LOCUS       NM_021090               8987 bp    mRNA    linear   PRI 20-OCT-2024
DEFINITION  Homo sapiens myotubularin related protein 3 (MTMR3), transcript
            variant 3, mRNA.
ACCESSION   NM_021090
VERSION     NM_021090.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8987)
  AUTHORS   Elhelaly,M., Shaker,O.G., Ayeldeen,G., Elsergany,A.R. and
            Mostafa,N.
  TITLE     Breast cancer risk is associated with the HULC rs7763881, MTMR3
            rs12537 polymorphisms, and serum levels of HULC and MTMR3 in
            Egyptian patients
  JOURNAL   Mol Biol Rep 50 (12), 10073-10081 (2023)
   PUBMED   37910386
  REMARK    GeneRIF: Breast cancer risk is associated with the HULC rs7763881,
            MTMR3 rs12537 polymorphisms, and serum levels of HULC and MTMR3 in
            Egyptian patients.
REFERENCE   2  (bases 1 to 8987)
  AUTHORS   Wei,X., Feng,Y., Fu,Y., Liu,F., Chen,Q., Zhang,W., Zhao,Y.,
            Huang,X., Chen,Y., Li,Q. and Zhang,Q.
  TITLE     miR-100-5p is upregulated in multiple myeloma and involves in the
            pathogenesis of multiple myeloma through targeting MTMR3
  JOURNAL   Hematology 28 (1), 2196857 (2023)
   PUBMED   37014739
  REMARK    GeneRIF: miR-100-5p is upregulated in multiple myeloma and involves
            in the pathogenesis of multiple myeloma through targeting MTMR3.
REFERENCE   3  (bases 1 to 8987)
  AUTHORS   Wang,Y.N., Gan,T., Qu,S., Xu,L.L., Hu,Y., Liu,L.J., Shi,S.F.,
            Lv,J.C., Tsoi,L.C., Patrick,M.T., He,K., Berthier,C.C., Xu,H.J.,
            Zhou,X.J. and Zhang,H.
  TITLE     MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA
            immunity in IgA nephropathy
  JOURNAL   Kidney Int 104 (3), 562-576 (2023)
   PUBMED   37414396
  REMARK    GeneRIF: MTMR3 risk alleles enhance Toll Like Receptor 9-induced
            IgA immunity in IgA nephropathy.
REFERENCE   4  (bases 1 to 8987)
  AUTHORS   Sun,G., Li,Z., He,Z., Wang,W., Wang,S., Zhang,X., Cao,J., Xu,P.,
            Wang,H., Huang,X., Xia,Y., Lv,J., Xuan,Z., Jiang,T., Fang,L.,
            Yang,J., Zhang,D., Xu,H. and Xu,Z.
  TITLE     Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer
            by miR-99a-5p-mediated induction of MTMR3 expression
  JOURNAL   J Exp Clin Cancer Res 39 (1), 246 (2020)
   PUBMED   33198772
  REMARK    GeneRIF: Circular RNA MCTP2 inhibits cisplatin resistance in
            gastric cancer by miR-99a-5p-mediated induction of MTMR3
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8987)
  AUTHORS   Wang,B., Mao,J.H., Wang,B.Y., Wang,L.X., Wen,H.Y., Xu,L.J., Fu,J.X.
            and Yang,H.
  TITLE     Exosomal miR-1910-3p promotes proliferation, metastasis, and
            autophagy of breast cancer cells by targeting MTMR3 and activating
            the NF-kappaB signaling pathway
  JOURNAL   Cancer Lett 489, 87-99 (2020)
   PUBMED   32531321
  REMARK    GeneRIF: Exosomal miR-1910-3p promotes proliferation, metastasis,
            and autophagy of breast cancer cells by targeting MTMR3 and
            activating the NF-kappaB signaling pathway.
REFERENCE   6  (bases 1 to 8987)
  AUTHORS   Taylor,G.S., Maehama,T. and Dixon,J.E.
  TITLE     Myotubularin, a protein tyrosine phosphatase mutated in myotubular
            myopathy, dephosphorylates the lipid second messenger,
            phosphatidylinositol 3-phosphate
  JOURNAL   Proc Natl Acad Sci U S A 97 (16), 8910-8915 (2000)
   PUBMED   10900271
REFERENCE   7  (bases 1 to 8987)
  AUTHORS   Zhao,R., Qi,Y. and Zhao,Z.J.
