LOCUS       NM_005958               1289 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens melatonin receptor 1A (MTNR1A), mRNA.
ACCESSION   NM_005958
VERSION     NM_005958.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Bisikirska,B., Labella,R., Cuesta-Dominguez,A., Luo,N., De
            Angelis,J., Mosialou,I., Lin,C.S., Beck,D., Lata,S., Shyu,P.T.,
            McMahon,D.J., Guo,E., Hagen,J., Chung,W.K., Shane,E., Cohen,A. and
            Kousteni,S.
  TITLE     Melatonin receptor 1A variants as genetic cause of idiopathic
            osteoporosis
  JOURNAL   Sci Transl Med 16 (769), eadj0085 (2024)
   PUBMED   39413162
  REMARK    GeneRIF: Melatonin receptor 1A variants as genetic cause of
            idiopathic osteoporosis.
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Daher,G., Santos-Bezerra,D.P., Cavaleiro,A.M., Pelaes,T.S.,
            Admoni,S.N., Perez,R.V., Machado,C.G., do Amaral,F.G.,
            Cipolla-Neto,J. and Correa-Giannella,M.L.
  TITLE     Rs4862705 in the melatonin receptor 1A gene is associated with
            renal function decline in type 1 diabetes individuals
  JOURNAL   Front Endocrinol (Lausanne) 15, 1331012 (2024)
   PUBMED   38549765
  REMARK    GeneRIF: Rs4862705 in the melatonin receptor 1A gene is associated
            with renal function decline in type 1 diabetes individuals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Li,Q., Zhang,S., Wang,H., Wang,Z., Zhang,X., Wang,Y. and Yuan,J.
  TITLE     Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B
            genes polymorphisms and their interactions with type 2 diabetes
            among steelworkers: a case-control study
  JOURNAL   BMC Genomics 24 (1), 232 (2023)
   PUBMED   37138267
  REMARK    GeneRIF: Association of rotating night shift work, CLOCK, MTNR1A,
            MTNR1B genes polymorphisms and their interactions with type 2
            diabetes among steelworkers: a case-control study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Amin,M. and Gragnoli,C.
  TITLE     Melatonin receptor 1A (MTNR1A) gene linkage and association to type
            2 diabetes in Italian families
  JOURNAL   Eur Rev Med Pharmacol Sci 27 (10), 4688-4692 (2023)
   PUBMED   37259752
  REMARK    GeneRIF: Melatonin receptor 1A (MTNR1A) gene linkage and
            association to type 2 diabetes in Italian families.
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   Kolomeichuk,S.N., Korneva,V.A., Kuznetsova,T.Y.,
            Korostovtseva,L.S., Bochkarev,M.V., Sviryaev,Y.V. and
            Blagonravov,M.L.
  TITLE     MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and
            Arterial Stiffness in Persons without Arterial Hypertension
  JOURNAL   Bull Exp Biol Med 174 (4), 460-463 (2023)
   PUBMED   36892670
  REMARK    GeneRIF: MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor
            and Arterial Stiffness in Persons without Arterial Hypertension.
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Witt-Enderby,P.A. and Dubocovich,M.L.
  TITLE     Characterization and regulation of the human ML1A melatonin
            receptor stably expressed in Chinese hamster ovary cells
  JOURNAL   Mol Pharmacol 50 (1), 166-174 (1996)
   PUBMED   8700109
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Slaugenhaupt,S.A., Roca,A.L., Liebert,C.B., Altherr,M.R.,
            Gusella,J.F. and Reppert,S.M.
  TITLE     Mapping of the gene for the Mel1a-melatonin receptor to human
            chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)
  JOURNAL   Genomics 27 (2), 355-357 (1995)
   PUBMED   7558006
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Reppert,S.M., Weaver,D.R. and Ebisawa,T.
  TITLE     Cloning and characterization of a mammalian melatonin receptor that
            mediates reproductive and circadian responses
  JOURNAL   Neuron 13 (5), 1177-1185 (1994)
   PUBMED   7946354
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Khan,A.U. and Olson,D.L.
  TITLE     Physical therapy and exercise-induced bronchospasm
  JOURNAL   Phys Ther 55 (8), 878-881 (1975)
   PUBMED   1144527
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC126297.1 and BC074946.2.
            
            On Dec 11, 2015 this sequence version replaced NM_005958.3.
