LOCUS       NM_178812               7662 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens metadherin (MTDH), transcript variant 1, mRNA.
ACCESSION   NM_178812
VERSION     NM_178812.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7662)
  AUTHORS   Liu,S., Hao,X., Miao,D. and Zhang,Y.
  TITLE     A Study on the Binding Mechanism and the Impact of Key Residue
            Mutations between SND1 and MTDH Peptide through Molecular Dynamics
            Simulations
  JOURNAL   J Phys Chem B 128 (38), 9074-9085 (2024)
   PUBMED   39276108
  REMARK    GeneRIF: A Study on the Binding Mechanism and the Impact of Key
            Residue Mutations between SND1 and MTDH Peptide through Molecular
            Dynamics Simulations.
REFERENCE   2  (bases 1 to 7662)
  AUTHORS   Jiang,J., Wang,L., Li,Q., Wang,Y. and Wang,Z.
  TITLE     HIV-1 gp120 amplifies astrocyte elevated gene-1 activity to
            compromise the integrity of the outer blood-retinal barrier
  JOURNAL   AIDS 38 (6), 779-789 (2024)
   PUBMED   38578957
  REMARK    GeneRIF: HIV-1 gp120 amplifies astrocyte elevated gene-1 activity
            to compromise the integrity of the outer blood-retinal barrier.
REFERENCE   3  (bases 1 to 7662)
  AUTHORS   Wang,N., Xu,J., Wang,Y., Zhang,X. and Zhang,H.
  TITLE     USP7 promotes cervical cancer progression by stabilizing MTDH
            expression through deubiquitination
  JOURNAL   J Cancer Res Clin Oncol 150 (4), 196 (2024)
   PUBMED   38625581
  REMARK    GeneRIF: USP7 promotes cervical cancer progression by stabilizing
            MTDH expression through deubiquitination.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7662)
  AUTHORS   Abd Elhameed,Z.A., Tag El Din,L.M., Sherif,T., Abdel Aal,A.M.,
            Moeen,A.M., Abd El Hakeem,E.N. and Abdelrahman,E.M.
  TITLE     Plasma metadherin mRNA expression in bladder cancer
  JOURNAL   Egypt J Immunol 31 (2), 28-43 (2024)
   PUBMED   38615202
  REMARK    GeneRIF: Plasma metadherin mRNA expression in bladder cancer.
REFERENCE   5  (bases 1 to 7662)
  AUTHORS   Wang,Y.Y., Shen,M.M. and Gao,J.
  TITLE     Metadherin promotes stem cell phenotypes and correlated with immune
            infiltration in hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 30 (8), 901-918 (2024)
   PUBMED   38516242
  REMARK    GeneRIF: Metadherin promotes stem cell phenotypes and correlated
            with immune infiltration in hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 7662)
  AUTHORS   Emdad,L., Sarkar,D., Su,Z.Z., Randolph,A., Boukerche,H., Valerie,K.
            and Fisher,P.B.
  TITLE     Activation of the nuclear factor kappaB pathway by astrocyte
            elevated gene-1: implications for tumor progression and metastasis
  JOURNAL   Cancer Res 66 (3), 1509-1516 (2006)
   PUBMED   16452207
REFERENCE   7  (bases 1 to 7662)
  AUTHORS   Kang,D.C., Su,Z.Z., Sarkar,D., Emdad,L., Volsky,D.J. and
            Fisher,P.B.
  TITLE     Cloning and characterization of HIV-1-inducible astrocyte elevated
            gene-1, AEG-1
  JOURNAL   Gene 353 (1), 8-15 (2005)
   PUBMED   15927426
REFERENCE   8  (bases 1 to 7662)
  AUTHORS   Britt,D.E., Yang,D.F., Yang,D.Q., Flanagan,D., Callanan,H.,
            Lim,Y.P., Lin,S.H. and Hixson,D.C.
  TITLE     Identification of a novel protein, LYRIC, localized to tight
            junctions of polarized epithelial cells
  JOURNAL   Exp Cell Res 300 (1), 134-148 (2004)
   PUBMED   15383321
  REMARK    GeneRIF: a novel protein LYRIC is recruited during the maturation
            of the tight junction complex.
REFERENCE   9  (bases 1 to 7662)
  AUTHORS   Brown,D.M. and Ruoslahti,E.