  TITLE     FYVE-DSP1, a dual-specificity protein phosphatase containing an
            FYVE domain
  JOURNAL   Biochem Biophys Res Commun 270 (1), 222-229 (2000)
   PUBMED   10733931
REFERENCE   8  (bases 1 to 8987)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   9  (bases 1 to 8987)
  AUTHORS   Laporte,J., Blondeau,F., Buj-Bello,A., Tentler,D., Kretz,C.,
            Dahl,N. and Mandel,J.L.
  TITLE     Characterization of the myotubularin dual specificity phosphatase
            gene family from yeast to human
  JOURNAL   Hum Mol Genet 7 (11), 1703-1712 (1998)
   PUBMED   9736772
  REMARK    GeneRIF: MTMR3 belongs to the myotubularin family of
            phosphoinositides phosphatases
REFERENCE   10 (bases 1 to 8987)
  AUTHORS   Laporte,J., Hu,L.J., Kretz,C., Mandel,J.L., Kioschis,P., Coy,J.F.,
            Klauck,S.M., Poustka,A. and Dahl,N.
  TITLE     A gene mutated in X-linked myotubular myopathy defines a new
            putative tyrosine phosphatase family conserved in yeast
  JOURNAL   Nat Genet 13 (2), 175-182 (1996)
   PUBMED   8640223
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA126318.1, AB002369.1,
            AC003071.1 and BU733010.1.
            
            On Jun 2, 2019 this sequence version replaced NM_021090.3.
            
            Summary: This gene encodes a member of the myotubularin dual
            specificity protein phosphatase gene family. The encoded protein is
            structurally similar to myotubularin but in addition contains a
            FYVE domain and an N-terminal PH-GRAM domain. The protein can
            self-associate and also form heteromers with another myotubularin
            related protein. The protein binds to phosphoinositide lipids
            through the PH-GRAM domain, and can hydrolyze
            phosphatidylinositol(3)-phosphate and
            phosphatidylinositol(3,5)-biphosphate in vitro. The encoded protein
            has been observed to have a perinuclear, possibly membrane-bound,
            distribution in cells, but it has also been found free in the
            cytoplasm. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) is the longest transcript and
            encodes the longest isoform (c).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.190550.1, BC152455.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401950.7/ ENSP00000384651.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                DA126318.1         6-81
            77-5962             AB002369.1         1-5886
            5963-8595           AC003071.1         19891-22523
            8596-8987           BU733010.1         17-408              c
FEATURES             Location/Qualifiers
     source          1..8987
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..8987
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="myotubularin related protein 3"
                     /db_xref="GeneID:8897"
                     /db_xref="HGNC:HGNC:7451"
                     /db_xref="MIM:603558"
     exon            1..186
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            187..239
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            240..326
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..3920
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /EC_number="3.1.3.95"
                     /note="isoform c is encoded by transcript variant 3; zinc
                     finger, FYVE domain containing 10; FYVE (Fab1 YGLO23 Vsp27
                     EEA1 domain) dual-specificity protein phosphatase; zinc
                     finger FYVE domain-containing protein 10; FYVE
                     domain-containing dual specificity protein phosphatase 1;
                     phosphatidylinositol-3-phosphate phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase;
