LOCUS       NM_004958               8721 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens mechanistic target of rapamycin kinase (MTOR),
            transcript variant 1, mRNA.
ACCESSION   NM_004958
VERSION     NM_004958.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8721)
  AUTHORS   Azimzadeh,M., Cheah,P.S. and Ling,K.H.
  TITLE     Brain insulin resistance in Down syndrome: Involvement of
            PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its
            potential as a therapeutic target
  JOURNAL   Biochem Biophys Res Commun 733, 150713 (2024)
   PUBMED   39307112
  REMARK    GeneRIF: Brain insulin resistance in Down syndrome: Involvement of
            PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its
            potential as a therapeutic target.
            Review article
REFERENCE   2  (bases 1 to 8721)
  AUTHORS   Xue,Z., Liu,J., Xing,W., Mu,F., Wu,Y., Zhao,J., Liu,X., Wang,D.,
            Wang,J., Li,X., Wang,J. and Huang,B.
  TITLE     Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2
            polarization by activating the PI3K-AKT-mTOR signaling pathway
  JOURNAL   J Nanobiotechnology 22 (1), 628 (2024)
   PUBMED   39407269
  REMARK    GeneRIF: Hypoxic glioma-derived exosomal miR-25-3p promotes
            macrophage M2 polarization by activating the PI3K-AKT-mTOR
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8721)
  AUTHORS   Witucki,L. and Jakubowski,H.
  TITLE     Homocysteine metabolites impair the PHF8/H4K20me1/mTOR/autophagy
            pathway by upregulating the expression of histone demethylase
            PHF8-targeting microRNAs in human vascular endothelial cells and
            mice
  JOURNAL   FASEB J 38 (18), e70072 (2024)
   PUBMED   39323294
  REMARK    GeneRIF: Homocysteine metabolites impair the
            PHF8/H4K20me1/mTOR/autophagy pathway by upregulating the expression
            of histone demethylase PHF8-targeting microRNAs in human vascular
            endothelial cells and mice.
REFERENCE   4  (bases 1 to 8721)
  AUTHORS   Zhan,J., Harwood,F., Have,S.T., Lamond,A., Phillips,A.H.,
            Kriwacki,R.W., Halder,P., Cardone,M. and Grosveld,G.C.
  TITLE     Assembly of mTORC3 Involves Binding of ETV7 to Two Separate
            Sequences in the mTOR Kinase Domain
  JOURNAL   Int J Mol Sci 25 (18), 10042 (2024)
   PUBMED   39337528
  REMARK    GeneRIF: Assembly of mTORC3 Involves Binding of ETV7 to Two
            Separate Sequences in the mTOR Kinase Domain.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8721)
  AUTHORS   Gordon,D.E., Jang,G.M., Bouhaddou,M., Xu,J., Obernier,K.,
            White,K.M., O'Meara,M.J., Rezelj,V.V., Guo,J.Z., Swaney,D.L.,
            Tummino,T.A., Huttenhain,R., Kaake,R.M., Richards,A.L.,
            Tutuncuoglu,B., Foussard,H., Batra,J., Haas,K., Modak,M., Kim,M.,
            Haas,P., Polacco,B.J., Braberg,H., Fabius,J.M., Eckhardt,M.,
            Soucheray,M., Bennett,M.J., Cakir,M., McGregor,M.J., Li,Q.,
            Meyer,B., Roesch,F., Vallet,T., Mac Kain,A., Miorin,L., Moreno,E.,
            Naing,Z.Z.C., Zhou,Y., Peng,S., Shi,Y., Zhang,Z., Shen,W.,
            Kirby,I.T., Melnyk,J.E., Chorba,J.S., Lou,K., Dai,S.A.,
