LOCUS       NM_001378067            5987 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens myotubularin related protein 4 (MTMR4), transcript
            variant 3, mRNA.
ACCESSION   NM_001378067 XM_005257784
VERSION     NM_001378067.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5987)
  AUTHORS   Lee,Y.K., Sala,L., Mura,M., Rocchetti,M., Pedrazzini,M., Ran,X.,
            Mak,T.S.H., Crotti,L., Sham,P.C., Torre,E., Zaza,A., Schwartz,P.J.,
            Tse,H.F. and Gnecchi,M.
  TITLE     MTMR4 SNVs modulate ion channel degradation and clinical severity
            in congenital long QT syndrome: insights in the mechanism of action
            of protective modifier genes
  JOURNAL   Cardiovasc Res 117 (3), 767-779 (2021)
   PUBMED   32173736
  REMARK    GeneRIF: MTMR4 SNVs modulate ion channel degradation and clinical
            severity in congenital long QT syndrome: insights in the mechanism
            of action of protective modifier genes.
REFERENCE   2  (bases 1 to 5987)
  AUTHORS   Sheffield,D.A., Jepsen,M.R., Feeney,S.J., Bertucci,M.C.,
            Sriratana,A., Naughtin,M.J., Dyson,J.M., Coppel,R.L. and
            Mitchell,C.A.
  TITLE     The myotubularin MTMR4 regulates phagosomal phosphatidylinositol
            3-phosphate turnover and phagocytosis
  JOURNAL   J Biol Chem 294 (45), 16684-16697 (2019)
   PUBMED   31543504
REFERENCE   3  (bases 1 to 5987)
  AUTHORS   Pham,H.Q., Yoshioka,K., Mohri,H., Nakata,H., Aki,S., Ishimaru,K.,
            Takuwa,N. and Takuwa,Y.
  TITLE     MTMR4, a phosphoinositide-specific 3'-phosphatase, regulates TFEB
            activity and the endocytic and autophagic pathways
  JOURNAL   Genes Cells (2018) In press
   PUBMED   29962048
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 5987)
  AUTHORS   Teo,W.X., Kerr,M.C. and Teasdale,R.D.
  TITLE     MTMR4 Is Required for the Stability of the Salmonella-Containing
            Vacuole
  JOURNAL   Front Cell Infect Microbiol 6, 91 (2016)
   PUBMED   27625994
  REMARK    GeneRIF: Here the authors demonstrate that green fluorescent
            protein-tagged MTMR4 is recruited to the Salmonella-containing
            vacuole and infection of cells depleted of endogenous MTMR4 results
            in a decrease in viable intracellular Salmonella.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5987)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B.,
            Pelletier,L. and Gingras,A.C.
  TITLE     Myotubularin-related proteins 3 and 4 interact with polo-like
            kinase 1 and centrosomal protein of 55 kDa to ensure proper
            abscission
  JOURNAL   Mol Cell Proteomics 14 (4), 946-960 (2015)
   PUBMED   25659891
  REMARK    GeneRIF: myotubularin-related protein 3 and myotubularin-related
            protein 4 may act as a bridge between CEP55 and polo-like kinase 1,
            ensuring proper CEP55 phosphorylation and regulating CEP55
            recruitment to the midbody.
REFERENCE   6  (bases 1 to 5987)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   7  (bases 1 to 5987)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   8  (bases 1 to 5987)
  AUTHORS   Zhao,R., Qi,Y., Chen,J. and Zhao,Z.J.
  TITLE     FYVE-DSP2, a FYVE domain-containing dual specificity protein
            phosphatase that dephosphorylates phosphotidylinositol 3-phosphate
  JOURNAL   Exp Cell Res 265 (2), 329-338 (2001)
   PUBMED   11302699
REFERENCE   9  (bases 1 to 5987)
  AUTHORS   Avela,K., Lipsanen-Nyman,M., Idanheimo,N., Seemanova,E.,
            Rosengren,S., Makela,T.P., Perheentupa,J., Chapelle,A.D. and
            Lehesjoki,A.E.
