LOCUS       NM_001413076            5107 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens mitochondrial fission regulator 1 (MTFR1), transcript
            variant 11, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001413076
VERSION     NM_001413076.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5107)
  AUTHORS   Li,Q.Y., Guo,Q., Luo,W.M., Luo,X.Y., Ji,Y.M., Xu,L.Q., Guo,J.L.,
            Shi,R.S., Li,F., Lin,C.Y., Zhang,J. and Ke,D.
  TITLE     Overexpression of MTFR1 promotes cancer progression and
            drug-resistance on cisplatin and is related to the immune
            microenvironment in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 16 (1), 66-88 (2024)
   PUBMED   38170222
  REMARK    GeneRIF: Overexpression of MTFR1 promotes cancer progression and
            drug-resistance on cisplatin and is related to the immune
            microenvironment in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 5107)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 5107)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5107)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5107)
  AUTHORS   Chen,P., Zhong,J., Ye,J., He,Y., Liang,Z., Cheng,Y., Zheng,J.,
            Chen,H. and Chen,C.
  TITLE     miR-324-5p protects against oxidative stress-induced endothelial
            progenitor cell injury by targeting Mtfr1
  JOURNAL   J Cell Physiol 234 (12), 22082-22092 (2019)
   PUBMED   31066044
  REMARK    GeneRIF: Our results suggested that miR-324-5p protects against
            oxidative stress-induced endothelial progenitor cells injury by
            regulating Mtfr1.
REFERENCE   6  (bases 1 to 5107)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5107)
  AUTHORS   Monticone,M., Tonachini,L., Tavella,S., Degan,P., Biticchi,R.,
            Palombi,F., Puglisi,R., Boitani,C., Cancedda,R. and Castagnola,P.
  TITLE     Impaired expression of genes coding for reactive oxygen species
            scavenging enzymes in testes of Mtfr1/Chppr-deficient mice
  JOURNAL   Reproduction 134 (3), 483-492 (2007)
   PUBMED   17709566
  REMARK    GeneRIF: reports the role of mouse Mtfr1 in protecting cells from
            reactive oxygen species using Mtfr1-deficient mice.
REFERENCE   8  (bases 1 to 5107)
  AUTHORS   Tonachini,L., Monticone,M., Puri,C., Tacchetti,C., Pinton,P.,
            Rizzuto,R., Cancedda,R., Tavella,S. and Castagnola,P.
  TITLE     Chondrocyte protein with a poly-proline region (CHPPR) is a novel
            mitochondrial protein and promotes mitochondrial fission
  JOURNAL   J Cell Physiol 201 (3), 470-482 (2004)
   PUBMED   15389597
  REMARK    GeneRIF: reports full-length mRNA sequence of human MTFR1.
REFERENCE   9  (bases 1 to 5107)
  AUTHORS   Tonachini,L., Monticone,M., Di Marco,E., Zerega,B., Cancedda,R. and
            Castagnola,P.
  TITLE     Chondrocyte protein with a poly-proline region is a novel protein
            expressed by chondrocytes in vitro and in vivo
  JOURNAL   Biochim Biophys Acta 1577 (3), 421-429 (2002)
   PUBMED   12359332
  REMARK    GeneRIF: presents partial sequence of a human homolog of chicken
            MTFR1
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055822.10.
