LOCUS       XM_017008222           10132 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens methylenetetrahydrofolate dehydrogenase
            (NADP+ dependent) 2 like (MTHFD2L), transcript variant X6, mRNA.
ACCESSION   XM_017008222
VERSION     XM_017008222.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000004.12) annotated using gene prediction method: Gnomon.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017008222.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10132
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
     gene            1..10132
                     /gene="MTHFD2L"
                     /note="methylenetetrahydrofolate dehydrogenase (NADP+
                     dependent) 2 like; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 123 long SRA reads, 2
                     Proteins, and 98% coverage of the annotated genomic
                     feature by RNAseq alignments, including 12 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:441024"
                     /db_xref="HGNC:HGNC:31865"
                     /db_xref="MIM:614047"
     CDS             22..873
                     /gene="MTHFD2L"
                     /codon_start=1
                     /product="bifunctional methylenetetrahydrofolate
                     dehydrogenase/cyclohydrolase 2, mitochondrial isoform X6"
                     /protein_id="XP_016863711.2"
                     /db_xref="GeneID:441024"
                     /db_xref="HGNC:HGNC:31865"
                     /db_xref="MIM:614047"
                     /translation="MTVPVRGFSLLRGRLGRAPALGRSTAPSVRAPGEPGSAFRGFRS
                     SGVRHEAIIISGTEMAKHIQKEIQRGVESWVSLGNRRPHLSIILVGDNPASHTYVRNK
                     IRAASAVGICSELILKPKDVSQEELLDVTDQLNMDPRVSGILVQLPLPDHVDERTICN
                     GIAPEKDVDGFHIINIGRLCLDQHSLIPATASAVWEIIKRTGIQTFGKNVVVAGRSKN
                     VGMPIAMLLHTDGEHERPGGDATVTIAHRYTPKEQLKIHTQLADIIIVAAAPVSALPC
                     PGLALRG"
     polyA_site      10132
                     /gene="MTHFD2L"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 ggaagccggg gatccgcggc catgacggtg ccggtccgcg gcttctcgct gctccgcggc
       61 cgccttggcc gagcgccggc gttgggcaga agcacagcac cctccgtaag ggcaccggga
      121 gagcccggga gtgcgttccg gggctttcgg agcagcggtg tgagacatga agccattatt
      181 atatcaggaa ccgaaatggc caagcatatc cagaaagaaa tacagcgagg tgtggaatca
      241 tgggtttccc ttggaaacag aagacctcac ctcagtataa ttttagtggg agataaccca
      301 gcaagccata catatgtcag gaataagata agagctgcct ctgctgtagg tatttgtagt
      361 gagctcattc taaaacctaa ggatgtttct caggaagaac ttttggacgt aactgatcaa
      421 ttgaatatgg acccaagagt cagcggtata ttagttcagt taccactacc agaccacgtt
      481 gatgagcgaa caatatgcaa tggaattgcc ccagaaaaag atgtagatgg atttcatatt
      541 atcaatattg gaagattgtg ccttgatcag cattctctca tacctgccac tgccagtgct
      601 gtttgggaaa taataaaaag aacaggaatt caaacatttg gaaaaaatgt ggttgtggct
      661 ggaagatcca agaacgtagg gatgcctatt gccatgcttt tacacactga tggagagcat
