LOCUS       NM_145808               3782 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens myotrophin (MTPN), mRNA.
ACCESSION   NM_145808
VERSION     NM_145808.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3782)
  AUTHORS   Wang,Y., Zhang,W., Chen,L., Chen,W., Xu,S., Tang,L., Yang,Y.,
            Li,Q., Jiang,Q. and Miao,L.
  TITLE     The ATO/miRNA-885-5p/MTPN axis induces reversal of drug-resistance
            in cholangiocarcinoma
  JOURNAL   Cell Oncol (Dordr) 44 (4), 907-916 (2021)
   PUBMED   34170484
  REMARK    GeneRIF: The ATO/miRNA-885-5p/MTPN axis induces reversal of
            drug-resistance in cholangiocarcinoma.
REFERENCE   2  (bases 1 to 3782)
  AUTHORS   Takeda,S., Koike,R., Nagae,T., Fujiwara,I., Narita,A., Maeda,Y. and
            Ota,M.
  TITLE     Crystal structure of human V-1 in the apo form
  JOURNAL   Acta Crystallogr F Struct Biol Commun 77 (Pt 1), 13-21 (2021)
   PUBMED   33439151
  REMARK    GeneRIF: Crystal structure of human V-1 in the apo form.
REFERENCE   3  (bases 1 to 3782)
  AUTHORS   Wang,C., Sha,Y., Wang,S., Chi,Q., Sung,K.L.P., Xu,K. and Yang,L.
  TITLE     Lysyl oxidase suppresses the inflammatory response in anterior
            cruciate ligament fibroblasts and promotes tissue regeneration by
            targeting myotrophin via the nuclear factor-kappa B pathway
  JOURNAL   J Tissue Eng Regen Med 14 (8), 1063-1076 (2020)
   PUBMED   32483895
  REMARK    GeneRIF: Lysyl oxidase suppresses the inflammatory response in
            anterior cruciate ligament fibroblasts and promotes tissue
            regeneration by targeting myotrophin via the nuclear factor-kappa B
            pathway.
REFERENCE   4  (bases 1 to 3782)
  AUTHORS   Johnson,B., McConnell,P., Kozlov,A.G., Mekel,M., Lohman,T.M.,
            Gross,M.L., Amarasinghe,G.K. and Cooper,J.A.
  TITLE     Allosteric Coupling of CARMIL and V-1 Binding to Capping Protein
            Revealed by Hydrogen-Deuterium Exchange
  JOURNAL   Cell Rep 23 (9), 2795-2804 (2018)
   PUBMED   29847807
  REMARK    GeneRIF: V-1 and CARMIL induce changes in both proteins' binding
            sites on the surface of capping proteins, along with a set of
            internal residues.
REFERENCE   5  (bases 1 to 3782)
  AUTHORS   Perri,M., Caroleo,M.C., Liu,N., Gallelli,L., De Sarro,G.,
            Kagechika,H. and Cione,E.
  TITLE     9-cis Retinoic acid modulates myotrophin expression and its miR in
            physiological and pathophysiological cell models
  JOURNAL   Exp Cell Res 354 (1), 25-30 (2017)
   PUBMED   28300567
  REMARK    GeneRIF: In our findings 9cRA emerges has a hormone with a
            regulatory action on miR-375 that in most cases interfere with Mtpn
            expression.
REFERENCE   6  (bases 1 to 3782)
  AUTHORS   Mitra,S., Timur,A.A., Gupta,S., Wang,Q. and Sen,S.
  TITLE     Assignment of myotrophin to human chromosome band 7q33-->q35 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 151-152 (2001)
   PUBMED   11474205
REFERENCE   7  (bases 1 to 3782)
  AUTHORS   Anderson,K.M., Berrebi-Bertrand,I., Kirkpatrick,R.B.,
            McQueney,M.S., Underwood,D.C., Rouanet,S. and Chabot-Fletcher,M.
  TITLE     cDNA sequence and characterization of the gene that encodes human
            myotrophin/V-1 protein, a mediator of cardiac hypertrophy
  JOURNAL   J Mol Cell Cardiol 31 (4), 705-719 (1999)
   PUBMED   10329199
REFERENCE   8  (bases 1 to 3782)
  AUTHORS   Sivasubramanian,N., Adhikary,G., Sil,P.C. and Sen,S.
  TITLE     Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in
            vitro
  JOURNAL   J Biol Chem 271 (5), 2812-2816 (1996)
   PUBMED   8576259
REFERENCE   9  (bases 1 to 3782)
  AUTHORS   Sil,P., Misono,K. and Sen,S.
