LOCUS       NM_138384               3424 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosome associated GTPase 1 (MTG1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_138384
VERSION     NM_138384.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Boyraz,B., Tajiri,R., Alwaqfi,R.R., Paula,A.D.C., Ye,Q.,
            Nielsen,G.P., Hung,Y.P., Oliva,E., Weigelt,B., Hisaoka,M. and
            Watkins,J.C.
  TITLE     Vulvar angiomyofibroblastoma is molecularly defined by recurrent
            MTG1-CYP2E1 fusions
  JOURNAL   Histopathology 81 (6), 841-846 (2022)
   PUBMED   36177509
  REMARK    GeneRIF: Vulvar angiomyofibroblastoma is molecularly defined by
            recurrent MTG1-CYP2E1 fusions.
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Tajiri,R., Shiba,E., Iwamura,R., Kubo,C., Nawata,A., Harada,H.,
            Yoshino,K. and Hisaoka,M.
  TITLE     Potential pathogenetic link between angiomyofibroblastoma and
            superficial myofibroblastoma in the female lower genital tract
            based on a novel MTG1-CYP2E1 fusion
  JOURNAL   Mod Pathol 34 (12), 2222-2228 (2021)
   PUBMED   34385605
  REMARK    GeneRIF: Potential pathogenetic link between angiomyofibroblastoma
            and superficial myofibroblastoma in the female lower genital tract
            based on a novel MTG1-CYP2E1 fusion.
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Xu,D., Zhao,Y., Weng,X., Lu,Y., Li,W., Tang,K., Chen,W., Liu,Z.,
            Qi,X., Zheng,J., Fassett,J., Zhang,Y. and Xu,Y.
  TITLE     Novel role of mitochondrial GTPases 1 in pathological cardiac
            hypertrophy
  JOURNAL   J Mol Cell Cardiol 128, 105-116 (2019)
   PUBMED   30707992
  REMARK    GeneRIF: dampening oxidative stress with N-acetylcysteine (NAC)
            lowered hypertrophy in MTG1 KO to WT levels. Collectively, our data
            indicate that MTG1 protects against pressure overload-induced
            cardiac hypertrophy and dysfunction by preserving mitochondrial
            function and reducing oxidative stress and downstream TAK1 stress
            signaling.
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   7  (bases 1 to 3424)
  AUTHORS   Premzl,M., Gready,J.E., Jermiin,L.S., Simonic,T. and Marshall
            Graves,J.A.
  TITLE     Evolution of vertebrate genes related to prion and Shadoo
            proteins--clues from comparative genomic analysis
  JOURNAL   Mol Biol Evol 21 (12), 2210-2231 (2004)
   PUBMED   15342797
REFERENCE   8  (bases 1 to 3424)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   9  (bases 1 to 3424)
  AUTHORS   Premzl,M., Sangiorgio,L., Strumbo,B., Marshall Graves,J.A.,
            Simonic,T. and Gready,J.E.
  TITLE     Shadoo, a new protein highly conserved from fish to mammals and
            with similarity to prion protein
  JOURNAL   Gene 314, 89-102 (2003)
   PUBMED   14527721
REFERENCE   10 (bases 1 to 3424)
  AUTHORS   Barrientos,A., Korr,D., Barwell,K.J., Sjulsen,C., Gajewski,C.D.,
            Manfredi,G., Ackerman,S. and Tzagoloff,A.
