LOCUS       NM_017762               4985 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myotubularin related protein 10 (MTMR10), mRNA.
ACCESSION   NM_017762
VERSION     NM_017762.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4985)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4985)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   3  (bases 1 to 4985)
  AUTHORS   Lorenzo,O., Urbe,S. and Clague,M.J.
  TITLE     Systematic analysis of myotubularins: heteromeric interactions,
            subcellular localisation and endosome related functions
  JOURNAL   J Cell Sci 119 (Pt 14), 2953-2959 (2006)
   PUBMED   16787938
REFERENCE   4  (bases 1 to 4985)
  AUTHORS   Wishart,M.J. and Dixon,J.E.
  TITLE     PTEN and myotubularin phosphatases: from 3-phosphoinositide
            dephosphorylation to disease
  JOURNAL   Trends Cell Biol 12 (12), 579-585 (2002)
   PUBMED   12495846
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090829.3, AL598227.1, AL832603.1, AC087481.9, BC094750.1 and
            AA461184.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017762.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832603.1, SRR1803614.25324.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000435680.6/ ENSP00000402537.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC090829.3         79319-79342         c
            25-57               AL598227.1         2-34
            58-439              AL832603.1         29-410
            440-440             AC087481.9         6028-6028
            441-1145            AL832603.1         412-1116
            1146-2717           BC094750.1         1262-2833
            2718-4457           AC087481.9         39764-41503
            4458-4985           AA461184.1         9-536               c
FEATURES             Location/Qualifiers
     source          1..4985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..4985
                     /gene="MTMR10"
                     /note="myotubularin related protein 10"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
     exon            1..182
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2456
                     /gene="MTMR10"
                     /note="inactive phosphatidylinositol 3-phosphatase 10"
                     /codon_start=1
                     /product="myotubularin-related protein 10"
                     /protein_id="NP_060232.2"
                     /db_xref="CCDS:CCDS45204.1"
                     /db_xref="GeneID:54893"
                     /db_xref="HGNC:HGNC:25999"
                     /translation="MFSLKPPKPTFRSYLLPPPQTDDKINSEPKIKKLEPVLLPGEIV
                     VNEVNFVRKCIATDTSQYDLWGKLICSNFKISFITDDPMPLQKFHYRNLLLGEHDVPL
                     TCIEQIVTVNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPESAKKVC
                     LAIAHYSQPTDLQLLFAFEYVGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGSSQKT
                     PLFETYSDWDREIKRTGASGWRVCSINEGYMISTCLPEYIVVPSSLADQDLKIFSHSF
                     VGRRMPLWCWSHSNGSALVRMALIKDVLQQRKIDQRICNAITKSHPQRSDVYKSDLDK
                     TLPNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYML
                     ESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRC
                     NHLKRSEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSP
                     HQRVKQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTAKDRTLFHNPFYIGKSTPCIQ
                     NGSVKSFKRTKKSYSSTLRGMPSALKNGIISDQELLPRRNSLILKPKPDPAQQTDSQN
                     SDTEQYFREWFSKPANLHGVILPRVSGTHIKLWKLCYFRWVPEAQISLGGSITAFHKL
                     SLLADEVDVLSRMLRQQRSGPLEACYGELGQSRMYFNASGPHHTDTSGTPEFLSSSFP
                     FSPVGNLCRRSILGTPLSKFLSGAKIWLSTETLANED"
     exon            183..243