  TITLE     Myotrophin in human cardiomyopathic heart
  JOURNAL   Circ Res 73 (1), 98-108 (1993)
   PUBMED   8508536
REFERENCE   10 (bases 1 to 3782)
  AUTHORS   Mukherjee,D.P., McTiernan,C.F. and Sen,S.
  TITLE     Myotrophin induces early response genes and enhances cardiac gene
            expression
  JOURNAL   Hypertension 21 (2), 142-148 (1993)
   PUBMED   8428777
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA325130.1, AL834231.1 and
            CB530008.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145808.3.
            
            Summary: The transcript produced from this gene is bi-cistronic and
            can encode both myotrophin and leucine zipper protein 6. The
            myotrophin protein is associated with cardiac hypertrophy, where it
            is involved in the conversion of NFkappa B p50-p65 heterodimers to
            p50-p50 and p65-p65 homodimers. This protein also has a potential
            function in cerebellar morphogenesis, and it may be involved in the
            differentiation of cerebellar neurons, particularly of granule
            cells. A cryptic ORF at the 3' end of this transcript uses a novel
            internal ribosome entry site and a non-AUG translation initiation
            codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen
            that is associated with myeloproliferative disease. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.846398.1,
                                           SRR1803615.197334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            bicistronic transcript :: PMID: 16982933
            MANE Ensembl match     :: ENST00000393085.4/ ENSP00000376800.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                DA325130.1         98-140
            44-3781             AL834231.1         13-3750
            3782-3782           CB530008.1         22-22               c
FEATURES             Location/Qualifiers
     source          1..3782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q33"
     gene            1..3782
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /note="myotrophin"
                     /db_xref="GeneID:136319"
                     /db_xref="HGNC:HGNC:15667"
                     /db_xref="MIM:606484"
     exon            1..331
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..616
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /note="granule cell differentiation protein; protein V-1"
                     /codon_start=1
                     /product="myotrophin"
                     /protein_id="NP_665807.1"
                     /db_xref="CCDS:CCDS5842.1"
                     /db_xref="GeneID:136319"
                     /db_xref="HGNC:HGNC:15667"
                     /db_xref="MIM:606484"
                     /translation="MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAAD
                     CGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGL
                     TAFEATDNQAIKALLQ"
     exon            332..445
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..529
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..3782
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3761..3766
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /note="hexamer: AATAAA"
     polyA_site      3782
                     /gene="MTPN"
                     /gene_synonym="GCDP; V-1"
                     /note="major polyA site"
ORIGIN      
        1 aagtgtaaag gttcctgcct ctcctcggcc aggcggaacc tctctgctgg gcccggtggc
       61 cgcaaaagaa ctttctttct cccgcccgaa cggtcgccgc ggccaactgc ctcgcccgcc
      121 tggcagccta accctccttc tcttcttctc ctctccggct tcgcgcggcc ctgcctccct
      181 ctcgcccggc ggcatccgct tgctgctgcc accgcctcct catcttctgc ccggccaacc
      241 ggcctgcccc gctgcagtga tgtgcgacaa ggagttcatg tgggccctga aaaacggaga
      301 cttggatgag gtgaaagact atgtggccaa gggagaagat gtcaaccgga cactagaagg
      361 tggaaggaaa cctcttcatt atgcagcaga ttgtgggcag cttgaaatcc tggaatttct
      421 gctgctgaaa ggagcagata ttaatgctcc agataaacat catattactc ctcttctgtc
      481 tgctgtctat gagggtcatg tttcctgtgt gaaattgctt ctgtcaaagg gtgctgataa