  TITLE     MTG1 codes for a conserved protein required for mitochondrial
            translation
  JOURNAL   Mol Biol Cell 14 (6), 2292-2302 (2003)
   PUBMED   12808030
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL360181.37, AL161645.14 and AI344070.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138384.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.69027.1,
                                           SRR1660803.57003.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000317502.11/
                                                  ENSP00000323047.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL360181.37        101670-101845
            177-241             AL360181.37        103226-103290
            242-346             AL360181.37        103676-103780
            347-427             AL360181.37        105948-106028
            428-484             AL360181.37        106683-106739
            485-575             AL360181.37        107042-107132
            576-637             AL360181.37        109042-109103
            638-734             AL360181.37        109662-109758
            735-816             AL360181.37        110205-110286
            817-929             AL161645.14        4121-4233
            930-3290            AL161645.14        4667-7027
            3291-3424           AI344070.1         98-231
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..3424
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /note="mitochondrial ribosome associated GTPase 1"
                     /db_xref="GeneID:92170"
                     /db_xref="HGNC:HGNC:32159"
     exon            1..176
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..1069
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /note="GTP-binding protein 7 (putative); mitochondrial
                     GTPase 1 homolog"
                     /codon_start=1
                     /product="mitochondrial ribosome-associated GTPase 1"
                     /protein_id="NP_612393.2"
                     /db_xref="CCDS:CCDS31320.1"
                     /db_xref="GeneID:92170"
                     /db_xref="HGNC:HGNC:32159"
                     /translation="MRLTPRALCSAAQAAWRENFPLCGRDVARWFPGHMAKGLKKMQS
                     SLKLVDCIIEVHDARIPLSGRNPLFQETLGLKPHLLVLNKMDLADLTEQQKIMQHLEG
                     EGLKNVIFTNCVKDENVKQIIPMVTELIGRSHRYHRKENLEYCIMVIGVPNVGKSSLI
                     NSLRRQHLRKGKATRVGGEPGITRAVMSKIQVSERPLMFLLDTPGVLAPRIESVETGL
                     KLALCGTVLDHLVGEETMADYLLYTLNKHQRFGYVQHYGLGSACDNVERVLKSVAVKL
                     GKTQKVKVLTGTGNVNIIQPNYPAAARDFLQTFRRGLLGSVMLDLDVLRGHPPAETLP
                     "
     exon            177..241
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            242..346
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            347..427
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            428..484
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            485..575
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            576..637
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..734
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            735..816
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            817..929
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     exon            930..3424
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1390
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
                     /note="major polyA site"
     polyA_site      1433
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
     polyA_site      3424
                     /gene="MTG1"
                     /gene_synonym="GTP; GTPBP7"
ORIGIN      
        1 agaggcgggt cgcagcggcg cagaggaggt cagctgcggg agcgtttccg gggacggtgc
       61 cgccatgaga ttgaccccgc gcgcgctgtg cagcgccgcc caggccgcct ggcgggagaa
      121 cttccccctg tgcggtcgcg acgtggcgcg ctggttcccg ggccacatgg ccaaggggct
      181 gaagaagatg cagagcagcc tgaagctggt ggactgtatc atcgaggtcc acgatgcccg
