LOCUS       NM_018109               5560 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitochondrial poly(A) polymerase (MTPAP), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_018109
VERSION     NM_018109.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5560)
  AUTHORS   Kim,J., Taketomi,T., Yamada,A., Uematsu,Y., Ueda,K., Chiba,T. and
            Tsuruta,F.
  TITLE     USP4 regulates TUT1 ubiquitination status in concert with SART3
  JOURNAL   Biochem Biophys Res Commun 701, 149557 (2024)
   PUBMED   38310689
  REMARK    GeneRIF: USP4 regulates TUT1 ubiquitination status in concert with
            SART3.
REFERENCE   2  (bases 1 to 5560)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 5560)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5560)
  AUTHORS   Van Eyck,L., Bruni,F., Ronan,A., Briggs,T.A., Roscioli,T.,
            Rice,G.I., Vassallo,G., Rodero,M.P., He,L., Taylor,R.W.,
            Livingston,J.H., Chrzanowska-Lightowlers,Z.M.A. and Crow,Y.J.
  TITLE     Biallelic Mutations in MTPAP Associated with a Lethal
            Encephalopathy
  JOURNAL   Neuropediatrics 51 (3), 178-184 (2020)
   PUBMED   31779033
  REMARK    GeneRIF: Biallelic Mutations in MTPAP Associated with a Lethal
            Encephalopathy.
REFERENCE   5  (bases 1 to 5560)
  AUTHORS   Furuya,N., Kakuta,S., Sumiyoshi,K., Ando,M., Nonaka,R., Suzuki,A.,
            Kazuno,S., Saiki,S. and Hattori,N.
  TITLE     NDP52 interacts with mitochondrial RNA poly(A) polymerase to
            promote mitophagy
  JOURNAL   EMBO Rep 19 (12) (2018)
   PUBMED   30309841
  REMARK    GeneRIF: These results indicate that NDP52 and MTPAP form an
            autophagy receptor complex, which enhances autophagic elimination
            of damaged mitochondria.
REFERENCE   6  (bases 1 to 5560)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5560)
  AUTHORS   Nagaike,T., Suzuki,T., Katoh,T. and Ueda,T.
  TITLE     Human mitochondrial mRNAs are stabilized with polyadenylation
            regulated by mitochondria-specific poly(A) polymerase and
            polynucleotide phosphorylase
  JOURNAL   J Biol Chem 280 (20), 19721-19727 (2005)
   PUBMED   15769737
REFERENCE   8  (bases 1 to 5560)
  AUTHORS   Tomecki,R., Dmochowska,A., Gewartowski,K., Dziembowski,A. and
            Stepien,P.P.
  TITLE     Identification of a novel human nuclear-encoded mitochondrial
            poly(A) polymerase
  JOURNAL   Nucleic Acids Res 32 (20), 6001-6014 (2004)
   PUBMED   15547249
  REMARK    GeneRIF: Cloning of a human nuclear-encoded mitochondrial poly(A)
            polymerase (hmtPAP)that has a role in mitochondrial RNA processing.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5560)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 5560)
  AUTHORS   Keller,W. and Martin,G.
  TITLE     Gene regulation: reviving the message
  JOURNAL   Nature 419 (6904), 267-268 (2002)
   PUBMED   12239557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161651.13 and AL353796.16.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 4, 2020 this sequence version replaced NM_018109.3.