      541 gactgtgaaa ggcccagatg gactgaccgc ctttgaagcc actgacaacc aggcaatcaa
      601 agctcttctc cagtgatgga tggatggact gataactccg gaagaatgac tctcctgtgg
      661 cctcacactg ctgcctgtct gtctgtcact ctctatctgc cagcttcttc agctaaatac
      721 tttaagaggg gtgaggggag agagaaattc ataacaaatc cgactaccag aaaaaaaaaa
      781 ttgttttgga ggaggggcaa aaggaaccat gatcaggctt ttactgggat tcctgatcaa
      841 gtaagcctct tccctttcta ataaaatata caccttatac ccaagggaga gcaaagacaa
      901 aatacaccag taacatttga ccttttcagc tccctagcta atttattaga ttgtgttgaa
      961 ggtctgattc tacaaaggcc aactctacat atttggtagc cctaactgtc tgagcagtag
     1021 tggctgctgt gatgtaaact tagggtgctg agataagcaa ttagctctag ccttctgcct
     1081 taagaatgca ctctactggg gatttcctgg catagttaag agcgctgcct ataaggttgg
     1141 tgaccaaatc tttcctcggt gactttaagc tttatgtgaa agcttagtta aggtgaggag
     1201 gggcacactc ctaaattgct ggatgactga actttggatt ttctctcccc tttcacatgg
     1261 atttcatgtc tctttagata aaactgacta gttttattta taaaatctta agttttggaa
     1321 gtctaaagga gaaaccattc cagtatgcat atttttttct cctctagatt catacattta
     1381 tatagcattg aaacactttc aaactcctgc tggtagtaaa aggggattta aaaatagaat
     1441 catagccata agcctgttag tatcatatga agagagaaca gttatcttag tacctatgga
     1501 ttttctttat ttgctgtttg aatggattga ccttggttat gtgttgagaa ttaaggaaca
     1561 ttctttgaaa tgcctctctc agacccatct tggaggctga ttacttactg caccaaagct
     1621 atcactgggg tgagatttac tgtttggaca aatttagccc catcccttca aaaatacact
     1681 tgtaaccagg tttcccagag ttgttgatag gcttctgctg aacatatgcc aacccacctg
     1741 cataatatat ttttgttgct tttataaatc atgcattaca taaagtgtga caacttcaaa
     1801 atgtattctc tgttcttgga atacagtgcc ctaaaatggt gttcttatga cctgcagaaa
     1861 atatttacac atatttccaa atatttattt catgagcagt acagctaatt aaaatatata
     1921 agcttaaatt ttatatctta catttaaaat attaagattc ctttgacttg ccatccatat
     1981 aagcttgcta aaaatattaa gaccaagtca tgcaataatt gaatgtacct caaattttta
     2041 ggggagggtg ggttagggac tgatactcag attgtggata ataattgaat tggtttttaa
     2101 aggcaacata gcattctaca gcagggttaa tctattatca agaacagtca ccctggttaa
     2161 taacaagttt tactgatcag ttgctggttg gttggttggt tggcatgtgg gtgtgtgggt
     2221 gtataggtgt gtgtgggtgt gtgtgtgtat ttttccccat gagtcctttt tttaatcctg
     2281 tggctttttc acttacaact agcctaaccc tgtaattttc ctacatccaa gaaaacaatc
     2341 acaaagtagt ggtttaaata ctttgttgta tttggctaat tttgctgtct taatgcagcc
     2401 tattaagagt tgggttaaaa atcagtaatc agtactttat tacatcactg aactaaaata
     2461 tggagacatc ctcattgaaa atggagggca ctctatcagt ctataactat caacgtagtg
     2521 caacagggtg ttttgatacc tttgttttca cctcttgaca taatgctatt taaaggcttg
     2581 aatttttccc tttatataat tttcaccttt actttcaaag tgttttgttg tagttggcta
     2641 ttgcagagag tgcattgtcc tatcattcct aaacctggtc tgctttctac attcatggta
     2701 tggaaaccat gtgattcttt gtacagttta tcctgatgtt gcttgtaatg cagtagaggc
     2761 tatttcgcct tcgcttttct ttctcgacct ttttgtaaac cctataatta tgaagcgatt
     2821 gcttgagaaa ataacatata aacatagaat agaatagact gaccaagatg gttcacagtt
     2881 tcttttttta actaggttat ttataatgta tttctgaacc acttggcaga caaattcaca
     2941 acacttaatg ttcatatttt gagtaaagga agctaaaacc atgtttgctt tctggtacta
     3001 catgcattag cgaaaggtta agtaagtttt gttctccact gaagtaatac ttaacatctc
     3061 agaaaaaatt ttgcatgttc tgtagttttg tattaaatca gtcatttcat atgcactata
     3121 tcaagtacaa acaggtagtt tacctgttta tagtagtgta ctaacaaagt ctcccttgca
     3181 gcttcagact gttatctata ggcttatcgt tcaaatacag cacttgaata tcccaagtag
     3241 ttcttctacg catagctcac ctttctaaac ccagttaagc atggaagaga ggtagtaggt
     3301 aggtgcagtg tgtggaagct gcaaacaagt aggcctttta ttcattgata tcttttccca
     3361 agtactggat tttaaatctg tatgtatctg tttgattttt ttttctaata tttcagttga
     3421 gctgctgttt tcttccatgc aatattgtat actcaattgt gtatagaaga agctggtgag
     3481 agtgccctcc tacataaata agcaattgca gtgttttgca tgcaaaatat aaaaaattta
     3541 aattgtcctg attctatttt gtaaatggag aaacaatcat atctttctaa gcggtaatgg
     3601 aggaagacta gtgctttgtg cattttgata tatttgagtt cattttttcc acaatgtcat
     3661 acttttgacg cagttgggtt tctcataagt atcctagttc atgtacatcc gaatgctaaa
     3721 taatactgtg ttttaagttt tgtgttgcaa gaacaaatgg aataaacttg aattgtgcta
     3781 ca
//
