LOCUS       NM_005955               7937 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens metal regulatory transcription factor 1 (MTF1), mRNA.
ACCESSION   NM_005955
VERSION     NM_005955.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7937)
  AUTHORS   Cheng,Y., Zhang,C., Li,Q., Yang,X., Chen,W., He,K. and Chen,M.
  TITLE     MTF1 genetic variants are associated with lung cancer risk in the
            Chinese Han population
  JOURNAL   BMC Cancer 24 (1), 778 (2024)
   PUBMED   38943058
  REMARK    GeneRIF: MTF1 genetic variants are associated with lung cancer risk
            in the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7937)
  AUTHORS   Huang,F., Su,Z., Yang,J., Zhao,X. and Xu,Y.
  TITLE     Knocking-down long non-coding RNA LINC01094 prohibits chondrocyte
            apoptosis via regulating microRNA-577/metal-regulatory
            transcription factor 1 axis
  JOURNAL   J Orthop Surg (Hong Kong) 32 (2), 10225536241254588 (2024)
   PUBMED   38758016
  REMARK    GeneRIF: Knocking-down long non-coding RNA LINC01094 prohibits
            chondrocyte apoptosis via regulating microRNA-577/metal-regulatory
            transcription factor 1 axis.
REFERENCE   3  (bases 1 to 7937)
  AUTHORS   Wright,G.M. and Black,J.C.
  TITLE     Genomic Redistribution of Metal-Response Transcription Factor-1
            (MTF-1) in Cadmium Resistant Cells
  JOURNAL   Cells 12 (6), 953 (2023)
   PUBMED   36980293
  REMARK    GeneRIF: Genomic Redistribution of Metal-Response Transcription
            Factor-1 (MTF-1) in Cadmium Resistant Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7937)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 7937)
  AUTHORS   Hardyman,J.E., Tyson,J., Jackson,K.A., Aldridge,C., Cockell,S.J.,
            Wakeling,L.A., Valentine,R.A. and Ford,D.
  TITLE     Zinc sensing by metal-responsive transcription factor 1 (MTF1)
            controls metallothionein and ZnT1 expression to buffer the
            sensitivity of the transcriptome response to zinc
  JOURNAL   Metallomics 8 (3), 337-343 (2016)
   PUBMED   26824222
  REMARK    GeneRIF: MTF1 heads a hierarchy of zinc sensors, and through
            controlling the expression of a raft of metallothioneins and other
            key proteins involved in controlling intracellular zinc levels
            (e.g. ZnT1) alters zinc buffering capacity and total cellular zinc
            content.
REFERENCE   6  (bases 1 to 7937)
  AUTHORS   Saydam,N., Georgiev,O., Nakano,M.Y., Greber,U.F. and Schaffner,W.
  TITLE     Nucleo-cytoplasmic trafficking of metal-regulatory transcription
            factor 1 is regulated by diverse stress signals
  JOURNAL   J Biol Chem 276 (27), 25487-25495 (2001)
   PUBMED   11306562
REFERENCE   7  (bases 1 to 7937)
  AUTHORS   Otsuka,F., Okugaito,I., Ohsawa,M., Iwamatsu,A., Suzuki,K. and
            Koizumi,S.
  TITLE     Novel responses of ZRF, a variant of human MTF-1, to in vivo
            treatment with heavy metals
  JOURNAL   Biochim Biophys Acta 1492 (2-3), 330-340 (2000)
   PUBMED   11004505
REFERENCE   8  (bases 1 to 7937)
  AUTHORS   Chen,X., Chu,M. and Giedroc,D.P.
  TITLE     MRE-Binding transcription factor-1: weak zinc-binding finger
            domains 5 and 6 modulate the structure, affinity, and specificity
            of the metal-response element complex
  JOURNAL   Biochemistry 38 (39), 12915-12925 (1999)
   PUBMED   10504263
REFERENCE   9  (bases 1 to 7937)
  AUTHORS   Gunes,C., Heuchel,R., Georgiev,O., Muller,K.H., Lichtlen,P.,
            Bluthmann,H., Marino,S., Aguzzi,A. and Schaffner,W.
  TITLE     Embryonic lethality and liver degeneration in mice lacking the
            metal-responsive transcriptional activator MTF-1
  JOURNAL   EMBO J 17 (10), 2846-2854 (1998)
   PUBMED   9582278
REFERENCE   10 (bases 1 to 7937)
  AUTHORS   Brugnera,E., Georgiev,O., Radtke,F., Heuchel,R., Baker,E.,
            Sutherland,G.R. and Schaffner,W.
