LOCUS       NM_006980               3941 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial transcription termination factor 1
            (MTERF1), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_006980
VERSION     NM_006980.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3941)
  AUTHORS   Lin,C., Yang,H., Luo,Q. and Liu,Q.
  TITLE     FAK mediates hypoxia-induced pulmonary artery smooth muscle cell
            proliferation by modulating mitochondrial transcription termination
            factor 1/cyclin D1
  JOURNAL   Clin Transl Sci 17 (3), e13767 (2024)
   PUBMED   38488492
  REMARK    GeneRIF: FAK mediates hypoxia-induced pulmonary artery smooth
            muscle cell proliferation by modulating mitochondrial transcription
            termination factor 1/cyclin D1.
REFERENCE   2  (bases 1 to 3941)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 3941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3941)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3941)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3941)
  AUTHORS   Asin-Cayuela,J., Schwend,T., Farge,G. and Gustafsson,C.M.
  TITLE     The human mitochondrial transcription termination factor (mTERF) is
            fully active in vitro in the non-phosphorylated form
  JOURNAL   J Biol Chem 280 (27), 25499-25505 (2005)
   PUBMED   15899902
  REMARK    GeneRIF: monomeric human mTERF is fully active in its
            non-phosphorylated form and that the protein does not require
            additional cellular factors to terminate mitochondrial
            transcription in vitro
REFERENCE   7  (bases 1 to 3941)
  AUTHORS   Prieto-Martin,A., Montoya,J. and Martinez-Azorin,F.
  TITLE     Phosphorylation of rat mitochondrial transcription termination
            factor (mTERF) is required for transcription termination but not
            for binding to DNA
  JOURNAL   Nucleic Acids Res 32 (7), 2059-2068 (2004)
   PUBMED   15087485
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3941)
  AUTHORS   Asin-Cayuela,J., Helm,M. and Attardi,G.
  TITLE     A monomer-to-trimer transition of the human mitochondrial
            transcription termination factor (mTERF) is associated with a loss
            of in vitro activity
  JOURNAL   J Biol Chem 279 (15), 15670-15677 (2004)
   PUBMED   14744862
  REMARK    GeneRIF: mTERF exists in mitochondria in two forms, an active
            monomer and an inactive large size complex
REFERENCE   9  (bases 1 to 3941)
  AUTHORS   Fernandez-Silva,P., Martinez-Azorin,F., Micol,V. and Attardi,G.
  TITLE     The human mitochondrial transcription termination factor (mTERF) is
            a multizipper protein but binds to DNA as a monomer, with evidence
            pointing to intramolecular leucine zipper interactions
  JOURNAL   EMBO J 16 (5), 1066-1079 (1997)
   PUBMED   9118945
REFERENCE   10 (bases 1 to 3941)
  AUTHORS   Daga,A., Micol,V., Hess,D., Aebersold,R. and Attardi,G.
  TITLE     Molecular characterization of the transcription termination factor
            from human mitochondria
  JOURNAL   J Biol Chem 268 (11), 8123-8130 (1993)
   PUBMED   7681833
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK222730.1, BC130391.1, BU740531.1 and AC003086.1.
            
            On May 17, 2019 this sequence version replaced NM_006980.4.
