LOCUS       XM_017010702            3573 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens methylenetetrahydrofolate dehydrogenase
            (NADP+ dependent) 1 like (MTHFD1L), transcript variant X4, mRNA.
ACCESSION   XM_017010702
VERSION     XM_017010702.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017010702.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3573
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..3573
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /note="methylenetetrahydrofolate dehydrogenase (NADP+
                     dependent) 1 like; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 2 mRNAs, 43 ESTs, 223
                     long SRA reads, 14 Proteins, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     18 samples with support for all annotated introns"
                     /db_xref="GeneID:25902"
                     /db_xref="HGNC:HGNC:21055"
                     /db_xref="MIM:611427"
     CDS             122..3061
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /codon_start=1
                     /product="monofunctional C1-tetrahydrofolate synthase,
                     mitochondrial isoform X3"
                     /protein_id="XP_016866191.1"
                     /db_xref="GeneID:25902"
                     /db_xref="HGNC:HGNC:21055"
                     /db_xref="MIM:611427"
                     /translation="MGTRLPLVLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGRE
                     GLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFKPVLAI
                     IQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQI
                     SENLFSNKVLNALKPEKDVDGVTDINLGKLVRGDAHECFVSPVAKAVIELLEKSVGVN
                     LDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPE
                     EIPLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSS
                     GRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIY
                     GKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSF
                     ACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRI
                     LHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLD
                     IDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLA
                     DMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGP
                     FANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVV
                     LVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVV
                     ALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRF
                     QFLYDVQVPIVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLS
                     LSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMPGLPTRPCFYDIDLDTET
                     EQVKGLF"
     polyA_site      3573
                     /gene="MTHFD1L"
                     /gene_synonym="dJ292B18.2; FTHFSDC1; MTC1THFS"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 gaggaagcgc caggtccttc ccgccgccgc cgccgccgcc gccgcctgct cccctggcac
       61 gcgccccgcc gccctcggca gccgcagctc cgtgtcccct gagaaccagc cgtcccgcgc
      121 catgggcacg cgtctgccgc tcgtcctgcg ccagctccgc cgcccgcccc agcccccggg
      181 ccctccgcgc cgcctccgtg tgccctgtcg cgctagcagc ggcggcggcg gaggcggcgg
      241 cggtggccgg gagggcctgc ttggacagcg gcggccgcag gatggccagg cccggagcag
      301 ctgcagcccc ggcggccgaa cgcccgcggc gcgggactcc atcgtcagag aagtcattca
      361 gaattcaaaa gaagttctaa gtttattgca agaaaaaaac cctgccttca agccggttct
      421 tgcaattatc caggcaggtg acgacaactt gatgcaggaa atcaaccaga atttggctga
      481 ggaggctggt ctgaacatca ctcacatttg cctccctcca gatagcagtg aagccgagat
      541 tatagatgaa atcttaaaga tcaatgaaga taccagagta catggccttg cccttcagat