      721 gaacggccag gaggtgatgc aactgtgaca atagctcaca gatacacccc caaagagcaa
      781 ctgaagattc atacgcagct ggcagatatt atcatagttg ctgcagcccc agtgtctgcc
      841 cttccctgcc ctggtctggc cctgagaggc tgactaatga agatggcctc acctgtgttc
      901 ctctgacact ggctcccagc aaggtttggc actagtagga tatctgaagg agaagaagag
      961 aaatgtcaag tcatggtgtt tcttctctac tcttttccac ttctactgtc tttctcttcc
     1021 tcctgcatcg atagcttttg ctcagcatcc tttccccgac agctaaggct ctcactgggc
     1081 tgcagtaaca ccatttcctc acccctacag acctaggaat ggtacaagct tcctccagtt
     1141 tctaatctct aagagctgca acagcttttg tttttatctt agcctgaata tatcgctgta
     1201 aaaattattt cattactata tggggtggat tctgtttccc atggagatac cgacagaagc
     1261 agatctgtat gaagtaaagg cacaaatcaa gaaccattcc tgggggaaga gcatcccgag
     1321 cagaggaaac agcagatacc aaagtcctta ggcaggagca tgcttgatgt attccagaac
     1381 acaggtcttt gacggcttat tatattactc tgattttaat aaaatattaa taaattatga
     1441 ggatactagt aagaaatgtt gttgggaagg tagccagggt taactcatga aggacgttgt
     1501 cggccatggt taggattttg atataagcca agaatggctg acagcagatc aacatggtct
     1561 gacttaggtt ttaaaggact gatcacacct ttaaaaacat atcagacctc atgtctgcag
     1621 ttgtgtcaaa aactgacttt agaggtgtaa aagtagaaac agagaggaga ggtattgcaa
     1681 tttcatttaa tgggtctaga ttttgctcta atttgttttg tatttgaaca catagtttca
     1741 atcaaattta ataaaatatc tgattcttct ataggccctt ttctggaacc tagaacatat
     1801 acatgactgc aggaacagta gttggctcct catagagtaa aaatagaaat gttctttttc
     1861 ccagaaaaaa aatcagtaag ctggtacaga taaccatacc acattgcctg tttttccaaa
     1921 aaattacatt tgggtgatat caaatgcaaa tttttgaact gcattgacag aagtcaggca
     1981 tgtttagaga gttagtaaac tttttcagac cacagatcag cattaagtga aatactgctt
     2041 cagccactga taccttcatg gcagataagt attatactga cttcttttta gagacacttc
     2101 tgttcacaca caagacacag aatttgttga ataaagagga atttgaatgc tcatctttgt
     2161 ccgtttctaa ccttaggaag aatgaagttt acattatcct taaaaggtat tatttgacta
     2221 atgttaacag cttgtacaga atatttgact attgtcctta gataacattt atcaaatatt
     2281 atattgaatg agtattttat tctagtggag gaaaatctct catcatgcct tcctactcgt
     2341 ggtttgtttt attattatga caaatggcac atgggtgatc acaatccact tgcaagaaac
     2401 actgatattc tcttgtaact aagtcaaagc ttatgccata atgccaacac tgttgtcctc
     2461 cttgagttta tcctctctag ctttctttgt aaaggcctaa atcagccttg agtacagata
     2521 tttaaaaaga agacaggaaa agaaaaagaa aaggaaaata aaggaacaga aggacaagga
     2581 agactcaagc ctatataaaa taaacaagac aggagccagg aggtactcaa gctttaggtg
     2641 tggtgggtgt tgaggctgtc ccacaagcat cccgctgagg gtattttctt accaccagag
     2701 ggcgccagtc aggtgagcag ctacttcaga tgtagccaag ttggccatac accatgctaa
     2761 tactagttag aagacatttt aaacaaagac agtgggaaga agtcctgttc cttgcttttt
     2821 tatttcacct ttaatgcctc ttactaaata caaaagtatg ttgaatgtag aagacagatt
     2881 tgtatgtagt tctgcagtct tcttgaagaa ataaatattt agccaatggg aaatttaggg
     2941 gaagaaaatt gagaatttat aagaaacaac taaagattgc tacatttcca gttaattaat
     3001 aatcacctgg agaagttagg gataaaacat gtaggcattt ataaattata gaaagaatgt