            
            Summary: This gene encodes a mitochondrial transcription
            termination factor. This protein participates in attenuating
            transcription from the mitochondrial genome; this attenuation
            allows higher levels of expression of 16S ribosomal RNA relative to
            the tRNA gene downstream. The product of this gene has three
            leucine zipper motifs bracketed by two basic domains that are all
            required for DNA binding. There is evidence that, for this protein,
            the zippers participate in intramolecular interactions that
            establish the three-dimensional structure required for DNA binding.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.54514.1,
                                           SRR1803616.262270.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000351870.8/
                                                  ENSP00000248643.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-930               AK222730.1         19-948
            931-1568            BC130391.1         875-1512
            1569-1994           BU740531.1         16-441              c
            1995-3941           AC003086.1         26425-28371         c
FEATURES             Location/Qualifiers
     source          1..3941
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.2"
     gene            1..3941
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="mitochondrial transcription termination factor 1"
                     /db_xref="GeneID:7978"
                     /db_xref="HGNC:HGNC:21463"
                     /db_xref="MIM:602318"
     exon            1..46
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /inference="alignment:Splign:2.1.0"
     exon            47..105
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1276
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; transcription termination factor,
                     mitochondrial; transcription termination factor 1,
                     mitochondrial"
                     /codon_start=1
                     /product="transcription termination factor 1,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_008911.1"
                     /db_xref="CCDS:CCDS5621.1"
                     /db_xref="GeneID:7978"
                     /db_xref="HGNC:HGNC:21463"
                     /db_xref="MIM:602318"
                     /translation="MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRF
                     SAENIFKSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRMIT
                     NEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIVTSDLEIVNIL
                     ERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVEFL
                     QAAGLSLGHNDPADFVRKIIFKNPFILIQSTKRVKANIEFLRSTFNLNSEELLVLICG
                     PGAEILDLSNDYARRSYANIKEKLFSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDC
                     LMEENISISQIIENPRVLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKL
                     KKLSRFA"
     exon            106..3941
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1957..1962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="hexamer: AATAAA"
     regulatory      1978..1983
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="hexamer: AATATA"
     polyA_site      1979
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="major polyA site"
     polyA_site      1994
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
                     /note="hexamer: TATAAA"
     polyA_site      3264
                     /gene="MTERF1"
                     /gene_synonym="MTERF"
ORIGIN      
        1 agaggcggaa gtaaaagcga actacagtgg atgggtgcag ttcaggagat agctgttctc
       61 cagcctttct ggagggatgc agagcctttc cttaggacaa acaagcattt caaaaggttt
      121 gaactaccta accattatgg caccaggaaa cctctggcat atgagaaata actttctctt
      181 tggttcaaga tgttggatga ctcgattttc agcagaaaac atcttcaaat cagtttcatt
      241 taggcttttt ggtgtgaagt gtcataatac agacagtgag cctttgaaaa atgaggacct
      301 actgaaaaac ttacttacta tgggagtaga tattgacatg gcaaggaaac gacagcctgg
      361 agtttttcat aggatgatta ccaatgagca ggacctgaag atgttccttc tttccaaagg
      421 agctagcaaa gaagtgatcg ctagcatcat atcaagatat ccacgagcaa taacacgtac
      481 tcccgagaat ctttcaaaac ggtgggatct gtggagaaag attgtgacat cagaccttga
