LOCUS       NM_001384134             427 bp    mRNA    linear   PRI 22-MAR-2024
DEFINITION  Homo sapiens mitoregulin (MTLN), mRNA.
ACCESSION   NM_001384134
VERSION     NM_001384134.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 427)
  AUTHORS   Iwai,M., Kajino,T., Nakatochi,M., Yanagisawa,K., Hosono,Y.,
            Isomura,H., Shimada,Y., Suzuki,M., Taguchi,A. and Takahashi,T.
  TITLE     Long non-coding RNA TILR constitutively represses TP53 and
            apoptosis in lung cancer
  JOURNAL   Oncogene 42 (5), 364-373 (2023)
   PUBMED   36522487
  REMARK    GeneRIF: Long non-coding RNA TILR constitutively represses TP53 and
            apoptosis in lung cancer.
REFERENCE   2  (bases 1 to 427)
  AUTHORS   Friesen,M., Warren,C.R., Yu,H., Toyohara,T., Ding,Q.,
            Florido,M.H.C., Sayre,C., Pope,B.D., Goff,L.A., Rinn,J.L. and
            Cowan,C.A.
  TITLE     Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes
  JOURNAL   Stem Cell Reports 14 (4), 590-602 (2020)
   PUBMED   32243843
  REMARK    GeneRIF: Mitoregulin Controls beta-Oxidation in Human and Mouse
            Adipocytes.
REFERENCE   3  (bases 1 to 427)
  AUTHORS   Lai,Y., Zhou,B., Tan,Q., Xu,J., Wan,T. and Zhang,L.
  TITLE     LINC00116 enhances cervical cancer tumorigenesis through
            miR-106a/c-Jun pathway
  JOURNAL   J Cell Biochem 121 (3), 2247-2257 (2020)
   PUBMED   31693227
  REMARK    GeneRIF: LINC00116 enhances cervical cancer tumorigenesis through
            miR-106a/c-Jun pathway.
REFERENCE   4  (bases 1 to 427)
  AUTHORS   Chugunova,A., Loseva,E., Mazin,P., Mitina,A., Navalayeu,T.,
            Bilan,D., Vishnyakova,P., Marey,M., Golovina,A., Serebryakova,M.,
            Pletnev,P., Rubtsova,M., Mair,W., Vanyushkina,A., Khaitovich,P.,
            Belousov,V., Vysokikh,M., Sergiev,P. and Dontsova,O.
  TITLE     LINC00116 codes for a mitochondrial peptide linking respiration and
            lipid metabolism
  JOURNAL   Proc Natl Acad Sci U S A 116 (11), 4940-4945 (2019)
   PUBMED   30796188
REFERENCE   5  (bases 1 to 427)
  AUTHORS   Stein,C.S., Jadiya,P., Zhang,X., McLendon,J.M., Abouassaly,G.M.,
            Witmer,N.H., Anderson,E.J., Elrod,J.W. and Boudreau,R.L.
  TITLE     Mitoregulin: A lncRNA-Encoded Microprotein that Supports
            Mitochondrial Supercomplexes and Respiratory Efficiency
  JOURNAL   Cell Rep 23 (13), 3710-3720 (2018)
   PUBMED   29949756
REFERENCE   6  (bases 1 to 427)
  AUTHORS   Makarewich,C.A., Baskin,K.K., Munir,A.Z., Bezprozvannaya,S.,
            Sharma,G., Khemtong,C., Shah,A.M., McAnally,J.R., Malloy,C.R.,
            Szweda,L.I., Bassel-Duby,R. and Olson,E.N.
  TITLE     MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid
            beta-Oxidation
  JOURNAL   Cell Rep 23 (13), 3701-3709 (2018)
   PUBMED   29949755
REFERENCE   7  (bases 1 to 427)
  AUTHORS   Crappe,J., Van Criekinge,W., Trooskens,G., Hayakawa,E., Luyten,W.,
            Baggerman,G. and Menschaert,G.
  TITLE     Combining in silico prediction and ribosome profiling in a
            genome-wide search for novel putatively coding sORFs
  JOURNAL   BMC Genomics 14, 648 (2013)
   PUBMED   24059539
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140479.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031315.2, BU589328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMEA2159080
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611969.5/ ENSP00000485064.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               AC140479.3         73715-74047         c
            334-427             AC140479.3         73029-73122         c
FEATURES             Location/Qualifiers
     source          1..427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q13"
     gene            1..427
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /note="mitoregulin"
                     /db_xref="GeneID:205251"
                     /db_xref="HGNC:HGNC:27339"
                     /db_xref="MIM:620770"
     exon            1..333
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..193
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /note="long intergenic non-protein coding RNA 116; small
                     integral membrane protein 37; micropeptide regulator of
                     beta-oxidation; lncRNA encoded micropeptide; micropeptide
                     in mitochondria; TP53-inhibiting lncRNA"
                     /codon_start=1
                     /product="mitoregulin"
                     /protein_id="NP_001371063.1"
                     /db_xref="CCDS:CCDS92837.1"
                     /db_xref="GeneID:205251"
                     /db_xref="HGNC:HGNC:27339"
                     /db_xref="MIM:620770"
                     /translation="MADVSERTLQLSVLVAFASGVLLGWQANRLRRRYLDWRKRRLQD
                     KLAATQKKLDLA"
     exon            334..427
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      409..414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /note="hexamer: AATAAA"
     polyA_site      427
                     /gene="MTLN"
                     /gene_synonym="LEMP; LINC00116; MOXI; MPM; NCRNA00116;
                     SMIM37; TILR"
                     /note="major polyA site"
ORIGIN      
        1 gcgctgcacg ccggcggcag ccatggcgga tgtgtcagag aggacactgc agttgtccgt
       61 gctagtagcc ttcgcttctg gagtactcct gggctggcag gcgaaccgac tgcggaggcg
      121 ctacttggac tggaggaaaa ggaggctgca ggacaagctg gcggcgacgc agaagaagct
      181 ggacctggcc tgagactctg cgccttccgc cccattctgt ccccctcatg gccaccttgc
      241 catgtccgcg ccggagcccc ggtccgccgg cgcccagaac caggcttgcc acacagtccc
      301 cgcctgccat ggccggctct tcctggagtg ttgcttgttg aagatgcata tagactaccg
      361 gaaagaaatg acttcttctt gcactttatg aatcaatttt atttttaaaa taaaaaaatt
      421 aaacatc
//