      601 ctctgagaac ttgtttagca acaaagtcct caatgccttg aaaccagaaa aagatgtgga
      661 tggagtaaca gacataaacc tggggaagct ggtgcgaggg gatgcccatg aatgttttgt
      721 ttcacctgtt gccaaagctg taattgaact tcttgaaaaa tcagtaggtg tcaacctaga
      781 tggaaagaag attttggtag tgggggccca tgggtctttg gaagctgctc tacaatgcct
      841 gttccagaga aaagggtcca tgacaatgag catccagtgg aaaacacgcc agcttcaaag
      901 caagcttcac gaggctgaca ttgtggtcct aggctcacct aagccagaag agattcccct
      961 tacttggata caaccaggaa ctactgttct caactgctcc catgacttcc tgtcagggaa
     1021 ggttgggtgt ggctctccaa gaatacattt tggtggactc attgaggaag atgatgtgat
     1081 tctccttgct gcagctctgc gaattcagaa catggtcagt agtggaagga gatggcttcg
     1141 tgaacagcag cacaggcggt ggagacttca ctgcttgaaa cttcagcctc tctcccctgt
     1201 gccaagtgac attgagattt caagaggaca aactccaaaa gctgtggatg tccttgccaa
     1261 ggagattgga ttgcttgcag atgaaattga aatctatggc aaaagcaaag ccaaagtacg
     1321 tttgtccgtg ctagaaaggt taaaggatca agcagatgga aaatacgtct tagttgctgg
     1381 gatcacaccc acccctcttg gagaagggaa gagcacagtc accatcgggc ttgtgcaggc
     1441 tctgaccgca cacctgaatg tcaactcctt tgcctgcttg aggcagcctt cccaaggacc
     1501 gacgtttgga gtgaaaggag gagccgcggg tggtggatat gcccaggtca tccccatgga
     1561 ggagttcaac cttcacttga ctggagacat ccacgccatc accgctgcca ataacttgct
     1621 ggctgccgcc atcgacacga ggattcttca tgaaaacacg caaacagata aggctctgta
     1681 taatcggctg gttcctttag tgaatggtgt cagagaattt tcagaaattc agcttgctcg
     1741 gctaaaaaaa ctgggaataa ataagactga tccgagcaca ctgacagaag aggaagtgag
     1801 taaatttgcc cgtctcgaca tcgacccatc taccatcacg tggcagagag tattggatac
     1861 aaatgaccga tttctacgaa aaataaccat cgggcaggga aacacagaga agggccatta
     1921 ccggcaggcg cagtttgaca tcgcagtggc cagcgagatc atggcggtgc tggccctgac
     1981 ggacagcctc gcagacatga aggcacggct gggaaggatg gtggtggcca gtgacaaaag
     2041 cgggcagcct gtgacagcag atgatttggg ggtgacaggt gctttgacag ttttgatgaa
     2101 agatgcaata aaaccaaacc tgatgcagac cctggaaggg acacctgtgt tcgtgcatgc
     2161 gggccctttt gctaacattg ctcacggcaa ctcttcagtg ttggctgata aaattgccct
     2221 gaaactggtt ggtgaagaag gatttgtagt gaccgaagct ggctttggtg ctgacatcgg
     2281 aatggagaaa ttcttcaaca tcaagtgccg agcttccggc ttggtgccca acgtggttgt
     2341 gttagtggca acggtgcgag ctctgaagat gcatggaggc gggccaagtg taacggctgg
     2401 tgttcctctt aagaaagaat atacagagga gaacatccag ctggtggcag acggctgctg
     2461 taacctccag aagcaaattc agatcactca gctctttggg gttcccgttg tggtggctct
     2521 gaatgtcttc aagaccgaca cccgcgctga gattgacttg gtgtgtgagc ttgcaaagcg
     2581 ggctggtgcc tttgatgcag tcccctgcta tcactggtcc gttggtggaa aaggatcggt
     2641 ggacttggct cgggctgtga gagaggctgc gagtaaaaga agccgattcc agttcctgta
     2701 tgatgttcag gttccaattg tggacaagat aaggaccatt gctcaggctg tctatggagc
     2761 caaagatatt gaactctctc ctgaggcaca agccaaaata gatcgttaca ctcaacaggg
     2821 ttttggaaat ttgcccatct gcatggcaaa gacccacctt tctctatctc accaacctga
     2881 caaaaaaggt gtgccaaggg acttcatctt acctatcagt gacgtccggg ccagcatagg
     2941 cgctgggttc atttaccctt tggtcggaac gatgagcacc atgccaggac tgcccacccg
     3001 gccctgcttt tatgacatag atcttgatac cgaaacagaa caagttaaag gcttgttcta
     3061 agtggacaag gctctcacag gacccgatgc aggtggcagc catctcctcc tcggcatctt
     3121 ggccgccctc agaccccttg tgaagcccaa gatcgtcaaa aagagaacca agaagttcat
     3181 ccggcaccag tcagaccatt atgtcaaaat taagcgtaac tggtggaaac ccagaggcat
     3241 tgacaacagg gttcgtagaa gattcagggt ccagatcttg atgcccaaca ctggttatgg
     3301 gagcaacaaa aaaacaaagc acatgctgcc cagtggcttc cggaagttcc tggtccacaa
     3361 cgtcaaggag ctggaagtgc tgctgatgtg caacaatcgt acttgtgccg agatcgctca
     3421 caatgtttcc tccaagaacc gcaaagccat cgtggaaaga gctgcccaac tggccatcac
     3481 agtcaccaac cccagtgcca ggctgtgcag cgaagaaaat gagtagacag ctcgtgtgca
     3541 cattttctgt ttaaataaat gtaaaaacag cca
//