  TITLE     Metadherin, a cell surface protein in breast tumors that mediates
            lung metastasis
  JOURNAL   Cancer Cell 5 (4), 365-374 (2004)
   PUBMED   15093543
  REMARK    GeneRIF: overexpression of metadherin is associated with metastatic
            breast cancer
REFERENCE   10 (bases 1 to 7662)
  AUTHORS   Sutherland,H.G., Lam,Y.W., Briers,S., Lamond,A.I. and Bickmore,W.A.
  TITLE     3D3/lyric: a novel transmembrane protein of the endoplasmic
            reticulum and nuclear envelope, which is also present in the
            nucleolus
  JOURNAL   Exp Cell Res 294 (1), 94-105 (2004)
   PUBMED   14980505
  REMARK    GeneRIF: 3D3/lyric is localized to the membrane of the endoplasmic
            reticulum, nuclear envelope, and the nucleolus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045642.1, AY082966.1, AF411226.1 and AP003357.2.
            
            On May 9, 2018 this sequence version replaced NM_178812.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.94577.1,
                                           SRR1660803.126933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336273.8/ ENSP00000338235.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-554               BC045642.1         6-559
            555-2276            AY082966.1         310-2031
            2277-3715           AF411226.1         2173-3611
            3716-7662           AP003357.2         48208-52154
FEATURES             Location/Qualifiers
     source          1..7662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.1"
     gene            1..7662
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="metadherin"
                     /db_xref="GeneID:92140"
                     /db_xref="HGNC:HGNC:29608"
                     /db_xref="MIM:610323"
     exon            1..704
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..2072
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     metastasis adhesion protein; protein LYRIC; 3D3/LYRIC;
                     astrocyte elevated gene-1 protein; lysine-rich CEACAM1
                     co-isolated protein; astrocyte elevated gene 1"
                     /codon_start=1
                     /product="protein LYRIC isoform 1"
                     /protein_id="NP_848927.2"
                     /db_xref="CCDS:CCDS6274.1"
                     /db_xref="GeneID:92140"
                     /db_xref="HGNC:HGNC:29608"
                     /db_xref="MIM:610323"
                     /translation="MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEP
                     KRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDD
                     LALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNE
                     KSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLD
                     STIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLN
                     ENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGK
                     DWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNS
                     DWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKK
                     KQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQP
                     IKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSW
                     ESPKQIKKKKKARRET"
     exon            705..806
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..891
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1068
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1134
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1371
