LOCUS       NM_015360               3961 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Mtr4 exosome RNA helicase (MTREX), mRNA.
ACCESSION   NM_015360
VERSION     NM_015360.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3961)
  AUTHORS   Yu,L., Jiang,L., Wu,M., Dou,W., Ji,K., Zhou,J., Kim,J. and Xu,Y.
  TITLE     RNA helicase MTR4 drives tumorigenesis of nasopharyngeal carcinoma
            by regulating the expression of key cell cycle genes
  JOURNAL   Protein Cell 14 (2), 149-152 (2023)
   PUBMED   36929008
  REMARK    GeneRIF: RNA helicase MTR4 drives tumorigenesis of nasopharyngeal
            carcinoma by regulating the expression of key cell cycle genes.
REFERENCE   2  (bases 1 to 3961)
  AUTHORS   Miyao,S., Saito,K., Oshima,R., Kawahara,K. and Nagahama,M.
  TITLE     MTR4 adaptor PICT1 functions in two distinct steps during pre-rRNA
            processing
  JOURNAL   Biochem Biophys Res Commun 637, 203-209 (2022)
   PUBMED   36403484
  REMARK    GeneRIF: MTR4 adaptor PICT1 functions in two distinct steps during
            pre-rRNA processing.
REFERENCE   3  (bases 1 to 3961)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3961)
  AUTHORS   Ishida,Y.I., Miyao,S., Saito,M., Hiraishi,N. and Nagahama,M.
  TITLE     Interactome analysis of the Tudor domain-containing protein SPF30
            which associates with the MTR4-exosome RNA-decay machinery under
            the regulation of AAA-ATPase NVL2
  JOURNAL   Int J Biochem Cell Biol 132, 105919 (2021)
   PUBMED   33422691
  REMARK    GeneRIF: Interactome analysis of the Tudor domain-containing
            protein SPF30 which associates with the MTR4-exosome RNA-decay
            machinery under the regulation of AAA-ATPase NVL2.
REFERENCE   5  (bases 1 to 3961)
  AUTHORS   Olsen,K.J. and Johnson,S.J.
  TITLE     Mtr4 RNA helicase structures and interactions
  JOURNAL   Biol Chem 402 (5), 605-616 (2021)
   PUBMED   33857361
  REMARK    GeneRIF: Mtr4 RNA helicase structures and interactions.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3961)
  AUTHORS   Jurica,M.S., Licklider,L.J., Gygi,S.R., Grigorieff,N. and
            Moore,M.J.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   7  (bases 1 to 3961)
  AUTHORS   Raijmakers,R., Noordman,Y.E., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Protein-protein interactions of hCsl4p with other human exosome
            subunits
  JOURNAL   J Mol Biol 315 (4), 809-818 (2002)
   PUBMED   11812149
REFERENCE   8  (bases 1 to 3961)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   9  (bases 1 to 3961)
  AUTHORS   Chen,C.Y., Gherzi,R., Ong,S.E., Chan,E.L., Raijmakers,R.,
            Pruijn,G.J., Stoecklin,G., Moroni,C., Mann,M. and Karin,M.
  TITLE     AU binding proteins recruit the exosome to degrade ARE-containing
            mRNAs
  JOURNAL   Cell 107 (4), 451-464 (2001)
   PUBMED   11719186
REFERENCE   10 (bases 1 to 3961)
  AUTHORS   Brouwer,R., Allmang,C., Raijmakers,R., van Aarssen,Y.,
            Egberts,W.V., Petfalski,E., van Venrooij,W.J., Tollervey,D. and
            Pruijn,G.J.