  TITLE     Cloning, chromosomal mapping and characterization of the human
            metal-regulatory transcription factor MTF-1
  JOURNAL   Nucleic Acids Res 22 (15), 3167-3173 (1994)
   PUBMED   8065932
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014454.1, X78710.1,
            AL929472.21 and AI915521.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005955.2.
            
            Summary: This gene encodes a transcription factor that induces
            expression of metallothioneins and other genes involved in metal
            homeostasis in response to heavy metals such as cadmium, zinc,
            copper, and silver. The protein is a nucleocytoplasmic shuttling
            protein that accumulates in the nucleus upon heavy metal exposure
            and binds to promoters containing a metal-responsive element (MRE).
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.11515.1,
                                           SRR1660809.38972.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373036.5/ ENSP00000362127.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1282              BC014454.1         4-1285
            1283-3332           X78710.1           1253-3302
            3333-7757           AL929472.21        38480-42904         c
            7758-7937           AI915521.1         22-201              c
FEATURES             Location/Qualifiers
     source          1..7937
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..7937
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="metal regulatory transcription factor 1"
                     /db_xref="GeneID:4520"
                     /db_xref="HGNC:HGNC:7428"
                     /db_xref="MIM:600172"
     exon            1..62
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            63..521
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2375
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="zinc regulatory factor; MRE-binding transcription
                     factor-1; metal-responsive transcription factor 1;
                     transcription factor MTF-1"
                     /codon_start=1
                     /product="metal regulatory transcription factor 1"
                     /protein_id="NP_005946.2"
                     /db_xref="CCDS:CCDS30676.1"
                     /db_xref="GeneID:4520"
                     /db_xref="HGNC:HGNC:7428"
                     /db_xref="MIM:600172"
                     /translation="MGEHSPDNNIIYFEAEEDELTPDDKMLRFVDKNGLVPSSSGTVY
                     DRTTVLIEQDPGTLEDEDDDGQCGEHLPFLVGGEEGFHLIDHEAMSQGYVQHIISPDQ
                     IHLTINPGSTPMPRNIEGATLTLQSECPETKRKEVKRYQCTFEGCPRTYSTAGNLRTH
                     QKTHRGEYTFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLK
                     AHQRLHTGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHL
                     KTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNH
                     SLCLSDLSLLSTDSELRENSSTTQGQDLSTISPAIIFESMFQNSDDTAIQEDPQQTAS
                     LTESFNGDAESVSDVPPSTGNSASLSLPLVLQPGLSEPPQPLLPASAPSAPPPAPSLG
                     PGSQQAAFGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPQPIVPGLSVVAGASAS
                     AAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTNNPTITITPTPNTAILQSSLV
                     MGEQNLQWILNGATSSPQNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVI
                     IIKQEEACQCQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAP
                     VPGSSSSTLPSSCEQSRQAETPSDPQTETLSAMDVSEFLSLQSLDTPSNLIPIEALLQ
                     GEEEMGLTSSFSK"
     exon            522..760