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            244..380
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            381..453
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            454..596
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            597..687
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            688..880
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            881..968
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1057
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1188
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1258
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1329
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1499
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1670
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1853
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..4985
                     /gene="MTMR10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4963..4968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTMR10"
                     /note="hexamer: AATAAA"
     polyA_site      4985
                     /gene="MTMR10"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcccg gctcggctgg ccgcagaaag ggcctgggcg gccgcactga gagctttacg
       61 cccggaggcg tcggcgctgc cactggcccg cgacgggaac ggggcgaaaa ggcggcggca
      121 ccatgttctc cctcaagccg cccaaaccca ccttcaggtc ctacctcctg ccaccgcccc
      181 agactgacga taagatcaat tcggaaccga agattaaaaa actggagcca gtccttttgc
      241 caggagaaat tgtcgtaaat gaagtcaatt ttgtgagaaa atgcattgca acagacacaa
      301 gccagtacga tttgtgggga aagctgatat gcagtaactt caaaatctcc tttattacag
      361 atgacccaat gccattacag aaattccatt acagaaacct tcttcttggt gaacacgatg
      421 tccctttaac atgtattgag caaattgtca cagtaaacga ccacaagagg aagcagaaag
      481 tcctaggccc caaccagaaa ctgaaattta atccaacaga gttaattatt tattgtaaag
      541 atttcagaat tgtcagattt cgctttgatg aatcaggtcc cgaaagtgct aaaaaggtat
      601 gccttgcaat agctcattat tcccagccaa cagacctcca gctactcttt gcatttgaat
      661 atgttgggaa aaaataccac aattcagcaa acaaaattaa tggaattccc tcaggagatg
      721 gaggaggagg aggaggagga ggtaatggag ctggtggtgg cagcagccag aaaactccac
      781 tctttgaaac ttactcggat tgggacagag aaatcaagag gacaggtgct tccgggtgga
      841 gagtttgttc tattaacgag ggttacatga tatccacttg ccttccagaa tacattgtag
      901 tgccaagttc tttagcagac caagatctaa agatcttttc ccattctttt gttgggagaa
      961 ggatgccact ctggtgctgg agccactcta acggcagtgc tcttgtgcga atggccctca
     1021 tcaaagacgt gctgcagcag aggaagattg accagaggat ttgtaatgca ataactaaaa
     1081 gtcacccaca gagaagtgat gtttacaaat cagatttgga taagaccttg cctaatattc
     1141 aagaagtaca ggcagcattt gtaaaactga agcagctatg cgttaatgag ccttttgaag
     1201 aaactgaaga gaaatggtta tcttcactgg aaaatactcg atggttagaa tatgtaaggg
     1261 cattccttaa gcattcagca gaacttgtat acatgctaga aagcaaacat ctctctgtag
     1321 tcctacaaga ggaggaagga agagacttga gctgttgtgt agcttctctt gttcaagtga
     1381 tgctggatcc ctattttagg acaattactg gatttcagag tctgatacag aaggagtggg
     1441 tcatggcagg atatcagttt ctagacagat gcaaccatct aaagagatca gagaaagagt
     1501 ctcctttatt tttgctattc ttggatgcca cctggcagct gttagaacaa tatcctgcag
     1561 cttttgagtt ctccgaaacc tacctggcag tgttgtatga cagcacccgg atctcactgt
     1621 ttggcacctt cctgttcaac tcccctcacc agcgagtgaa gcaaagcacg gaatttgcta
     1681 taagcaaaaa catccaattg ggtgatgaga agggcttaaa attcccctct gtttgggact
     1741 ggtctctcca gtttacagca aaggatcgca cccttttcca taaccccttc tacattggaa
     1801 agagcacacc ttgtatacag aatggctccg tgaagtcttt taaacggaca aagaaaagct
     1861 acagctccac actaagagga atgccgtctg ccttaaagaa tggaatcatc agtgaccaag
     1921 aattacttcc aaggagaaat tcattgatat taaaaccaaa gccagatcca gctcagcaaa
     1981 ccgacagcca gaacagtgat acggagcagt attttagaga atggttttcc aaacccgcca
