LOCUS       NM_001400265            3996 bp    mRNA    linear   PRI 04-FEB-2024
DEFINITION  Homo sapiens MTCL family member 3 (MTCL3), mRNA.
ACCESSION   NM_001400265
VERSION     NM_001400265.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3996)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL583806.7 and AL096711.9.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC143043.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN03465403, SAMN03465404 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000525778.6/ ENSP00000434570.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-757               AL583806.7         964-1720            c
            758-1946            AL096711.9         81508-82696         c
            1947-2171           AL096711.9         80817-81041         c
            2172-2330           AL096711.9         78885-79043         c
            2331-2402           AL096711.9         48907-48978         c
            2403-3578           AL096711.9         41287-42462         c
            3579-3996           AL096711.9         38968-39385         c
FEATURES             Location/Qualifiers
     source          1..3996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..3996
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /note="MTCL family member 3"
                     /db_xref="GeneID:387104"
                     /db_xref="HGNC:HGNC:21494"
     exon            1..757
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1946
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             846..3689
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /note="protein SOGA3; SOGA family member 3; microtubule
                     cross-linking factor 3"
                     /codon_start=1
                     /product="microtubule cross-linking factor 3 precursor"
                     /protein_id="NP_001387194.1"
                     /db_xref="CCDS:CCDS43505.1"
                     /db_xref="GeneID:387104"
                     /db_xref="HGNC:HGNC:21494"
                     /translation="MSQPPIGGAAPATAAASPAAAATEARLHPEGSSRKQQRAQSPAR
                     PRDSSLRQTIAATRSPVGAGTKLNSVRQQQLQQQQQQGNKTGSRTGPPASIRGGGGGA
                     EKATPLAPKGAAPGAVQPVAGAEAAPAATLAALGGRRPGPPEEPPRELESVPSKLGEP
                     PPLGEGGGGGGEGGGAGGGSGEREGGAPQPPPPRGWRGKGVRAQQRGGSGGEGASPSP
                     SSSSAGKTPGTGSRNSGSGVAGGGSGGGGSYWKEGCLQSELIQFHLKKERAAAAAAAA
                     QMHAKNGGGSSSRSSPVSGPPAVCETLAVASASPMAAAAEGPQQSAEGSASGGGMQAA
                     APPSSQPHPQQLQEQEEMQEEMEKLREENETLKNEIDELRTEMDEMRDTFFEEDACQL
                     QEMRHELERANKNCRILQYRLRKAERKRLRYAQTGEIDGELLRSLEQDLKVAKDVSVR
                     LHHELENVEEKRTTTEDENEKLRQQLIEVEIAKQALQNELEKMKELSLKRRGSKDLPK
                     SEKKAQQTPTEEDNEDLKCQLQFVKEEAALMRKKMAKIDKEKDRFEHELQKYRSFYGD
                     LDSPLPKGEAGGPPSTREAELKLRLRLVEEEANILGRKIVELEVENRGLKAELDDLRG
                     DDFNGSANPLMREQSESLSELRQHLQLVEDETELLRRNVADLEEQNKRITAELNKYKY