     3061 gagtgaatat aaaaaataaa tcccatataa ccagacaata ggaataaagt attgccagaa
     3121 tgaccatatc atgcattgtg tgtgggaact aaacaaatac aaatagcagt gggtatttaa
     3181 aggaaatagt gatctaatgg cagaggtagc cagaacgggg agggctagat cactgtcata
     3241 atgagaatgt cagcatatat ggaaacaacc tcatctagga gaactcaggg tagaaggagg
     3301 aggattgcgt gatatatatc agaaagaatg ataatgtctg agagatgaga gtgaagaatg
     3361 tggtaatgaa atcttgacac aagcttgaag aaagtaaaag aggaaatcct gtgtgaagat
     3421 cctgagacat gaatattagc ttatttaata ttaatgtcat ccctccagtt tctcatagta
     3481 ctactcctac tggcttatat atcactcacc tttttaaaat tgcccccaaa attgagattt
     3541 agactcagtt agaagcttag atctgcagaa tcagaccctg tcacactatg caattagaag
     3601 taagtagctt caagtcccta ctcaaagcca aatctctgag ttcacagaga gagttaacaa
     3661 gtttctagag tactttaatg taccatggtt atagcacata gtacctgttt atagttgtta
     3721 tcttcattag actacagcag gtaaaggcgt ggtatttttt tttaagcttg ctaggtaagt
     3781 gcttagaaca atatctaaca catagtggtt gcccagtaaa tgtgagctgt gttgattttg
     3841 agattataac tacaataaga actttttcaa attgatacat atttagccga tataatctaa
     3901 ttttttaaga tggaattatt ctagttgttg gatttacaca ctgtagcatt atttttggga
     3961 actaccaaat tattccagtt tgtcatcata aagtagttgc taaagcaata aaaagtgaaa
     4021 tatttattca tgaaagagta gttcatgtca ttaagtgtat gaatggagtg atttaggtgt
     4081 aaatgttaag attaagaaat gatgggaaag gtggccgggt gcagtggctt acatctgtaa
     4141 tcctagcact ttgggaggct caggtgggtg gatcacctgt ggtcaggagt ttgagaccag
     4201 cctgtccaac atggtgaaac cctgtctcta ctaaaaatac aaaaattagc caggtgtggt
     4261 ggtgggtgcc tgtaatccca gctactcaag aggctgaggc aggagaatca cttgaacccg
     4321 ggaggcggag gttgcagtga gccgagatca caccactgca ctccagcctg ggcaacagag
     4381 caagactctg tctcagaaaa aaaaaaaaaa gaaaaaagaa aaaaagaaat tatgggaaag
     4441 gtgaagaaag agtaaggaga ctattacatc taaagaacag taagagtact ggatggttga
     4501 aaggggagga gcagtttagg gaaaggctaa atcagctttg cacaagctac tgataaagaa
     4561 gggaaagcta gccagtatca attctaagat catgttggag atcattgggc tttctcgtat
     4621 ctgctttaag gaaactgtag gctatcctaa gtctgtaaaa ttctaggaat cttcattatt
     4681 cagcaggata ggcaagtttt tttagacatt gtccacatta ccctccaccc atctgagtaa
     4741 actctgaaac tatattcagg aaatgagctg ctgagtcaat gccacttgca tgtcaagctc
     4801 tggatgcagt gtcacggtgg tgaaagctgg catttttggc cactaagcca tcccttccag
     4861 catgacgaat gaaccttcac agttgtaact ttagagtgtc tattgcaaca cttttaatga
     4921 cagataccat gatataaaac aggataaatg ggcaatttag taactcagaa tattcatact
     4981 tacttgtcat aaagtacaaa gtgaccaacg aatttccttt caccacttct ccaatcatat
     5041 tatcaagtct tagaaacact cccatcaaac attatcctag ggctcaatag ggttttcccc
     5101 cgggtgtatt tcctcctcct tgaaacaggg ttcgtaattt tcaggaaacc aggacatgga
     5161 gaagttccaa ggggtggggc aaggaaatag ctccaccatc cccacagctc atgcaacccg
     5221 ggagtacaac ttgctcactt acggccctga gtgcttcctg agtgatgcca gcacatttca
     5281 tggcttcact catactatag tcctttccat atctcatttc ttatttgtta ttgtccagct
     5341 tgtcctcttt tgctagcctc tgctactcca cttaagggtt ccttccctcc ttcctaaaag