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1470
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1595
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1703
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1844
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2001
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..7662
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3698..3703
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="hexamer: AATAAA"
     polyA_site      3716
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="major polyA site"
     regulatory      5650..5655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="hexamer: AACAAA"
     polyA_site      5675
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
     regulatory      7640..7645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
                     /note="hexamer: AATGAA"
     polyA_site      7662
                     /gene="MTDH"
                     /gene_synonym="3D3; AEG-1; AEG1; LYRIC; LYRIC/3D3"
ORIGIN      
        1 aagccgccat tgttccgccg agggaggaca gcggggcctg gcgctggcgc cgagacgccg
       61 cttagcggcc gccactggag acactccctc ccgcctcccg ggtctcctgg cggcggcgga
      121 gtgaggctga cagcggggaa cctgggagac ccctccgccc tccccgcggt ggcagcggcc
      181 gatccccggc tccggcgcga gggacggccg cgatgcgctc ggcctgaggt tacccggccc
      241 ggcccttcct cgcttccctc gactattcca ctgcgtctcc gcgccccggc gtcatcctgc
      301 gagtccctct gacgggaggg aagatggctg cacggagctg gcaggacgag ctggcccagc
      361 aggccgagga gggctcggcc cggctgcggg aaatgctctc ggtcggccta ggctttctgc
      421 gcaccgagct gggcctcgac ctggggctgg agccgaaacg gtaccccggc tgggtgatcc
      481 tggtgggcac tggcgcgctc gggctgctgc tgctgtttct gctgggctac ggctgggccg
      541 cggcttgcgc cggcgcccgc aaaaagcgga ggagcccgcc ccgcaagcgg gaggaggcgg
      601 cggccgtgcc ggccgcggcc cccgacgacc tggccttgct gaagaatctc cggagcgagg
      661 aacagaagaa gaagaaccgg aagaaactgt ccgagaagcc caaaccaaat gggcggactg
      721 ttgaagtggc tgagggtgaa gctgttcgaa cacctcaaag tgtaacagca aagcagccac
      781 cagagattga caagaaaaat gaaaagtcaa agaaaaataa gaagaaatca aagtcagatg
      841 ctaaagcagt gcaaaacagt tcacgccatg atggaaagga agttgatgaa ggagcctggg
      901 aaactaaaat tagtcacaga gagaaacgac agcagcgtaa acgtgataag gtgctgactg
      961 attctggttc attggattca actatccctg ggatagaaaa taccatcaca gttaccaccg
     1021 agcaacttac aaccgcatca tttcctgttg gttccaagaa gaataaaggt gattctcatc
     1081 taaatgttca agttagcaac tttaaatctg gaaaaggaga ttctacactt caggtttctt
     1141 caggattgaa tgaaaacctc actgtcaatg gaggaggctg gaatgaaaag tctgtaaaac
     1201 tctcctcaca gatcagtgca ggtgaggaga agtggaactc cgtttcacct gcttctgcag
     1261 gaaagaggaa aactgagcca tctgcctgga gtcaagacac tggagatgct aatacaaatg
     1321 gaaaagactg gggaaggagt tggagtgacc gttcaatatt ttctggcatt gggtctactg
     1381 ctgagccagt ttctcagtct accacttctg attatcagtg ggatgttagc cgtaatcaac
     1441 cctatatcga tgatgaatgg tctgggttaa atggtctgtc ttctgctgat cccaactctg
     1501 attggaatgc accagcagaa gagtggggca attgggtaga cgaagaaaga gcttcacttc
     1561 taaagtccca ggaaccaatt cctgatgatc aaaaggtctc agatgatgat aaagaaaagg
     1621 gagagggagc tcttccaact gggaaatcca aaaagaaaaa aaagaaaaag aagaagcaag
     1681 gtgaagataa ctctactgca caggacacag aagaattaga aaaagagatt agagaagacc
     1741 ttccagtgaa tacctctaaa acccgtccaa aacaggaaaa agctttttcc ttgaagacca
     1801 taagcactag tgatccagcc gaagtactcg tcaaaaatag ccagcctatc aagactcttc
     1861 cacctgctac ttctaccgag ccatctgtaa tcttatcaaa aagtgattct gacaagagct
     1921 cttcccaagt gccgccaata ctacaagaga cagataaatc caagtcaaat accaagcaaa
     1981 atagtgtgcc tccttcacag accaagtctg aaactagctg ggaatctccc aaacaaataa