            
            Summary: The protein encoded by this gene is a member of the DNA
            polymerase type-B-like family. This enzyme synthesizes the 3'
            poly(A) tail of mitochondrial transcripts and plays a role in
            replication-dependent histone mRNA degradation.[provided by RefSeq,
            Jan 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2678712.1,
                                           SRR14038196.569501.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000263063.9/
                                                  ENSP00000263063.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL161651.13        31710-31869         c
            161-333             AL161651.13        24059-24231         c
            334-558             AL161651.13        22817-23041         c
            559-783             AL161651.13        19394-19618         c
            784-995             AL161651.13        9015-9226           c
            996-1222            AL161651.13        4982-5208           c
            1223-1315           AL353796.16        54025-54117         c
            1316-1389           AL353796.16        53870-53943         c
            1390-5560           AL353796.16        47708-51878         c
FEATURES             Location/Qualifiers
     source          1..5560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.23"
     gene            1..5560
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /note="mitochondrial poly(A) polymerase"
                     /db_xref="GeneID:55149"
                     /db_xref="HGNC:HGNC:25532"
                     /db_xref="MIM:613669"
     exon            1..160
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1752
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /EC_number="2.7.7.19"
                     /note="TUTase 1; terminal uridylyltransferase 1;
                     polynucleotide adenylyltransferase; PAP-associated
                     domain-containing protein 1"
                     /codon_start=1
                     /product="poly(A) RNA polymerase, mitochondrial precursor"
                     /protein_id="NP_060579.3"
                     /db_xref="CCDS:CCDS7165.1"
                     /db_xref="GeneID:55149"
                     /db_xref="HGNC:HGNC:25532"
                     /db_xref="MIM:613669"
                     /translation="MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDE
                     QPSGSVETGFEDKIPKRRFSEMQNERREQAQRTVLIHCPEKISENKFLKYLSQFGPIN
                     NHFFYESFGLYAVVEFCQKESIGSLQNGTHTPSTAMETAIPFRSRFFNLKLKNQTSER
                     SRVRSSNQLPRSNKQLFELLCYAESIDDQLNTLLKEFQLTEENTKLRYLTCSLIEDMA
                     AAYFPDCIVRPFGSSVNTFGKLGCDLDMFLDLDETRNLSAHKISGNFLMEFQVKNVPS
                     ERIATQKILSVLGECLDHFGPGCVGVQKILNARCPLVRFSHQASGFQCDLTTNNRIAL
                     TSSELLYIYGALDSRVRALVFSVRCWARAHSLTSSIPGAWITNFSLTMMVIFFLQRRS
                     PPILPTLDSLKTLADAEDKCVIEGNNCTFVRDLSRIKPSQNTETLELLLKEFFEYFGN
                     FAFDKNSINIRQGREQNKPDSSPLYIQNPFETSLNISKNVSQSQLQKFVDLARESAWI
                     LQQEDTDRPSISSNRPWGLVSLLLPSAPNRKSFTKKKSNKFAIETVKNLLESLKGNRT
                     ENFTKTSGKRTISTQT"
     exon            161..333
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            334..558
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            559..783
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            784..995
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1222
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1315
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1389
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..5560
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2511..2516
