LOCUS       NM_001145862            2840 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens myotubularin related protein 11 (MTMR11), transcript
            variant 1, mRNA.
ACCESSION   NM_001145862
VERSION     NM_001145862.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2840)
  AUTHORS   Fernandez-Navarro,P., Gonzalez-Neira,A., Pita,G., Diaz-Uriarte,R.,
            Tais Moreno,L., Ederra,M., Pedraz-Pingarron,C.,
            Sanchez-Contador,C., Vazquez-Carrete,J.A., Moreo,P., Vidal,C.,
            Salas-Trejo,D., Stone,J., Southey,M.C., Hopper,J.L.,
            Perez-Gomez,B., Benitez,J. and Pollan,M.
  TITLE     Genome wide association study identifies a novel putative
            mammographic density locus at 1q12-q21
  JOURNAL   Int J Cancer 136 (10), 2427-2436 (2015)
   PUBMED   25353672
  REMARK    GeneRIF: Genome wide association study shows evidence of
            association between mammographic density and SNPs in high linkage
            disequilibrium with rs11205277, rs11205303 in gene MTMR11 and
            rs67807996 in gene OTUD7B.
REFERENCE   2  (bases 1 to 2840)
  AUTHORS   van der Valk,R.J., Kreiner-Moller,E., Kooijman,M.N., Guxens,M.,
            Stergiakouli,E., Saaf,A., Bradfield,J.P., Geller,F., Hayes,M.G.,
            Cousminer,D.L., Korner,A., Thiering,E., Curtin,J.A., Myhre,R.,
            Huikari,V., Joro,R., Kerkhof,M., Warrington,N.M., Pitkanen,N.,
            Ntalla,I., Horikoshi,M., Veijola,R., Freathy,R.M., Teo,Y.Y.,
            Barton,S.J., Evans,D.M., Kemp,J.P., St Pourcain,B., Ring,S.M.,
            Davey Smith,G., Bergstrom,A., Kull,I., Hakonarson,H., Mentch,F.D.,
            Bisgaard,H., Chawes,B., Stokholm,J., Waage,J., Eriksen,P.,
            Sevelsted,A., Melbye,M., van Duijn,C.M., Medina-Gomez,C.,
            Hofman,A., de Jongste,J.C., Taal,H.R., Uitterlinden,A.G.,
            Armstrong,L.L., Eriksson,J., Palotie,A., Bustamante,M.,
            Estivill,X., Gonzalez,J.R., Llop,S., Kiess,W., Mahajan,A.,
            Flexeder,C., Tiesler,C.M., Murray,C.S., Simpson,A., Magnus,P.,
            Sengpiel,V., Hartikainen,A.L., Keinanen-Kiukaanniemi,S., Lewin,A.,
            Da Silva Couto Alves,A., Blakemore,A.I., Buxton,J.L., Kaakinen,M.,
            Rodriguez,A., Sebert,S., Vaarasmaki,M., Lakka,T., Lindi,V.,
            Gehring,U., Postma,D.S., Ang,W., Newnham,J.P., Lyytikainen,L.P.,
            Pahkala,K., Raitakari,O.T., Panoutsopoulou,K., Zeggini,E.,
            Boomsma,D.I., Groen-Blokhuis,M., Ilonen,J., Franke,L.,
            Hirschhorn,J.N., Pers,T.H., Liang,L., Huang,J., Hocher,B., Knip,M.,
            Saw,S.M., Holloway,J.W., Melen,E., Grant,S.F., Feenstra,B.,
            Lowe,W.L., Widen,E., Sergeyev,E., Grallert,H., Custovic,A.,
            Jacobsson,B., Jarvelin,M.R., Atalay,M., Koppelman,G.H.,
            Pennell,C.E., Niinikoski,H., Dedoussis,G.V., Mccarthy,M.I.,
            Frayling,T.M., Sunyer,J., Timpson,N.J., Rivadeneira,F.,
            Bonnelykke,K. and Jaddoe,V.W.
