LOCUS       NM_004685               5117 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens myotubularin related protein 6 (MTMR6), transcript
            variant 1, mRNA.
ACCESSION   NM_004685
VERSION     NM_004685.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5117)
  AUTHORS   Parveen,S., Majumder,S., Bodhale,N., Biswal,N.R., Pandey,S.P.,
            Dutta,A., Patra,P., Bhattacharya-Majumdar,S., Pal,C., Majumdar,S.
            and Saha,B.
  TITLE     Myotubularin-related protein 6 is an ion channel-associated
            pro-leishmanial phosphatase
  JOURNAL   Int Immunopharmacol 129, 111644 (2024)
   PUBMED   38330797
  REMARK    GeneRIF: Myotubularin-related protein 6 is an ion
            channel-associated pro-leishmanial phosphatase.
REFERENCE   2  (bases 1 to 5117)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5117)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5117)
  AUTHORS   Wang,Y., Lei,X., Gao,C., Xue,Y., Li,X., Wang,H. and Feng,Y.
  TITLE     MiR-506-3p suppresses the proliferation of ovarian cancer cells by
            negatively regulating the expression of MTMR6
  JOURNAL   J Biosci 44 (6) (2019)
   PUBMED   31894107
  REMARK    GeneRIF: rescue experiments using MTMR6 overexpression further
            verified that MTMR6 was a functional target of miR-506-3p. Our data
            indicate that miR-506-3p might serve as a tumor suppressor gene and
            propose a new regulatory mechanism of MTMR6 by miR-506-3p in
            ovarian cancer .
REFERENCE   5  (bases 1 to 5117)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 5117)
  AUTHORS   Mochizuki,Y. and Majerus,P.W.
  TITLE     Characterization of myotubularin-related protein 7 and its binding
            partner, myotubularin-related protein 9
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 9768-9773 (2003)
   PUBMED   12890864
REFERENCE   7  (bases 1 to 5117)
  AUTHORS   Nandurkar,H.H., Layton,M., Laporte,J., Selan,C., Corcoran,L.,
            Caldwell,K.K., Mochizuki,Y., Majerus,P.W. and Mitchell,C.A.
  TITLE     Identification of myotubularin as the lipid phosphatase catalytic
            subunit associated with the 3-phosphatase adapter protein, 3-PAP
  JOURNAL   Proc Natl Acad Sci U S A 100 (15), 8660-8665 (2003)
   PUBMED   12847286
  REMARK    GeneRIF: Identification of myotubularin as the lipid phosphatase
            catalytic subunit associated with the 3-phosphatase adapter
            protein, 3-PAP.
REFERENCE   8  (bases 1 to 5117)
  AUTHORS   Schaletzky,J., Dove,S.K., Short,B., Lorenzo,O., Clague,M.J. and
            Barr,F.A.
  TITLE     Phosphatidylinositol-5-phosphate activation and conserved substrate
            specificity of the myotubularin phosphatidylinositol 3-phosphatases
  JOURNAL   Curr Biol 13 (6), 504-509 (2003)
   PUBMED   12646134
  REMARK    GeneRIF: investigation of MTM1 and MTMR6 and finding that they use
            PtdIns(3,5)P2 in addition to PtdIns3P as a substrate in vitro
REFERENCE   9  (bases 1 to 5117)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 5117)
  AUTHORS   Laporte,J., Blondeau,F., Buj-Bello,A., Tentler,D., Kretz,C.,
            Dahl,N. and Mandel,J.L.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590787.24.
