LOCUS       NM_001351264            3618 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial nucleoid associated protein 1 (MTNAP1),
            transcript variant 7, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001351264 XM_005257487
VERSION     NM_001351264.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3618)
  AUTHORS   Wu,H., Zhang,W., Xu,F., Peng,K., Liu,X., Ding,W., Ma,Q., Cheng,H.
            and Wang,X.
  TITLE     C17orf80 binds the mitochondrial genome to promote its replication
  JOURNAL   J Cell Biol 222 (10) (2023)
   PUBMED   37676315
  REMARK    GeneRIF: C17orf80 binds the mitochondrial genome to promote its
            replication.
REFERENCE   2  (bases 1 to 3618)
  AUTHORS   Potter,A., Hangas,A., Goffart,S., Huynen,M.A., Cabrera-Orefice,A.
            and Spelbrink,J.N.
  TITLE     Uncharacterized protein C17orf80 - a novel interactor of human
            mitochondrial nucleoids
  JOURNAL   J Cell Sci 136 (15) (2023)
   PUBMED   37401363
  REMARK    GeneRIF: Uncharacterized protein C17orf80 - a novel interactor of
            human mitochondrial nucleoids.
REFERENCE   3  (bases 1 to 3618)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 3618)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 3618)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   6  (bases 1 to 3618)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC097641.6 and AC087301.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001351264.1.
            
            Transcript Variant: This variant (7) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 7 encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.172481.1,
                                           SRR1803613.148801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000535032.7/
                                                  ENSP00000440551.2
            RefSeq Select criteria             :: based on manual assertion,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC097641.6         4739-4795           c
            58-163              AC097641.6         3903-4008           c
            164-1683            AC097641.6         233-1752            c
            1684-1791           AC087301.8         207008-207115       c
            1792-1899           AC087301.8         206356-206463       c
            1900-3618           AC087301.8         200400-202118       c
FEATURES             Location/Qualifiers
     source          1..3618
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3618
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /note="mitochondrial nucleoid associated protein 1"
                     /db_xref="GeneID:55028"
                     /db_xref="HGNC:HGNC:29601"
                     /db_xref="MIM:620717"
     exon            1..57
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            58..163
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            164..1683
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2000
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /note="isoform a is encoded by transcript variant 7; lung
                     cancer-related protein 8; human lung cancer oncogene 8
                     protein; cell migration-inducing gene 3 protein;
                     sperm-expressed protein 1; uncharacterized protein
