LOCUS       NM_007358               4075 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens metal response element binding transcription factor 2
            (MTF2), transcript variant 1, mRNA.
ACCESSION   NM_007358
VERSION     NM_007358.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4075)
  AUTHORS   Hu,X., Liu,Y., Shen,H., Zhang,T. and Liang,T.
  TITLE     MTF2 facilitates the advancement of osteosarcoma through mediating
            EZH2/SFRP1/Wnt signaling
  JOURNAL   J Orthop Surg Res 19 (1), 467 (2024)
   PUBMED   39118123
  REMARK    GeneRIF: MTF2 facilitates the advancement of osteosarcoma through
            mediating EZH2/SFRP1/Wnt signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4075)
  AUTHORS   Ngubo,M., Moradi,F., Ito,C.Y. and Stanford,W.L.
  TITLE     Tissue-Specific Tumour Suppressor and Oncogenic Activities of the
            Polycomb-like Protein MTF2
  JOURNAL   Genes (Basel) 14 (10), 1879 (2023)
   PUBMED   37895228
  REMARK    GeneRIF: Tissue-Specific Tumour Suppressor and Oncogenic Activities
            of the Polycomb-like Protein MTF2.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4075)
  AUTHORS   Tang,C., Lv,Y., Ding,K., Cao,Y., Ma,Z., Yang,L., Zhang,Q., Zhou,H.,
            Wang,Y., Liu,Z. and Cao,X.
  TITLE     Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human Tumors
  JOURNAL   Curr Probl Cancer 47 (3), 100957 (2023)
   PUBMED   37027952
  REMARK    GeneRIF: Comprehensive Pan-Cancer Analysis of MTF2 Effects on Human
            Tumors.
REFERENCE   4  (bases 1 to 4075)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 4075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4075)
  AUTHORS   Musselman,C.A., Avvakumov,N., Watanabe,R., Abraham,C.G.,
            Lalonde,M.E., Hong,Z., Allen,C., Roy,S., Nunez,J.K., Nickoloff,J.,
            Kulesza,C.A., Yasui,A., Cote,J. and Kutateladze,T.G.
  TITLE     Molecular basis for H3K36me3 recognition by the Tudor domain of
            PHF1
  JOURNAL   Nat Struct Mol Biol 19 (12), 1266-1272 (2012)
   PUBMED   23142980
REFERENCE   7  (bases 1 to 4075)
  AUTHORS   Wang,S., Robertson,G.P. and Zhu,J.
  TITLE     A novel human homologue of Drosophila polycomblike gene is
            up-regulated in multiple cancers
  JOURNAL   Gene 343 (1), 69-78 (2004)
   PUBMED   15563832
REFERENCE   8  (bases 1 to 4075)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   9  (bases 1 to 4075)
  AUTHORS   Mididoddi,S., McGuirt,J.P., Sens,M.A., Todd,J.H. and Sens,D.A.
  TITLE     Isoform-specific expression of metallothionein mRNA in the
            developing and adult human kidney
  JOURNAL   Toxicol Lett 85 (1), 17-27 (1996)
   PUBMED   8619255
REFERENCE   10 (bases 1 to 4075)
  AUTHORS   Inouye,C., Remondelli,P., Karin,M. and Elledge,S.
  TITLE     Isolation of a cDNA encoding a metal response element binding
            protein using a novel expression cloning procedure: the one hybrid
            system
  JOURNAL   DNA Cell Biol 13 (7), 731-742 (1994)
   PUBMED   7772254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB173315.1, AJ010014.1, BC001897.1, AF086908.1, CA417978.1,
            AL117354.12 and BQ025793.1.