            
            On Jul 13, 2020 this sequence version replaced NM_004685.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.8323.1, AL832017.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381801.6/ ENSP00000371221.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               AL590787.24        72499-72763         c
            266-382             AL590787.24        59346-59462         c
            383-545             AL590787.24        53054-53216         c
            546-703             AL590787.24        51404-51561         c
            704-832             AL590787.24        51094-51222         c
            833-967             AL590787.24        46943-47077         c
            968-1100            AL590787.24        43835-43967         c
            1101-1210           AL590787.24        43011-43120         c
            1211-1336           AL590787.24        42471-42596         c
            1337-1386           AL590787.24        39660-39709         c
            1387-1587           AL590787.24        39039-39239         c
            1588-1719           AL590787.24        37128-37259         c
            1720-1846           AL590787.24        36924-37050         c
            1847-5117           AL590787.24        31497-34767         c
FEATURES             Location/Qualifiers
     source          1..5117
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..5117
                     /gene="MTMR6"
                     /note="myotubularin related protein 6"
                     /db_xref="GeneID:9107"
                     /db_xref="HGNC:HGNC:7453"
                     /db_xref="MIM:603561"
     exon            1..265
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..2107
                     /gene="MTMR6"
                     /EC_number="3.1.3.95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR6"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR6 isoform 1"
                     /protein_id="NP_004676.3"
                     /db_xref="CCDS:CCDS9313.1"
                     /db_xref="GeneID:9107"
                     /db_xref="HGNC:HGNC:7453"
                     /db_xref="MIM:603561"
                     /translation="MEHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFIDSHQK
                     ETWILHHHIASVEKLALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQA
                     KYEDLYAFSYNPKQNDSERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYP
                     RELYVPRIASKPIIVGSSKFRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSARCLEDE
                     HLLQAISKANPVNRYMYVMDTRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHV
                     MRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLV
                     HCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKDWISFGHKFSERCGQLDGDPKE
                     VSPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKL
                     KEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHP
                     RQSVFNIIMNMNEQNKQLEKDIKDLESKIKQRKNKQTDGILTKELLHSVHPESPNLKT
                     SLCFKEQTLLPVNDALRTIEGSSPADNRYSEYAEEFSKSEPAVVSLEYGVARMTC"
     exon            266..382
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            383..545
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            546..703
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            704..832
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            833..967
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1100
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1210
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1336