  TITLE     Gene encoding a new RING-B-box-Coiled-coil protein is mutated in
            mulibrey nanism
  JOURNAL   Nat Genet 25 (3), 298-301 (2000)
   PUBMED   10888877
REFERENCE   10 (bases 1 to 5987)
  AUTHORS   Laporte,J., Blondeau,F., Buj-Bello,A., Tentler,D., Kretz,C.,
            Dahl,N. and Mandel,J.L.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
  REMARK    GeneRIF: MTMR4 belongs to the myotubularin family of
            phosphoinositides phosphatases
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005666.1.
            
            On Jan 27, 2020 this sequence version replaced XM_005257784.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.13342.1,
                                           SRR14038193.2414364.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682306.1/ ENSP00000507664.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-276               AC005666.1         92512-92787         c
            277-366             AC005666.1         91001-91090         c
            367-483             AC005666.1         90539-90655         c
            484-566             AC005666.1         89578-89660         c
            567-727             AC005666.1         86830-86990         c
            728-824             AC005666.1         86617-86713         c
            825-938             AC005666.1         86310-86423         c
            939-1135            AC005666.1         85272-85468         c
            1136-1264           AC005666.1         84892-85020         c
            1265-1376           AC005666.1         83621-83732         c
            1377-1572           AC005666.1         82928-83123         c
            1573-1758           AC005666.1         82452-82637         c
            1759-1929           AC005666.1         82199-82369         c
            1930-2084           AC005666.1         81893-82047         c
            2085-3483           AC005666.1         73081-74479         c
            3484-3594           AC005666.1         70991-71101         c
            3595-3683           AC005666.1         70660-70748         c
            3684-5987           AC005666.1         67686-69989         c
FEATURES             Location/Qualifiers
     source          1..5987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..5987
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /note="myotubularin related protein 4"
                     /db_xref="GeneID:9110"
                     /db_xref="HGNC:HGNC:7452"
                     /db_xref="MIM:603559"
     exon            1..276
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..3861
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /EC_number="3.1.3.95"
                     /note="isoform 3 is encoded by transcript variant 3; zinc
                     finger, FYVE domain containing 11;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase; zinc
                     finger FYVE domain-containing protein 11; FYVE
                     domain-containing dual specificity protein phosphatase 2;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR4 isoform 3"
                     /protein_id="NP_001364996.1"
                     /db_xref="CCDS:CCDS92367.1"
                     /db_xref="GeneID:9110"
                     /db_xref="HGNC:HGNC:7452"
                     /db_xref="MIM:603559"
                     /translation="MSLTARVSCSMLSCFGEEGPPSLEYIQAKDLFPPKELVKEEENL
                     QVPFTVLQGEGVEFLGRAADALIAISNYRLHIKFKDSVINVPLRMIDSVESRDMFQLH