            
            Summary: This gene encodes a mitochondrial protein that is
            characterized by a poly-proline rich region. A chicken homolog of
            this protein promotes mitochondrial fission and the mouse homolog
            protects cells from oxidative stress. A related pseudogene of this
            gene is found on chromosome X. [provided by RefSeq, Mar 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.2788964.1,
                                           SRR14038193.286678.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC055822.10        157631-157681       c
            52-197              AC055822.10        132397-132542       c
            198-296             AC055822.10        119964-120062       c
            297-412             AC055822.10        108656-108771       c
            413-648             AC055822.10        97486-97721         c
            649-895             AC055822.10        95159-95405         c
            896-1064            AC055822.10        94404-94572         c
            1065-1166           AC055822.10        82934-83035         c
            1167-5107           AC055822.10        73159-77099         c
FEATURES             Location/Qualifiers
     source          1..5107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..5107
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="mitochondrial fission regulator 1"
                     /db_xref="GeneID:9650"
                     /db_xref="HGNC:HGNC:29510"
                     /db_xref="MIM:619414"
     exon            1..51
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            52..197
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1118
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 11; chondrocyte protein with a poly-proline
                     region"
                     /codon_start=1
                     /product="mitochondrial fission regulator 1 isoform 4
                     precursor"
                     /protein_id="NP_001400005.1"
                     /db_xref="GeneID:9650"
                     /db_xref="HGNC:HGNC:29510"
                     /db_xref="MIM:619414"
                     /translation="MLGWIKRLIRMVFQQVGVSMQSVLWSRKPYGSSRSIVRKIGTNL
                     SLIQCPRVQFQINSHATEWSPSHPGEDAVASFADVGWVAKEEGECSARLRTEVRSRPP
                     LQDDLLFFEKAPSRQISLPDLSQEEPQLKTPALANEEALQKICALENELAALRAQIAK
                     IVTQQEQQNLTAGDLDSTTFGTIPPHPPPPPPPLPPPALGLHQSTSAVDLIKERREKR
                     ANAGKTLVKNNPKKPEMPNMLEILKEMNSVKLRSVKRSEQDVKPKPVDATDPAALIAE
                     ALKKKFAYRYRSDSQDEVEKGIPKSESEATSERVLSLPAGFIQPHVSKHCLG"
     exon            198..296
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..412
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..648
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..895
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1166
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..5107
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="hexamer: AATAAA"
     polyA_site      1853
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="major polyA site"
     regulatory      4435..4440
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="hexamer: AATAAA"
     polyA_site      4464
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
