LOCUS       NM_001033050            1784 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial transcription termination factor 2
            (MTERF2), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001033050
VERSION     NM_001033050.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1784)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1784)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1784)
  AUTHORS   Han,Y., Gao,P., Qiu,S., Zhang,L., Yang,L., Zuo,J., Zhong,C., Zhu,S.
            and Liu,W.
  TITLE     MTERF2 contributes to MPP(+)-induced mitochondrial dysfunction and
            cell damage
  JOURNAL   Biochem Biophys Res Commun 471 (1), 177-183 (2016)
   PUBMED   26826381
  REMARK    GeneRIF: These findings demonstrate that MTERF2 contributes to
            MPP(+)-induced mitochondrial disruption and cell damage.
REFERENCE   4  (bases 1 to 1784)
  AUTHORS   Hyvarinen,A.K., Pohjoismaki,J.L., Holt,I.J. and Jacobs,H.T.
  TITLE     Overexpression of MTERFD1 or MTERFD3 impairs the completion of
            mitochondrial DNA replication
  JOURNAL   Mol Biol Rep 38 (2), 1321-1328 (2011)
   PUBMED   20577816
  REMARK    GeneRIF: MTERFD1 and MTERFD3 have a role in impairing the
            completion of mitochondrial DNA replication
REFERENCE   5  (bases 1 to 1784)
  AUTHORS   Spahr,H., Samuelsson,T., Hallberg,B.M. and Gustafsson,C.M.
  TITLE     Structure of mitochondrial transcription termination factor 3
            reveals a novel nucleic acid-binding domain
  JOURNAL   Biochem Biophys Res Commun 397 (3), 386-390 (2010)
   PUBMED   20430012
  REMARK    GeneRIF: MTERF-domain of human MTERF3 forms a half-doughnut-shaped
            right-handed superhelix.
REFERENCE   6  (bases 1 to 1784)
  AUTHORS   Pellegrini,M., Asin-Cayuela,J., Erdjument-Bromage,H., Tempst,P.,
            Larsson,N.G. and Gustafsson,C.M.
  TITLE     MTERF2 is a nucleoid component in mammalian mitochondria
  JOURNAL   Biochim Biophys Acta 1787 (5), 296-302 (2009)
   PUBMED   19366608
REFERENCE   7  (bases 1 to 1784)
  AUTHORS   Chen,Y., Zhou,G., Yu,M., He,Y., Tang,W., Lai,J., He,J., Liu,W. and
            Tan,D.
  TITLE     Cloning and functional analysis of human mTERFL encoding a novel
            mitochondrial transcription termination factor-like protein
  JOURNAL   Biochem Biophys Res Commun 337 (4), 1112-1118 (2005)
   PUBMED   16226716
  REMARK    GeneRIF: mTERFL is a novel mTERF family member and a
            serum-inhibitory factor probably participating in the regulation of
            cell growth
REFERENCE   8  (bases 1 to 1784)
  AUTHORS   Linder,T., Park,C.B., Asin-Cayuela,J., Pellegrini,M., Larsson,N.G.,
            Falkenberg,M., Samuelsson,T. and Gustafsson,C.M.
  TITLE     A family of putative transcription termination factors shared
            amongst metazoans and plants
  JOURNAL   Curr Genet 48 (4), 265-269 (2005)
   PUBMED   16193327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024124.1, BC025984.1 and AC007541.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001033050.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.362250.1,
                                           SRR1803616.175706.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000240050.9/
                                                  ENSP00000240050.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              AK024124.1         6-1057
            1053-1658           BC025984.1         1047-1652
            1659-1784           AC007541.9         95417-95542
FEATURES             Location/Qualifiers
     source          1..1784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.3"
     gene            1..1784
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="mitochondrial transcription termination factor 2"
                     /db_xref="GeneID:80298"
                     /db_xref="HGNC:HGNC:30779"
                     /db_xref="MIM:616929"
     exon            1..178
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /inference="alignment:Splign:2.1.0"
     exon            179..289
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /inference="alignment:Splign:2.1.0"
