LOCUS       NM_001018025            2184 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens mature T cell proliferation 1 (MTCP1), mRNA.
ACCESSION   NM_001018025
VERSION     NM_001018025.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2184)
  AUTHORS   Walker,J.S., Hing,Z.A., Sher,S., Cronin,J., Williams,K.,
            Harrington,B., Skinner,J.N., Cempre,C.B., Gregory,C.T., Pan,A.,
            Yano,M., Beaver,L.P., Walker,B.R., Labanowska,J.M., Heerema,N.A.,
            Mrozek,K., Woyach,J.A., Ruppert,A.S., Lehman,A., Ozer,H.G.,
            Coppola,V., Yan,P., Byrd,J.C., Blachly,J.S. and Lapalombella,R.
  TITLE     Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and
            chronic lymphocytic leukemia
  JOURNAL   Nat Commun 12 (1), 6338 (2021)
   PUBMED   34732719
  REMARK    GeneRIF: Rare t(X;14)(q28;q32) translocation reveals link between
            MTCP1 and chronic lymphocytic leukemia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2184)
  AUTHORS   Wang,L., McDonnell,S.K., Hebbring,S.J., Cunningham,J.M., St
            Sauver,J., Cerhan,J.R., Isaya,G., Schaid,D.J. and Thibodeau,S.N.
  TITLE     Polymorphisms in mitochondrial genes and prostate cancer risk
  JOURNAL   Cancer Epidemiol Biomarkers Prev 17 (12), 3558-3566 (2008)
   PUBMED   19064571
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2184)
  AUTHORS   Joiner,M., Le Toriellec,E., Despouy,G. and Stern,M.H.
  TITLE     The MTCP1 oncogene modifies T-cell homeostasis before
            leukemogenesis in transgenic mice
  JOURNAL   Leukemia 21 (2), 362-366 (2007)
   PUBMED   17136114
  REMARK    GeneRIF: Transgenic mice overexpressing MTCP1 develop leukemias
            with a CD8 central memory phenotype in most cases.
REFERENCE   4  (bases 1 to 2184)
  AUTHORS   Laine,J., Kunstle,G., Obata,T. and Noguchi,M.
  TITLE     Differential regulation of Akt kinase isoforms by the members of
            the TCL1 oncogene family
  JOURNAL   J Biol Chem 277 (5), 3743-3751 (2002)
   PUBMED   11707444
REFERENCE   5  (bases 1 to 2184)
  AUTHORS   Laine,J., Kunstle,G., Obata,T., Sha,M. and Noguchi,M.
  TITLE     The protooncogene TCL1 is an Akt kinase coactivator
  JOURNAL   Mol Cell 6 (2), 395-407 (2000)
   PUBMED   10983986
REFERENCE   6  (bases 1 to 2184)
  AUTHORS   Madani,A., Choukroun,V., Soulier,J., Cacheux,V., Claisse,J.F.,
            Valensi,F., Daliphard,S., Cazin,B., Levy,V., Leblond,V.,
            Daniel,M.T., Sigaux,F. and Stern,M.H.
  TITLE     Expression of p13MTCP1 is restricted to mature T-cell
            proliferations with t(X;14) translocations
  JOURNAL   Blood 87 (5), 1923-1927 (1996)
   PUBMED   8634440
REFERENCE   7  (bases 1 to 2184)
  AUTHORS   Thick,J., Mak,Y.F., Metcalfe,J., Beatty,D. and Taylor,A.M.
  TITLE     A gene on chromosome Xq28 associated with T-cell prolymphocytic
            leukemia in two patients with ataxia telangiectasia
  JOURNAL   Leukemia 8 (4), 564-573 (1994)
   PUBMED   8152252
REFERENCE   8  (bases 1 to 2184)
  AUTHORS   Fisch,P., Forster,A., Sherrington,P.D., Dyer,M.J. and Rabbitts,T.H.