                     /note="hexamer: AATAAA"
     polyA_site      5107
                     /gene="MTFR1"
                     /gene_synonym="CHPPR; FAM54A2"
ORIGIN      
        1 aagctagaag cctgaggagc cggagagggt gctggctgcc gcgcggccga gtgtgtttta
       61 tggaccatgt gctgctatgt atgcctgaag aagtacttga aatgcaaatt tggggagact
      121 ttgccatata aatgcttggc tggattaagc gcctaattag gatggttttt caacaagttg
      181 gagtaagcat gcaatcggta ctttggtcta ggaagccata tggttcgtct cgaagtatcg
      241 taaggaaaat tggtactaat ttgtctctga ttcagtgtcc aagagttcag tttcagatta
      301 acagccatgc aacagaatgg agtcccagcc acccaggaga ggatgcagtg gcgtcttttg
      361 ctgatgttgg atgggtagcc aaagaagaag gagagtgttc agcaagacta aggacagagg
      421 tcagatcaag gccacccctt caggatgacc ttcttttctt tgagaaggcc ccaagcagac
      481 agatttcctt accagacttg tctcaagaag agcctcagct gaagacccca gcgctggcaa
      541 atgaggaagc actgcagaag atttgcgctc tcgaaaatga acttgctgct ctcagagctc
      601 agattgccaa aattgtgacc cagcaggagc agcaaaatct cactgcaggt gacttagatt
      661 ctaccacatt tggtaccata ccaccacacc ctccacctcc cccaccgccc ctgcctcccc
      721 ctgcactggg gctccaccaa agtacatctg ctgttgatct gattaaagaa cgaagagaga
      781 aaagagccaa tgctggaaag actttggtta agaacaatcc aaagaaacct gaaatgccaa
      841 atatgctaga gatccttaaa gagatgaaca gtgtaaaact tcggtcagtg aagaggtcag
      901 agcaagatgt gaagcccaag ccagtggatg ctactgaccc tgctgccctc atagcagagg
      961 ctctgaaaaa gaaatttgct tatcggtatc gaagtgatag ccaagatgaa gttgaaaaag
     1021 gaattccaaa gtctgaatca gaggccacct cagagagagt gttgtccctt ccagctggct
     1081 ttattcagcc ccacgtgtcc aagcattgtc tgggatagcc ttgtattgga aaacctggcc
     1141 cattctgtaa ataaaggctc cactagtgcc tgagatctga aggcagaagg aagattcaaa
     1201 tagaaagaat aatggcccat tcaacagctg actcctacag acattctgac taagatgcct
     1261 gttgcaattc ccctgagcaa cttaataact gtgttttcaa ggttaaactc aagaaccaat
     1321 cagttatctg taaatgaata tccaactttt ctgaaaggaa aaaggtaaca tgttaatata
     1381 aacagcaaat acatacatca tttataaaac tgcctcagat caattaacaa gataaacata
     1441 cttaaaaaaa attcttgcct tttgttttaa tgggccatag caaatactat ctctgtataa
     1501 tgatcagtaa agagctgtca aatagataaa aagactcaca atattgaatg ttaaaacaaa
     1561 ccctaaatga agaaaacatt aaataatgct attaggtagt attccttatt tccattttta
     1621 ttaaatctga gaactcaaca gggttaatca tcaaatgaaa aacatgattt ttaaaaaggg
     1681 aataatgaag caaacatttt aatctgtctt aattttaaga acccataatt tacatataca
     1741 gtgtgtttaa gcaattttcg tatttgtact acagcaaaaa atgattttac ttaccagaag
     1801 tattgtcata ctccaaatgg tatccgtgaa taaagattta aaaaaataaa aaataaagtc
     1861 cagctttttt ctcatggtca ttacacaaaa cagtttttta tacagttgtt ttaaattatg
     1921 aaagggaaac cagagaacag caagtggaac ttaaatttta atactcaaac atatttttat
     1981 acctcaccac ttttcttgaa gtggatggtt tcaatccact ttcatggttt gctgacgtgc
     2041 attttccctc agtgcaacat tactaaaaag cttgtgtgtg gaccacacta tggcaatgac
     2101 gtgagatttt ataaaccatc accatcgtgt tagccttatt cacattaatg ttttttatta
     2161 ggttctaaaa tagcccattt attttttttt cctaaaatat tagggttttt tccattcatt
     2221 attatatcct atagctctag aagtgtgact ccaggattat gctattgagg acataaggca
     2281 ctctctttac tttcttgtca gttttgaaaa cttctgggaa cagattttaa tgaatctatt
     2341 taatgtaata gaatgtttac attccatcca atttaccttt atacctagac cttaaggttt
     2401 tattcagctg agtatggaaa tgtgtaatat ctatttatgt aaataagtag taaactatgg
     2461 ctgagcaatt gtgtatttga gtaaatttta tagtattcaa acccatggaa tagtctttga
