LOCUS       NM_005959               1634 bp    mRNA    linear   PRI 27-FEB-2025
DEFINITION  Homo sapiens melatonin receptor 1B (MTNR1B), mRNA.
ACCESSION   NM_005959
VERSION     NM_005959.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1634)
  AUTHORS   Kim,J.I. and Cheon,H.G.
  TITLE     Melatonin ameliorates hepatic fibrosis via the melatonin receptor
            2-mediated upregulation of BMAL1 and anti-oxidative enzymes
  JOURNAL   Eur J Pharmacol 966, 176337 (2024)
   PUBMED   38246330
  REMARK    GeneRIF: Melatonin ameliorates hepatic fibrosis via the melatonin
            receptor 2-mediated upregulation of BMAL1 and anti-oxidative
            enzymes.
REFERENCE   2  (bases 1 to 1634)
  AUTHORS   Heianza,Y., Zhou,T., Wang,X., Furtado,J.D., Appel,L.J., Sacks,F.M.
            and Qi,L.
  TITLE     MTNR1B genotype and effects of carbohydrate quantity and dietary
            glycaemic index on glycaemic response to an oral glucose load: the
            OmniCarb trial
  JOURNAL   Diabetologia 67 (3), 506-515 (2024)
   PUBMED   38052941
  REMARK    GeneRIF: MTNR1B genotype and effects of carbohydrate quantity and
            dietary glycaemic index on glycaemic response to an oral glucose
            load: the OmniCarb trial.
REFERENCE   3  (bases 1 to 1634)
  AUTHORS   Zhang,Y., Zhao,K., Jin,L., Zhou,Y., Shang,X., Wang,X. and Yu,H.
  TITLE     MTNR1B gene variations and high pre-pregnancy BMI increase
            gestational diabetes mellitus risk in Chinese women
  JOURNAL   Gene 894, 148023 (2024)
   PUBMED   38007162
  REMARK    GeneRIF: MTNR1B gene variations and high pre-pregnancy BMI increase
            gestational diabetes mellitus risk in Chinese women.
REFERENCE   4  (bases 1 to 1634)
  AUTHORS   Kaabi,Y.A.
  TITLE     MTNR 1B (rs10830963) Gene Polymorphism, but not MTNR 1A
            (rs2119882), Associated with Type 2 Diabetes Mellitus Risk in Saudi
            Arabia
  JOURNAL   Clin Lab 70 (1) (2024)
   PUBMED   38213225
  REMARK    GeneRIF: MTNR 1B (rs10830963) Gene Polymorphism, but not MTNR 1A
            (rs2119882), Associated with Type 2 Diabetes Mellitus Risk in Saudi
            Arabia.
REFERENCE   5  (bases 1 to 1634)
  AUTHORS   Abid,F., Ahmed,S., Noushad,S., Farhat,S. and Fatima,S.S.
  TITLE     Relationship Between Genetic Variant Of OXTR (Rs53576) And MTNR1B
            (Rs1387153) And Symptoms Of Psychological Stress In Females With
            Gestational Diabetes Mellitus
  JOURNAL   J Pak Med Assoc 73 (11), 2209-2213 (2023)
   PUBMED   38013530
  REMARK    GeneRIF: Relationship Between Genetic Variant Of OXTR (Rs53576) And
            MTNR1B (Rs1387153) And Symptoms Of Psychological Stress In Females
            With Gestational Diabetes Mellitus.
REFERENCE   6  (bases 1 to 1634)
  AUTHORS   Ebisawa,T., Uchiyama,M., Kajimura,N., Kamei,Y., Shibui,K., Kim,K.,
            Kudo,Y., Iwase,T., Sugishita,M., Jodoi,T., Ikeda,M., Ozeki,Y.,
            Watanabe,T., Sekimoto,M., Katoh,M., Yamada,N., Toyoshima,R.,
            Okawa,M., Takahashi,K. and Yamauchi,T.
  TITLE     Genetic polymorphisms of human melatonin 1b receptor gene in
            circadian rhythm sleep disorders and controls
  JOURNAL   Neurosci Lett 280 (1), 29-32 (2000)
   PUBMED   10696804
REFERENCE   7  (bases 1 to 1634)
  AUTHORS   Niles,L.P., Wang,J., Shen,L., Lobb,D.K. and Younglai,E.V.
  TITLE     Melatonin receptor mRNA expression in human granulosa cells
  JOURNAL   Mol Cell Endocrinol 156 (1-2), 107-110 (1999)
   PUBMED   10612428
REFERENCE   8  (bases 1 to 1634)
  AUTHORS   Brzezinski,A.
  TITLE     Melatonin in humans
  JOURNAL   N Engl J Med 336 (3), 186-195 (1997)
   PUBMED   8988899
  REMARK    Review article
REFERENCE   9  (bases 1 to 1634)
  AUTHORS   Reppert,S.M., Weaver,D.R., Ebisawa,T., Mahle,C.D. and
            Kolakowski,L.F. Jr.
  TITLE     Cloning of a melatonin-related receptor from human pituitary
  JOURNAL   FEBS Lett 386 (2-3), 219-224 (1996)
   PUBMED   8647286
REFERENCE   10 (bases 1 to 1634)
  AUTHORS   Reppert,S.M., Godson,C., Mahle,C.D., Weaver,D.R., Slaugenhaupt,S.A.
            and Gusella,J.F.