            
            On Nov 22, 2018 this sequence version replaced NM_007358.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.150221.1,
                                           SRR1803616.57240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370298.9/ ENSP00000359321.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 DB173315.1         49-51
            4-1179              AJ010014.1         3-1178
            1180-1432           BC001897.1         1147-1399
            1433-2088           AF086908.1         1282-1937
            2089-2577           CA417978.1         16-504              c
            2578-3682           AL117354.12        28091-29195         c
            3683-4075           BQ025793.1         22-414              c
FEATURES             Location/Qualifiers
     source          1..4075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..4075
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="metal response element binding transcription factor
                     2"
                     /db_xref="GeneID:22823"
                     /db_xref="HGNC:HGNC:29535"
                     /db_xref="MIM:609882"
     exon            1..249
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..2026
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="isoform a is encoded by transcript variant 1;
                     putative DNA binding protein; polycomb-like 2; hPCl2;
                     polycomb-like protein 2; metal regulatory transcription
                     factor 2; metal-response element DNA-binding protein M96;
                     tudor domain containing 19A"
                     /codon_start=1
                     /product="metal-response element-binding transcription
                     factor 2 isoform a"
                     /protein_id="NP_031384.1"
                     /db_xref="CCDS:CCDS742.1"
                     /db_xref="GeneID:22823"
                     /db_xref="HGNC:HGNC:29535"
                     /db_xref="MIM:609882"
                     /translation="MRDSTGAGNSLVHKRSPLRRNQKTPTSLTKLSLQDGHKAKKPAC
                     KFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGE
                     MVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTT
                     KRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQ
                     CCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYN
                     LSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSG
                     KEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPISDSREVSNG
                     IEKKGKKKSVGRPPGPYTRKMIQKTAEPLLDKESISENPTLDLPCSIGRTEGTAHSSN
                     TSDVDFTGASSAKETTSSSISRHYGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRAL
                     QTQNSEIVKDDEGKEDYQFDELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGE
                     KYRVLARRVTLDGKVQYLVEWEGATAS"
     exon            250..448
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            449..530
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            531..626
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            627..727
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            728..876
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            877..972
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1041
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1165
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1233
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1404
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1510
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1563
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1668
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..4075
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2283..2288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="hexamer: ATTAAA"
     polyA_site      2303
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="major polyA site"
     regulatory      4035..4040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="hexamer: ATTAAA"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="hexamer: ATTAAA"
     polyA_site      4056
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="major polyA site"
     polyA_site      4075
                     /gene="MTF2"
                     /gene_synonym="dJ976O13.2; M96; PCL2; TDRD19A"
                     /note="major polyA site"
ORIGIN      
        1 agtccgcggg aaaccaaaat ggcgaggggc tgtattgaag tgggctgtgt ttgaggccgg
       61 tgtaagaacg ctcattctac ccccaaccct tgtctccaag gacctcggtt tgtgcgtgca
      121 tatgtgccgg gtacccggtg gggcgggtgc ccagtaagtg ctcggactcg caggggaagc
      181 gcccacgggg acggattggt tgttttttcc tgtatgaagc ggttggcacc actgaagtga
      241 ccgaatgaga gactctacag gggcaggtaa ttcactggtc cacaagcggt ctcctttacg