  CONSRTM   Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium;
            Genetic Investigation of ANthropometric Traits (GIANT) Consortium;
            Early Growth Genetics (EGG) Consortium
  TITLE     A novel common variant in DCST2 is associated with length in early
            life and height in adulthood
  JOURNAL   Hum Mol Genet 24 (4), 1155-1168 (2015)
   PUBMED   25281659
REFERENCE   3  (bases 1 to 2840)
  AUTHORS   Berndt,S.I., Gustafsson,S., Magi,R., Ganna,A., Wheeler,E.,
            Feitosa,M.F., Justice,A.E., Monda,K.L., Croteau-Chonka,D.C.,
            Day,F.R., Esko,T., Fall,T., Ferreira,T., Gentilini,D.,
            Jackson,A.U., Luan,J., Randall,J.C., Vedantam,S., Willer,C.J.,
            Winkler,T.W., Wood,A.R., Workalemahu,T., Hu,Y.J., Lee,S.H.,
            Liang,L., Lin,D.Y., Min,J.L., Neale,B.M., Thorleifsson,G., Yang,J.,
            Albrecht,E., Amin,N., Bragg-Gresham,J.L., Cadby,G., den Heijer,M.,
            Eklund,N., Fischer,K., Goel,A., Hottenga,J.J., Huffman,J.E.,
            Jarick,I., Johansson,A., Johnson,T., Kanoni,S., Kleber,M.E.,
            Konig,I.R., Kristiansson,K., Kutalik,Z., Lamina,C., Lecoeur,C.,
            Li,G., Mangino,M., McArdle,W.L., Medina-Gomez,C.,
            Muller-Nurasyid,M., Ngwa,J.S., Nolte,I.M., Paternoster,L.,
            Pechlivanis,S., Perola,M., Peters,M.J., Preuss,M., Rose,L.M.,
            Shi,J., Shungin,D., Smith,A.V., Strawbridge,R.J., Surakka,I.,
            Teumer,A., Trip,M.D., Tyrer,J., Van Vliet-Ostaptchouk,J.V.,
            Vandenput,L., Waite,L.L., Zhao,J.H., Absher,D., Asselbergs,F.W.,
            Atalay,M., Attwood,A.P., Balmforth,A.J., Basart,H., Beilby,J.,
            Bonnycastle,L.L., Brambilla,P., Bruinenberg,M., Campbell,H.,
            Chasman,D.I., Chines,P.S., Collins,F.S., Connell,J.M.,
            Cookson,W.O., de Faire,U., de Vegt,F., Dei,M., Dimitriou,M.,
            Edkins,S., Estrada,K., Evans,D.M., Farrall,M., Ferrario,M.M.,
            Ferrieres,J., Franke,L., Frau,F., Gejman,P.V., Grallert,H.,
            Gronberg,H., Gudnason,V., Hall,A.S., Hall,P., Hartikainen,A.L.,
            Hayward,C., Heard-Costa,N.L., Heath,A.C., Hebebrand,J., Homuth,G.,
            Hu,F.B., Hunt,S.E., Hypponen,E., Iribarren,C., Jacobs,K.B.,
            Jansson,J.O., Jula,A., Kahonen,M., Kathiresan,S., Kee,F.,
            Khaw,K.T., Kivimaki,M., Koenig,W., Kraja,A.T., Kumari,M.,
            Kuulasmaa,K., Kuusisto,J., Laitinen,J.H., Lakka,T.A.,
            Langenberg,C., Launer,L.J., Lind,L., Lindstrom,J., Liu,J.,
            Liuzzi,A., Lokki,M.L., Lorentzon,M., Madden,P.A., Magnusson,P.K.,
            Manunta,P., Marek,D., Marz,W., Mateo Leach,I., McKnight,B.,
            Medland,S.E., Mihailov,E., Milani,L., Montgomery,G.W., Mooser,V.,