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /note="hexamer: AATAAA"
     polyA_site      2535
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /note="major polyA site"
     regulatory      5538..5543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
                     /note="hexamer: AATAAA"
     polyA_site      5560
                     /gene="MTPAP"
                     /gene_synonym="PAPD1; SPAX4; TENT6"
ORIGIN      
        1 gcaatggcgg ttcccggcgt ggggctcttg acccgtttga acctgtgtgc ccggagaaga
       61 actcgagtcc agcggcctat cgtcaggctt ttgagttgcc caggaactgt ggccaaagac
      121 cttaggagag acgagcagcc ttcagggagc gtggagacag gctttgaaga caagattccc
      181 aaaaggagat tctctgagat gcaaaatgaa agacgagaac aggcacagcg gactgtttta
      241 atacattgcc cagagaaaat cagtgaaaac aagtttctta aatatttatc ccaatttgga
      301 cctattaata atcatttctt ctatgaaagc tttggtctct atgctgtcgt agaattttgc
      361 caaaaggaaa gcataggttc actgcagaat gggactcata ctccaagcac ggccatggag
      421 actgcaattc cattcagatc acgtttcttc aatctgaagt tgaaaaacca gacttctgaa
      481 cggtcacgcg tacggtcaag taatcagttg ccacgttcaa acaagcagct ttttgaatta
      541 ctttgttatg cagaaagtat agacgatcag ctgaacactc tcttgaagga gttccagcta
      601 acagaggaga acactaagct ccgatatctc acctgttctc ttattgaaga catggccgcc
      661 gcgtattttc cagactgcat agtcagaccc tttggctcct cagtcaacac ttttgggaag
      721 ttaggatgtg atttggacat gtttttggat ctagatgaaa ccagaaacct cagcgctcac
      781 aagatctcag gaaattttct gatggaattt caagtgaaaa atgttccttc agaaagaatt
      841 gcaactcaga agatcctgtc tgtgttagga gagtgccttg accactttgg ccctggctgt
      901 gtgggtgtgc aaaaaatatt aaatgcccgg tgtccgctcg tgaggttctc acaccaggcc
      961 tccggatttc agtgtgattt gactacgaac aataggattg ccttgacaag ttccgaactc
     1021 ctttatatat atggtgccct agactcaaga gtgagagcct tggtgttcag tgtacggtgc
     1081 tgggctcgag cacattcact aacaagtagt attcctggtg catggattac aaatttctcc
     1141 cttacaatga tggtcatctt ttttctccag agaagatcac cccctattct tccaacacta
     1201 gattccttaa aaaccctagc agatgcagaa gataaatgtg taatagaagg caacaactgc
     1261 acatttgttc gtgacttgag tagaattaaa ccttcacaga acacagaaac attagaatta
     1321 ctactgaagg aattttttga gtattttggc aattttgctt tcgataaaaa ttccataaat
     1381 attcgacagg gaagggagca aaacaaacct gattcttctc ctctgtacat tcagaatcca
     1441 tttgaaactt ctctcaacat aagcaaaaat gtaagtcaaa gccagctgca aaaatttgta
     1501 gatttggccc gagaaagtgc ctggatttta caacaggaag atacagatcg accttccata
     1561 tcaagtaatc ggccctgggg gctggtatcc ctattgctac catctgctcc aaacagaaag
     1621 tcctttacca agaagaaaag caataagttt gcaattgaaa cagtcaaaaa cttgctagaa
     1681 tctttaaaag gtaacagaac agaaaatttc acaaaaacca gtgggaagag aacaattagt
     1741 actcagacat gatggctgct acattgtgta aagaactggg cttagcctat caaatggtct
     1801 gtggacttac ttggaaaaac tgatttgaaa ctttcacaga tctcagcttt catctgatgt
     1861 cacttttcat gatcttctca ttggccccct taacctggtc tgaagttctg ggatgttttc
     1921 agtttgatca gtctgatact cagtggcact ttattaaaac atcagctgtg gagtgtggcg
     1981 gtgcacacct gtagtcccag ctgctcagga ggctgaggca ggaggatctc ttgagcccag
     2041 gattttgaat ccatcgtgga caacatagca agattccatc tctaaaaaaa atgaaaataa
     2101 acataagcca caaggaatgg gtgaaagatt attgtaatgt gctttaacta aataggtaaa
     2161 tatactaaac aaatgctaaa actcagtttt aggatgaaac cattgttgat atccacatca
     2221 gtccctgttt agaaaacatt taaaatgact tttagttatg tacagtacgt tggcaatgaa
     2281 tacattaagc ttcaaaattt ggtagtgctc tcgaatatgt atatttgtat ttttcaagcg
     2341 aagttctctt attcacatat aaattaaagt gggttggtac tgatatcaaa aaatgtttat
     2401 gtttttagaa cagacatttc agtcactgca ttcttaggta ttccaaacca aatatgatga
     2461 catcaataga ttgcatttta aaaatattgt ttgatttttc tattttcaaa aataaaattc
     2521 tgtttctaac taaaatgtga tattcccagt attccttcac atctcttttg agaactcccc