      301 tcgaaaccaa aagaccccaa catccttgac caagctgtct ttacaggatg gacataaagc
      361 caaaaagcca gcatgtaaat ttgaagaggg tcaggatgtc ctagctagat ggtcagatgg
      421 cttgttttat cttggcacta tcaaaaagat aaacatattg aaacagagct gcttcatcat
      481 atttgaagac agttctaaat cctgggttct ctggaaggac attcaaacag gagccactgg
      541 aagtggggaa atggtctgta caatatgtca agaagagtat tcagaagctc ccaatgaaat
      601 ggttatatgt gacaagtgtg gccaaggata tcatcagttg tgtcacacac ctcatattga
      661 ttccagtgtg attgattcag atgaaaaatg gctctgtcgg cagtgtgttt ttgcaacaac
      721 aacaaagagg ggtggtgcac ttaagaaagg accaaatgcc aaagcattgc aagtcatgaa
      781 gcagacatta ccctatagtg tggcagacct tgaatgggat gcaggtcata aaaccaatgt
      841 ccagcagtgt tactgctatt gtggaggccc tggagactgg tatttgaaga tgctacagtg
      901 ctgcaaatgt aagcagtggt ttcatgaggc ttgtgtgcaa tgccttcaaa agccaatgct
      961 atttggagac agattttata cgtttatatg ctctgtctgc agttctggac cagaatacct
     1021 caaacgtcta ccattacagt gggtagatat agcacaccta tgcctttaca acctaagtgt
     1081 tattcataag aagaaatact ttgattctga acttgagctt atgacataca ttaatgaaaa
     1141 ctgggataga ttgcaccctg gagagctggc agacacacca aaatctgaaa gatatgagca
     1201 tgttctggag gcattaaatg attacaagac catgtttatg tctgggaaag aaataaagaa
     1261 gaagaagcat ttgtttgggt tgcgaattcg tgttcctcct gtgccaccaa atgtggcttt
     1321 caaagcagag aaagaacctg aaggaacatc tcatgaattt aaaattaaag gcagaaaggc
     1381 atccaaacct atatctgatt caagggaagt aagcaatggc atagaaaaaa aaggaaagaa
     1441 aaaatctgta ggtcgtccac ctggcccata tacaagaaaa atgattcaaa aaactgctga
     1501 gccacttttg gataaggaat caatttcaga gaatcctact ttggatttac cttgttctat
     1561 agggagaact gagggaactg cacattcatc caatacctca gatgtggatt tcacgggtgc
     1621 ttccagtgca aaagaaacta cctcgtctag catttccagg cattatggat tatctgactc
     1681 cagaaaaaga acgcgtacag gaagatcttg gcctgctgca ataccacatt tgcggagaag
     1741 aagaggtcgt cttccaagaa gagcactcca gactcagaac tcagaaattg taaaagatga
     1801 tgaaggcaaa gaagattatc agtttgatga actcaacaca gagattctga ataacttagc
     1861 agatcaggag ttacaactca atcatctaaa gaactccatt accagttatt ttggtgctgc
     1921 aggtagaata gcatgtggcg aaaaataccg agttttggca cgtcgggtga cacttgatgg
     1981 aaaggtgcag tatcttgtgg aatgggaagg agcaactgca tcctgactgt aggactgaac
     2041 attatgttca ctgcactctg attttctgta ggtacagttc aaagccctaa aggagtctgg
     2101 cttttactat ctttcttaaa aaaaaaaaaa agtcaaaaaa attcaaaaaa ggggatgata
     2161 ctagccttaa catgtacctg tcaatgttat ggatattgtc ataaaaaggt atcttttaaa
     2221 aatcagaaca gagacttaat tttttaaatc ttaagatttg tagaatgttt ctaggatagg
     2281 atattaaaaa tgattgaaac ccatgcatgg tgttagacaa tttttctaat tattccattg
     2341 agtcagtttt ttgtgattag tgattatcag agcaaacatc atgtagatag cacaagtatt
     2401 tggagaaacg ttgtttgttt tgttaccaaa atgttggaaa aatttatttc aatacctttt
     2461 agatttcata aagtgcagtg tatataatgc ctactgaaag actgtaaaat attgaaattt
     2521 tctttcaagc aaagtgtaaa aaaatatatt gagcctgtaa attgctctgt gactagactt
     2581 cattgtcgtc ttaatatatt cttgcatgtg catatatata cacacgtgta tatatatgtg
     2641 tgtgattatg tgacctatgc aatacaaatt atgggaatgg gcagctttgg agtatatatc
     2701 ccataattct tttttcagga atagttgcag tatttacaca gcagcatttc ttctcaggct
     2761 tttattgggt gctgttgctt gctatgtatg aagagaaatg tgtcagacaa gtttagtgtg
     2821 ttctgaagaa gggtgtgaac aacagtgttc atgggctttt agaatgcttt tcacttttag
     2881 tccttgtaac tcagctgttc agtacctaaa acaaattcaa ataatatgaa cattatctcc
     2941 tactagaagt aacgttttca agttttcatg gcacattatg attgtaaatg tctctcattt
     3001 ttaacagtaa gtctatagga gtcccgtgaa gattcctgaa atgtctgtag taactgttag
     3061 tcatgtttga ataagtgtag tatgaacaaa gtattttatt gcacagggtt aacaaacagt
     3121 atgttgccag ctgaggctac tgctgtttta ttacaacatt acctcttgtt tttataaagt
     3181 gtaccaagat ttaaattgat aactttattt tacttgtaaa aaaaaagttt cttttatcac
     3241 cagtgttaca gttgtcttct gtttcttttt gttttgtttt atttgttttc ctttttagcc
     3301 aaagagtgaa cagaagattt tcttattttg gtggctattc attttacttt taaaagtgat
     3361 tggtggattt tagactaatt atgggggaat ttgccaccaa aataaaaaat atgtaaagtg
     3421 tagtgattac agagtggtta aaatgtgggt tagtacttat ttattccatt aattgattat
     3481 ttgactgttt ataaagaaag ttgctttatt tctttaaaca tcttcaaaag atgatccttt
     3541 cttgtcacat tatagccaaa agaagcagag aacttcattg tctgcatttg gttcctggtt
     3601 ggccaggtat aaatgagctt tacaaaagtg caaattaaaa actgttactt ctgtttacct
     3661 ccaccaaaac ttgattttcc cctagctatt aatttaaggt tgcctttcct gcagctgcaa
     3721 tattttgaat aacacacaga gtttgtgttg atttttgaat gtttgtttat atctaggggt
     3781 aatgaaaaat gtaaatcccg tgtatcctta ttcactccac ctgtatcata ttatttcatt
     3841 ttccccaaag tcctttaatt ctaactgaac accagcagta tttttagaaa tttttcttta
     3901 acatacttgg aagatgattt atccagctga actgtcttta gacgtaatta ttgtgaatgt
     3961 ctgttttatt ttctcatggt ggttcacatg gctctgatgt tcagtttgta tttttggaat
     4021 tgctttactt agaaattaaa acagaccaac attaaatgtg tgtatttttt aaaga
//