            Barrio-Hernandez,I., Memon,D., Hernandez-Armenta,C., Lyu,J.,
            Mathy,C.J.P., Perica,T., Pilla,K.B., Ganesan,S.J., Saltzberg,D.J.,
            Rakesh,R., Liu,X., Rosenthal,S.B., Calviello,L., Venkataramanan,S.,
            Liboy-Lugo,J., Lin,Y., Huang,X.P., Liu,Y., Wankowicz,S.A., Bohn,M.,
            Safari,M., Ugur,F.S., Koh,C., Savar,N.S., Tran,Q.D., Shengjuler,D.,
            Fletcher,S.J., O'Neal,M.C., Cai,Y., Chang,J.C.J., Broadhurst,D.J.,
            Klippsten,S., Sharp,P.P., Wenzell,N.A., Kuzuoglu-Ozturk,D.,
            Wang,H.Y., Trenker,R., Young,J.M., Cavero,D.A., Hiatt,J.,
            Roth,T.L., Rathore,U., Subramanian,A., Noack,J., Hubert,M.,
            Stroud,R.M., Frankel,A.D., Rosenberg,O.S., Verba,K.A., Agard,D.A.,
            Ott,M., Emerman,M., Jura,N., von Zastrow,M., Verdin,E.,
            Ashworth,A., Schwartz,O., d'Enfert,C., Mukherjee,S., Jacobson,M.,
            Malik,H.S., Fujimori,D.G., Ideker,T., Craik,C.S., Floor,S.N.,
            Fraser,J.S., Gross,J.D., Sali,A., Roth,B.L., Ruggero,D.,
            Taunton,J., Kortemme,T., Beltrao,P., Vignuzzi,M., Garcia-Sastre,A.,
            Shokat,K.M., Shoichet,B.K. and Krogan,N.J.
  TITLE     A SARS-CoV-2 protein interaction map reveals targets for drug
            repurposing
  JOURNAL   Nature 583 (7816), 459-468 (2020)
   PUBMED   32353859
REFERENCE   6  (bases 1 to 8721)
  AUTHORS   Zhou,Y., Hou,Y., Shen,J., Huang,Y., Martin,W. and Cheng,F.
  TITLE     Network-based drug repurposing for novel coronavirus
            2019-nCoV/SARS-CoV-2
  JOURNAL   Cell Discov 6, 14 (2020)
   PUBMED   32194980
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8721)
  AUTHORS   Chen,J., Zheng,X.F., Brown,E.J. and Schreiber,S.L.
  TITLE     Identification of an 11-kDa FKBP12-rapamycin-binding domain within
            the 289-kDa FKBP12-rapamycin-associated protein and
            characterization of a critical serine residue
  JOURNAL   Proc Natl Acad Sci U S A 92 (11), 4947-4951 (1995)
   PUBMED   7539137
REFERENCE   8  (bases 1 to 8721)
  AUTHORS   Chiu,M.I., Katz,H. and Berlin,V.
  TITLE     RAPT1, a mammalian homolog of yeast Tor, interacts with the
            FKBP12/rapamycin complex
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 12574-12578 (1994)
   PUBMED   7809080
REFERENCE   9  (bases 1 to 8721)
  AUTHORS   Haystead,T.A., Haystead,C.M., Hu,C., Lin,T.A. and Lawrence,J.C. Jr.
  TITLE     Phosphorylation of PHAS-I by mitogen-activated protein (MAP)
            kinase. Identification of a site phosphorylated by MAP kinase in
            vitro and in response to insulin in rat adipocytes
  JOURNAL   J Biol Chem 269 (37), 23185-23191 (1994)
   PUBMED   8083223
REFERENCE   10 (bases 1 to 8721)
  AUTHORS   Brown,E.J., Albers,M.W., Shin,T.B., Ichikawa,K., Keith,C.T.,
            Lane,W.S. and Schreiber,S.L.
  TITLE     A mammalian protein targeted by G1-arresting rapamycin-receptor
            complex
  JOURNAL   Nature 369 (6483), 756-758 (1994)
   PUBMED   8008069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP250183.1, DC403129.1,
            L34075.1, U88966.1, BC117166.1, AB209995.1 and AA725390.1.
            
            On May 17, 2019 this sequence version replaced NM_004958.3.