     2041 aaaagaagaa aaaagccaga cgagaaacgt gaaatttttt ttcctgaatt ggacatgtgt
     2101 ttgcaaacac ttgtcttgaa gattatgctg tttatgcaat aatttgtgaa catgtacaga
     2161 gttttatata aatttaaacc aatttttaaa acaaaactgc ggacaccacc ataaaaatgg
     2221 aatcaaaaga aagttaattt atgaaattaa gaggtcagca gaatatactc agtgatggaa
     2281 gacacttggg aaagtctttt taatagaaca agaacgatct taatttaaga atattatcct
     2341 ggtttaacaa cagtgccctg tttacaacag attgtgccct atctcatctg cagccgagga
     2401 ataaaggatt ctgattagaa agagggttgc ctacagatta gtaagcaatt ccttggatct
     2461 tatgcacaga acttgtacca tttgaatctg ttttatgctt aaatcaaagt gctttgatca
     2521 aatgcataac ctgccatatc tttacatatt tgttggtagc aatttgtatt aaagaaatca
     2581 caagtgcaaa taaaaagtca tttatcattt gtttaactaa actgtcatgg tttagtttac
     2641 aatttttaaa aagttcttaa aatactgaaa atgcagttga cacttgtgta tggcttatga
     2701 agttattttt gatagtctta cattacttga attgttcaaa gtacagtata ttttaaatta
     2761 agaaaagtga actatatgta tttgttttat acatttaagg cttagactca taaataatgc
     2821 tattgtttat gatttgaaaa ctttcaggca aaatccaatt tacatttttc ccttccctag
     2881 caattacttt tttccagctt caactcttct tagttactaa tactttgttg actttaaaaa
     2941 tgaaatcatt cacaaacttt tggtatatga tggagaatga aaaactagag tcagacagct
     3001 ttaattgaca ttgtcaacac ctccagttat caggaataca tttttttact gccttaacct
     3061 gtagtgcgta gaatatgcat caatttcttg aaggagattc atgtttttat aagaattttc
     3121 atgtaattat tgcaattgtg gtcaaataag gaacgtttcc tgcttgaaat tatattgatt
     3181 taaatgatgt gtgagatgtt tcaccatttt caggcactgt gtaattctat tgtaataaac
     3241 tggcaggtat ctttgtaact ataaatagtg catgctcagc catgtacact gtaaatagcc
     3301 tttaccaaac gtgtttgaca aggaccataa ttaacatcac ttagtgaatt gtgataaaga
     3361 aaaaaaagcc atgatttatt cgatgtgatt ggcttgtttt tatgtggcgc caagaacgaa
     3421 cctgtttaac agctgtaacc aatggtactg atctatccat ccaatgttgt cattatattt
     3481 gactgtggtt caacagtatt gcgttgtcag actaggaaag ctaaacgaac aaaatggttt
     3541 tagttttgct gaagactggc cttattaatg gacagctttc ctaacaagag attattaact
     3601 tttatcaggt gttaacatct gtttcaggaa catggcagta tgtttacatg tcagaagttt
     3661 tgtttaattc tatggtattt ctaaattgac ttgtttaaat aaattcagca aatggatagc
     3721 attgtttttt atttgcttca atatgggggt agataatagc taaagagcca aggatgaatt
     3781 tcttcaaatg actttattct gttagcttta cataggtgtt ggaggattcc taaggtgtca
     3841 gcattttgta aaggtaccac aaaggagaag ttgataggga atctaatttt agaatgtgcc
     3901 aaatggtctg tgctcaacaa tataattgaa ctctctcaac tctacctcac catttcttta
     3961 tctcaaaatt ctgttggctt tgtcaaacgt tggattttat ttctgcagcc tagtatctcc
     4021 ccattctacc acctatgcca gatgttaaag acagcagatg ttttgaggag aatggcattg
     4081 tggagatgca gagatgcgtt gctaagttga ggtggatcca gtatagagat acctctattt
     4141 cttctttatg gctcaagagc taggacttgg attttgtttt aagagatggc agctggccgg
     4201 gtgcagtggc tcacgtctgt aatcccagca ctttgggagg ccgaggcagg tggatcacga
     4261 ggtcaggagt tcaagaccag cctggccaag agggtgaaac cccatcttta ctaaaaatac
     4321 aaaaaaaaaa attagctggg tgtggtggtg ggctcctgta atcccagcta ctcaggaggc
     4381 taaggcagag aatcatttga acccaggaga cggagtttgc aaagccaaga tcgtgccact
     4441 gcactccagc ctgggcaaca gaaggagact ccgtctcaaa aaaaaaaaaa agatggcagc
     4501 tatataaatg ataaaattaa ttacattctc tttcacatgc atgaggtgca aactctgtca
     4561 caaagtattt taattacctt ttaccttgtt tcatagatct ttatgtgaca taaaaacagt
     4621 ttctggcacg gtggctcacg cctgtaatcc tagcactttg ggaggctgag gcaggtggat
     4681 cacctgaggt caggagtttg agaccagcct ggccaatatg gtgaaacccc atctctacaa
     4741 aatttgcaaa aagtagatgg gtgtggtagt gggcgcctgt aatcccagct actcaggagg
     4801 ttgaggcaga gaatcgcttg aacccggggg gtggaggttg cagtgagctg agatcgcacc