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1386
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1587
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1719
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1846
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..5117
                     /gene="MTMR6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR6"
                     /note="hexamer: GATAAA"
     polyA_site      4107
                     /gene="MTMR6"
                     /note="major polyA site"
     regulatory      5093..5098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR6"
                     /note="hexamer: AATAAA"
     polyA_site      5117
                     /gene="MTMR6"
ORIGIN      
        1 acacacgctc tgtctgcctg ccccgagtcc cccgggaggc cgcggggttt ggggaagtgt
       61 ttctaggaga cggcgctcac cggctgcacc tgcgccgttg acgccaccgg ggccggcaga
      121 cagacccgcg gcgctggctg gtggagggag ttcccgcttg ctctctgtcg ctgtcaccgc
      181 cctgtttctg tagccgtatg gtacgcctgt gagaccggct gccggctgac gtctccttgc
      241 gatggagcat atccggacga ccaaggtcga acaagtaaaa ttacttgacc gattcagtac
      301 cagcaacaag tcattaacag gaacactgta tcttacggct acacatctat tatttatcga
      361 ctctcatcaa aaagaaacct ggatattaca ccaccatatt gcctcagtag agaaacttgc
      421 tttgactact tctggatgcc cccttgtgat acagtgcaag aacttcagaa ctgtgcattt
      481 cattgttccc agagaaagag attgccatga tatttacaac tctttgctac aactgtcaaa
      541 acaagcaaaa tatgaagatc tctatgcatt ttcttataat cccaaacaaa atgattcaga
      601 acgactacaa ggctggcagc tcattgatct cgctgaggaa tataagagga tgggagtgcc
      661 aaactcacac tggcagttgt ctgatgccaa ccgggactac aagatttgtg aaacttaccc
      721 cagagaactt tatgttcccc ggatagcaag caaaccaata attgttggta gttccaagtt
      781 ccggagcaag ggaagattcc cagttctttc ctactatcat caagataagg aggctgccat
      841 ttgtcgatgt agtcagccac tctctggatt cagtgccagg tgcctggagg atgaacattt
      901 gcttcaagcc attagtaaag ccaatccagt caatcgctat atgtacgtca tggataccag
      961 gccaaaactg aatgcaatgg ccaacagagc agctggaaaa ggttatgaaa atgaagacaa
     1021 ctattccaat attagatttc agtttgttgg aattgaaaat attcatgtca tgaggtccag
     1081 ccttcagaaa ttattggaag tcaatggcac taaagggctt tctgtcaatg atttctactc
     1141 cggtttggag agctcgggat ggcttcgcca tatcaaagct gttatggatg ctgcaatctt
     1201 cttggccaaa gcaataacag ttgaaaatgc aagtgtgttg gtgcattgtt ccgatggttg
     1261 ggataggact tcccaggttt gttccctggg ttctctttta ttggattcct actacaggac
     1321 aatcaaagga ttcatggttt taatagaaaa ggattggatc tcttttggac ataaattttc
     1381 agagaggtgt ggccagttgg atggtgaccc aaaggaagtc tcaccagtgt ttactcagtt
     1441 cttggaatgt gtgtggcatt tgaccgaaca gtttccacaa gcctttgaat tcagtgaagc
     1501 atttcttctt cagatccatg agcatattca ttcatgccag tttggaaact tccttggaaa
     1561 ttgtcagaag gaaagagaag agctcaagtt gaaggagaag acttattccc tgtggccatt
     1621 tcttttggaa gaccaaaaga agtacttaaa tcctctctac agttccgaat ctcacagatt
     1681 tacagttttg gagccaaata cagtatcttt caattttaag ttttggagga acatgtacca
     1741 tcaatttgat cgaacactgc atcctaggca gtctgtattt aatataatta tgaatatgaa
     1801 tgagcaaaat aaacaattag agaaagatat taaagaccta gaatctaaaa ttaaacaacg
     1861 caaaaataag caaacagatg gcatcctcac caaggaattg ttacattcag ttcatcctga
     1921 atcacctaac ctcaaaactt ccctgtgttt taaagagcag actctgctac ccgtaaatga
     1981 tgctcttcga actatagagg gcagcagccc ggcagataat cgttatagtg aatatgcaga
     2041 agagttttct aaatcagaac ctgctgtggt cagcttagag tatggtgtgg caagaatgac
     2101 ttgttagact catagagttt tttctgcaat gattgcagta caagaaaagg attattgtga
     2161 ggatggtctg taagcataac caaaaggaat ttgtctaata acaattttag ggtttaacag
     2221 taggctaata gttgaaggaa ggataataac tacccttgtg agagaaataa gtcattttaa