  TITLE     The chromosomal translocation t(X;14)(q28;q11) in T-cell
            pro-lymphocytic leukaemia breaks within one gene and activates
            another
  JOURNAL   Oncogene 8 (12), 3271-3276 (1993)
   PUBMED   8247530
REFERENCE   9  (bases 1 to 2184)
  AUTHORS   Stern,M.H., Soulier,J., Rosenzwajg,M., Nakahara,K., Canki-Klain,N.,
            Aurias,A., Sigaux,F. and Kirsch,I.R.
  TITLE     MTCP-1: a novel gene on the human chromosome Xq28 translocated to
            the T cell receptor alpha/delta locus in mature T cell
            proliferations
  JOURNAL   Oncogene 8 (9), 2475-2483 (1993)
   PUBMED   8361760
REFERENCE   10 (bases 1 to 2184)
  AUTHORS   Kenwrick,S., Levinson,B., Taylor,S., Shapiro,A. and Gitschier,J.
  TITLE     Isolation and sequence of two genes associated with a CpG island 5'
            of the factor VIII gene
  JOURNAL   Hum Mol Genet 1 (3), 179-186 (1992)
   PUBMED   1303175
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX470111.4, AW976554.1 and
            AA744518.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001018025.3.
            
            Summary: This gene was identified by involvement in some t(X;14)
            translocations associated with mature T-cell proliferations. This
            region has a complex gene structure, with a common promoter and 5'
            exon spliced to two different sets of 3' exons that encode two
            different proteins. This gene represents the upstream 13 kDa
            protein that is a member of the TCL1 family. This protein may be
            involved in leukemogenesis. [provided by RefSeq, Mar 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX341834.2, ERR3218371.393469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000369476.8/
                                                  ENSP00000358488.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-443               BX470111.4         46033-46475
            444-595             BX470111.4         51112-51263
            596-766             BX470111.4         51380-51550
            767-818             BX470111.4         51632-51683
            819-1831            BX470111.4         51770-52782
            1832-1898           AW976554.1         286-352             c
            1899-2184           AA744518.1         10-295              c
FEATURES             Location/Qualifiers
     source          1..2184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..2184
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="mature T cell proliferation 1"
                     /db_xref="GeneID:4515"
                     /db_xref="HGNC:HGNC:7423"
                     /db_xref="MIM:300116"
     exon            1..443
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /inference="alignment:Splign:2.1.0"
     exon            444..595
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..814
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="mature T-cell proliferation-1 type B1; MTCP-1 type
                     B1; TCL1 family AKT coactivator C"
                     /codon_start=1
                     /product="protein p13 MTCP-1"
                     /protein_id="NP_001018025.1"
                     /db_xref="CCDS:CCDS44027.1"
                     /db_xref="GeneID:4515"
                     /db_xref="HGNC:HGNC:7423"
                     /db_xref="MIM:300116"
                     /translation="MAGEDVGAPPDHLWVHQEGIYRDEYQRTWVAVVEEETSFLRARV
                     QQIQVPLGDAARPSHLLTSQLPLMWQLYPEERYMDNNSRLWQIQHHLMVRGVQELLLK
                     LLPDD"
     exon            596..766