                     phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3"
                     /codon_start=1
                     /product="phosphatidylinositol-3,5-bisphosphate
                     3-phosphatase MTMR3 isoform c"
                     /protein_id="NP_066576.1"
                     /db_xref="CCDS:CCDS13870.1"
                     /db_xref="GeneID:8897"
                     /db_xref="HGNC:HGNC:7451"
                     /db_xref="MIM:603558"
                     /translation="MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEF
                     VGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFS
                     TFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSR
                     FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRI
                     PAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRN
                     TSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCE
                     CPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLL
                     KSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWL
                     DFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
                     YSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHV
                     RNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNT
                     VPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAA
                     GVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLH
                     QDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRI
                     EEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKS
                     VSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSP
                     CALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSR
                     QLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQR
                     LRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQN
                     CLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGN
                     VFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN"
     exon            327..416
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            417..533
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            534..616
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            617..783
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            784..880
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            881..994
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1200
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1332
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1444
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1640
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1826
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1997
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2143
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..3548
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3549..3659
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3660..3748
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     exon            3749..8987
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5953..5958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="hexamer: AATAAA"
     polyA_site      5978
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="major polyA site"
     regulatory      8601..8606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="hexamer: AATAAA"
     polyA_site      8627
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="major polyA site"
     regulatory      8964..8969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
                     /note="hexamer: AATAAA"
     polyA_site      8987
                     /gene="MTMR3"