  TITLE     Three novel components of the human exosome
  JOURNAL   J Biol Chem 276 (9), 6177-6184 (2001)
   PUBMED   11110791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX640789.1 and BC065258.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015360.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.5879.1,
                                           SRR1660803.33243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000230640.10/ ENSP00000230640.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BX640789.1         202-221
            21-3961             BC065258.1         1-3941
FEATURES             Location/Qualifiers
     source          1..3961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..3961
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /note="Mtr4 exosome RNA helicase"
                     /db_xref="GeneID:23517"
                     /db_xref="HGNC:HGNC:18734"
                     /db_xref="MIM:618122"
     exon            1..159
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..3154
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /EC_number="3.6.4.13"
                     /note="functional spliceosome-associated protein 118;
                     ATP-dependent helicase SKIV2L2; Ski2 like RNA helicase 2;
                     TRAMP-like complex helicase; ATP-dependent RNA helicase
                     SKIV2L2; superkiller viralicidic activity 2-like 2;
                     ATP-dependent RNA helicase DOB1"
                     /codon_start=1
                     /product="exosome RNA helicase MTR4"
                     /protein_id="NP_056175.3"
                     /db_xref="CCDS:CCDS3967.1"
                     /db_xref="GeneID:23517"
                     /db_xref="HGNC:HGNC:18734"
                     /db_xref="MIM:618122"
                     /translation="MADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKA
                     GKRFDGKLQSESTNNGKNKRDVDFEGTDEPIFGKKPRIEESITEDLSLADLMPRVKVQ
                     SVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQREAIQCVDNNQSVLVS
                     AHTSAGKTVCAEYAIALALREKQRVIFTSPIKALSNQKYREMYEEFQDVGLMTGDVTI
                     NPTASCLVMTTEILRSMLYRGSEVMREVAWVIFDEIHYMRDSERGVVWEETIILLPDN
                     VHYVFLSATIPNARQFAEWICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDE
                     NGDFREDNFNTAMQVLRDAGDLAKGDQKGRKGGTKGPSNVFKIVKMIMERNFQPVIIF
                     SFSKKDCEAYALQMTKLDFNTDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKR
                     GIGIHHGGLLPILKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKD
                     FRWISSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSAFHLT
                     YNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEEQYNKIVIPNEESVV
                     IYYKIRQQLAKLGKEIEEYIHKPKYCLPFLQPGRLVKVKNEGDDFGWGVVVNFSKKSN
                     VKPNSGELDPLYVVEVLLRCSKESLKNSATEAAKPAKPDEKGEMQVVPVLVHLLSAIS
                     SVRLYIPKDLRPVDNRQSVLKSIQEVQKRFPDGIPLLDPIDDMGIQDQGLKKVIQKVE
                     AFEHRMYSHPLHNDPNLETVYTLCEKKAQIAIDIKSAKRELKKARTVLQMDELKCRKR
                     VLRRLGFATSSDVIEMKGRVACEISSADELLLTEMMFNGLFNDLSAEQATALLSCFVF
                     QENSSEMPKLTEQLAGPLRQMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYT
                     WATGATFAHICKMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKI
                     KRDIVFAASLYL"
     exon            160..297
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..364
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            365..427
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..540
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            541..715
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            716..806
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..931
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1030
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1133
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1265
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1345
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1456
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1558
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1684
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1835
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2008
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2077
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2206
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2317
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2506
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2507..2670
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2776
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2833
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2834..2996
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3101
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     exon            3102..3961
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3338..3343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /note="hexamer: AATAAA"
     polyA_site      3362
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /note="major polyA site"
     regulatory      3943..3948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /note="hexamer: AATAAA"