                     KSGGHDSARHHDNAKTEALQEELKAARLQINELSGKVMQLQYENRVLMSNMQRYDLAS
                     HLGIRGSPRDSDAESDAGKKESDDDSRPPHRKREGPIGGESDSEEVRNIRCLTPTRSF
                     YPAPGPWPKSFSDRQQMKDIRSEAERLGKTIDRLIADTSTIITEARIYVANGDLFGLM
                     DEEDDGSRIREHELLYRINAQMKAFRKELQTFIDRLEVPKSADDRGAEEPISVSQMFQ
                     PIILLILILVLFSSLSYTTIFKLVFLFTLFFVL"
     exon            1947..2171
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2330
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2402
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..3578
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3996
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /note="hexamer: AGTAAA"
     polyA_site      3795
                     /gene="MTCL3"
                     /gene_synonym="C6orf174; dJ403A15.3; SOGA3"
                     /note="major polyA site"
ORIGIN      
        1 agcagccgcc agccagctgc atcaggagat gttagtcacg cccggaaggc tgttctagtc
       61 cgcctccttg gaaaagaagc tcaagtaaat aattgatgga gaatgaccga acccaggaca
      121 aagctttgca ggaaaccagt gcatccgtgt tcgagcggtt ttgggatcct ctgccaagta
      181 cgggataaga gaatagagca aggagtttga gcgctgctgc caatcttcca tctcgggcgt
      241 ggctctggcc tttttgtctc tttatcccgc cactccccac ccccgtcccc cgtccccctc
      301 cccgccttct tctctttcct cttgaaagta acctctcttt ggttacttct accctatcgt
      361 cccttgcaat cccgccttct ctcctgccca gttcggtgag gtcagctcat gaacatctct
      421 gcacttcctg gggagcgtct ggcccagctt ggtacctcgc gtgttagcct gctgagagct
      481 gcagctccag cccagccgcg gaccgccggg aagtcacccg ctctgggggc agctgaatct
      541 tgacgttacc gccattgttt ggagaaatcg agtgggtgtg gaactgcggc gagcgagccc
      601 aaagtcatgc tcagccggaa agtcgcatac aataatatga agttgaactt tcctcggcgc
      661 agaaaggcac aataataaac cctgagatcc ccggaatatc agaaggaaag tgctgttgat
      721 ttgttcagct acttggaaac ctcgcctctg ctgagaactt aggaaggaag gttggcggcg
      781 gtgaagaggg aagaggatga tctagtaatg ggctcttcca aatcgcatct ggtaggttca
      841 tagccatgag tcagccacca atcgggggcg ctgcccctgc cacagcagca gcttctcccg
      901 ccgctgcagc cactgaggct cgtctgcacc cggagggcag cagcagaaag cagcagcgag
      961 ctcagtcacc cgctagaccg agggacagtt cgctgcgaca gacaatcgcg gccacccggt
     1021 ccccagtggg ggccggcact aaactcaatt ctgttcggca gcagcagctg cagcagcagc
     1081 aacagcaggg taacaagacc gggagccgca cggggccgcc cgccagcatc cgaggaggcg
     1141 gaggtggggc cgagaaggcg acgcccctgg cgcccaaagg ggccgctccg ggagctgtcc
     1201 agcctgtggc tggtgctgaa gcggcccccg ccgcgaccct ggccgctttg ggcggcagga
     1261 ggcccggacc gcccgaggag ccgcctcggg agctagagtc cgtgccctcg aaactcgggg
     1321 aaccccctcc gctcggagaa gggggaggag ggggcgggga aggaggagga gccggcggcg
     1381 gctccgggga aagggagggg ggcgctccgc agccgccgcc gcccaggggc tggcgaggga
     1441 aaggcgtacg cgctcagcag aggggcggca gcggcgggga gggggcctcc ccttctccat
     1501 cctcctcttc tgcgggcaaa accccaggaa ccggcagcag aaactccgga agcggcgttg
     1561 cggggggcgg cagcggtggt ggagggagct actggaaaga aggatgtctg cagtctgagc