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            761..892
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            893..966
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1103
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1181
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1284
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1880
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1944
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..7937
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="hexamer: CATAAA"
     polyA_site      2698
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="major polyA site"
     regulatory      7920..7925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="hexamer: ATTAAA"
     polyA_site      7937
                     /gene="MTF1"
                     /gene_synonym="MTF-1; ZRF"
                     /note="major polyA site"
ORIGIN      
        1 aatcatggtg ccgctgggga ggggagaagc tgctgctgcc gccgttgccg ggagccgcgg
       61 agacaagtca ttacgttttc atttctcaca actgggctga gcacaactga accatggggg
      121 aacacagtcc agacaacaac atcatctact ttgaggcaga ggaagatgag ctgacccccg
      181 atgataaaat gctcaggttt gtggataaaa acggactggt gccttcctca tctggaactg
      241 tttatgatag gaccactgtt cttattgagc aggaccctgg cactttggag gatgaagatg
      301 acgacggaca gtgcggagaa cacttgcctt ttctagtagg gggtgaagag ggctttcacc
      361 tgatagatca tgaagcaatg tcccagggtt atgtgcagca cattatctca ccagatcaga
      421 ttcatttgac aataaaccct ggttccacac ccatgccaag aaatattgaa ggtgcaaccc
      481 tcactctgca gtcggaatgt ccggaaacaa aacgtaaaga agtaaagcgg taccaatgta
      541 cctttgaggg ctgtccccgc acctacagca cagcaggcaa cctgcgaacc caccagaaga
      601 ctcaccgagg agagtacacc tttgtctgta atcaggaggg ctgtggcaaa gccttcctta
      661 cctcttacag cctcaggatc cacgtgcgag tgcacacgaa ggagaagcca tttgagtgtg
      721 acgtgcaggg ctgtgagaag gcattcaaca cactgtacag gctgaaagca catcagaggc
      781 ttcacacagg gaaaacgttt aactgtgaat ctgaaggctg cagcaaatac ttcaccacac
      841 tcagtgatct gaggaagcac attcgaactc atacagggga aaagccattt cggtgcgatc
      901 acgatggctg tggaaaagca tttgcagcaa gccaccacct taaaactcac gttcgtacac
      961 atactggtga aagacccttc ttctgcccca gtaatggctg tgagaaaaca ttcagcactc
     1021 aatacagtct caaaagtcac atgaaaggtc atgataacaa aggacactca tacaatgcac
     1081 ttccacaaca caatggatca gaggatacaa atcactcact ttgtctaagt gacttgagcc
     1141 ttctgtccac agattctgaa ttgcgagaaa attccagtac gacccagggc caggacctca
     1201 gcacaatttc accagcaatc atctttgaat caatgttcca gaattcagat gatacggcaa
     1261 ttcaggaaga tcctcaacag acagcttcct tgactgaaag ttttaatggt gatgcagagt
     1321 cagtcagtga tgttccgcca tccacaggaa attcagcatc tttatctctt ccacttgtac
     1381 tgcaacctgg cctctccgag ccaccccagc ctctactacc tgcctcagct ccgtctgctc
     1441 ctccgcctgc tccctcccta ggacctggct cccagcaagc tgcatttggc aacccccctg
     1501 ctctcttaca acctccagaa gtgcctgttc cccacagcac acagtttgct gctaatcatc
     1561 aagagtttct tccgcacccc caggcaccgc agcccattgt accaggactt tctgttgttg
     1621 ctggggcttc tgcatcagca gcggcagtgg catcagctgt ggcagcacca gccccaccac
     1681 aaagtactac tgagcccctg ccagccatgg tccagactct gcccctgggt gccaactctg
     1741 tcctaactaa taatcccaca ataaccatca ccccaactcc caacacagct atcctgcagt
     1801 ccagcctagt catgggagaa cagaacttac aatggatatt aaatggtgcc accagttctc
     1861 cacaaaacca agaacaaatt cagcaagcat ctaaagttga gaaggtgttt tttaccactg
     1921 cagtaccagt agccagtagc ccagggagct ctgtccagca gattggcctc agtgttcctg
     1981 tgatcatcat caaacaagaa gaggcatgtc agtgtcagtg tgcatgccgg gactctgcaa
     2041 aggagcgggc atccagcagg agaaagggct gctcctcccc accccctcca gagccgagcc
     2101 cccaggctcc tgatgggccc agcctgcagc tcccagcgca gactttctct tcagcccctg