     5401 ttgtcattat tttcatggta cagagtagtg aaaatgcaca ggcctttcta aagtaagaat
     5461 tccaggattt aaattccagc tctgagactt gctgattgtg agcttggtct catttctgaa
     5521 tctcaatctg ttcattgatg tgatttaaat gataataata aaagtaacct ttcatagcga
     5581 tgtctacttt atatttttga tcttaactat gctgatctaa gtagaatttc ccatatctaa
     5641 aatgatgcct tttacttatt gaaaggcatt ttagtgtggt ttatgtgtaa taccaaataa
     5701 agaatattta acacttctca aaaaaaaacc ttttgcatag tgtaatcaag ctagccaatc
     5761 catgtaaaga gcatagcaca gtgcccagta tattgcaaat attcaataag tgttatgtgt
     5821 taatgtattc tatgttaggc attgcatgtg aatatttaaa caatttagaa atgataaatc
     5881 agttgattat taagctacaa cttagcataa ctaaaagaat atacttcttg gttgcttttg
     5941 atactaatac agtatcagag tagagtagtt cttataagca taaataaatt aagaagtgac
     6001 ttacacatga gggaccaact ttatggaaac tttattttta tacttaagat gtatgccttc
     6061 tcaggatgac atcagcactt gttcatagat gtgtattatg ttgttccctg gatgaattcc
     6121 ttattgcctc tccctccttt ggaacaacct gactttgaga ggggagatag ggaaggccga
     6181 ggcacttaga tgaaagggat ttttttctct caggccttta tccaccgtcc cagtctccct
     6241 ctctctctgt ttctacctca tcttcccacc tcaggctatt ctggccctca caacccatgc
     6301 ccaaagccta agttactaag taagcaaagc ttccctggcc tgcagtgagc tttgtcaata
     6361 cctgagaggg cagcctgact actgatattt ttcttggtgt cagtaataca tccttactgc
     6421 aaaaacttag aaaacttgga caatagagag ggagggaaag aaccttaatc ccaaccaaag
     6481 tgaaataagg taaacaattt gatgtttgac cttgtactgt tttatattta tacatagatc
     6541 taaatattta aacaattctt ttgccttgta tatactattt gtatttagca gctctacacc
     6601 atgtacgtgc ttcttcataa aatgctttct tccaaaacag acttctaatg actctatagt
     6661 attgagtgct atggatatac taaattttat ttattcagtt cttgactatt ggacatttag
     6721 atagttccct gagttttact gttatgaata atgcagcaaa cagctgtaaa catcttagat
     6781 tatttgcatc gtaacccata atatttatcg tattggtctt aagtttattt tcttagtaat
     6841 tattacttat attctaaaaa caaatgaaca tttaagcttg gtgtataata aaggcttaca
     6901 cgtgtgttta atattaaagc atatttcata ccttacctgt gcatttatgt aaagttttaa
     6961 cagagagagg agatagctgt gtctcgtttg taacccattc tccaggcctg ttaccattac
     7021 caatcagtat actatgaagc tttagatcct tatctttcca caagagaaga tagaagccta
     7081 gtgtgtgggg aaggggactc aaatatgaag tggggtgtag tatcaaaaga aacgtggtct
     7141 ttaaagtaaa gagggtttgg ttttaaattc aattttaact ttaaaaatca catctaactc
     7201 tctgggcttt attttcagct atcgcaaaat ggaggtagta atactagtgt ttataaactg
     7261 tcatgagaat tacatcctta gcacataatg gctactaagt gaaggtagtt tcccttccct
     7321 tcattctcct attgtgtggt gagctcctat tgtgtggtga gccaatcact aaaattacaa
     7381 catgttttaa atgaaaatat atgaaaattt attatctatt atgaaaagac tttaactttc
     7441 taatactttg gtaatataga ctgtacaaaa acatgtacaa acttttatat gtttccttgc
     7501 tcgttagcct caaataagca aaaacatttt tccaagatcg atcacctcag aaccatcaca
     7561 aagttttatt tttttttctt catttgactg agacccttgt gtttttctcc tcaacttgtt
     7621 ctaattacag ggacttttga aaagggggaa tcttttcatc tctaggtttt ttcaatctat
     7681 ggtattagta catggttagc tgaggttgat tttttttctt ttgaggctct tctctcaaca
     7741 catatatatg tactatttct gatttttcat gagtaaaaca agcattgata gcaatatcca