                     C17orf80"
                     /codon_start=1
                     /product="mitochondrial nucleoid-associated protein 1
                     isoform a"
                     /protein_id="NP_001338193.2"
                     /db_xref="CCDS:CCDS11694.1"
                     /db_xref="GeneID:55028"
                     /db_xref="HGNC:HGNC:29601"
                     /db_xref="MIM:620717"
                     /translation="MSDNPPRMEVCPYCKKPFKRLKSHLPYCKMIGPTIPTDQKVYQS
                     KPATLPRAKKMKGPIKDLIKAKGKELETENEERNSKLVVDKPEQTVKTFPLPAVGLER
                     AATTKADKDIKNPIQPSFKMLKNTKPMTTFQEETKAQFYASEKTSPKRELAKDLPKSG
                     ESRCNPSEAGASLLVGSIEPSLSNQDRKYSSTLPNDVQTTSGDLKLDKIDPQRQELLV
                     KLLDVPTGDCHISPKNVSDGVKRVRTLLSNERDSKGRDHLSGVPTDVTVTETPEKNTE
                     SLILSLKMSSLGKIQVMEKQEKGLTLGVETCGSKGNAEKSMSATEKQERTVMSHGCEN
                     FNTRDSVTGKESQGERPHLSLFIPRETTYQFHSVSQSSSQSLASLATTFLQEKKAEAQ
                     NHHCVPDVKALMESPEGQLSLEPKSDSQFQASHTGCQSPLCSAQRHTPQSPFTNHAAA
                     AGRKTLRSCMGLEWFPELYPGYLGLGVLPGKPQCWNAMTQKPQLISPQGERLSQVSLL
                     ERSSTHIRSLEPPAGLTTSNFSLMRLLGAVQKGWIRCNTTIRKSGFGGITMLFTGYFV
                     LCCSWSFRRLKKLCRPLPWKSTVPPCIGVAKTTGDCRSKTCLD"
     exon            1684..1791
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1899
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..3618
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3516..3521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /note="hexamer: AATAAA"
     polyA_site      3539
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /note="major polyA site"
     regulatory      3592..3597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
                     /note="hexamer: AATAAA"
     polyA_site      3618
                     /gene="MTNAP1"
                     /gene_synonym="C17orf80; HLC-8; MIG3; SPEP1"
ORIGIN      
        1 gagaaaggac ctcccctggg gtggcagaag cgctcgcctg ttcacagcca acggagggct
       61 gacattcacg tttcattctg ccacactcgg gaacggtgat cggggaagca tggggatccg
      121 ggagaagcac ccacaaaact agcatcctcc tggaggagct cgggaatagg atgagtgata
      181 atccacccag aatggaagtg tgtccttact gtaagaagcc atttaaacga ttaaaatccc
      241 acttgccata ctgtaagatg ataggaccaa ccatacctac tgatcaaaaa gtttatcagt
      301 ccaagccagc tacactccca cgtgctaaaa agatgaaagg accaatcaaa gatttaatta
      361 aagctaaagg gaaagagtta gagacagaga atgaagaaag aaattctaag ttggtggtgg
      421 acaaaccaga acagacagtg aagacctttc cactgccagc tgttggtttg gaaagagcag
      481 ctactacaaa ggcagataaa gacatcaaga atccaatcca accatccttc aaaatgttaa
      541 aaaatactaa accaatgact actttccaag aagaaaccaa ggctcagttt tacgcatcag
      601 agaaaacctc tcctaaaaga gaacttgcca aagatttgcc taaatcagga gaaagtcgat
      661 gtaatccttc agaagctgga gcgtctttac tggttggctc aatagaacct tctttgtcaa
      721 atcaagatag aaaatattcc tcaactctac ctaatgatgt acaaactacc tctggtgatc
      781 tcaaattgga caaaattgat ccccaaagac aggaacttct agtaaaatta ctagatgtgc
      841 ctactggtga ttgtcatatt tctccaaaga atgtcagtga tggggttaaa agggtaagaa
      901 cattattaag caatgagaga gattccaaag gcagggatca cctctcagga gtccctactg
      961 atgttacagt tactgagact ccagaaaaga acacagaatc cctcatttta agccttaaaa