     exon            290..1784
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             347..1504
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="mTERF domain-containing protein 3, mitochondrial;
                     mitochondrial transcription termination factor-like
                     protein; MTERF domain containing 3; transcription
                     termination factor 2, mitochondrial; mTERF-like"
                     /codon_start=1
                     /product="transcription termination factor 2,
                     mitochondrial precursor"
                     /protein_id="NP_001028222.1"
                     /db_xref="CCDS:CCDS9111.1"
                     /db_xref="GeneID:80298"
                     /db_xref="HGNC:HGNC:30779"
                     /db_xref="MIM:616929"
                     /translation="MLWKLLLRSQSCRLCSFRKMRSPPKYRPFLACFTYTTDKQSSKE
                     NTRTVEKLYKCSVDIRKIRRLKGWVLLEDETYVEEIANILQELGADETAVASILERCP
                     EAIVCSPTAVNTQRKLWQLVCKNEEELIKLIEQFPESFFTIKDQENQKLNVQFFQELG
                     LKNVVISRLLTAAPNVFHNPVEKNKQMVRILQESYLDVGGSEANMKVWLLKLLSQNPF
                     ILLNSPTAIKETLEFLQEQGFTSFEILQLLSKLKGFLFQLCPRSIQNSISFSKNAFKC
                     TDHDLKQLVLKCPALLYYSVPVLEERMQGLLREGISIAQIRETPMVLELTPQIVQYRI
                     RKLNSSGYRIKDGHLANLNGSKKEFEANFGKIQAKKVRPLFNPVAPLNVEE"
     regulatory      1486..1491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="hexamer: ATTAAA"
     polyA_site      1504
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="major polyA site"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="hexamer: TATAAA"
     polyA_site      1697
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
                     /note="hexamer: ATTAAA"
     polyA_site      1784
                     /gene="MTERF2"
                     /gene_synonym="MTERFD3; mTERFL"
ORIGIN      
        1 actgatggcc tggttggcgc tgctgagaac tgtcgggagc ttcttgagac cgaggaccga
       61 aatcccggct ccaggcctcg gggactgcgg actgtgggga ggctggccgg agagagaggg
      121 aaggacgggg cctggccccc gggactccct gtgccttgct tggagctgac gccgacggtt
      181 tattgcaggg aactgacaag atcacatttt gagaagaagt tggaaagaat cccaagtgga
      241 tgaactgaat atctggatga ggacaagatc tgtggggaga gactgtaaga tagaatgagt
      301 ccatttaagt cccaggacgg tggaaactag ctagtagatt gcagccatgt tgtggaagct
      361 gctgctgaga tcccagtcct gcaggctgtg ttctttcaga aagatgcgat cacctccaaa
      421 atacagacct ttcttagcat gcttcaccta tacaactgat aaacagtcga gcaaagaaaa
      481 tacaagaaca gtggaaaagc tctataaatg ttcagttgac attaggaaaa ttcgtagatt
      541 aaaaggatgg gtacttttag aggatgaaac ctatgttgaa gaaattgcga atattttaca
      601 agaactaggt gccgatgaga ctgctgtagc cagtattttg gaacgctgcc cggaagcaat
      661 tgtctgtagt ccaaccgctg ttaacaccca gagaaaactc tggcagttgg tctgcaaaaa
      721 tgaggaagag ttaatcaagt taatagagca gtttccagaa tctttcttta ctattaaaga
      781 ccaagagaac cagaagctga atgttcagtt ctttcaagag ttgggactaa aaaatgtggt
      841 cattagcaga cttttgacag ctgcacctaa tgtttttcat aatcctgttg agaagaataa
      901 gcaaatggta agaattctcc aagagagtta tctagatgta ggtggctctg aggccaacat
      961 gaaagtttgg ctactaaaat tgttaagcca aaacccattt attttgttaa attctcccac
     1021 agctataaag gaaacactag aatttctcca ggagcaaggt ttcaccagct ttgaaattct
     1081 ccagcttcta tccaaactca aaggatttct ttttcaactt tgcccaagaa gtatacagaa
     1141 tagtatttcc ttctctaaaa atgcttttaa atgcacagat catgacctga agcaattagt
     1201 tttgaaatgt cctgcccttt tatattattc tgttccagtt ttagaagaga gaatgcaagg
     1261 attattgaga gaaggaattt ccatagctca gataagagag acgccaatgg ttcttgaatt
     1321 aacaccacag atagtacagt acaggataag gaaactgaat tcctcaggct acagaataaa
     1381 ggatggacat ctagcaaatc taaatggatc aaaaaaagag tttgaagcta attttggcaa
     1441 aattcaggcc aaaaaagtaa ggccattatt taaccctgtg gcaccattaa atgttgaaga
     1501 atgacatact gactgttgtt gcttctttct agcagtgcag ggtgaaacta actagcaaag
     1561 acaaaaattc aggcagtttg tagacaccag taattttaag aacctgctta gcttctgtgt
     1621 tgtatttaag ttatctctaa atagataaat tctgactcat gtgccatatt ataaaatata
     1681 aatcatattt attttaataa ggttggtaac ttttaccttg aaccattatt tcaaaaactc
     1741 atatactatt aaatggcata tcagtgtgat actttataag tgaa
//