            
            Summary: The protein encoded by this gene belongs to a family of
            phosphatidylinositol kinase-related kinases. These kinases mediate
            cellular responses to stresses such as DNA damage and nutrient
            deprivation. This kinase is a component of two distinct complexes,
            mTORC1, which controls protein synthesis, cell growth and
            proliferation, and mTORC2, which is a regulator of the actin
            cytoskeleton, and promotes cell survival and cell cycle
            progression. This protein acts as the target for the cell-cycle
            arrest and immunosuppressive effects of the FKBP12-rapamycin
            complex. Inhibitors of mTOR are used in organ transplants as
            immunosuppressants, and are being evaluated for their therapeutic
            potential in SARS-CoV-2 infections. Mutations in this gene are
            associated with Smith-Kingsmore syndrome and somatic focal cortical
            dysplasia type II. The ANGPTL7 gene is located in an intron of this
            gene. [provided by RefSeq, Aug 2020].
            
            Transcript Variant: Variants 1 and 2 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U88966.1, SRR18074967.3489518.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 treatment
            MANE Ensembl match     :: ENST00000361445.9/ ENSP00000354558.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP250183.1         6-17
            13-61               DC403129.1         5-53
            62-1557             L34075.1           20-1515
            1558-1564           U88966.1           1516-1522
            1565-3117           L34075.1           1523-3075
            3118-3343           U88966.1           3073-3298
            3344-5673           BC117166.1         3241-5570
            5674-8720           AB209995.1         5655-8701
            8721-8721           AA725390.1         13-13               c
FEATURES             Location/Qualifiers
     source          1..8721
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..8721
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /note="mechanistic target of rapamycin kinase"
                     /db_xref="GeneID:2475"
                     /db_xref="HGNC:HGNC:3942"
                     /db_xref="MIM:601231"
     exon            1..107
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            108..283
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..7771
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mammalian target of rapamycin; FK506 binding protein
                     12-rapamycin associated protein 2; rapamycin and FKBP12
                     target 1; mechanistic target of rapamycin
                     (serine/threonine kinase); serine/threonine-protein kinase
                     mTOR; FKBP12-rapamycin complex-associated protein 1;
                     FKBP-rapamycin associated protein; rapamycin associated
                     protein FRAP2; rapamycin target protein 1;
                     tyrosine-protein kinase mTOR; FK506-binding protein
                     12-rapamycin complex-associated protein 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase mTOR isoform 1"
                     /protein_id="NP_004949.1"
                     /db_xref="CCDS:CCDS127.1"
                     /db_xref="GeneID:2475"
                     /db_xref="HGNC:HGNC:3942"
                     /db_xref="MIM:601231"
                     /translation="MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKEL
                     QHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNAT
                     RIGRFANYLRNLLPSNDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADR
                     NEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLI
                     LTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISS
                     MEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQSNALVGLL
                     GYSSHQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTI
                     LNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKV
                     YLPRVLDIIRAALPPKDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPM
                     LAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLA
                     SPGLTTLPEASDVGSITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAAR
                     TCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDER
                     FDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTE
                     LEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNV
                     LATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVE
                     PYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASA
                     VSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVV
                     QAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPY
                     MDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSP
                     GRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEAPLPSRKAALETVDRLTESL
                     DFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRI
                     NHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHVST
                     INLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
                     AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDN
                     GIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYA
                     MKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLH
                     QQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLAL
                     HQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPE
                     RREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLAL
                     AHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQ
                     QAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDR
                     SWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAATATTTA
                     STEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNL
                     QDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIH
                     QLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEEL
                     IRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAY
                     GRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLM
                     CRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHE
                     DLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHA
                     LIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLK
                     SPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEV
                     AMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFV
                     YDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIH
                     SFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENL
                     CQCYIGWCPFW"
     exon            284..392
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            393..625
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            626..826
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            827..961
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1237
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1346
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1533
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1662
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1907
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2123
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2329
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..2452
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..2542
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2635
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2770
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2771..2900
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3151
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3238
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3239..3406
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3519
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3682
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3683..3775
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3776..3922
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            3923..4065
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4066..4228
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4374
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4375..4450
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4590
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4591..4691
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4692..4807
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4885
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4886..4993
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            4994..5119
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5120..5251
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5252..5367
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5368..5485
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5486..5734
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5735..5835
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5836..5932
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            5933..6031
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6032..6154
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6155..6337
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6338..6472
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6473..6647
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6648..6783
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6784..6931
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            6932..7054
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7055..7137
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7138..7210
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7211..7285
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7286..7421