                     ISCKDSKVVRCHFSTFKQCQEWLSRLSRATARPAKPEDLFAFAYHAWCLGLTEEDQHT
                     HLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKEL
                     ENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALD
                     PGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARSYTAAVAN
                     RAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKW
                     LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQ
                     VLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAF
                     LVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDM
                     VLHPVCHVRALHLWTAVYLPASSPCTLGEENMDLYLSPVAQSQEFSGRSLDRLPKTRS
                     MDDLLSACDTSSPLTRTSSDPNLNNHCQEVRVGLEPWHSNPEGSETSFVDSGVGGPQQ
                     TVGEVGLPPPLPSSQKDYLSNKPFKSHKSCSPSYKLLNTAVPREMKSNTSDPEIKVLE
                     ETKGPAPDPSAQDELGRTLDGIGEPPEHCPETEAVSALSKVISNKCDGVCNFPESSQN
                     SPTGTPQQAQPDSMLGVPSKCVLDHSLSTVCNPPSAACQTPLDPSTDFLNQDPSGSVA
                     SISHQEQLSSVPDLTHGEEDIGKRGNNRNGQLLENPRFGKMPLELVRKPISQSQISEF
                     SFLGSNWDSFQGMVTSFPSGEATPRRLLSYGCCSKRPNSKQMRATGPCFGGQWAQREG
                     VKSPVCSSHSNGHCTGPGGKNQMWLSSHPKQVSSTKPVPLNCPSPVPPLYLDDDGLPF
                     PTDVIQHRLRQIEAGYKQEVEQLRRQVRELQMRLDIRHCCAPPAEPPMDYEDDFTCLK
                     ESDGSDTEDFGSDHSEDCLSEASWEPVDKKETEVTRWVPDHMASHCYNCDCEFWLAKR
                     RHHCRNCGNVFCAGCCHLKLPIPDQQLYDPVLVCNSCYEHIQVSRARELMSQQLKKPI
                     ATASS"
     exon            277..366
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            367..483
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            484..566
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            567..727
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            728..824
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            825..938
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1135
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1264
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1376
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1572
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1758
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1929
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2084
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..3483
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3484..3594
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3683
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     exon            3684..5987
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5968..5973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /note="hexamer: AATAAA"
     polyA_site      5987
                     /gene="MTMR4"
                     /gene_synonym="FYVE-DSP2; ZFYVE11"
                     /note="major polyA site"
ORIGIN      
        1 cccctccctt ctgcactcgt gcgggagggc ggagctgggc ccgctccatt gtggagagga
       61 ggggagaggc gcgcgggagc cgcgcggagg cccggccacc agcgccctag cctcttggcc
      121 gccgcggctg cacctggcga gccccgcagc cgggatgcgg cgggcgcccg gggctggcgg
      181 gcagcgcagc ggctccgggg acatgtgcgc tggcccagac cgcccgcgac catgagcctg
      241 accgcccgcg tctcctgctc catgcttagc tgcttcggtg aggaggggcc ccccagcctg
      301 gagtacatcc aagccaagga tctgttcccc cccaaggaac tagtgaagga ggaagagaat
      361 cttcaggtcc ccttcacagt gctgcagggt gagggagtag agttcctggg ccgggcagcc
      421 gatgccctca ttgccatctc taactaccgg ctgcatatca aattcaagga ctctgtcatc