                     /gene_synonym="FYVE-DSP1; ZFYVE10"
ORIGIN      
        1 gctctgtgtg gccgctgccg ccatgttgtt gtggttgtga gaaggcggcg gcggcggcgg
       61 agtagcagcc ggacgagacg tcccagcggc tcaggcgctg cccagcgccg gccctggcag
      121 ggagcctggt ggggtggcgg agggggagac tgtgccgtgg agggcctcgc catgtcctgc
      181 tgcccgactt ccttgtgaaa cctcctagta gaaaaagttc ttgggacaaa cttcatttga
      241 cttcaccata agggaaagaa gagagccttg ttggacactg aagaagggac ggggatttct
      301 cctcctaatc tgggcctctt gtcatggatg aagagactcg gcacagcctt gagtgcatcc
      361 aggccaatca gatctttccc aggaagcagc tgatccggga ggatgagaat cttcaggttc
      421 ctttccttga acttcatgga gagagcacag agtttgtggg ccgtgccgag gatgccatca
      481 ttgccctttc caattacaga cttcacatca agttcaagga gtctcttgtt aatgttccat
      541 tacagcttat agaaagtgtt gaatgccgag atatatttca gcttcatttg acttgcaaag
      601 actgcaaagt tatcaggtgt cagttttcaa cctttgagca gtgtcaagag tggctgaaga
      661 gactgaacaa cgcaatccga ccacctgcta aaatagaaga tctcttctca tttgcatacc
      721 atgcttggtg catggaggtc tatgccagtg aaaaagagca acatggagac ctgtgcagac
      781 caggggagca tgtaacttca aggtttaaaa acgaggtgga gaggatgggt tttgatatga
      841 acaacgcctg gaggatttcc aacatcaatg agaagtacaa attatgtggt agctatcctc
      901 aagagctcat agtgcctgcc tggatcactg acaaagaact ggaaagtgta tcaagtttca
      961 ggtcctggaa gcgcatccct gccgtcatct acaggcacca gagcaatgga gctgtcattg
     1021 cccgctgtgg acagccagag gttagctggt ggggctggcg aaatgcagat gatgagcatc
     1081 tggtacagtc agtagccaaa gcttgtgcct ctgactcccg atcgagtggc agcaagctgt
     1141 caactaggaa cacttctcga gactttccca atgggggaga cctttctgac gtggagttcg
     1201 attcttctct gtcaaatgct tcaggagcag agagtttagc catccaaccg cagaagcttt
     1261 tgatcttgga tgcacgctcc tatgcagctg ctgtggcaaa ccgagccaaa ggaggaggct
     1321 gcgaatgccc agagtattac ccaaactgtg aagttgtgtt tatggggatg gcaaacattc
     1381 attctattcg gaggagtttt cagtctctgc ggttgctgtg cactcagatg ccagatccgg
     1441 gaaattggct atcagctctt gaaagcacaa aatggctcca tcacttgtct gtgcttctga
     1501 aatcagcgct tctggtagtg catgctgtgg atcaggatca gcggccggtg ctagtacact
     1561 gctcagatgg ctgggaccgc accccccaga ttgtggcatt ggctaagctc ttgctggacc
     1621 cttattaccg aaccatagag ggtttccagg tcctcgtgga aatggagtgg ctggattttg
     1681 gccataaatt tgctgaccgg tgtggtcatg gggagaactc ggatgatctg aatgaacgtt
     1741 gcccagtgtt tctgcagtgg cttgactgtg ttcatcagct tcagaggcaa tttccttgct
     1801 cttttgagtt caatgaagca ttccttgtga aactggtgca gcatacctat tcctgcctgt
     1861 ttggaacatt cctgtgcaac aacgccaagg agagagggga aaagcatact caggaacgga
     1921 catgttccgt gtggtcactt cttcgggcag gcaacaaggc tttcaaaaac ctactgtatt
     1981 cctctcagtc agaagccgtg ctgtaccctg tgtgccatgt gcgtaacctg atgctgtgga
     2041 gtgcagtgta cctgccctgc ccatccccaa ccacccctgt ggacgacagc tgtgcaccat
     2101 acccagcccc aggcaccagc cctgatgatc cccccctgag ccggctacca aagactagat
     2161 catacgacaa tctgaccaca gcctgtgaca acacagtgcc tctggccagc cggcgctgca
     2221 gcgaccccag cctgaacgag aagtggcagg agcaccggcg ctcactagag ctgagcagcc
     2281 tggctggccc tggagaggat cccctttctg ccgacagcct agggaagccc accagagtgc
     2341 cggggggtgc cgagctttct gttgcagccg gagtagctga ggggcagatg gagaacatct
     2401 tgcaggaggc caccaaagag gagagtggag tagaggaacc tgcccacagg gcaggcattg
     2461 agatacagga gggtaaagag gaccctctct tagaaaagga gagcaggagg aagacacctg
     2521 aggcctcagc cattggactt caccaagacc cagaactggg tgatgctgct ctgaggagcc
     2581 atctggatat gagctggcct ctgttctcac agggcatttc tgaacagcag agtgggctca
     2641 gtgttctcct cagttctctc caggtccccc ccaggggaga ggattccctg gaggtccctg
     2701 tggagcagtt tcgaatagaa gagattgcag agggtaggga ggaagcagtt cttccaatcc
     2761 cagtagatgc aaaagttggc tatggtacct cacagtcatg ttctctgcta ccttcccaag
     2821 tcccttttga gaccagagga ccaaacgtgg acagttctac agacatgtta gtggaagata
     2881 aggtgaagtc agtaagtggg ccccaaggtc atcatagatc ttgccttgta aatagtggca