     2521 taaaaataac tatccattaa aatgttaccg actatatagt aggatagctc taaattacta
     2581 aaattgtata taatttatta aatttgacaa acactgaaaa ctgtggaaca cctgaacata
     2641 acaattttta aaactttata aaattacttt gccaacttaa cttctataac cagtaacaaa
     2701 ttaaatttgt cttaatccaa cctacctgct ttctaatggc agatgtgaga ataagcctga
     2761 ttctctcaat aagcccactg cagatctcca gtggtgattt tccagtactg aggtattcta
     2821 caacaaagga cgtttctgag ttacttaatg atacgtctct ttctggacat atcattacta
     2881 acaatactgt tagcaatatt aatctggtta aaattctaac attcattgag aatttatttt
     2941 cattactttc atttcttcaa aatatgaaag attttctaga atgcaaaaat aataaatctt
     3001 gatgataaaa ttgcactaac cttgtataaa gttgccaagt aatggttagt tttaataagg
     3061 aaaggttgat taacacctgg atgatccaga tcatgagtgg cagctgcaat taagctcagc
     3121 aagatatccc aaggagttac agaattggca agctgaagtg tgacaaaaga ataatgaatc
     3181 acagatatat ctaaaataag ctctacgcca tcacagtagt tttgaattag cagccaatgg
     3241 tagtggtggt aatctcctcc cccttcacgt cattcctcag gtggttgttc attaggttca
     3301 ccaagcacat ctgccaggtc ctgatctcat caccacactg gcaaagccat gatacaacag
     3361 tggccctgcc catgtggagt ttacagagtt catccttagg ccatttcatt tttaacaagc
     3421 ttaattaaaa tggcagctaa aacataaacc gttctttttg agaaataatg gctttaaaat
     3481 gacaaacata gtttggcaca tttttattac tgtagccatt actgaacaaa agatctaaaa
     3541 ttttaagggt gtttatttat caacaaattg gttattggat ttcaataatg taatctaaga
     3601 tgtaaggtta ttcctttagt cctgatgttt aaggaggcta ctgagtaatc atgttaagtg
     3661 gaagtctatg tcaagtctgt gataaaatcc tcccctaacg gatggctaca ttcataacaa
     3721 tgatacaatg tattcatgtc agggaaagca atcttgcaca ccagaaattg taactttact
     3781 ctcaataatc attaccaaac ttatttaata atcacaataa ataaaagttt atgattagct
     3841 gacaaatgtt caatgataaa aaagatcacc ttgactatat catctgcttt tcatgaaatg
     3901 cctctcattt tctggcaaac ttggccagat ttgtgttccc acagcacctc atgacctgcc
     3961 acaataccac tcatcagagc atggtattat ttaggtttac gttaggacag tgctgactaa
     4021 actgtaatga tcctgtgctc taacagtgaa aatttttgag catacaccac ttatattaag
     4081 tatatgtact tatggattat tatactgaac taacatttat atgttataca acaaagataa
     4141 aaactgaaaa ttttaaaaat gagataaaaa taattttaga ttcaaattct attgttttct
     4201 ttctctgcta gaacgaatca atcatctctt tctactccct gtgttaagtt catctcagtc
     4261 agagaaatca ctgtctgagg gcttgaatct cctggaaaac tgtaagctac ctggaagcag
     4321 agatgcatat tatttatttt tgtatcgcat ataattagta cacggagaag gtcaatgaat
     4381 aggagaagat gaagaaaatt atttcctctt taggatatac aaaagcattg aaaaaataaa
     4441 gcattctaaa gcgctgctta ctaatcaaga tgaacagaat gcataggata taaagcatac
     4501 tgcatataaa gcaatctccc ctccttgaca tatacatgaa tgggcatggg tgtctatgtc
     4561 ttatgaacat gtaatttatt aggcagtatg caaaggggtt acattcttat tggcagaaga
     4621 atagacatcc tgggagaata caataatcca aaattagact gatttaaaaa attaatgtat
     4681 gactgcacat gacatcaaaa cattctcagg tatattaaag agttaaccat taaaaatagg
     4741 aacatgacaa taagcaactg aattctcaaa aattctgtga agagaaagta actttaaaaa
     4801 caaatcacac atgcaaaaaa atatttgata taaaaatgta acatttctgc ttgtaaaaaa
     4861 aaacctttca tcagaaacaa aattttcaat attataacaa agacaaggac ttcaataact
     4921 taacttttta aggtggatta aaagacagat gttatttcca ttctgtgatt acatctgtta
     4981 agagctgaca acaaagaaat gtcaaaaaag aaactacaga ttatttaaca tatgtgaagg
     5041 tcagctttta cttgtatctg caaagccatc attagggttc tttttcaata aaatagaaaa
     5101 ctattaa
//