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /inference="alignment:Splign:2.1.0"
     exon            767..818
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /inference="alignment:Splign:2.1.0"
     exon            819..2184
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="hexamer: AATAAA"
     polyA_site      1853
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="major polyA site"
     regulatory      2021..2026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="hexamer: AATACA"
     polyA_site      2040
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="major polyA site"
     regulatory      2159..2164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
                     /note="hexamer: AATAAA"
     polyA_site      2184
                     /gene="MTCP1"
                     /gene_synonym="P13MTCP1; p8MTCP1; TCL1C"
ORIGIN      
        1 gtactctgtg agcggcgccc gggcgcctgg gcaggcgcct cccgagtacc ggcgcccatt
       61 ttgcccgccc gctaaggaga cccgtgcgcg gcctacacgc ttgggggaca gccctttaag
      121 acgacatctc cgcgaacgcc ggcctcttga gccaggggga cgctcttttg aaagtcagtc
      181 ccaaaacagt taaggtttta ttttattttg ttttatttcc aagtcacagc ccccgaatct
      241 cgtacaactc tccctggacc acttccggtt gccggcccgc gcctcataac ttcggttcga
      301 gtgacctcgg cccgggatgc ccctcggctc accccgggct cacgtcgcga tcctggcttg
      361 agtggcccag ggtgggagac ctggaagttt tagcctagct gttctcaagg cggattaatt
      421 agcccaagaa acattatatt catgcttagg tggagaaaag cagggctaga attggaaccc
      481 aaagcccaga atggcaggag aggatgtggg ggctccaccc gatcacctct gggttcacca
      541 agagggtatc taccgcgacg aataccagcg cacgtgggtg gccgtcgtgg aagaggagac
      601 gagtttccta agggcacgag tccagcaaat tcaggttccc ttaggtgacg cagctaggcc
      661 aagtcacctt cttacctccc agctacctct catgtggcaa ctctacccgg aggagcgcta
      721 catggataac aactctcgct tgtggcagat acagcatcat ttaatggtca ggggagtaca
      781 ggagctgttg cttaagcttt tgcctgatga ctaacctggt gctgggattc tacgaagata
      841 tgctcctttg ttctgttcag tatttggcaa tcacttcatc cactactgca gtgcacccac
      901 ccttgggcct ggggggaggg agtgggttga aaaactgctc aagaaacaga agtttagcaa
      961 gggtcatgaa gaatactgca agtgaaactg cagagagagg ttacgtaggc agaaagcaag
     1021 tcaacaaaag cacttagtca ggatccgtaa cttgaaattg actcctttgg aaattgccat
     1081 agaaccctta atggacatca tcggctggac ctgggatctg atgaatccca caaaagtcag
     1141 caccttctac agaacagatg ccctgatcac caaggacttg gtactgattt agagagaaga
     1201 gagcagctcc tagcagcatc aacatctatt tgtcgcttat ttgccctgca gcaattcacc
     1261 tgcctttcct tctcccatcc tgtaaatatc ctaggttttg ctccagtgtt tcccatccca
     1321 gtactgacct aatttggatc tgctgagtat ttagagggct ctgaaaagag atatgcattg
     1381 atgaaattag ctacaaaggc ttgtgggcct ttttttctat ctgaaatcgt gtcttcaaat
     1441 tactggaagt tgctgatcaa aattgtgggc tcttgaattc attctctgat tacagatatt
     1501 ttaaataagc tggtttctat aagaacttca agaaaaacca ttttagctgc ttaactggca
     1561 cctttctcag gaagtaataa caccaaatat tgctgattcc taggaaaaca tttactactt
     1621 gtaaagaatt tcctgagtta aagtagttat aacagtttat atacattaaa agtaaggttt
     1681 tactttaaaa aaaaaagtct tgggaataat agctaccatg tattggagtc ctttccaggc
     1741 actattgtat gtactttata tactttatca catttaatcc tcctgtcaat gctttgaggt
     1801 aggtatgatt cccattttat atatgagtaa taaaaaaagc tcaaggagtt taatcattta
     1861 tcaagggttt cttctgcgaa tgatagagcc aggctgcgcc gtcggctcct ctagcctaac
     1921 gttggtttac agtattcaaa aagagttgat tgaattcaag gttttttttc catgtaaagc
     1981 tatttatatc ttccaagcct aatgaaatgg atattataaa aatacagttg attcatccta
     2041 tgtttgggaa gagtattttt agtgtaatta ttttccagca attgtaaggg catatactgc
     2101 ttgtctcaga agaaaattcc acgtagaggg gctttaaagt ctttatggaa aaaagaaaaa
     2161 taaaaatcat ttttcttgtt ttag
//