     2941 aggacaggct tcctcagacc atggaaccca gcccttcaga gacaagcctg gtcgagaggc
     3001 cccaagtggg gtctgtggtg cataggactt cccttggcag cactctcagc ctgacacgtt
     3061 ccccttgtgc cttgccttta gccgaatgta aagaggggct tgtgtgcaat ggtgccccag
     3121 agactgaaaa cagggcctca gagcagcccc caggtcttag caccctccag atgtacccca
     3181 cacccaatgg gcattgcgcc aatggggagg ctggtaggag caaggactca ctgagccgtc
     3241 agctgtctgc tatgagctgc agctctgccc acttacactc aaggaacttg caccacaagt
     3301 ggctgcatag ccactcagga aggccatctg caaccagcag ccccgaccag ccttcccgca
     3361 gccacctgga cgatgatggc atgtcagtgt acacagacac gatccaacag cgcctgcgtc
     3421 agattgagtc aggccaccag caggaagtag aaactttgaa gaaacaagtc caggagctga
     3481 agagtcgcct ggagagccag tacctgacca gctccctaca ctttaatgga gactttgggg
     3541 atgaggtgac ttcaatcccc gactcggaaa gcaatctgga tcagaactgt ttgtctcgct
     3601 gcagcacaga gattttctct gaagccagct gggagcaggt ggataaacag gacacagaga
     3661 tgacccgttg gcttcctgac cacctggccg cccactgcta tgcgtgcgac agtgccttct
     3721 ggcttgccag caggaagcac cactgcagga attgtgggaa cgtattctgc tccagttgtt
     3781 gtaaccagaa ggttccagtt cccagccagc agctctttga acccagtcga gtatgcaagt
     3841 cttgctatag cagcctacat cccacaagct ccagcattga ccttgaactg gataagccca
     3901 ttgctgccac ttccaactga agctcagtga cctgggtggg cagtggccaa gctgctgttc
     3961 ctatgacagg cccactcaac ctgggcagac cgagaggccc gtgcactttg gaatgggagc
     4021 gtggaaccac ctgtacagag tgacagattt gggatgcacc actggattgt agattgattt
     4081 ttctttcctg tccccctact ccctccctac cttttccatc ctcctcctct gccttcaaaa
     4141 aaggaaactt tcccttggtt gtcttaattt tttttttttt tgatggaaga ccaagggttg
     4201 ccaggcccac tgtaactgcc gagctgcctg ctgtcacgtg acactgaggg atggcttgtt
     4261 tcttccgggt gggaggatgg tggtcagagc caggagtatg gagatctgag accgtgagca
     4321 gggaagaaag ccagtgctaa catgcaacca ttcctcacgc caccgccaca tcagagctgg
     4381 ttgggaaccc tttgctgctg gggaggctgg aagcatattc cccaagagca ctgccctggg
     4441 catcatctcc ctcctgcgag gagctgagcc agtcccctca cagatggata aatgaggctg
     4501 atgtttggag ggagaggcac acggtaaatg gcatcccctt aggcgcctct ttgggaaagg
     4561 aaagtggatg ctcctttgag gcaggcgagg ggctgggagt gggtagccgt catgttgtcc
     4621 cccgtgggat cccattttta acttgaccca gattgtcttg ggctcctttt actttcaggg
     4681 ggctgctttc ctgggccagg ctgtgtagca cttcccaccc tcaggcatga gtacagactg
     4741 gtcaaaatgt ttatgcagtc aaggccaaag cctgccctga gcccagacac acctgggtcc
     4801 ccattctggg gcctggtccc ctaaacaatc tcttcctcag ccagcacagg gaaatccaga
     4861 ctcagggttc cagaaatccc ccgttcccaa accaaaccaa tcatggatct tccctttaag
     4921 gggtagaatc agcctttaga gttacaagcc cctggaaaag ggagcaggtc ccatacaatc
     4981 agcctttctc ctcttctctt cttgggacag gaataactgc tgagcagtcc ccctttgcca
     5041 ctcctggctg tctgagtggg cacttgtctg gctgctggcc agcagtgaag ggccacttgg
     5101 tgacttcgta gggttcctta gagaagtgac atggccttga ggagattcag ggcacctttc
     5161 ctcagtgagc tttgatatgg tccaaaaaca gccttaaatc aagaatattt gtggaggtag
     5221 gtgtggggaa ggttggagaa gagttaggtt tgtgctttgt aatcttggca tccatgtttt
     5281 gtgcctgccc tccctcttgg ggaggccatg cttgactctg ctgaaagctg ctaactggtg
     5341 acagggtgga tcatggtgag gactaggggt aaggtcaggg aatgcttaag ctctggccct
     5401 gccctgtatt cctcttcccc ttggtagcag ttccctgacc aagggcaagg tgtgtctcag
     5461 gaaggtggtt ctgtgcatgc ctgggtgtgg ttaaggcgtg gcccagaagg cttccctggt
     5521 gctctcagtc caggcaaagc ccagagcatc tgagcacgtc tctgacttcc agtggcaaca
     5581 cagtttgaac gtggtgaaac agggtgtagt tcttttccac attctgtgtc atctagtcgt
     5641 gcaggtaggg aaaaagttgg tctaattgaa gattgtgcat ttcctagtga caggtgccaa
     5701 gaggttatga tacgggtttc ttgggtctga tgtacagtgt gaataaatgc ttgcagctct
     5761 tagctctttt ttgatcgatg aagcactttt ttattaatat tttcctttgt taaaggagga
     5821 accgtaactc tccatagctg tacatataac ccttttctcc taaagaggag tcagtcagtg
     5881 ctcctatatt tttcattttt tgtcaaagca agaagtaaat actttagaat tgttaaatat
     5941 ataaataaag caaataaagt tgagtgttcc acatggtagc atttgctaac acttcctaat