     7801 aaaaagcttc agtaaagaac aatttatatc aaagatcttt cttcactgtg gagaatcaca
     7861 gacttccttg gaaatatact ttagatggtc aaatgataca tcatttaaac ttaattctat
     7921 ttgggtccat gcatgtatat catgggcttg ggaagaagtg aggttcttcc tttcaagtta
     7981 tgtctgtagc ctttgatatt atcactttgt tatattttta tgtccaggtc tttaaaaggt
     8041 ttatgttagg aaatacttaa atatacccaa aagtgtataa gaataatgtt aattaaaacg
     8101 ttaacactta tgttatcaat acctaaattt gacagatgtg aatattatgt atattttcaa
     8161 tctacctgtt ttatatttct ataacttgct ttgttttgac taatgctatg actttcaagt
     8221 ttgcccatgc taatagatgt agcactattt ctataatact caattgctga gtatccattt
     8281 tctgttgatg aatatgtatg ctatttccaa tatattgcta ttatgaacag ttctgtaatg
     8341 tttaagttta tacatatttt cttggagact cattcattca tccatccagc aaacactaat
     8401 tttgccactg gtacatatta agccatatag caggcattag aaaaatatat atatataaac
     8461 ttggttcagc tcttgagaag tccagacact agtggaggag aaagatgtgc aaacaaatta
     8521 gtgtaataca gcttgctagt gcaatattag atacatgtat gtatgtatat gtacatgtct
     8581 atctgtttag aaaaggagac agtgtgtgtg tgtgtgtgtg tgtgtttacg tgtgtaagag
     8641 acacagatag attgaaaaat aaaaacagag agagagagca tcattggaga ggaagtaata
     8701 gctcttttcc tctgactctg aaaagtacat gaatgagtcg ggtttcatcc cacagaatga
     8761 acagaaattc actaggcaga ataaaaggca atgagacttc tggcagctta gagctataaa
     8821 atgctatgca tatagcaaag aaaatattta ctctttcaaa atgacaggtg cctgtctgtg
     8881 agttgtgaaa gatgaagcat aacatttagg aaaaaccaga tatcataata aattaagaaa
     8941 ttttaatttt atcctgtagg tcataggcaa cctttaaata attagaagca ctgaaataac
     9001 atcatatttg aattttagaa agatcacttg gatagcccct gtgcagggat aaaactggaa
     9061 gtagcattga tgtagttcta cactaataca ggagtagatg aaagtgagaa ggaaaaacag
     9121 gaagtagact agaaaggctt actggcttta gagactaagt atatggtgtt gccattaaca
     9181 aggaaggtat atagaaagga agcaaagttt gagagaagta aagatgagtg agtgggagga
     9241 gataattaat tcaatgtgaa tgtgttgagt tgatgacact aggtgttata ttcaggtgga
     9301 aaagtccagg agagggttga gatatgtggg tgtggggttt gggagagagc tctgttctgg
     9361 agtgataatt ttggaagtca ttaatatcag ggatattgga cacgaattca tggataaaac
     9421 catctagaat aagtctgttt atagtgcatg gactgaattt ctatttcaga catctttgaa
     9481 gtgtgttggt tgatatggtt acttctataa cattgccttc ttgcttctgt atacctagtg
     9541 ccaatgaaag atagcctatt cttattccag catctacttc aattgatcgt ataagaaaaa
     9601 aactggtatt tttatgaagc tttgttgttt catacctgtt gttcttttgt taccccgacc
     9661 tttatcggct tgaaagcatt gtttgagtaa catgagagaa tgtatttgat aaaccaaaat
     9721 gtgccatata gtggagacaa aattgtgtcc taaaaataaa atgatggact ttacttcata
     9781 aatgtttaat tttttacatg taaaagatta aatttaaact tctttaatgt aatgtaaact
     9841 tctttaataa atgttcccag caggcagaat tttttgtttt tgcttgcatt tgtagtcttt
     9901 gcatactgga tttattgtga ccatctaatg ctcagttaat ttctattatc tgacttgtcc
     9961 aggttaccag cttgatctga tttttacagt tttattgctc acagcctatt atatcttcac
    10021 agcacttttt tctgtgacca acagcctggt tttagtaact ctggatttcc catgtccatt
    10081 atttgattat gttaatgctt tctaaaacac aaataaattg ttttctcaat tc
//