            
            Summary: This gene encodes one of two high affinity forms of a
            receptor for melatonin, the primary hormone secreted by the pineal
            gland. This receptor is a G-protein coupled, 7-transmembrane
            receptor that is responsible for melatonin effects on mammalian
            circadian rhythm and reproductive alterations affected by day
            length. The receptor is an integral membrane protein that is
            readily detectable and localized to two specific regions of the
            brain. The hypothalamic suprachiasmatic nucleus appears to be
            involved in circadian rhythm while the hypophysial pars tuberalis
            may be responsible for the reproductive effects of melatonin.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126297.1, SRR1660805.196710.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307161.5/ ENSP00000302811.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1284              BC126297.1         1-1284
            1285-1289           BC074946.2         1101-1105
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.2"
     gene            1..1289
                     /gene="MTNR1A"
                     /gene_synonym="MEL-1A-R; MT1"
                     /note="melatonin receptor 1A"
                     /db_xref="GeneID:4543"
                     /db_xref="HGNC:HGNC:7463"
                     /db_xref="MIM:600665"
     exon            1..386
                     /gene="MTNR1A"
                     /gene_synonym="MEL-1A-R; MT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1255
                     /gene="MTNR1A"
                     /gene_synonym="MEL-1A-R; MT1"
                     /note="mel1a receptor"
                     /codon_start=1
                     /product="melatonin receptor type 1A"
                     /protein_id="NP_005949.1"
                     /db_xref="CCDS:CCDS3848.1"
                     /db_xref="GeneID:4543"
                     /db_xref="HGNC:HGNC:7463"
                     /db_xref="MIM:600665"
                     /translation="MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILG
                     NLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQV
                     SGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVL
                     PNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVR
                     QRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWL
                     FVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWK
                     PSPLMTNNNVVKVDSV"
     exon            387..1289
                     /gene="MTNR1A"
                     /gene_synonym="MEL-1A-R; MT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaatccaa gcgggctcgc ggcggacacc aggtgtcacc tggccgtggc gtccggcgcg
       61 gcgtgggcgt ccgggggcgc ggcgtggagg agcgcgcggg atggggcgtg ggcgcgggga
      121 gcgccgggcg gagccttaac aagtggtcgg gcgggcggac gaggcgggcg atggccccgc
      181 ggccgggacg cgcacaggga ccatgcaggg caacggcagc gcgctgccca acgcctccca
      241 gcccgtgctc cgcggggacg gcgcgcggcc ctcgtggctg gcgtccgccc tggcctgcgt
      301 cctcatcttc accatcgtgg tggacatcct gggcaacctc ctggtcatcc tgtcggtgta
      361 tcggaacaag aagctcagga acgcaggaaa catctttgtg gtgagcttag cggtggcaga
      421 cctggtggtg gccatttatc cgtacccgtt ggtgctgatg tcgatattta acaacgggtg
      481 gaacctgggc tatctgcact gccaagtcag tgggttcctg atgggcctga gcgtcatcgg
      541 ctccatattc aacatcaccg gcatcgccat caaccgctac tgctacatct gccacagtct
      601 caagtacgac aaactgtaca gcagcaagaa ctccctctgc tacgtgctcc tcatatggct
      661 cctgacgctg gcggccgtcc tgcccaacct ccgtgcaggg actctccagt acgacccgag
      721 gatctactcg tgcaccttcg cccagtccgt cagctccgcc tacaccatcg ccgtggtggt
      781 tttccacttc ctcgtcccca tgatcatagt catcttctgt tacctgagaa tatggatcct
      841 ggttctccag gtcagacaga gggtgaaacc tgaccgcaaa cccaaactga aaccacagga
      901 cttcaggaat tttgtcacca tgtttgtggt ttttgtcctt tttgccattt gctgggctcc
      961 tctgaacttc attggcctgg ccgtggcctc tgaccccgcc agcatggtgc ctaggatccc
     1021 agagtggctg tttgtggcca gttactacat ggcgtatttc aacagctgcc tcaatgccat
     1081 tatatacggg ctactgaacc aaaatttcag gaaggaatac aggagaatta tagtctcgct
     1141 ctgtacagcc agggtgttct ttgtggacag ctctaacgac gtggccgata gggttaaatg
     1201 gaaaccgtct ccactgatga ccaacaataa tgtagtaaag gtggactccg tttaaaaaag
     1261 caccacgttc cgggtgagat ggacacgct
//