     2161 ttcccgggtc atcatcctct accttgccct cctcctgtga gcaaagccga caagcagaga
     2221 ctccttcaga ccctcagaca gaaacattaa gtgccatgga tgtgtcagag tttctatccc
     2281 tccagagcct ggacaccccg tccaatctga ttcccattga agcactactg cagggggagg
     2341 aggagatggg cctcaccagc agcttctcca agtgaagggc ccatgtgtgc tcacctctgg
     2401 gaaaagcggg tgagcaggag gcatgaggta caatgcctgc catcatgggt cagaaatttg
     2461 aaggatgaag aaatctactg tttgaaatcc tcacctttca gacgtatttt ctttattcac
     2521 atcccaggag catccatttt aaggaactat tctttggaaa aaaacaaaaa acaaaaaaaa
     2581 caacaaaaaa agctaagtta taagtgaact gtttggctgc actgtatgtc acttttgctt
     2641 gttgtcatgt gaacttggaa actaaggtta ctcgtgtgca taaaaattct aaatgaaagg
     2701 gtgtggtttc catcaatctg atgctgccca tcgcttgcac tggggtcttt gtggatcggg
     2761 caggagtttt cagtgtgttg ggtgttgctc cttcctatgt gtcttttgaa tctgaggctg
     2821 acatttgctt ggaaggccag acccttgctc catcagagag ggcagtggca aaggccagtg
     2881 aggcagctgt gagttggaca gggttcaggt gagatggtgt tgtcatttgt gcttagtgtt
     2941 ggtggtgctc agggtggata acacgggtcg ttctgcagcc cgcttcagca caaataggca
     3001 gcttaaggcc tggctcacag gctgtggggt tgatctggct ctgcagaggc cctaggcagc
     3061 ttgttgactg ctgtctgttg atgacgtgtg tgcaaagcag gctctagcaa catgatcact
     3121 gtccttgcct tcctggttct ttctctcggt tggttgccag ggcttgcaga tcgcagtgaa
     3181 ttttccttgg ggaacatcgc tgttttgtcc tagagtgaac ttgtggctta tggccagtgc
     3241 tgtttggtgg tctgccttct ttttaatggt attttcttcc tcagagcaga agggctgcat
     3301 tttgcttatc agaagaaggt gcagatttaa gggaattcat atgaggtggc atgtaattgg
     3361 caggccaggt gtcctggttc caggttccag ccaggctttg ggttgccccc tccatctctg
     3421 cccccctctg gattttgcat acagcctcat acagtgcaaa caaggatgtg acttgctcag
     3481 cttagtcatg tgatttattt aaaaaaaaaa aaaaaagaaa cacaaaacga tgatcttcta
     3541 ctcagggtat agcaaaacaa aaaaattccc tttccaccaa aaagcctgaa atgttgcaat
     3601 aagttatctc atttggaatg tttcattaag ttgtgttata ggaaaaaatt gtgtgtgtgt
     3661 gttatagaat tatatccata tgtctgcctt tggctccaag tcattgcctc ttaaaataaa
     3721 agatacaatc catactagca tgaaaagttt ccctcaacag gctatattaa catagtcatg
     3781 agtgctgacc aaactcaccg agctcagagg ccaggcatgg cctgaggtgc agaataggcc
     3841 tctgcctccc aagagccctt tccttgccct gagcaaggag tggtgttcca caaacaaggc
     3901 tgctcttcta agccaacagt gtcaggcagg aagcagccat aattttgcct tgcattttca
     3961 ttccctaatg taaagggatc tgcattggtc actctcctgt tctctgagcc attgctcagg
     4021 gccagccaag atattattga gaacagataa tttaccttgg agccagaggc cctccctgcc
     4081 tttagcaagg atgttcaggg acagacaaag agggcagtgg tggtgaatgt tgttactgcc
     4141 atgaggagaa atggcagtaa gaaatcttaa ctacaagcag ccaatttctc attccaggac
     4201 cctagccaga ataattgact tctttttttt tttgagacag agttttgctt ttgttgccct
     4261 ggctggagtg cagtggcgca atcttggctc accgcaacct ccacttccca ggttcaagca
     4321 attctgcctc agcctcccga gtagctggga ttacaggcat gcgccaccac gcctggctaa
     4381 ttttgtattt ttagtagaga cggggtttct ccatgttggt caggctggtc tcgaactccc
     4441 aacgtcaggt gatcctcccg cctcagtctc ccaaagtgct gggattacag gtgtgagcca
     4501 ccatgcctgg tctagggaat tgacttcttt ttgaccttct gcactccctt ccccaaaagg
     4561 attgtggctt ctgttgacca ttgacctcag cagaagttga taaggcagga ggtttccagt
     4621 cctcctggaa aaccaactgc tgagcatgag ttgtccttgg ctgtctctgg gcctcgcacc
     4681 catgggaagt tttgaggtag ggcccttgct gtttacaact tctgagagag tagtgatggg
     4741 accccaaagt aagcttgtat cagagggcag taatgacctt cccatatccc catcctgtgg
     4801 tcacctggga tttgggttcc ctggggcgga agtgggaaat aggagcccag ggaaggacat
     4861 ctgaagcacc cacagtttaa atagcgactc ttcttggtta gccagggctg tgctcatgtt
     4921 gggccctacc caggtcagtg gccttttcac tctcaaagat cgggggtgac gaagcagcat
     4981 cttaaacagt gtttaggctg acagattttt ccagttgaag aagctgaagt atctgccttt