      541 aattgtaaat attttggaac gttctcctga atcctttttt cggtccaata acaacctaaa
      601 cttagagaat aatataaagt tcctctactc agttggattg acccgtaaat gcctttgtcg
      661 attgttgacc aatgcccctc gtaccttctc caatagtctt gatctgaata aacagatggt
      721 tgaatttttg caggcagccg gtttgtcatt gggtcacaat gatcccgcag attttgtcag
      781 aaagataatt tttaaaaacc cttttatctt aattcagagc accaagcggg tgaaagctaa
      841 cattgaattc ttacggtcaa ctttcaattt gaacagtgag gaactgctgg ttctgatatg
      901 tggtccagga gctgaaatcc tagacctttc caatgactat gccagaagaa gctacgcaaa
      961 catcaaagag aagctgtttt ctcttggatg tactgaagaa gaggtacaga agtttgtctt
     1021 aagctatcca gatgtgatct tcttggcaga gaaaaagttt aatgataaaa tagactgcct
     1081 catggaagaa aacattagca tttcacaaat aatcgaaaat cctcgggttc tggattcaag
     1141 cataagtact ttaaaaagtc gaatcaaaga attggtaaat gctggctgta acttgagtac
     1201 tttaaacatc actcttctat cttggagtaa aaaaagatat gaagctaaat tgaaaaagtt
     1261 aagcagattt gcctaaggat gccaatgttt ttaattctca ggaactgtga atatgttatg
     1321 ccacattgca aaagaatttt gcagaagtga ttaatttaaa atgttattaa gggccttgag
     1381 atggggagat tatcctgaat tactttggag ggcctaatat aattgtaggg atctttaaaa
     1441 gttgaagagg gaggcaaaag aggaggtcag agtgatcctg tataagaaag acaactactt
     1501 ttgaaggaag ttaaaaggtg gctttgaagg aggaagacac cttgagccaa ggaatgaagg
     1561 gggcctgtaa aaaaagattg aaaaggcaag gaaacagatt ctccattaga gtccccagaa
     1621 aggaatgcag ccttgctggc acctttttag cccagtgaga tcaatgtcaa acttctgacc
     1681 cacagaacca taagatggta aatttgtgtt gttttaaacc actgagtcag tgataatttg
     1741 ctgaagaagc aaatagatta acatagcaac taagtagatg attagttgca ttataggtga
     1801 agtcaaaaat acagtccttt agtaaagtct ctatttcttc cttttataag agtaattata
     1861 tttaaaaaat ctacctaccc ttctggaatt gctaatgtta gtgtttataa agtcttaaat
     1921 gtgtgcataa aaaactaaat gtgaatataa aatctaaata aaggaatatg tttgcctaat
     1981 atagtttaag gaaatgataa tcatttctgt gcattttgtt ggcatttcag ctaatattaa
     2041 agagtaattt tcagaggcat tgacttaaaa aatggcaaat cagataatgt cggtattttc
     2101 aagatacaat ctagctctga cataaactga aagacgtgag acaaattata tgaccttaat
     2161 tttaattgtt ttccagaggc atttgttttc tagatgtggt ttttgaatta aataacataa
     2221 tggtgctcaa ccttttaaac ctcatttgct atcagtgata cttcaaaaaa ccttattcct
     2281 actattgata aaaacaatat gtctgctttt ctaaggccat ttatatattc aacgatactc
     2341 ctattataat ttggttaact atttgatggc aagcatggca tagtttagaa agcaagagct
     2401 ttagagtgat gtatctgggc accattcctg agtaacttgt gttaatgttt taaatttact
     2461 aaacctgttt ttctcatctg taacaccaga aattgacctt ccagagttgg taggaatcaa
     2521 atgaaaaagc acctctaagg tttcttgcac atagtaatga tgcaatcagt gatagctata
     2581 ataaaaagat agtattttaa aaagcagctt tatacataat tcacatattc aatttaccta
     2641 tttaaagtct aacacagttc aatttatata tagagttgtg caactttatc ttccattgct
     2701 tataatacat ttataattta ttggaaaatt tataaggaaa atgaatttct tacagttatg
     2761 gaagctgaga aatcctaggt tgaggggcca catctggtga gagccttctt gctggtgggg
     2821 actctgaaga gtcctgaggc ggcacagtgt atcacatggc gattgctaat gtacttaggt
     2881 ctcttttcct cttataaagc caccagtcca ctcccatgat agcctattaa ttcattaatc
     2941 catgaataga ttaatcaatt tctgatgaca tagcccttat gatccagtca cctcttaaag
     3001 gccccacctc tcaatactgc cacattgggg attaaatttc aacatgagtt ttggagggga
     3061 tggatagtca aaccatagca gcaaccatca ccacaatcta gttttagaat atgtttgcag
     3121 tcctaacaga aaccttgtac ctgttagtga atccccatta tttccctcca tttgttcccc
     3181 caagcctaag caaaaatgaa tctgttttct gtgtctataa atttgtttat tctgagcatt
     3241 tcatataaat ggaatcatac agtatggtct tttgtgactg gcttctttca cttagcatat
     3301 tttcaaggtt catccatgta gcacatatta gtatttcatt ttttttggca agtaatattc
     3361 cattgtatgg gtacagtagt attgggaata cattttactg ttatggctta aagtattgat
     3421 ttcttaagtc ttctgaattg tacgcgagtg ttttctgagg tattgttttg gaatctaaca
     3481 agctcataag ggacttgaag gaggtgggta gaagagataa tagtttattg acatcagcag
     3541 atcataggat tgtagctggg ctgatgagaa atggtatagc aacgatagtt gcaagtggcc
     3601 agagagaatg tgggttgcac tgaagtacag tacagcactt gatcattggg cagtagggga
     3661 tgggggaagg aaaactttgg agaaacaaac agataatgcc tgtcaggcaa aattaacatg
     3721 tcatacttta aggtttgagt ctgatcaagg gagagtcaat tctttttttt taaagataga
     3781 attatagaaa tattggccag ccatgtaatc ccagctcacg cctgtaatcc cagcaatttg
     3841 ggaggccgag gtgggaggat tgcttgagcc caggagttca agaccagcct gggtaatact
     3901 agcaagatat cattgctagt agggaaaaaa aaaaaaaaaa a
//