      481 aacgtccccc tccggatgat tgacagtgtg gagagccgtg atatgttcca gttgcacatt
      541 tcctgcaagg actccaaagt ggtgaggtgc cacttctcca cttttaagca gtgccaagag
      601 tggctctcac ggctaagccg agccacagca agacctgcca agcctgaaga cctctttgcc
      661 tttgcctacc atgcctggtg cctggggctg accgaggagg accagcacac tcacctatgt
      721 cagccaggtg agcacatacg ttgtcgacag gaggcggagc ttgcaaggat gggctttgac
      781 ctgcagaacg tctggagagt ctcacacatc aacagcaact acaaattgtg ccccagttac
      841 ccccagaagc tgctggttcc tgtgtggatc actgacaaag agctggagaa cgtggcttcc
      901 ttccgctcct ggaagcggat tcccgtggtt gtgtatagac acttgcgcaa tggggctgcc
      961 atcgcccgct gcagccagcc agagatcagc tggtggggct ggcgcaatgc tgatgatgag
     1021 tacctggtca cgtccattgc taaagcctgt gccctggacc cggggacaag ggccactggg
     1081 ggctccctca gcaccgggaa taatgatacc agcgaggcgt gtgatgctga ctttgattct
     1141 tctctgactg cgtgctctgg agtggagagc acagcagctc ctcaaaagct gctgatcctg
     1201 gatgcgcgat cctacacggc agcagtggcc aaccgggcca agggtggagg ctgtgaatgt
     1261 gaagagtact atcccaactg tgaggtcgtg ttcatgggaa tggccaacat ccatgccatc
     1321 cggaacagct ttcagtacct ccgggctgtg tgtagccaga tgccggatcc tagcaactgg
     1381 ttgtcggcac tggagagtac caaatggctg cagcacttgt cggtgatgct aaaagcagct
     1441 gtgctggtgg ctaatacagt agaccgggaa ggccggcctg tgctggtaca ctgctcagat
     1501 ggctgggacc gcacaccgca gatcgtagcc ctggccaaaa tattactgga cccatattac
     1561 aggacgttgg agggcttcca agtgttagtg gagtctgact ggctggattt tgggcacaag
     1621 tttggagatc gctgtggcca ccaagagaat gtggaggacc aaaacgaaca atgccctgtg
     1681 ttcctccagt ggcttgattc tgttcatcag ttgcttaagc agttcccctg cctgtttgaa
     1741 tttaatgaag cattcctggt aaaactggtg caacacacat actcctgcct ctacggcacc
     1801 ttcctggcca acaacccctg tgagcgagag aagcgcaaca tctacaagcg gacctgctct
     1861 gtgtgggcgc tccttcgagc tggcaataaa aactttcata acttcctcta cacacccagc
     1921 tcagacatgg tcctgcatcc tgtttgtcat gtccgggccc tgcacctctg gacagctgtt
     1981 tatctgccag catcatctcc atgcacactt ggggaagaaa acatggatct ttacctttcc
     2041 ccagtggccc agagccagga gttctctggc cgctctctgg acagattacc taaaaccaga
     2101 tccatggatg atcttctttc tgcctgtgac acaagcagcc ccctgactcg tacatccagt
     2161 gaccctaacc tgaataacca ctgtcaggag gtcagggtag gcctggagcc ctggcacagc
     2221 aatcctgagg gatcagagac aagctttgtg gactctgggg taggagggcc tcagcaaact
     2281 gtaggagaag tgggtcttcc tcctcctctg cccagcagcc agaaagacta cttgagcaat
     2341 aaacctttca agagtcacaa aagctgttct ccaagttaca aactgcttaa taccgcagtg
     2401 cctcgggaaa tgaagagcaa cacctctgat cctgagatca aagtcctaga agagactaag
     2461 ggaccagctc cagacccttc tgcccaggat gagctgggta ggactttaga tggcataggg
     2521 gagccacctg aacattgtcc tgaaacagaa gctgtcagtg cactctccaa ggtcatttct
     2581 aacaagtgtg atggagtttg taattttcct gagtcttccc agaactctcc tacaggtacg
     2641 ccccaacagg cccagccaga ctccatgcta ggtgtgccct ccaagtgtgt tcttgatcac
     2701 agcctcagca ccgtttgcaa cccaccgagt gctgcctgcc aaactcctct agacccaagc
     2761 actgacttcc tcaaccaaga tccctcaggg tctgtggcaa gtatctccca ccaggaacaa
     2821 ctgagttctg tgccggatct gacccatggg gaggaagaca ttggtaaaag aggaaataat
     2881 aggaatgggc agttattgga aaatcctcgc tttgggaaaa tgccattgga attggtccgg
     2941 aagccaattt ctcagagcca gatcagtgag ttctcttttc tagggtccaa ctgggacagc
     3001 ttccaaggga tggtgacttc attcccaagt ggggaggcca cccctcggcg gctgctttcc
     3061 tatggctgtt gtagcaagag gccaaacagt aagcagatgc gggccacagg gccctgcttt
     3121 gggggccagt gggctcagag agaaggtgtg aagtcacctg tctgttctag tcattccaat
     3181 ggacattgta ctggcccagg aggaaagaac cagatgtggt tgtccagtca tccaaagcaa