      241 gatcccactt tcaggccgca accctctgtt tcaggaaacc cttgggctta agcctcactt
      301 gctggtcctc aacaagatgg acttggcgga tcttacagag cagcagaaaa ttatgcaaca
      361 cttagaagga gaaggcctaa aaaatgtcat ttttaccaac tgtgtaaagg atgaaaatgt
      421 caagcagatc atcccgatgg tcactgaact gattgggaga agccaccgct accaccgaaa
      481 agagaacctg gagtactgta tcatggtcat tggggtcccc aacgtgggca agtcctccct
      541 catcaactcc ctccggaggc agcacctcag gaaagggaaa gccaccaggg tgggtggcga
      601 gcctgggatc accagagctg tgatgtccaa aattcaggtc tctgagcggc ccctgatgtt
      661 cctgttggac actcctggcg tgctggctcc tcggattgaa agtgtggaga caggcctgaa
      721 gctggccctg tgtggaacgg tgctggacca cctggtcggg gaggagacca tggctgacta
      781 cctgctgtac accctcaaca aacaccagcg ctttgggtac gtgcagcact acggcctggg
      841 cagtgcctgt gacaacgtag agcgcgtgct gaagagtgtg gctgtgaagc tggggaagac
      901 gcagaaggtg aaggtgctca cgggcacggg taacgtgaac attattcagc ctaactatcc
      961 tgcggcagcc cgtgacttcc tgcagacttt ccgccgtggg ctgctgggtt ccgtgatgct
     1021 ggacctcgac gtcctgcggg gccacccccc ggctgagact ttgccctgaa cttgtccggg
     1081 tagggagggc cggaggcatg tggcctccca gacctcctga cctgggtggt tgaggctcaa
     1141 gacagctcac ccggtccaga agctccatgc tggtcactag ggtgctgtgc tctctggcgc
     1201 cccacagcct ggccagctcc agggacccca gttgcagggc ccaagcaggt gggagtggac
     1261 accaggcttc ccagtggacg tccctgagca gctccgcatg cttggttctc ccggagcttc
     1321 ctgctcaggc ctcttgagaa atggatgctg tctcagaagg agttaaagct ataacctgta
     1381 acctttaaaa tctccagtta aagggcctgt ttcttactgg cctgtgaggt gcaccgtagt
     1441 gccttgggcc tgtgtgttaa agctgctctc accagtgaaa cctaagaaat gagcaggttg
     1501 gcagctaggg tttgtgttgg aggctttcgg tccagtgtct tgcagtccta caacaagtga
     1561 gaggcttgct gccatcagag aggtttattt cacacttaca ggcacacaca gacacagacc
     1621 agagactccc agcagcagag cccaagcact ggcttcgccc ctcagtgccc tggggcatgt
     1681 tcagggcagg gttgaggggg acgccctgca catggctttg ctgtgcaatg actggaaggc
     1741 cgcccggcat gggcagtaga gacccctggc ctctgagcac cttctagctc acgggtagtg
     1801 ggattctgca ttagtggggc tgagagatgt gggggcccct ccagccccat tatagtgcac
     1861 ctgaaggggt ccacagcctg tgtcctagaa gagggaagag gaaggaaggt gggtggggct
     1921 ggtagtatgg actaaggtgc tgcaggacct ggggccaggg acatcctgtg cagaagctcc
     1981 ggctgcctct ttgcggtggt ggcctgaccg tcccacagca gcctccacca gggccctggt
     2041 gctcagtggc ccctctttgc tggctggctg cctctgctgc cccatacccc acacactcat
     2101 cagcctgaag ttagcccctg agtgccacct gcatcgtgcc ataaccctga ccgcctgggg
     2161 caggaagtat tcaggttggc tgtgtcagat gctaatgtgc tgaatcaaca gtcattgcag
     2221 atcacgaagt gtccatcata actggaacat tccatcagct tgcagtgctg tggtgtgtga
     2281 gggtctggtg cagctcagcc cattttccag gtgggcatct gcaaagttga gggggctccg
     2341 gtgggtctct ctgctgtgag gagactcaga ccaccccctg cctcctgggg gaaatgtcag
     2401 aagggcttct ctgcctatga ggatctgggg cagggcttgg ccttggcctg ctggtcttgg
     2461 aggcgttgag cttggtctgg aaggggtgga ggagcgtctg ggctcactgg gccaggggca
     2521 ttgctggcag tgtggacggg aggctgcagg gcgctgcctc ctgtggctta gtgccctgga
     2581 gctagagagc agtgcttggt tgagtcctgc caacagcttc cagatcctca cccaggccag
     2641 aacccaggcc agctggggaa ggcagaggct ggcagggccc gtggtgggtg ctggtcttga
     2701 ctttggtgtc cactgagtcc cgaggctcag gcccaggagg gatgcagtcc ggctgagggc
     2761 gaggctgtcc ccaggacatg gagagggtga gatcccaagg ccacggcggg gggcagggag
     2821 aacccctcct accctggatg agtgggtgac tggagagcta gagaacgtgg cagacccaag
     2881 acctctcagt gctgagccca tggaggatgc cccaggctgg cgggactggg aagcagaggg
     2941 ctggtcttaa cacaggtgtg tccagtgctg gaggcaagtc cttgtcgtga ctgtccagcg
     3001 ccactccatg tctctcctgt ccttggatgt tggggggctc agcctcttgc atgggtgtcc
     3061 tgctgggcgc tgggccccgc cactggcccc ctgcttgctt tggggtctga gttagctcct
     3121 ggctccactg agcaggccgt cagctgccag cccaccacgc ggatacccag gccctgttcc
     3181 gaggcctgga acagctgctt ccgaagaagg ggctgccttc agggaaatgc gtgcaccgtg
     3241 cagcctgtgc tgtgcccagg gaggcctctt cagcgggatt ggcagttgct gtgccctgag
     3301 aacaggcaga actgtgtgat ccctgaatgt gaacctgaag ttcaaaggac ttggaaagct
     3361 ctggaatgtg ttggtttttc ccccccaaaa tgggtcctaa ggagggtaaa gtgacttgtt
     3421 tcaa
//