            Muhleisen,T.W., Munroe,P.B., Musk,A.W., Narisu,N., Navis,G.,
            Nicholson,G., Nohr,E.A., Ong,K.K., Oostra,B.A., Palmer,C.N.,
            Palotie,A., Peden,J.F., Pedersen,N., Peters,A., Polasek,O.,
            Pouta,A., Pramstaller,P.P., Prokopenko,I., Putter,C.,
            Radhakrishnan,A., Raitakari,O., Rendon,A., Rivadeneira,F.,
            Rudan,I., Saaristo,T.E., Sambrook,J.G., Sanders,A.R., Sanna,S.,
            Saramies,J., Schipf,S., Schreiber,S., Schunkert,H., Shin,S.Y.,
            Signorini,S., Sinisalo,J., Skrobek,B., Soranzo,N., Stancakova,A.,
            Stark,K., Stephens,J.C., Stirrups,K., Stolk,R.P., Stumvoll,M.,
            Swift,A.J., Theodoraki,E.V., Thorand,B., Tregouet,D.A., Tremoli,E.,
            Van der Klauw,M.M., van Meurs,J.B., Vermeulen,S.H., Viikari,J.,
            Virtamo,J., Vitart,V., Waeber,G., Wang,Z., Widen,E., Wild,S.H.,
            Willemsen,G., Winkelmann,B.R., Witteman,J.C., Wolffenbuttel,B.H.,
            Wong,A., Wright,A.F., Zillikens,M.C., Amouyel,P., Boehm,B.O.,
            Boerwinkle,E., Boomsma,D.I., Caulfield,M.J., Chanock,S.J.,
            Cupples,L.A., Cusi,D., Dedoussis,G.V., Erdmann,J., Eriksson,J.G.,
            Franks,P.W., Froguel,P., Gieger,C., Gyllensten,U., Hamsten,A.,
            Harris,T.B., Hengstenberg,C., Hicks,A.A., Hingorani,A., Hinney,A.,
            Hofman,A., Hovingh,K.G., Hveem,K., Illig,T., Jarvelin,M.R.,
            Jockel,K.H., Keinanen-Kiukaanniemi,S.M., Kiemeney,L.A., Kuh,D.,
            Laakso,M., Lehtimaki,T., Levinson,D.F., Martin,N.G., Metspalu,A.,
            Morris,A.D., Nieminen,M.S., Njolstad,I., Ohlsson,C.,
            Oldehinkel,A.J., Ouwehand,W.H., Palmer,L.J., Penninx,B., Power,C.,
            Province,M.A., Psaty,B.M., Qi,L., Rauramaa,R., Ridker,P.M.,
            Ripatti,S., Salomaa,V., Samani,N.J., Snieder,H., Sorensen,T.I.,
            Spector,T.D., Stefansson,K., Tonjes,A., Tuomilehto,J.,
            Uitterlinden,A.G., Uusitupa,M., van der Harst,P., Vollenweider,P.,
            Wallaschofski,H., Wareham,N.J., Watkins,H., Wichmann,H.E.,
            Wilson,J.F., Abecasis,G.R., Assimes,T.L., Barroso,I., Boehnke,M.,
            Borecki,I.B., Deloukas,P., Fox,C.S., Frayling,T., Groop,L.C.,
            Haritunian,T., Heid,I.M., Hunter,D., Kaplan,R.C., Karpe,F.,
            Moffatt,M.F., Mohlke,K.L., O'Connell,J.R., Pawitan,Y., Schadt,E.E.,
            Schlessinger,D., Steinthorsdottir,V., Strachan,D.P.,
            Thorsteinsdottir,U., van Duijn,C.M., Visscher,P.M., Di Blasio,A.M.,
            Hirschhorn,J.N., Lindgren,C.M., Morris,A.P., Meyre,D., Scherag,A.,
            McCarthy,M.I., Speliotes,E.K., North,K.E., Loos,R.J. and
            Ingelsson,E.