     1021 tgagctcatt aggtaaaatc caagtcatgg agaaacaaga gaaaggactt accctgggag
     1081 tagagacgtg tgggagcaaa ggaaatgcag agaaaagtat gtctgcaaca gaaaagcagg
     1141 aacggactgt catgagccat ggctgtgaga acttcaacac cagggattca gtcacaggaa
     1201 aggagtctca aggggaaaga ccacatttaa gtttgttcat tccgagggag acgacttacc
     1261 agtttcattc tgtatcgcag tcaagtagtc aaagtcttgc ctctctagct acaacatttc
     1321 ttcaagaaaa gaaagcagaa gcccagaatc atcattgtgt ccctgatgta aaggcattaa
     1381 tggagagtcc cgagggacag ttatctctgg agcccaaatc tgatagtcag ttccaagcat
     1441 cacacactgg gtgccagagc cctttatgtt cagcccagcg tcacactcct cagagcccct
     1501 tcaccaatca tgctgcagct gctggcagga agactcttcg cagctgcatg gggctggagt
     1561 ggtttccaga gctctatcct ggttaccttg gactaggggt gttgccaggg aagcctcagt
     1621 gttggaatgc aatgacccag aagccacaac ttatcagtcc ccagggggaa agactctcac
     1681 aagtttcttt gttggaacga agctcaactc atataaggag tttggaaccc cctgccggac
     1741 ttacaacctc caacttctct ctaatgaggc tcttgggagc tgtacaaaaa ggctggatca
     1801 ggtgcaacac caccataagg aagagtggat tcggtggcat cacgatgctc ttcacaggat
     1861 acttcgtcct gtgttgtagc tggagtttca gacgtctgaa aaaattgtgc cgacccctgc
     1921 cctggaagag cacagtacct ccatgcattg gtgtggcgaa gacgactggg gattgccgct
     1981 ctaaaacatg tttggattag gaagcacgtt taagtaggag aagccttcgt gacttctctc
     2041 tagtgccttc gtgccctgtg ttgcccactg aattgccctg taacacctaa gtgtagtggt
     2101 agcattaagg gatagctttt cagccctcaa ggttatcagg agcatttgta tcactgctat
     2161 aaataaagta gtatcacttg tcataatcag ggtgctgaaa cataatgaaa aggtttaact
     2221 tagtcacagt aaatatttta tatccctgaa aataagttat ttaatgagaa tagaactatt
     2281 taatgatcca tgagtcctaa aaggatatct gccttgtatt gccaagttta aggcaaaggt
     2341 gagatcctgt attaataaga agacagcttt tttgtttgac attggtaagt accaagaatt
     2401 ctaactcaca tatagtagga aacaacaaaa agtctccact gacttctttg aattagatac
     2461 tgagaatcca caatacagta gtgtggataa ctttcaagaa gccattggaa acatctccac
     2521 attctgggat gacttgtaaa tgtctacaga gtaatggaag gaaaggcttc cttgtctgct
     2581 cattgctgcc acctgggttg ggaaaataat tgaagatgtt ttctcaagtc cttcaagaat
     2641 ctcttcttaa tgttcagaat agtttaagag cgttgttgag gtaaactgat agctgattat
     2701 tttctgagat ttagatctaa acaaactcag catgacgagg aagcacactt cacagctcca
     2761 gggtgcaata ctgatgtaaa gttgcctcgt gaggatacat ttttcgctca tgtatgcaaa
     2821 attcctatca gttcatttgc acagccagtt ccaatcatgt atgtgatcac cagattaaaa
     2881 gcttcatcca gaaagacaag actcctcaga acgaatagta gacaagtaag actgctaccc
     2941 acagaagcca gtacgcttca ggtgtgaggc ggggtaacta ctcatctctt cacagagcca
     3001 aggaaagaaa aagaacgtct ctaacatgat ttaccatttt aaacagcctt ataagttttg
     3061 tctcttaaaa tcatgctgca gaaggagggg gtaaaagtcg tgttctgccc tgtctgtggc
     3121 attggagtgc cccgctaggt aagaagcaac gcttagatct tgcttccagg cagcagcttg
     3181 aattcccgaa tcttcctgca aggtgcatac aaatgcagcg tgagaatcca tacacgtaat
     3241 ccatattcac cttcccatcc atcccgcaga agaggcatgg tgacacccag gctactgtcc
     3301 atgcttgaga ggacgtattt gaaggttctg ttactacaag ttgggaatat tcacggacat
     3361 gcctgaatac cccggctgta actcacacgt ggtctgtgta agtggattaa cctcggggcg
     3421 gccttgttta atcctgaata atatctgaaa gactgagttt acttgggaat gtgtagtttt
     3481 tctaatgcac attaaaattt attttagctg ttaaaaataa aatcatttta ttatcagcag
     3541 actcttttat actttatggg gcatctacat actacttccg ccactcttca taataaaatt
     3601 atttgtaaaa tataaaaa
//