     1621 tcatccagtt ccatctcaag aaggagcggg cggcagcggc ggcggccgcg gctcagatgc
     1681 acgctaagaa cggcggcggc agcagtagcc gcagctcccc ggtgtctggc ccccctgccg
     1741 tttgcgagac cctggccgtc gcctccgcct ccccaatggc ggcggcggcg gagggccccc
     1801 agcagagcgc agagggcagc gcgagcggcg ggggcatgca ggcggcagcg cccccttcgt
     1861 cgcagccgca cccgcagcag ctccaagagc aggaagaaat gcaagaggag atggagaagc
     1921 tgcgagagga aaacgagact ctcaagaacg agatcgatga gctgagaacc gagatggacg
     1981 agatgaggga cactttcttc gaggaggatg cctgtcaact gcaggaaatg cgccacgagt
     2041 tggagagagc caacaaaaac tgccggatcc tgcagtaccg cctccgcaaa gccgagcgca
     2101 aaaggctccg ctacgcccag accggggaaa tcgacgggga gctgttgcgc agcctggagc
     2161 aggacctcaa ggttgcaaag gatgtatctg tgagacttca ccatgaatta gaaaatgtgg
     2221 aagaaaagag aacaacaaca gaagatgaaa atgagaaact gaggcaacag ctcatagaag
     2281 ttgaaattgc aaagcaagct ttacagaatg aactggaaaa aatgaaagag ttatccttaa
     2341 aaagaagagg aagcaaagat ttgccaaaat ctgaaaaaaa ggctcaacag actcccacag
     2401 aggaggacaa tgaagatctg aagtgccagc tgcagtttgt taaggaagaa gccgctttga
     2461 tgagaaagaa aatggccaag attgataaag aaaaggacag atttgaacac gagctccaga
     2521 agtacagatc cttttatggg gatctggaca gtcctttgcc caaaggagaa gccggaggcc
     2581 ctcccagcac tagggaggcc gagctcaagc tacggctaag gctggtggag gaagaagcca
     2641 acatcctggg caggaaaatc gtcgaactgg aggtggagaa cagaggcctg aaggcggaac
     2701 tggacgacct taggggcgat gacttcaacg gctcggccaa cccgctcatg agggagcaga
     2761 gcgaatccct gtcggagctg cggcagcacc tgcagctggt ggaagacgag acggagctgc
     2821 tgcggaggaa cgtggccgac ctggaggagc agaacaagcg catcacggcg gagctcaaca
     2881 agtacaagta caagtccggc ggccacgaca gcgcgcggca ccacgacaac gccaagaccg
     2941 aggccctgca ggaggagctg aaggcggcgc gcctgcagat caacgagctc agcggcaagg
     3001 tcatgcagct gcagtacgag aaccgcgtgc ttatgtccaa catgcagcgc tacgacctgg
     3061 cctcgcacct gggcatccgc ggcagccccc gcgacagcga cgccgagagc gacgcgggca
     3121 agaaggagag cgacgacgac tcgcggcctc cgcaccgcaa gcgcgaaggg cccatcggcg
     3181 gcgagagcga ctcggaggag gtgcgcaaca tccgctgcct cacgcccact cgctccttct
     3241 acccggcgcc cgggccctgg cccaagagct tctccgatcg gcagcagatg aaggacatcc
     3301 gctcggaggc cgagcgcctg ggcaagacca tcgaccggct catcgccgac acgagcacca
     3361 tcatcaccga ggcgcgcatc tacgtggcca acggggacct gttcggactc atggacgagg
     3421 aggacgacgg cagccgcatc cgggagcacg agctgctcta ccgcatcaac gctcagatga
     3481 aggccttccg caaggagctg cagaccttca tcgaccgcct cgaggtgccc aagtctgcgg
     3541 acgaccgcgg cgccgaggag cccatttccg tgagtcagat gttccagcct atcattttac
     3601 ttattctcat tcttgtatta ttttcatcac tttcttacac aacaatattt aaacttgtct
     3661 tcctttttac actgtttttt gtactgtaaa tctttcatca tttaccattc attgtagtat
     3721 tttcagtttg tttattttgt tcacccttca agacaagaag taaaagaagt ataatttctg
     3781 tagtaaccaa tgctataaaa acactgaaga ctgcttattt ctttaaaaag atacaactca
     3841 tcttaccaag accaaattca ataagaagcc caaacactaa aatatttcag gtaagaaagt
     3901 gtgacatttt tctgtatgaa ttgttttaat ttttacttct ttttttcatc ctgtttgtct
     3961 cctcttgata aataattggc atactgaata taaaaa
//