  TITLE     Genome-wide meta-analysis identifies 11 new loci for anthropometric
            traits and provides insights into genetic architecture
  JOURNAL   Nat Genet 45 (5), 501-512 (2013)
   PUBMED   23563607
REFERENCE   4  (bases 1 to 2840)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
REFERENCE   5  (bases 1 to 2840)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   6  (bases 1 to 2840)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   7  (bases 1 to 2840)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     PTEN and myotubularin phosphatases: from 3-phosphoinositide
            dephosphorylation to disease
  JOURNAL   Trends Cell Biol 12 (12), 579-585 (2002)
   PUBMED   12495846
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB474756.2, AK298775.1, BC100819.2 and BC064372.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001145862.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.280634.1, AK298775.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439741.4/ ENSP00000391668.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DB474756.2         24-35
            13-487              AK298775.1         1-475
            488-2396            BC100819.2         167-2075
            2397-2840           BC064372.1         2377-2820
FEATURES             Location/Qualifiers
     source          1..2840
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..2840
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /note="myotubularin related protein 11"
                     /db_xref="GeneID:10903"
                     /db_xref="HGNC:HGNC:24307"
     exon            1..298
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..2362
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /note="isoform a is encoded by transcript variant 1;
                     cisplatin resistance associated; hCRA; cisplatin
                     resistance-associated protein; inactive
                     phosphatidylinositol 3-phosphatase 11"
                     /codon_start=1
                     /product="myotubularin-related protein 11 isoform a"
                     /protein_id="NP_001139334.1"
                     /db_xref="CCDS:CCDS72902.1"
                     /db_xref="GeneID:10903"
                     /db_xref="HGNC:HGNC:24307"
                     /translation="MWWGGRGQSFNIAPQKEEPEMGSVQENRMPEPRSRQPSSCLASR
                     CLPGEQILAWAPGVRKGLEPELSGTLICTNFRVTFQPCGWQWNQDTPLNSEYDFALVN
                     IGRLEAVSGLSRVQLLRPGSLHKFIPEEILIHGRDFRLLRVGFEAGGLEPQAFQVTMA
                     IVQARAQSNQAQQYSGITLSKAGQGSGSRKPPIPLMETAEDWETERKKQAARGWRVST
                     VNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLLRCGGFY
                     TASDPNKEDIRAVELMLQAGHSDVVLVDTMDELPSLADVQLAHLRLRALCLPDSSVAE
                     DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLL
                     SAPEARTLFGFQSLVQREWVAAGHPFLTRLGGTGASEEAPVFLLFLDCVWQLLQQFPA
                     DFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGKQSGQLNSYTQVYTPGYSQPPAGNS
                     FNLQLSVWDWDLRYSNAQILQFQNPGYDPEHCPDSWLPRPQPSFMVPGPPSSVWLFSR
                     GALTPLNQLCPWRDSPSLLAVSSRWLPRPAISSESLADQEWGLPSHWGACPLPPGLLL
                     PGYLGPQIRLWRRCYLRGRPEVQMGLSAPTISGLQDELSHLQELLRKWTPRISPEDHS
                     KKRDPHTILNPTEIAGILKGRAEGDLG"
     exon            299..374
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            375..496
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            497..557
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            558..700
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            701..779
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            780..915
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1003
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1092
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1217
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1284
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1355
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1522