     3241 gtctctagca caaagcccgt tccactgaac tgcccttctc cagtgcctcc tctgtatttg
     3301 gatgatgatg gactcccctt tcccacggat gtgatccagc ataggttacg gcaaatcgaa
     3361 gcagggtaca aacaagaggt ggagcagcta cgtcgacagg tgcgtgagct tcagatgagg
     3421 ctggacatcc gtcactgctg tgcccctcca gcagagcccc ccatggacta tgaggatgat
     3481 tttacatgtt tgaaggagtc agatggcagt gatactgagg attttggctc tgatcacagt
     3541 gaagactgcc tttcagaagc aagctgggaa cctgttgata agaaagagac tgaggtgact
     3601 cgctgggttc cagaccatat ggcatcacac tgctataact gtgactgtga attctggttg
     3661 gccaaacgaa gacaccattg cagaaattgt gggaatgtat tttgtgctgg atgctgccac
     3721 ctgaagctgc ccattcctga tcagcaactc tatgacccag ttctcgtctg taactcatgt
     3781 tacgaacaca ttcaagtctc tcgtgccagg gaactcatga gccaacagct gaagaaaccc
     3841 attgctacag cttccagttg aatgccgggg agaaacctgt ccaattttag caggtttgaa
     3901 gggaggatct tcttcagttg tagtttggaa ggttccttgg tgtggctcat gaaatcacag
     3961 agctcagaga taccatcttg agaaatcctc cttggtatca tgaaactgga gcagaggaat
     4021 tgcaatttag caggaggtcc tctactggtg ataccctcac cttggggtaa tggtcctaac
     4081 ccagacccag ggtctggaag cttaatgttg agttggtgac tccagcctct ttctcctgga
     4141 ggtcacaaga tgatgattgc gtagatgttg cctggtgcaa agtgccccaa acagcaatag
     4201 aaaggcatat gtataaccaa actccaagtg ataaccagac ccatctctcc tccaccttga
     4261 caaaagcaga ttatagtata caaggtagga attcctgtcc tatttgagat gaactatatc
     4321 ctgtacctct gtgctctgtg tctgcatgaa ggctcagcct ttagaggcac tccttctagt
     4381 tgcattagta ctgtctttct gtggagtttg gtttgaagac tggctcagca agtggaggtt
     4441 tcaatgtatt tttcagttgg ctcatcagcc agcattggtg aatattcagt ttaggggaac
     4501 agttctaggg agtgagacat ttttgggagc agaggaaaac tctgctgatg ttcggtcctg
     4561 gcaaacattg agttattttg agctgtgaag gcagtcgtct ctgttacaca gtggcagctc
     4621 ttgagttatg cactgtgaag aatgagaagg gaaaagcaaa aattatcctt gtgaaatatc
     4681 tgctgattgt gccctactct ttgcacctga cttttcctag ttgtcctggt gctaacacag
     4741 gagctacacc ttgatcctct cctggcatga aaataaaaca aaggttttcg ttgttgttgt
     4801 tccattgccc atttccccca tgttgtcttt cccttggctg atgcctcctc tgggtcacat
     4861 tgcttcttat cctgaacact tgacaccttg agggtagaat ttagcgtttg gtttttacct
     4921 cctagcatat gctgtttggt atgtgagggt ttcagtacaa atgctgctgt ctatttctgt
     4981 gcacttaaca atggaaccca aacagaagag aataaagcct tgataccaaa attgggaaag
     5041 aacatgtgtc catttggacc aaacgttgtt ggtttttaaa aaattttatt ttgttttttt
     5101 gtttttgttt ttgttttttt tcatcttaat atgtaccagt ggcacttaac caaaagatac
     5161 agtgatatag ccatgtactg tgggtgggac agatacagtc tccttggcct ataatgaaac
     5221 cactaggact ttatacagtt ttccttaatt tgttgacata taaatggtaa attatattta
     5281 ggcttatcct gttttgaaat gatggtagtc atctttctta ctgctacttt catgttgctt
     5341 tctagaaaac agcatttcat tccaaaataa ctaggatctg catttagaac aagaatcatt
     5401 atttgtcctg accttttcag tcctacagag acgcatctgt ggttcttttg tacttgccat
     5461 agatgtaacc taaaaagttt tggcatattt aggtcagcct agcggaactt tttttttcat
     5521 ttaaatggag ctgaataatg gagattttgt gtctgcaaaa ttcctgagat cattgaaaaa
     5581 gtaacaagct gttccttgtt tctgatacat aaaattattt taagcatttt atcaatcatt
     5641 aaaatttact gccagttgtg agtggctttt taattaactt gtctttcatt gcacttcact
     5701 ctgcctgttt tcaaggggag taagattggt aacatttggg gagactgtat ctgtctactt
     5761 agcgtggctg ttttgaggga ctgtcccatc agtgaacaaa ctgcatggcc ttggagagag
     5821 actctgggct cttggctcag atgtgttcat caaatactcc tttcagagct gttgtgggtg
     5881 taagtgacat gatgtggcca aaaatccaaa ctgtgcagtt gcgttgtgac aaacatgcaa
     5941 tgtgctgtaa aaattcaata cagtttaaat aaaatctcta tattagt
//