     2281 ttgcatttcc agcaaggaat gacattcagt tctgtaagaa atgagtggta tttgatgtat
     2341 ttactcaaaa cacaatttgc actgtacact agtgaattga cgtttatgat ttatgttaat
     2401 tcagccaaac ataaataacc ttccttaagt acaatttaac ttcaagaaaa caaaatttga
     2461 caacatagtt tcttaataaa tgatatggca tgtactttca attatgtagc tttgtaacta
     2521 tgaatattta catattttgc cttttagtga tatttaatgt taaagtgcca tgaaaaatat
     2581 ttctaagaaa gccttaaatt cccagtggat tctttaccct taagttttac agcctacaac
     2641 aagatttttt gttttgtttt tcttctggtc agccttgttt tgtttgtaaa gaattgtgct
     2701 ctcattactg ctgggggtgc atgctacaat acttctatat aaacacttgt agaagtacac
     2761 tgttcacgtt tagcctgccc cacttttgta ttcaaaatta atgaaactga aggtttattc
     2821 tgatcataat ttgtttagtg ctacatttga taatttatta tttacagctt agaatattga
     2881 tttcttgaat acgtataagc acatttgact gtcttttata tatggattac tgcattccat
     2941 tgattcttat tttgtggttg gctttatttc tttcacaact gtgtaagttt aaagagctaa
     3001 agctctaaaa ctgttctgag aaacaatgaa tagtacatgt atatgtatat ttttaaactg
     3061 ccttattgct caatgagttg ctgttcctgg agtatctaac tttcagttta ctcaaaaact
     3121 tttgggtaaa taaaaaaggg aagtacagat agtttaggtt gtgcatggtt gcatgaattt
     3181 tgaagtcatt tctatgtgga gcattatttt tcttcttgtt aaatatagaa aaaaaaagag
     3241 attctagtac aaagttactg tttaacaaaa gcaacataaa ctctgggaaa gatttcattt
     3301 tgccatgtta tatttactgt ttattctgtg tactagtaca tatctttaaa ttaccaaaaa
     3361 acaagaaaca aaacataaaa accccaaaac tatcacttgg aattagcaat atcacccaac
     3421 tggctttaaa attgaaaatt taaataacat ggtggcatga agtacaattc gagtattagg
     3481 caatttgcat agtgttcctc atgctacttt ctgttacacc tctattatat tagttttgaa
     3541 tataaacatc tttttcagac caaaaaaaac tttattgtat gagagcttat cttatcctgt
     3601 ttatttttcc aatgcttttc tgtaatacat tatgtaattt aaaaaatatt cctttttaaa
     3661 cagcaacaga aatgcactat aaaatatagt atgtgattaa ccaatcctgc ttccatattt
     3721 aagcactggg aatggaaact taatctctgt gactacaaag ggaagttttt gtgccttggt
     3781 gttccagtca ctgattgtgg ttttagaatc ttctgtggct gacttcttgt attcaactct
     3841 ggtttattat cttaatcttc aacttcagac atatatttgt gtgtttatat gctcacaggt
     3901 ggactgagaa atcagttaca tcttaagtga cctacagggt atatgttggc aaaagcagac
     3961 tgtgtatatg tcttataaag ttgaatttat gttcagtgtg tttggaagtg tatagcatgt
     4021 aaattacttc atatatgatt taaaggtaat taaatgttca cattttactt tgaatgtttt
     4081 tcttctggat aaaacaaatg gaatcaagtt gtagttgttt tttttttctt ctcacctagg
     4141 caagtagact tgcccattac attaacataa cagcataagg tttgaggagt ttattttcca
     4201 aaagtttgtt gataaataat acctgtttca tacaaaaata atttccagaa tatttaaaat
     4261 aggtatagtg ggctaaaagg cccatcagat gtaggtaata atgtcattaa gttttcattt
     4321 tgttcctgtc acttgcttat attacaatca ctattttttt gtgcccttgc caacttgatg
     4381 gaaggcaggg tccattgagt acaaacattc gaggtgaaat gtctctccaa aggcagatct
     4441 ggatgtaaat atgaggaaga aaataactgg ctgacaagag gataatttta ttgagggtgt
     4501 tttgaaaagg tcagctaggc tagaagtagc tcagggaatc ttgagtaaag atgaagggaa
     4561 ctcttttaaa acaaattcaa tttatttggt cgggtagcag agcagggagg tggtgtcagt
     4621 caagcctgtt ttgaaacatt ttttgcagaa ggtcagcttt aaaatattga aaaatttcca
     4681 gttgacatgc taagttggat taaatgctga tcatttataa aactatatag ttgctgcaaa
     4741 agtaattggg gcttttgcca ttgaaagtga tgacaaaaac cgcaattact tttgcaccaa
     4801 cctaatacta cagttgcaga cttttattag tgacgctgat cttcattagt caagttttag
     4861 ttattttgtt ggcttttcca tgtagaattc caagtgacat taacatactt tgattaatta
     4921 aagaaaattt ggagactgtt taagatatat gtctagatat caatgtaaac tataagcttt
     4981 aggaacttac atctagaaga aagcctggaa tctagaataa ttatctcaaa aaaaagtata
     5041 tataccattg tacttgatat aagaaaatgt aaacatgaaa ccttgacatt ttaataaaca
     5101 gtatttgtgc tactcta
//