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1696
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1879
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2173
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2840
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /note="hexamer: ATTAAA"
     polyA_site      2840
                     /gene="MTMR11"
                     /gene_synonym="CRA"
                     /note="major polyA site"
ORIGIN      
        1 agagtcgact gaagtttccg aggagacttc tcaggctggg ctggacacac ctttccaagg
       61 acccccaaac tctgctccgt gcacgtcaaa tgctcctttc ccttgtgtcc aaccccctac
      121 ccctctccct aacacccctc ttctcaacaa gactcagcct ctccccgagg tgggtgagca
      181 tccttgaggt ttcccaccct taactgctgt gtccccggat ggagccagag aaatgtggtg
      241 ggggggccgg ggccagagtt tcaacattgc cccccagaag gaggagccag agatggggtc
      301 tgtccaggaa aataggatgc cggagcccag gagtcgtcag cctagcagtt gcctggcctc
      361 cagatgcctc ccaggggagc agatcctagc atgggcccca ggggtgagga agggcctgga
      421 accagaattg tctggaaccc tgatctgtac caactttagg gtcaccttcc agccctgtgg
      481 atggcagtgg aatcaggaca ctcccttgaa cagtgaatac gattttgccc tggtcaacat
      541 tggacgatta gaggctgtga gcggcttgtc ccgagtccag ctcctccgtc cagggtccct
      601 gcataaattt atccctgagg agattctgat tcatggccga gacttccggc tgctcagagt
      661 tggttttgag gctggaggcc tagagcctca ggcttttcag gtgaccatgg ccattgtcca
      721 agccagagct cagagcaatc aagcccaaca gtattcgggg ataaccctga gcaaggctgg
      781 ccagggttct ggctccagaa aaccaccaat tcctctcatg gagacagcgg aagactggga
      841 gactgagcgg aagaagcagg cagccagagg ctggagggtc agcacggtca acgagaggtt
      901 cgacgtagcc accagcctcc cccgttactt ctgggtccct aaccgaattc tggacagtga
      961 ggtcaggaga gcatttggcc actttcatca gggccgtgga ccgcgcttgt cctggcatca
     1021 ccctgggggc agtgatcttc tccgctgtgg aggcttctat acagccagtg accctaacaa
     1081 ggaggatatc agagcagtgg agttgatgct ccaggctggg cattcagatg ttgtcctggt
     1141 agacactatg gatgagctgc ccagccttgc agatgtccaa cttgcccacc tgaggctgag
     1201 ggccctctgc ctgcctgatt catctgtagc tgaggataaa tggctttcag ccctggaagg
     1261 aacacgatgg ctggactatg tcagggcttg tcttcgaaag gccagtgaca tttcagtatt
     1321 agtgacatcc agggttcgtt ctgtaatact tcaagagcgc ggtgatcgtg atctcaatgg
     1381 cctcctctct tcactcgtcc agctgctttc agcccccgaa gcccgaacac tgtttggctt
     1441 ccaatcacta gtacagcgag agtgggtggc agctggacat cccttcctga ctcggcttgg
     1501 gggaactggg gccagtgaag aggctccggt gtttctcctc ttccttgatt gtgtctggca
     1561 gctcctccag cagtttccag ctgattttga attctctgag tttttccttc ttgctcttca
     1621 tgacagtgtc agggttcctg acacccttac cttcctgaga aataccccct gggagcgcgg
     1681 aaagcagagc ggacagttaa actcctatac acaagtctac accccaggat actcccagcc
     1741 tccagctggg aactctttta acctgcagct gtctgtctgg gactgggatt tacgttatag
     1801 caatgcacag atactacaat tccagaatcc tggctatgac ccagaacact gtccagattc
     1861 ctggctccct agaccacagc caagcttcat ggttcctgga ccccccagtt ctgtgtggct
     1921 cttctctaga ggagcattga cccccctgaa tcagctctgt ccttggcggg acagtccttc
     1981 cctgctggca gtctcttctc gttggctccc tcgacctgct atctcctctg aaagcctggc
     2041 tgaccaggaa tggggtctcc cctcacattg gggagcttgc cctttacctc cagggctgct
     2101 gctgcctggg tatctgggac cccagatcag gctctggaga cgctgctacc tgaggggaag
     2161 gcctgaggtc cagatgggcc tctcagctcc cacaatctct ggcctccagg atgagctatc
     2221 ccatcttcag gagttattac ggaaatggac accaagaata tctcctgagg atcactccaa
     2281 gaaaagagat ccacatacca ttctcaatcc cactgaaatt gctggcattc tcaaaggcag
     2341 ggcagagggg gatctggggt agaggagggt tctgtctaat cttttttttt tttttttgta
     2401 tctgcacttg cagcctcagc tttcacactt cagcccttaa gttcactaag aaggtctgag
     2461 tttctgctgc agatagtggt gttaactgct ccaactcttg tcttgcttag tttctacaaa
     2521 tatttttgct tcttgtcatt tgaaggatta agaaacaaaa acaatccaga aattgatcgg
     2581 tttttttagg ccaatcccat cccttctgga taaccagatg ttaaatcatg agatcagaga
     2641 tgctgttcat cagtcccaac aagatggcct agaaatcgca ttctcacctc gccttgctgc
     2701 tgctttaatt ccaagttcta tttcttccct tatagttttc tatgggaatg aggcggatac
     2761 aggaaacacc ctatctcctc tgtatttttg tagtggaatt tctatttaag gggctcatta
     2821 aagcatagta tttatacaca
//
