta ctacgaatga tgccataaaa accactctgc tggtagaatt
      961 ggacatttca aatacagact tttcctatca gcctggagat gccttcagcg tgatctgccc
     1021 taacagtgat tctgaggtac aaagcctact ccaaagactg cagcttgaag ataaaagaga
     1081 gcactgcgtc cttttgaaaa taaaggcaga cacaaagaag aaaggagcta ccttacccca
     1141 gcatatacct gcgggatgtt ctctccagtt catttttacc tggtgtcttg aaatccgagc
     1201 aattcctaaa aaggcatttt tgcgagccct tgtggactat accagtgaca gtgctgaaaa
     1261 gcgcaggcta caggagctgt gcagtaaaca aggggcagcc gattatagcc gctttgtacg
     1321 agatgcctgt gcctgcttgt tggatctcct cctcgctttc ccttcttgcc agccaccact
     1381 cagtctcctg ctcgtgtttt ttccacttag gacctcccca aaatgctaag accgtgttgc
     1441 tgaatgaggc tgctcttctc accatcctgt cctcaggctg gccctctcac cctcttcagt
     1501 gaagtcttcg agaaccatca gcaggaatag gatgacagaa
//