     6001 tctttgccct gtggtttatc ccctcttcgt cccttttccc tctcacacag aagtgtttga
     6061 gggcctgctg ggaaactgac ctttggcaaa ggaaagctac agatagcctt ccgactctag
     6121 accttggcaa ggagcctcac catgatgttc aagcactgaa cgcatttcct cagtgatttt
     6181 gctcctaaaa tctcccaggc taaaagaggg caaagcagtc agggatctga cctggcagct
     6241 attcctcctt ctctgaagag ttcccatcag tagtcattac aactacctct cgcctcaagg
     6301 ctccattttt agctgctgct ctgatttcag ggcagccagt actctggccc cttcagtcgg
     6361 ggagtggaag gagatgtggg gtgggggtga gaaaatgctt ctgcctgttg ttcttgaagg
     6421 atagactatg ggtgggcaga gagaactggg ggcagaaatg gaattagatg tgattgggtt
     6481 atgcagtcaa ctagaggtct ccttcccgcc ctctctccac acagagagga acctctgctc
     6541 cttagctctt acagcaggac tgtggcatct agtcacttca atactagttc ttgctcttca
     6601 cagaggtaga tttttcttta ccctacagca ctgttgggca tccctcccat cacatgggtc
     6661 tgtgggtgag atatgttatg ctgttcctcc ctcgggaagg ttggtattga ggggtgcctt
     6721 gctccagagg cgccagccca gcatctgtgg tgagttggct aagatccaga gtgacctgct
     6781 cagagctccc cagaggcctt cactctttgg ggcagtctct ctagggtcac tttctgaatg
     6841 taccttctac ctaaagtata caaacacaaa gagccagctg agctggttct agtgtgaaag
     6901 ccgtaagtgc cacccagcag gcgtttgaaa acaagaaatc attcttctgt ggaaggagaa
     6961 tgtgccatct cagctaccct cagtccgcca ggcagcccag tctgtgtatt catatgaagt
     7021 tgtgaaaacc atgagtgtgt gccatggcca tcgtgtctac acacagccac tattgttcct
     7081 gtgggctagt ctccagcaaa ttaaaacact ggcatggcct aggaagggcg ttgcgagctc
     7141 ctaaatggaa agcttctctg ggggtaggga gatgaagagc caagatgctg gtgaagcagg
     7201 tgcagtgagg atccaaggca aggaattgcc ctgagggagg tggctgcata tggagaaagg
     7261 cagttctctg tgggcaaggc cagcttgctt caggctgtag agggaatttg gtctgaagca
     7321 acagggcatg aactgtgact ttgagctgcc aggttgtctt catctcagaa ctttcctatc
     7381 ctggcactct cgttaccttt cttctatacc ttggcctctg taactgcagt ccaaaacaag
     7441 ttacagctgc cttaatccac tgagattctc tatgaggatg tacagaaaag ttttcctgta
     7501 ataattttgc ttatatgcta actcttttca tgttagcaaa gaatattcta tgaattagaa
     7561 tgttactgtg gtagatctaa aggagaatga acagaaggtg ctggaggacc tgttaaacaa
     7621 tctctggcta ttaaaaaaca tcaagatgag aattaaaggc atatcctgat atacttgcct
     7681 gcttgcacat gaggctggga gatcccatgc ctgttgaagt taactctagc cctgacctct
     7741 attgatcttt tgggaatgag ggctgatttg aaggtgctgt tgcaggattt catttagctg
     7801 ctgccagttc aagtgacctg tccccagggc tgcagctgta tccacctgat tgcagtaggt
     7861 gagggctaac agcagaattt aaagtggacc ctgggctgtg gagcaaagtg actatccatt
     7921 tggacttttg gataatgtgg caggagtccc agctgtttaa tttctagtca cattttccag
     7981 aaagttgttc taagttgaga ttactgacaa gatttctcaa gggcaggacc agatatgtga
     8041 gagacttcta gttcagagct gacccctcta agcctctgac acttaaacac gagtcctgct
     8101 gtccccagca cacaactgca ctgaagcctt gttcctctcg gctggtgtag agctcatctg
     8161 catgttgtgt gcagatacca gtagcctccc tgcttgaaca ggcctctcct aggctaggca
     8221 ggtgttcaga ggcatgaagg tctgggcagg ggaagggcgt cttctgaaat gggagttacc
     8281 aggtttttaa atgctgctat tgttttattt accatttaag gtcttttcta ttatatctga
     8341 gtaactagtc agtttttctt acagtgctca tagcagttgt atttgaattg tattttcagt
     8401 gaaatttgtt ttacattgcc atttaaaatt ggcctttaac agcttcccaa ctagcttata
     8461 agattttttt ttttaatgaa aacataaccc atgaggctca gatgctgttg aagaaataaa
     8521 tggtatgttg ctgctgacag tagtgcttgc ctattgtaac agcattggtt ctgctgtagc
     8581 ctcggtgacc atttaagttg aataaatctg tcattttcac ccacaaacag ttgttgagcc
     8641 cctggatttg ggttgtcact gtggttctcc tgccagtgct ataatccagt gtcgtaggtg
     8701 cagggtatga atcagctcag cctcttagga gagaggggct ctcagcgagg agggggcggg
     8761 gggggggtca ctatttatct tccagaggca gggttcatgg attcctgatg tttagaggcg
     8821 gaagggacct taggtcacct acttccacgg ttttcatact gttctctggg gcctcgtgga
     8881 gagggagcct ccaggcccat tcaaagcttt attagattta aaagtaagat ctggtatgaa
     8941 gaaaggtttt gtttgtttct taaaataaaa agtctgaaaa tcactaa
//
