LOCUS       NM_015942               1463 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens mitochondrial transcription termination factor 3
            (MTERF3), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_015942
VERSION     NM_015942.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1463)
  AUTHORS   Zheng,Z., Zhao,Y., Yu,H., Wang,T., Li,J., Xu,L., Ding,C., He,L.,
            Wu,L. and Dong,Z.
  TITLE     Suppressing MTERF3 inhibits proliferation of human hepatocellular
            carcinoma via ROS-mediated p38 MAPK activation
  JOURNAL   Commun Biol 7 (1), 18 (2024)
   PUBMED   38177713
  REMARK    GeneRIF: Suppressing MTERF3 inhibits proliferation of human
            hepatocellular carcinoma via ROS-mediated p38 MAPK activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1463)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1463)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1463)
  AUTHORS   Liu,X., Cao,X., Liu,C., Cao,Y., Zhao,Q., Tan,X., Li,X., Xu,X.,
            Yu,E. and Wang,H.
  TITLE     MTERFD1 promotes cell growth and irradiation resistance in
            colorectal cancer by upregulating interleukin-6 and interleukin-11
  JOURNAL   Int J Biol Sci 15 (12), 2750-2762 (2019)
   PUBMED   31754344
  REMARK    GeneRIF: These results demonstrated that MTERFD1 played an
            oncogenic role in colorectal (CRC) development and enhanced
            irradiation resistance by regulating IL-6 and IL-11 in CRC cells.
            MTERFD1 may serve as a potential prognostic and therapeutic marker
            for radiotherapy in CRC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1463)
  AUTHORS   Antonicka,H., Choquet,K., Lin,Z.Y., Gingras,A.C., Kleinman,C.L. and
            Shoubridge,E.A.
  TITLE     A pseudouridine synthase module is essential for mitochondrial
            protein synthesis and cell viability
  JOURNAL   EMBO Rep 18 (1), 28-38 (2017)
   PUBMED   27974379
REFERENCE   6  (bases 1 to 1463)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1463)
  AUTHORS   Hyvarinen,A.K., Pohjoismaki,J.L., Holt,I.J. and Jacobs,H.T.
  TITLE     Overexpression of MTERFD1 or MTERFD3 impairs the completion of
            mitochondrial DNA replication
  JOURNAL   Mol Biol Rep 38 (2), 1321-1328 (2011)
   PUBMED   20577816
  REMARK    GeneRIF: MTERFD1 and MTERFD3 have a role in impairing the
            completion of mitochondrial DNA replication
REFERENCE   8  (bases 1 to 1463)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1463)
  AUTHORS   Park,C.B., Asin-Cayuela,J., Camara,Y., Shi,Y., Pellegrini,M.,
            Gaspari,M., Wibom,R., Hultenby,K., Erdjument-Bromage,H., Tempst,P.,
            Falkenberg,M., Gustafsson,C.M. and Larsson,N.G.
  TITLE     MTERF3 is a negative regulator of mammalian mtDNA transcription
  JOURNAL   Cell 130 (2), 273-285 (2007)
   PUBMED   17662942
REFERENCE   10 (bases 1 to 1463)
  AUTHORS   Linder,T., Park,C.B., Asin-Cayuela,J., Pellegrini,M., Larsson,N.G.,
            Falkenberg,M., Samuelsson,T. and Gustafsson,C.M.
  TITLE     A family of putative transcription termination factors shared
            amongst metazoans and plants
  JOURNAL   Curr Genet 48 (4), 265-269 (2005)
   PUBMED   16193327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY116693.1, BC012995.2 and AK309002.1.