  TITLE     Molecular characterization of a second melatonin receptor expressed
            in human retina and brain: the Mel1b melatonin receptor
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8734-8738 (1995)
   PUBMED   7568007
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003171.2 and AP002371.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 4, 2020 this sequence version replaced NM_005959.4.
            
            Summary: This gene encodes one of two high affinity forms of a
            receptor for melatonin, the primary hormone secreted by the pineal
            gland. This gene product is an integral membrane protein that is a
            G-protein coupled, 7-transmembrane receptor. It is found primarily
            in the retina and brain although this detection requires RT-PCR. It
            is thought to participate in light-dependent functions in the
            retina and may be involved in the neurobiological effects of
            melatonin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069163.1, U25341.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257068.3/ ENSP00000257068.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AP003171.2         131458-131755
            299-1634            AP002371.3         10887-12222
FEATURES             Location/Qualifiers
     source          1..1634
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.3"
     gene            1..1634
                     /gene="MTNR1B"
                     /gene_synonym="FGQTL2; MEL-1B-R; MT2"
                     /note="melatonin receptor 1B"
                     /db_xref="GeneID:4544"
                     /db_xref="HGNC:HGNC:7464"
                     /db_xref="MIM:600804"
     exon            1..298
                     /gene="MTNR1B"
                     /gene_synonym="FGQTL2; MEL-1B-R; MT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1164
                     /gene="MTNR1B"
                     /gene_synonym="FGQTL2; MEL-1B-R; MT2"
                     /note="melatonin receptor MEL1B; mel1b receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1B"
                     /protein_id="NP_005950.1"
                     /db_xref="CCDS:CCDS8290.1"
                     /db_xref="GeneID:4544"
                     /db_xref="HGNC:HGNC:7464"
                     /db_xref="MIM:600804"
                     /translation="MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALS
                     AVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIF
                     YDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLH
                     ICLIWLLTVVALLPNFFVGSLEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSF
                     CYLRIWVLVLQARRKAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAI
                     NPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQ
                     DASKGSHAEGLQSPAPPIIGVQHQADAL"
     exon            299..1634
                     /gene="MTNR1B"
                     /gene_synonym="FGQTL2; MEL-1B-R; MT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggctcagta ctgcgcgcgc cctgcggctg tccggggccg cgcggtggcc aaagcacagc
       61 gcgggagagt ctgcgatgtc agagaacggc tccttcgcca actgctgcga ggcgggcggg
      121 tgggcagtgc gcccgggctg gtcgggggct ggcagcgcgc ggccctccag gacccctcga
      181 cctccctggg tggctccagc gctgtccgcg gtgctcatcg tcaccaccgc cgtggacgtc
      241 gtgggcaacc tcctggtgat cctctccgtg ctcaggaacc gcaagctccg gaacgcaggt
      301 aatttgttct tggtgagtct ggcattggct gacctggtgg tggccttcta cccctacccg
      361 ctaatcctcg tggccatctt ctatgacggc tgggccctgg gggaggagca ctgcaaggcc
      421 agcgcctttg tgatgggcct gagcgtcatc ggctctgtct tcaatatcac tgccatcgcc
      481 attaaccgct actgctacat ctgccacagc atggcctacc accgaatcta ccggcgctgg
      541 cacacccctc tgcacatctg cctcatctgg ctcctcaccg tggtggcctt gctgcccaac
      601 ttctttgtgg ggtccctgga gtacgaccca cgcatctatt cctgcacctt catccagacc
      661 gccagcaccc agtacacggc ggcagtggtg gtcatccact tcctcctccc tatcgctgtc
      721 gtgtccttct gctacctgcg catctgggtg ctggtgcttc aggcccgcag gaaagccaag
      781 ccagagagca ggctgtgcct gaagcccagc gacttgcgga gctttctaac catgtttgtg
      841 gtgtttgtga tctttgccat ctgctgggct ccacttaact gcatcggcct cgctgtggcc
      901 atcaaccccc aagaaatggc tccccagatc cctgaggggc tatttgtcac tagctactta
      961 ctggcttatt tcaacagctg cctgaatgcc attgtctatg ggctcttgaa ccaaaacttc
     1021 cgcagggaat acaagaggat cctcttggcc ctttggaacc cacggcactg cattcaagat
     1081 gcttccaagg gcagccacgc ggaggggctg cagagcccag ctccacccat cattggtgtg
     1141 cagcaccagg cagatgctct ctagcctgga tctgaggcac accagcagca tgacaaactc
     1201 atgaaatggt gggagagagt ctgctgcaag ggtgagacca ggcagcctgc tgggccacac
     1261 tgtcctgttg gcatcacagc cccaaggctg ggggaacttc atgctgggac aagcagccca
     1321 tcaacgccat gggttcaggc tgatccagga gatgctcaca ggccacagga cctggaaaac
     1381 actcttggtg gtgtcttggg gatttggtgc acacaagacc aaggaaagga cagaatgagg
     1441 aaaggcctgg ggcagaagag cccaactcct tctcatagct gaccctcatc ctcctgcctt
     1501 ggcctcctgg ctgctttctc cccttccccc cagcgtggca ggatctcttc ctgttagcaa
     1561 ggatgaaaga gagaggtcag taggactgga acttggtaac tgcaagggcc tcaggtgggg
     1621 caggtgcaga gggc
//