     4861 actgcactcc agcatgaaag agcgagactc aatctcaaaa aaaaaaaagt ttctggcacc
     4921 tgaacaggaa ctggtttcca tcatcaactc agaaagcact aaaatctagg tggtgattca
     4981 gggaggagca ggggaagaca gcctcctatg gtggcatgaa taagatgctt ccagaactag
     5041 tagggaaata actaacctct tcaggcttta tcaggcctgg aggggaacct tgctcatgtt
     5101 agcaagaaag gtatcctaga gaagccactc aaaaggctcc ctaatccagc ctgtctccac
     5161 atacatactg aaaattcttc cctactctga ggcagggtgt agtggtttag gggtttctcc
     5221 agactggaat cctacctatc tgtaccgaca attgagcaaa caacagttga gagagtccaa
     5281 aaaaaaaagt attaaaatgt gattgatgta atttaccatg tttactttat gcatgcattt
     5341 tattggggag gggaggtcag aataattcac ccaaatctag tggtcttatt tcataggcta
     5401 atctggttta tatttgcatt aaagatactg gagggcaata tttacagagt ttagtttttc
     5461 ttaattaaaa acagtcctct attaatatag tgtgaaatat ctttcaaaat ttagagttta
     5521 ggtttaagat gtctactaga tatctttaag attttcctgt aaactcactg cacaaactgg
     5581 aattactttc caaaagactt agggaatgca aatatgttac tcataagatg cattgagtat
     5641 tgtaaataaa acaaaccatt tttgatttgt ttaaattgct cgttacagtt ctcttgtggg
     5701 gagggacttt gtcagtcatt ttgcatctta agctagacta aactttttgt tgttgttttc
     5761 ctaaaaccat aggtgcaagc tttgccgctg ggaagtcata ttgaattaag cacttttgaa
     5821 aatgtcactg tttgtgacac acaatgttct ctacagaaaa cttcttctat cttatgtcat
     5881 tttagcagta gatgtagctg cctgccacca ggtgcaatat gtcatttgca tcagcctttt
     5941 cagttaagga aattaaaact tggcatgcat tagttcatat gtatgaggtt ggctgtgtcc
     6001 ccaaacagca attgcttgta caagatagaa gtttgcttct cagctgggca tggtggctca
     6061 tgcctgtaat ccaagctctt tgggaggcca acgcgggagg attgtttgag cccaggagtt
     6121 tgaaaccatc ctgagcaata gagagacccc catctcgaca aaaaaaaaaa aaaaaaatta
     6181 gaaacaaaaa aaagattgtt tctctttcat attaaagttt gggaaggcaa tccagagccc
     6241 atatgacatt atgcagggtc agggatccgg gttctttcta tattgttcct ccccattctc
     6301 aacctgtagc tttttttttt tttcttttaa tgagataggg tctcactctg ttgcccaggc
     6361 tggagtgcag tggcacactt ctggctcact tcagcctgga actcccgggc tcgagctata
     6421 ttctcccact ttagcctcag cctccagagt acctgggact acaggtacac accaccatgc
     6481 ctggctaaat tttttttttt tttttttggt agagatgagg tcattgctat gttgcccagg
     6541 ctggccttga agtccagggc ttaagtgatc ctcctgcctt ggcctcccaa agtgctggtg
     6601 ttacaggtgt gagccaccac acctggccaa catgtggctt tcagttctta cttgaagaca
     6661 gctgctctag ctagaaactt cctatcggca tctgagccag ctggtagagg gcattacctc
     6721 ccccaccccc aagaacactt cttggaagtt acacacaata cataaacttc aatttcaaac
     6781 agttgcttgg tcccactagc catgaagctg gatgggacgt aatattctat ctgggttgtc
     6841 atgggccaaa ttaacatttt gagattctgt taggaagatg agaattggat aatgggcacc
     6901 tctaacagtg tctgtcagag ttgacataca ttgtgtatct cctgcaccaa agcatttttg
     6961 agatcaagtg ttcttccagc tgagcagaaa tttggaaggc tattcagtgc tgcttagtgt
     7021 agcagctaat aatgttccaa cttctatatg atagtttgct ttttgttttt tgtttttttc
     7081 tagagacaga gtctcgttgc ccaggctggt ctccaattcc tgggttcaag caatcctcct
     7141 gactcagcct cctaaatgct gggattacag gcatgaacca ctgtgcccag tctatatata
     7201 atagatttta gaagaaattt ctgccactca gtgactgctt taaattctag agacagaggc
     7261 tgagagaaac ttagtagcct gcctgcgcat actgcaagta cagactatat aacaagttga
     7321 aagagaatca ccctggtata taatatttta aaacatgaaa aaggcattac tattgttctg
     7381 gtctaagtac tctaacagga cgatgatttc taaccctagc atcatgacat gtatatagtg
     7441 tgttgtaaga catttgccag ctaatagtta cagtactgaa gcttgtgaat acgttaattg
     7501 agaaaacttt aagcaggttc aaagttatcc catgatagtg gcattcttat ttgtatatat
     7561 gtgctttcct tttttatttg tatcaaggca tttaaaatga atatatgtaa catgtaccta
     7621 agttttaaaa gcataataaa atgaacacat ctgaaaccac ca
//
