LOCUS       XM_047418617            2574 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens methylenetetrahydrofolate dehydrogenase
            (NADP+ dependent) 1 like (MTHFD1L), transcript variant X20, mRNA.
ACCESSION   XM_047418617
VERSION     XM_047418617.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2574
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..2574
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /note="methylenetetrahydrofolate dehydrogenase (NADP+
                     dependent) 1 like; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 27 ESTs, 131 long SRA
                     reads, and 95% coverage of the annotated genomic feature
                     by RNAseq alignments, including 9 samples with support for
                     all annotated introns"
                     /db_xref="GeneID:25902"
                     /db_xref="HGNC:HGNC:21055"
                     /db_xref="MIM:611427"
     CDS             122..2251
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /codon_start=1
                     /product="monofunctional C1-tetrahydrofolate synthase,
                     mitochondrial isoform X17"
                     /protein_id="XP_047274573.1"
                     /db_xref="GeneID:25902"
                     /db_xref="HGNC:HGNC:21055"
                     /db_xref="MIM:611427"
                     /translation="MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGRE
                     GLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAI
                     IQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQI
                     SENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSGVNL
                     DGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEE
                     IPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSG
                     RRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYG
                     KSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFA
                     CLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRIL
                     HENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDI
                     DPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLAD
                     MKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPF
                     ANIAHGNSSVLADKIALKLVGEEGFVG"
     polyA_site      2574
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaggaagcgc caggtccttc ccgccgccgc cgccgccgcc gccgcctgct cccctggcac
       61 gcgccccgcc gccctcggca gccgcagctc cgtgtcccct gagaaccagc cgtcccgcgc
      121 catgggcacg cgtctgccgc tcgtcctgcg ccagctccgc cgcccgcccc agcccccggg
      181 ccctccgcgc cgcctccgtg tgccctgtcg cgctagcagc ggcggcggcg gaggcggcgg
      241 cggtggccgg gagggcctgc ttggacagcg gcggccgcag gatggccagg cccggagcag
      301 ctgcagcccc ggcggccgaa cgcccgcggc gcgggactcc atcgtcagag aagtcattca
      361 gaattcaaaa gaagttctaa gtttattgca agaaaaaaac cctgccttca agccggttct
      421 tgcaattatc caggcaggtg acgacaactt gatgcaggaa atcaaccaga atttggctga
      481 ggaggctggt ctgaacatca ctcacatttg cctccctcca gatagcagtg aagccgagat
      541 tatagatgaa atcttaaaga tcaatgaaga taccagagta catggccttg cccttcagat
      601 ctctgagaac ttgtttagca acaaagtcct caatgccttg aaaccagaaa aagatgtgga
      661 tggagtaaca gacataaacc tggggaagct ggtgcgaggg gatgcccatg aatgttttgt
      721 ttcacctgtt gccaaagctg taattgaact tcttgaaaaa tcaggtgtca acctagatgg
      781 aaagaagatt ttggtagtgg gggcccatgg gtctttggaa gctgctctac aatgcctgtt
      841 ccagagaaaa gggtccatga caatgagcat ccagtggaaa acacgccagc ttcaaagcaa
      901 gcttcacgag gctgacattg tggtcctagg ctcacctaag ccagaagaga ttccccttac
      961 ttggatacaa ccaggaacta ctgttctcaa ctgctcccat gacttcctgt cagggaaggt
     1021 tgggtgtggc tctccaagaa tacattttgg tggactcatt gaggaagatg atgtgattct
     1081 ccttgctgca gctctgcgaa ttcagaacat ggtcagtagt ggaaggagat ggcttcgtga
     1141 acagcagcac aggcggtgga gacttcactg cttgaaactt cagcctctct cccctgtgcc
     1201 aagtgacatt gagatttcaa gaggacaaac tccaaaagct gtggatgtcc ttgccaagga
     1261 gattggattg cttgcagatg aaattgaaat ctatggcaaa agcaaagcca aagtacgttt
     1321 gtccgtgcta gaaaggttaa aggatcaagc agatggaaaa tacgtcttag ttgctgggat
     1381 cacacccacc cctcttggag aagggaagag cacagtcacc atcgggcttg tgcaggctct
     1441 gaccgcacac ctgaatgtca actcctttgc ctgcttgagg cagccttccc aaggaccgac
     1501 gtttggagtg aaaggaggag ccgcgggtgg tggatatgcc caggtcatcc ccatggagga
     1561 gttcaacctt cacttgactg gagacatcca cgccatcacc gctgccaata acttgctggc
     1621 tgccgccatc gacacgagga ttcttcatga aaacacgcaa acagataagg ctctgtataa
     1681 tcggctggtt cctttagtga atggtgtcag agaattttca gaaattcagc ttgctcggct
     1741 aaaaaaactg ggaataaata agactgatcc gagcacactg acagaagagg aagtgagtaa
     1801 atttgcccgt ctcgacatcg acccatctac catcacgtgg cagagagtat tggatacaaa
     1861 tgaccgattt ctacgaaaaa taaccatcgg gcagggaaac acagagaagg gccattaccg
     1921 gcaggcgcag tttgacatcg cagtggccag cgagatcatg gcggtgctgg ccctgacgga
     1981 cagcctcgca gacatgaagg cacggctggg aaggatggtg gtggccagtg acaaaagcgg
     2041 gcagcctgtg acagcagatg atttgggggt gacaggtgct ttgacagttt tgatgaaaga
     2101 tgcaataaaa ccaaacctga tgcagaccct ggaagggaca cctgtgttcg tgcatgcggg
     2161 cccttttgct aacattgctc acggcaactc ttcagtgttg gctgataaaa ttgccctgaa
     2221 actggttggt gaagaaggat ttgtaggcta acagctcact gcaacctcta cctcctgggc
     2281 tcgagcgatc ctcccacctc tgcctcctga gtagctgaga ctgcaggcac aatccactac
     2341 acccagccaa ttgttcaatt tttttctgga gatgaggtct cactacgttg cccaggctgg
     2401 tcttaaactc ctgagctcaa gtgatcgcct gcctcagcct cccaaaatgc tgggattaca
     2461 ggcatgaacc actgcgccca tccaaaagga tttaatttta tggtcaaatt ctacattgtc
     2521 tattgacttt aatattttta taaaattctt taaataaaat gtctttacct ggaa
//