            
            On May 17, 2019 this sequence version replaced NM_015942.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.472088.1,
                                           SRR3476690.1088065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145245, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000287025.4/
                                                  ENSP00000287025.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                HY116693.1         4-45
            43-1448             BC012995.2         1-1406
            1449-1463           AK309002.1         1511-1525
FEATURES             Location/Qualifiers
     source          1..1463
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..1463
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /note="mitochondrial transcription termination factor 3"
                     /db_xref="GeneID:51001"
                     /db_xref="HGNC:HGNC:24258"
                     /db_xref="MIM:616930"
     exon            1..110
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..454
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1374
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mTERF domain-containing protein 1,
                     mitochondrial; MTERF domain containing 1; transcription
                     termination factor 3, mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 3,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_057026.3"
                     /db_xref="CCDS:CCDS6270.1"
                     /db_xref="GeneID:51001"
                     /db_xref="HGNC:HGNC:24258"
                     /db_xref="MIM:616930"
                     /translation="MALSAQQIPRWFNSVKLRSLINAAQLTKRFTRPARTLLHGFSAQ
                     PQISSDNCFLQWGFKTYRTSSLWNSSQSTSSSSQENNSAQSSLLPSMNEQSQKTQNIS
                     SFDSELFLEELDELPPLSPMQPISEEEAIQIIADPPLPPASFTLRDYVDHSETLQKLV
                     LLGVDLSKIEKHPEAANLLLRLDFEKDIKQMLLFLKDVGIEDNQLGAFLTKNHAIFSE
                     DLENLKTRVAYLHSKNFSKADVAQMVRKAPFLLNFSVERLDNRLGFFQKELELSVKKT
                     RDLVVRLPRLLTGSLEPVKENMKVYRLELGFKHNEIQHMITRIPKMLTANKMKLTETF
                     DFVHNVMSIPHHIIVKFPQVFNTRLFKVKERHLFLTYLGRAQYDPAKPNYISLDKLVS
                     IPDEIFCEEIAKASVQDFEKFLKTL"
     exon            455..607
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..797
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            798..945
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1017
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1179
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1463
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /note="hexamer: AATGAA"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /note="hexamer: AATATA"
     polyA_site      1444
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
                     /note="major polyA site"
     polyA_site      1463
                     /gene="MTERF3"
                     /gene_synonym="CGI-12; MTERFD1"
ORIGIN      
        1 gtgtagggcg ggctgaggag ccggcgtgcg gcgcggcggg acgggacgtg cggcccagcg
       61 agttggtcgg tcccggggtc acccgctacg ggaagcaggc ctcgccacag actaagaaaa
      121 atggctttgt cagcccaaca gatacccaga tggtttaact cagttaagtt gaggagcctc
      181 attaatgctg cacaactcac aaaacgtttt actagaccag caagaacact gttacatggc
      241 ttttctgctc agcctcagat atcctctgac aattgctttc tccagtgggg atttaagact
      301 tacaggactt cctccttatg gaatagttcc cagtctacta gctcaagtag tcaggagaat
      361 aattctgccc aaagcagtct gcttccttcc atgaatgaac agtcacagaa gacacaaaat
      421 atatccagct ttgattctga gctgtttcta gaagaactgg atgaattgcc tccattgtct
      481 ccaatgcagc caatttcaga ggaagaggct attcagatta ttgcagaccc tccattgcca
      541 ccagcttcat tcacacttcg agactatgtg gatcattctg agactctgca gaagttggtt
      601 cttctaggcg tggatttgtc caagatagaa aaacatccag aagcagcaaa cctccttctg
      661 agactggatt ttgaaaaaga cattaagcaa atgcttctgt ttcttaaaga tgtgggtata
      721 gaggataacc aactgggagc attcctgaca aaaaatcatg caattttctc tgaagacctt
      781 gaaaatctga agaccagggt ggcttatctg cattcaaaaa atttcagtaa agcagatgtt
      841 gcacagatgg tcagaaaagc accatttttg ctgaactttt cagtggaaag actggataac
      901 agattgggat tttttcagaa agaacttgaa cttagtgtga agaagactag agatctggta
      961 gttcgtctcc caaggctgct aactggaagt ctggaacccg tgaaagaaaa tatgaaggtt
     1021 tatcgtcttg aacttggttt taaacataac gaaattcaac atatgatcac cagaatccca
     1081 aagatgttaa ctgcaaataa aatgaaactt accgagacgt ttgattttgt gcacaatgtg
     1141 atgagcattc cccaccacat cattgtcaag ttcccacagg tatttaatac aaggctgttt
     1201 aaggtcaaag aaagacactt gtttcttacc tatttaggaa gagcacagta tgatccagca
     1261 aaacctaact acatctcttt ggacaaacta gtatctattc ctgatgaaat attttgtgaa
     1321 gagattgcca aagcatcagt acaggacttt gaaaaattct taaaaacgct ttagattttt
     1381 atgtatgtta aaatgcagta ttgtaaagtg aatatatata tgaataaatg aatatatttt
     1441 taaatgcctc gggtctcaac tga
//