     5041 tgagggtgac tctagattac aagagagact atcagatcca atcagctttt gaaaaatcag
     5101 gaatgtgctt aaaatgccag tgagtggttg tgaagatcag gtttatttcc caggataggc
     5161 agtctttctt tccctccttt tccagttctc ttttcctacc tgtccttcca taagcctggt
     5221 ctctagtgcc gaggaccttg gagaagagag ggcccctagc taagctggag ccagaaagaa
     5281 ccttcatggt gagtgtggtt tcccaaactt gggaaatgaa cctagggtga ggttagggag
     5341 gatttgtaga attctagcag gtaaaaatca agcctttttc ccctcccata gtaaacttaa
     5401 ccattttcac cctgtacgtt atcttctagc tcctactaac atctccaatt agacaaccgc
     5461 ttcaaagggt gcttagcacc agggattggg gttcatggac ttaggaggtg gtaaggaaac
     5521 tggctggcac caccaaactg ccttagtgaa cttggccctt cccaggcagg taggttgggc
     5581 attgagggaa ggtggcccag tctttgctgg cagggtctgg ccagtctcat gggggcacca
     5641 ccagtttggt gacagaagtg gtgtcattta ttgaattcca cctccgttta gaaggagatc
     5701 atggtacaaa gcccaggagg ggccttaaga tgtgaagatc tctctgagta aaaggcaagg
     5761 ggcttctctt cttcacctct gggatagttg gtagatcgga gagttttatt ttcagggtca
     5821 aggctgtgga ctgatgggga tattggaggg tgggtgggtt ttcctgagag actttgtata
     5881 atgctgaatg tgtccagagg gacaagtttg cagaacctca tattggtata ttaaagaaat
     5941 aataaaataa aaaagcactt taggttattt tatctttaac ccgattgctg caatttcttt
     6001 tgtgtgtata tatacatata tatactttcc acaaagtttt attttttgct cagaataaaa
     6061 agttaaattg aggtgtgaaa agaaaagcac ttaccttggt gcaatatgtg tagcttgatg
     6121 gtcgttgtcc catgtggccc tggcctggca gcgtttttcc gctcaatcag ccctgtgctg
     6181 tgagactgtc catagggaaa cactattatg cattctcagc aaccgctcaa tctatgcaag
     6241 ccttccctgt gtgccccagg gcgccccctc aggctctctg aagaactgct gtgggtcctg
     6301 ttttctgctg actgttgagg ccctttttca tcacttcttg gtctctcgcc atcttttccc
     6361 tcttcaccat tacaaaatga tgcctgaaag gaaggaacag attgttccta ggtagaaacc
     6421 tggcaccttc tagactttta tatttgtaat cacatccatt gtccttaaag acttttccag
     6481 agtgattgaa accattgatt tgtggaactg caacaatatt tctcaagagt ttacaattgt
     6541 cttacaccac caatcagaaa tatgtttggg gaggcatggg tggcaggggg caacatgagc
     6601 catttccata ctgctcccca tactacctgt gttggttcct taagcaaaaa ggcctccagc
     6661 cttcattaaa tcctataaac aaacattaca tcccatgaat cattatcaac tttcttcctt
     6721 tactccacct cccccatttt atcttcaatt ctcaggctat agaatagaca agttttagaa
     6781 tatacttcag ccaaagcaga aggattttca tagatccaat atgcaaatag ttctgctgtg
     6841 acatagatca gaaattgtct gttccttaat atttgggggt ggaggcaaca aaactgaagc
     6901 atatttctga ttggttagcc attttggcct gtttcctctt gcatgttttt tagggagaga
     6961 gggaaacagt cctgtatttc ttctgatgcc ctttggggaa gccgacgacc actgggcatt
     7021 tctcactgtt actcctgttc aagagagggc ttctcagtct gcactgaaaa atgcaaatta
     7081 aactggatct ttatgtcaat gtgtacatag tacaagcttt tttactggaa ttgaggttta
     7141 aaaccacaca ctgccctttt ggtggtgtgc ctgttgggcc aaaaattggg tgataatgta
     7201 gtgtcacttt ctcagctcaa tgcagtttct actttttctt atgggaaaat ttttcataaa
     7261 acctttttgc accaaaaccc aggggtgttt tttgcaatat ccttgttatc ctcgtagtgt
     7321 gccaagtcag aggctttctc ttgccctttt cctgctgtgt tctcaggcct cccaagggct
     7381 atttgactca acagtctaca tccttcgttg tgttttggag aatgtggggg tgggggtcag
     7441 agttcaaggt gtctgttccc ttttcctgtg aactctttct agtccctatt tggggagggt
     7501 ggctggaaac agatttttgc tgaatttctg gctcagatct tctagccagg aaaggcaaga
     7561 gcccccaaga gccctttttt ttgacataca ctaatcattg gccggggtct tggtgacaac
     7621 ttttaaaatc ccaaatagtt ttatttggat tatgtaaaag taagtgtgaa acatgggaac
     7681 aacggacttc cactgagcga tgtgaaaacg ttacaggttc agtacttcca aaggaagaaa
     7741 cctccaaacc caaaaaagaa taaatatgaa tttgtatttt tgaagaatgt gaaataatgg
     7801 tgtttgctta attgctcatt ttgtataaac ttaatattgt actttaaaat atctgctaaa
     7861 aagtgaaaat ttaacttttt ggaattgaaa aagcaatatt aaatactaat gaaatcctaa
     7921 ttaaatgctt atttaaa
//