     2041 acctgcacgg tgttattctg ccacgtgtct ctggaacaca cataaaactg tggaaactgt
     2101 gctacttccg ctgggttccc gaggcccaga tcagcctggg tggctccatc acagcctttc
     2161 acaagctctc cctcctggct gatgaagtcg acgtactgag caggatgctg cggcaacagc
     2221 gcagtggccc cctggaggcc tgctatgggg agctgggcca gagcaggatg tacttcaacg
     2281 ccagcggccc tcaccacacc gacacctcgg ggacaccgga gtttctctcc tcctcatttc
     2341 cattttctcc tgtagggaat ctgtgcagac gaagcatttt aggaacacca ttaagcaaat
     2401 ttttaagtgg ggccaaaata tggttgtcta ctgagacatt agcaaatgaa gactaaaata
     2461 gggtgttttc tgaacatttt gagggaagct gtcaactttt ttcctctgaa ttaacattgc
     2521 taacctaggc gtttgaatct ctaataactt tatatgtaag aataatagtt ggaatttgca
     2581 ctaatattta aaaacatgtt gaatcatgct tctttcacac ttattttaag agagatgtaa
     2641 attttgttcc tgtcctcttt ctgtcattac aggtctggct cttgtaaccg tgatcaaact
     2701 gttcatgttg tctgctacat ttttgtctcc atccattttt cctaccacct cctgaaggct
     2761 atctgatagt cagtcacatt agcagcccca ggcagcagac aacaggaaag ttaggaaatt
     2821 tgtgtttcgt gtcattttta ggagcatctg ataaaacctc cagcaggttt taggaagtat
     2881 tcatgtattt ttctggttac tttctgtcgt ctctaattga actcacctga tgaaggttca
     2941 gtgttctggg gccagaattt atgattttag atcaccttct ttggaacctt agatcactgt
     3001 gttttgaaat catgagtttg cttttaactt catagggtca actttaaaat gatatgcact
     3061 gttaatttta aagcatttgc tgcagataat taaacttaga agtgcctttg actttaggat
     3121 acaaatatta cagaagaaaa tataatttca ctttttaaaa ttggggtggg aaaatcccat
     3181 tgcatatttg aaataggctt ttcatactaa gcttcatagc caggagtccc cagagtcttg
     3241 ttcctctgaa agccactggg gagtggcctc tggggtgctg attccacaga ggtgtatgct
     3301 gtagacagga gagtgccatc tatgccaaaa ctcgccctca aaaacaaaca aggcttgctg
     3361 ggaggcgtgc tgggcttggc catcagtatt tccagtgtgg taaactattg ctggcacttc
     3421 cccctggaaa taactaatga ggttacgagt tgggcacctg cacagatgtc cttctctcat
     3481 agttcctaat gcttaggaat agaggagaaa taaaaaaatg gattctctca aaacactgcc
     3541 atttgaatag cgacagaagt gctcccccag cccccaactt tggacagcaa agttgaggag
     3601 aatgagcaga cacagttgtt tgcttgatct gaatctctct aaagtaaagt atttccaaac
     3661 tgtgtgacaa gagcctacct accactgtag cggtcaaagc tgaagcttct tacagcagtg
     3721 aaacggggca ccacctcccc cacactcctc attccccgct taaaacatgg atactttcaa
     3781 atttgactgt ttcttaaact gccatcctaa gatatggaaa atttttatag taaagtgtct
     3841 agttagctta tttccttttc taaaacaagt gttttcaaga taactgtatt ttacctttat
     3901 atgtactgaa tagctgtttc tttttgaatt atttgccttt taaaatttga taatgtctct
     3961 ggatataaca ggacaggagt tcttaaaaaa tatcttaaga aattcacttt atgggtaaac
     4021 ccaaggtttt tgccaacttg ttgcctagaa aataagggct agtttcagtt tatacaaata
     4081 gaattattaa acattttaca gtccttgatt agaaaccaga cccaatctcc ttataacacc
     4141 acagcgtatc ctgccattga cagtgtaatc acaattctcc ctttttcatt tagctgcttt
     4201 tttattatta ctaaatgttt tggattgagc atttttccct ctgtaatttt cttccttcac
     4261 gtttatttta actcttgtag tattttattg ttgttaattt acaagtttaa aaatattagg
     4321 tactattaat aatggttaaa aatagaaaaa tgcatatttt tgtatgataa tcaaatgtaa
     4381 aatactttta tttttgctgg acagttgtta tatcatgatt attgtgctac agtttattgt
     4441 gcataatatg aaaaacaact atgacagcct tcagtcgggc cagggtgaag ctgcttatac
     4501 cacctctgcc gtcagaggga catgtggtga cagcagtggt gtggctgcac agggcgcact
     4561 agagagagct cagcacccct gctgcccgcc agcagagccc gtgctgaggg aatgccgcac
     4621 agatgctgat gcactgggtg aaatttctag tattgaacgt aaaggtgtac agtgtcttgc
     4681 tgttatttta tgatggaaac tgattttgaa accaaaaata gctaactaac tttatttaag
     4741 gaaaggatat taatttgtac taacagaggg tgaaagctgt tcacatttgt caacaaaatc
     4801 tgcttgctgc agtagtaacc tcaagtggtt aaaacttgat ttcccgagaa aactaaaacc
     4861 tttgtgccta aaattgatga cttgagttca agtgggatga gcaagaagat gtgttatctt
     4921 gttgttcaac agtattgaat gtgaaggaaa ttttgatggc ttaataaaat tccacagcga
     4981 ctgtt
//