     polyA_site      3961
                     /gene="MTREX"
                     /gene_synonym="Dob1; fSAP118; KIAA0052; Mtr4; SKIV2L2"
                     /note="major polyA site"
ORIGIN      
        1 agatttgctc tcactgctcc caaaaatggc ggacgcattc ggagatgagc tgttcagcgt
       61 gttcgagggc gactcgacca ctgcggcggg aaccaaaaaa gacaaggaaa aggacaaggg
      121 gaaatggaag gggcctccag ggtctgcaga caaggcaggg aaacgttttg atggtaaatt
      181 acaatcagaa tcaactaata atggaaaaaa taagagagat gtagatttcg aaggtacaga
      241 tgaacccatt tttggaaaga agcccaggat agaagagtca ataactgaag acttaagttt
      301 ggcagacctg atgcccagag tcaaggtaca atcagttgaa actgttgaag ggtgtacaca
      361 tgaggttgca cttcctgcag aagaggatta tttaccactt aaaccacgag ttggaaaagc
      421 tgctaaggaa tacccgttca ttcttgatgc ttttcaaaga gaggccattc agtgtgttga
      481 caataatcag tctgttctag tatctgcaca tacctcagcg ggaaaaacag tatgcgccga
      541 gtatgccatt gcattggcct taagggaaaa gcagcgtgta atatttacca gcccaattaa
      601 ggctctgagt aaccaaaaat accgtgaaat gtatgaagaa tttcaagatg ttggtttgat
      661 gactggtgat gttactatta atcctacggc atcttgtctt gttatgacca cagagatttt
      721 gagaagtatg ctttacagag gttccgaagt tatgagagaa gttgcttggg ttatatttga
      781 tgaaattcat tatatgagag attcagaacg tggtgtagta tgggaagaaa ctattatttt
      841 gcttcctgat aacgtccact atgtctttct ttcggctact attccaaatg cccgacagtt
      901 tgctgaatgg atttgccatt tacataaaca gccttgtcat gttatttaca cagattatcg
      961 gcccactcca ttgcaacact acatttttcc agcaggggga gatggcctgc atcttgtggt
     1021 tgatgaaaat ggtgacttca gagaagataa ttttaatact gcaatgcaag tgcttcgaga
     1081 tgcaggtgat ttggccaaag gagaccagaa agggcggaaa ggaggaacaa aaggaccatc
     1141 aaatgttttc aaaattgtga agatgattat ggaaagaaat ttccaacctg tgattatttt
     1201 cagttttagt aagaaagatt gtgaagccta tgcacttcaa atgaccaaat tagatttcaa
     1261 cacagatgaa gaaaagaaga tggttgaaga agtattcagt aatgcaattg attgcttatc
     1321 cgatgaagat aaaaaactcc ctcaggtaga acatgtactt cctcttttga agaggggaat
     1381 tggtattcac catggtggtt tacttcctat tttgaaagaa actatagaaa ttctcttttc
     1441 tgaaggattg ataaaggcct tatttgccac ggagaccttt gctatgggaa ttaacatgcc
     1501 agctagaact gttttattta caaatgcccg caaatttgat gggaaggatt tccgatggat
     1561 ttcttctggt gaatacattc agatgtctgg tcgtgctgga aggagaggaa tggatgatag
     1621 aggaattgta attcttatgg tagatgaaaa gatgagccca acaattggaa aacaattact
     1681 taagggctcc gctgatcctc taaatagtgc tttccatttg acctacaaca tggttttgaa
     1741 cttactacgt gtagaagaaa ttaatcctga gtacatgttg gaaaaatcct tctaccagtt
     1801 tcagcattat agagcaattc caggagtagt agagaaggta aagaattcag aagaacagta
     1861 taataaaata gtaattccca atgaagaaag tgtggttatc tattataaga ttagacagca
     1921 gcttgccaaa ttgggtaaag aaattgaaga atatattcac aaaccaaaat actgcttacc
     1981 ttttctacaa ccaggtcgtt tggtaaaggt aaagaatgaa ggagatgact ttggctgggg
     2041 agtagtggtg aatttctcaa aaaagtcaaa tgttaagcct aactctggtg aactggatcc
     2101 tttgtatgta gtagaagtac ttctgcgctg tagcaaagag agcttgaaaa attcagctac
     2161 agaagctgca aaaccagcta aacctgatga gaaaggagag atgcaggttg tcccagtttt
     2221 ggtgcatctc ctgtctgcta tcagcagtgt taggctttac attcctaaag accttcggcc
     2281 ggtggacaat agacagagtg ttttaaaatc aatacaggaa gttcagaaac gttttcctga
     2341 cggcatcccc ttattagacc ctattgatga tatgggcatt caagatcaag ggctgaaaaa
     2401 agtcattcag aaagtagaag cttttgagca tcgaatgtat tctcatccac ttcacaatga
     2461 tccaaatttg gaaactgtgt atacgctttg tgaaaaaaaa gcacagattg caatagatat
     2521 taaatctgca aagcgagaac tgaagaaagc aagaacagtc ctacaaatgg atgaactcaa
     2581 atgtcgcaaa cgtgttttaa gaaggttggg atttgctact tcttctgatg taatagagat
     2641 gaaaggacga gtggcttgtg agataagcag tgctgatgag ctccttctaa ctgagatgat
     2701 gtttaatggc cttttcaatg acctttctgc agaacaggca acagcattat taagctgctt
     2761 tgtgtttcaa gagaattcta gtgagatgcc caaattaaca gaacaattag caggaccact
     2821 tcgtcaaatg caggaatgtg ctaaaagaat tgcaaaagtt tcagcagaag ccaaattgga
     2881 aattgatgag gaaacttatc taagctcatt taaacctcac ttaatggatg tagtatatac
     2941 ctgggcaact ggagctacat ttgcccatat ctgcaaaatg acagatgtct ttgaaggcag
     3001 cataattcgt tgtatgaggc gcctggaaga attgcttcga caaatgtgtc aagcagcaaa
     3061 agccattgga aacactgagc tggaaaataa atttgcagaa ggaatcacca aaatcaagag
     3121 agatattgtg tttgctgcca gcctctactt gtagagtcag ctaaaggaat gtgagatttt
     3181 aaattattga ccacctgttt gattacagtt gactacaaat gcctgcaagt gtggatttgg
     3241 ttctcccata cattttaata tgtattatat ttaaatcaaa catcattcat agaaagcata
     3301 ttacatacat gtttatacat aagcattaca tttttttaat aaaaatgtat acaggtgggg
     3361 cactgttttg gtggaaggct tggagttttt ttaatgagtt tagagctatt agataaccac
     3421 tgagttaaag gtaactatgt acacacaaag tgtgcatcca agaggcatag cagcagcaga
     3481 agtctttaaa ggcttgtaca ccaggaagaa agatgcatcc tcttgccttg tggcaatcat
     3541 tttcctttag aaaacaggcc agcttcacct gggcaccctg ctgcctttca aggctggtga
     3601 ttgctcggat agtgattccc agttgttggt gtttcatgca gagttgtatg agagtcctcc
     3661 tcttttcttt ctttaaaaga agttctttct ttgaagaaat ccgatacata tacagcctac
     3721 agtgcaaaat atttaatggt ataatttaga tcaagttaaa aactacatac aaagttgtga
     3781 tcaacagcat cctaagataa atataaacaa aaggatatac tttgaggtgt acagattaag
     3841 catataaaaa attagagact aactgggatt ttttaaagat tattccaaat taagagttgc
     3901 tttgttatgc cttcagcaaa tagcttcatt ttgccaatac tgaataaaag agttatttct
     3961 a
//