     2581 tcttcctgca ggaaagagac atatttgtct ctcagtatat gcagaaaatt ggttccagga
     2641 ccatccacgt acacccagat ctgcacacac tgaactcctt cagtcctgtg gagcccgtgc
     2701 atgggagaat tccaccttgc acataagcag attttgcatc ctgtgaaagt actgtatttt
     2761 ctttctttct tttttttttt tttttttttt tgagacagag tctcgctctg tcgcccaggc
     2821 tagagtgcag tggcgcaatc tcggctcact gcaagctctg cctcccaggt tcacgccatt
     2881 ctcctgcctc agcctctctg agtagctggg actataggtg cccgccacca cgcccggaca
     2941 atttttttgt atttttagta gagacagggt ttcaccatgg tctcgatctc ccgacctcgt
     3001 gatcagccca cctcaacctc ccaaagtgct gggattacaa gcgtgagcca ccatgcctgg
     3061 ccgagaatac tgtattttca atccaagttt ggttggaaaa aatctgtgtg taaatggact
     3121 tcgcagttga aacccatgtt gttcaatggg caactgtata ttgaaattta atttccatta
     3181 cattctctgt ggagcaactt ttttgctttg tttcgttttg tttctgagac ggagttttgc
     3241 tcttgttgcc caggctgggg tgcaatggca caatctcagc tcactgcaac ctccgcctcc
     3301 cggattcaag tgattctcct gcctcagctg ggattacagg cgcccaccac caagcccagc
     3361 taatttttgt agttttagta gggacagggt ttcaccatgt tggccaggct gatctcgaac
     3421 tcctgacctc aggtgatcgc ccaccttggc cttccaaagt gttggaatta caggcgtgag
     3481 ccactgcacc tggcttctgt ggagtaactt tctatttaag aagcaagtaa ggcctgggca
     3541 tagcggcaca tgcctgtagt cccaggtact tgggaggccg aggcacaagg actgcttgaa
     3601 cctgggaggc agaggctgca gtgagctgag atcacagcac tgtactccat cctgggcgac
     3661 agtgagactc tctcaaagga aaagaagcaa gtagtatagt gtttaaaaac agacttgagc
     3721 gagactggct caatgacaag ttactcagtc tcttggggcc cctgtttgat ctgtaaaatg
     3781 gggatcatga tcagatcaat gtgaggatta agcgagggat gtaggaaaat gctaggtcag
     3841 tgcattttcc tggcgcgaag taaatgttac ttctctttaa ctgttgcctt tcggtgtttg
     3901 tggtatgtaa ttaccttttt tgctactcaa aattcagatt tagagtttgt agtactttaa
     3961 aaatttttcc catttaaatt ttatgtcaga aattataatg ggttctgcat gggatatttt
     4021 aagaaactca gcattgttat gaagcaaatg aattctgtgt ccttgtgtct gtgctattgg
     4081 attgcacatt tgacaccaac aaatatcagt gttctgtaca ggcgatgtct ttaaaagcca
     4141 tttttcattt gttctttatt ttgttgggct agaaatccat attgatttaa aaagcttaaa
     4201 aagcataaac cacttaaggg tttctaaatg aaattttttt ttctgttcac agatatttag
     4261 tcagatattt tcttttttag gttggtgcta ggtgtaatat ggttatttaa gcacataaag
     4321 tatgtgtatg ggttagcatt ttcttttctt tttggtaatt tgtaggacag ccttgacact
     4381 aggctgtttt acttttcaga atcagattta attatgtgat taattttaaa tctacaaaga
     4441 cttgtttttt gttttttttt ttgagagcaa atcttgctct gtcacccagg ctagactgca
     4501 gtggtgcgat ctcggctcac tgcaacctct gcctcctggg ttcaagcgat actcctgccc
     4561 cagcctccca agtaactggg attacaggcg cctgccacca tgcctagcta atttttgtat
     4621 gttagtagag acggggtttc accatgttgg ccaggctggt cttgaattcc tgacctcaag
     4681 tgatctacct gtctcagcct ctcaaagtgc tgggattaca ggttacaggt gtgagccacc
     4741 gcacctggcc tacaaagacc cttttttttt tttttttttg agatgggtct ccctctgtca
     4801 cccaggctgg agagtgcagt gatcttggct cactgaaacc tccacttccc gggttcaggt
     4861 gattcttctg cctcagcctc ctgagtagct gggattacag gtgcatgcca ccacacctgg
     4921 ctaagttttc tatttttagt agagatgggg ttttactctg ttggccaggc tggtctcgaa
     4981 ctcctgacct caggtgacct gcccacctcg ccctcccaaa atgctgggat tacaggcatg
     5041 agccaccacg cctggctgca aagacctttt aatacacagt tttaaagtct gttcaactga
     5101 atatagacta cagacaaata tattttctca taactttagt gtatcacaac ccagattttt
     5161 aaaatatttt tattacgtga tagtgataac tagcaattat ttgtcattgc tgtttcttaa
     5221 ttaaaaataa ttgcaatgtt aagtaaaact tttttcaagt ttttttcttc tataactatt
     5281 actaggcttt cattcagtag ctttcacctg taatgagttt tactaagtat gtgaaagtaa
     5341 ttttgatagg agactaccca gatcaaaacg atttcagcta tagcccacta gtataattcc
     5401 tggagctatt atccatcttt agaaaatttg agaattagcc agagactttc taggaaataa
     5461 cgattagcct gaaacgttat aggaaaactg tgtgtaatta tctcattcac cttcagttac
     5521 cataaaggag aagggaaaat aaagttgagt tgaaataaga
//