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7422..7487
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7488..7568
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7569..7649
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7650..7755
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     exon            7756..8721
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8694..8699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /note="hexamer: AATAAA"
     polyA_site      8721
                     /gene="MTOR"
                     /gene_synonym="FRAP; FRAP1; FRAP2; RAFT1; RAPT1; SKS"
                     /note="major polyA site"
ORIGIN      
        1 gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg
       61 gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa
      121 gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag
      181 cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc
      241 cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc
      301 tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc
      361 caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa
      421 tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc
      481 agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt
      541 taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg
      601 caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc
      661 taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga
      721 ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac
      781 aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga
      841 agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg
      901 gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga
      961 gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg
     1021 caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca
     1081 ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca
     1141 aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg
     1201 gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg
     1261 caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc
     1321 tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt
     1381 cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact
     1441 ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg
     1501 agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc
     1561 cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga
     1621 tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt
     1681 gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact
     1741 gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg
     1801 cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg
     1861 cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac
     1921 ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat
     1981 ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca
     2041 tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct
     2101 cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga
     2161 cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct
     2221 gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag
     2281 catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga
     2341 gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct
     2401 ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat
     2461 tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc
     2521 aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact
     2581 ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc
     2641 tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa
     2701 gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac
     2761 acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa
     2821 agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc
     2881 caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa
     2941 cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg
     3001 agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa
     3061 gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt
     3121 cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt
     3181 gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga
     3241 attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt
     3301 ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg
     3361 tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat
     3421 ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa
     3481 gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga
     3541 ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt
     3601 tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact
     3661 tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt
     3721 gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata
     3781 cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg
     3841 ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt
     3901 cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg
     3961 gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct
     4021 gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc
     4081 tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag
     4141 catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt
     4201 ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat
     4261 tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa
     4321 agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa
     4381 taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt
     4441 tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct
     4501 tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg
     4561 catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa
     4621 gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc
     4681 atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac
     4741 ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc
     4801 acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg
     4861 agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga
     4921 ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg
     4981 ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg
     5041 gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg
     5101 cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga
     5161 tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta
     5221 catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt
     5281 tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa
     5341 gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa
     5401 tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac
     5461 agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc
     5521 tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc
     5581 cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac
     5641 cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc
     5701 caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta
     5761 cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct
     5821 ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa
     5881 tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc
     5941 tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct
     6001 tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc
     6061 taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga
     6121 gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc
     6181 catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg
     6241 ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg
     6301 gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga
     6361 ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc
     6421 ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc
     6481 cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt
     6541 gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt
     6601 gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca
     6661 tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca
     6721 gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct
     6781 cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt
     6841 tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct
     6901 tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct
     6961 gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc
     7021 caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta
     7081 tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca
     7141 cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga
     7201 ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac
     7261 aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg
     7321 ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc
     7381 ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa
     7441 gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg
     7501 tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca
     7561 ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat
     7621 tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga
     7681 tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca
     7741 gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt
     7801 tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag
     7861 tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg
     7921 gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat
     7981 ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg
     8041 aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc
     8101 ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac
     8161 tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa
     8221 gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga
     8281 cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca
     8341 gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt
     8401 ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg
     8461 ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac
     8521 tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg
     8581 aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt
     8641 ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat
     8701 gacatcagaa ttttaaacat a
//
