LOCUS       NM_001395333            7079 bp    mRNA    linear   PRI 01-JAN-2024
DEFINITION  Homo sapiens microtubule crosslinking factor 1 (MTCL1), transcript
            variant 6, mRNA.
ACCESSION   NM_001395333
VERSION     NM_001395333.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7079)
  AUTHORS   Chen W, Caiyun L, Yang Y, Xinwei H, Nan L, Jiaming Y, Huirong Y,
            Kai W and Liucheng Y.
  TITLE     Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for
            regulation of cell proliferation and migration in Hirschsprung's
            disease
  JOURNAL   Pediatr Surg Int 40 (1), 25 (2023)
   PUBMED   38127107
  REMARK    GeneRIF: Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p
            for regulation of cell proliferation and migration in
            Hirschsprung's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7079)
  AUTHORS   Ferreira LT, Logarinho E, Macedo JC, Maia ARR and Maiato H.
  TITLE     SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for
            faithful chromosome segregation in human cells
  JOURNAL   Chromosome Res 29 (2), 159-173 (2021)
   PUBMED   33587225
  REMARK    GeneRIF: SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins
            required for faithful chromosome segregation in human cells.
REFERENCE   3  (bases 1 to 7079)
  AUTHORS   Krygier M, Kwarciany M, Wasilewska K, Pienkowski VM, Krawczynska N,
            Zielonka D, Kosinska J, Stawinski P, Rudzinska-Bar M,
            Boczarska-Jedynak M, Karaszewski B, Limon J, Slawek J, Ploski R and
            Rydzanicz M.
  TITLE     A study in a Polish ataxia cohort indicates genetic heterogeneity
            and points to MTCL1 as a novel candidate gene
  JOURNAL   Clin Genet 95 (3), 415-419 (2019)
   PUBMED   30548255
  REMARK    GeneRIF: We propose MTCL1 as a candidate gene for autosomal
            recessive cerebellar ataxia in humans. In addition, our study
            confirms the high diagnostic yield of NGS in early-onset cerebellar
            ataxias, with at least 50% detection rate in our ataxia cohort.
REFERENCE   4  (bases 1 to 7079)
  AUTHORS   Kader MA, Satake T, Yoshida M, Hayashi I and Suzuki A.
  TITLE     Molecular basis of the microtubule-regulating activity of
            microtubule crosslinking factor 1
  JOURNAL   PLoS One 12 (8), e0182641 (2017)
   PUBMED   28787032
  REMARK    GeneRIF: microtubule-regulating activity of microtubule
            crosslinking factor 1
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7079)
  AUTHORS   Hyodo T, Ito S, Asano-Inami E, Chen D and Senga T.
  TITLE     A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates
            the abundance of microtubule crosslinking factor 1
  JOURNAL   FEBS J 283 (19), 3662-3671 (2016)
   PUBMED   27521566
  REMARK    GeneRIF: results suggest that the PPP2R5E phosphatase may
            contribute to microtubule organization by stabilizing MTCL1.
REFERENCE   6  (bases 1 to 7079)
  AUTHORS   Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee
            MP, Goldstein AM and Taylor PR.
  TITLE     Replication of a genome-wide case-control study of esophageal
            squamous cell carcinoma
  JOURNAL   Int J Cancer 123 (7), 1610-1615 (2008)
   PUBMED   18649358
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7079)
  AUTHORS   Beausoleil SA, Villen J, Gerber SA, Rush J and Gygi SP.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
REFERENCE   8  (bases 1 to 7079)
  AUTHORS   Nousiainen M, Sillje HH, Sauer G, Nigg EA and Korner R.
  TITLE     Phosphoproteome analysis of the human mitotic spindle
  JOURNAL   Proc Natl Acad Sci U S A 103 (14), 5391-5396 (2006)
   PUBMED   16565220
REFERENCE   9  (bases 1 to 7079)
  AUTHORS   Brajenovic M, Joberty G, Kuster B, Bouwmeester T and Drewes G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   10 (bases 1 to 7079)
  AUTHORS   Perlman,S.
  TITLE     Hereditary Ataxia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301317
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000864.4 and AP001531.4.
            
            Transcript Variant: This variant (6) encodes the longest isoform
            (6).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000695636.1/ ENSP00000512073.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1158              AP000864.4         72944-74101
            1159-1383           AP000864.4         85812-86036
            1384-1542           AP000864.4         87726-87884
            1543-1602           AP000864.4         145221-145280
            1603-2916           AP000864.4         150918-152231
            2917-3072           AP000864.4         153324-153479
            3073-3195           AP000864.4         160386-160508
            3196-3426           AP000864.4         163620-163850
            3427-3621           AP000864.4         165485-165679
            3622-3789           AP001531.4         4642-4809
            3790-4044           AP001531.4         10728-10982
            4045-4341           AP001531.4         16712-17008
            4342-4373           AP001531.4         19216-19247
            4374-5907           AP001531.4         22448-23981
            5908-7079           AP001531.4         29356-30527
FEATURES             Location/Qualifiers
     source          1..7079
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.22"
     gene            1..7079
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /note="microtubule crosslinking factor 1"
                     /db_xref="GeneID:23255"
                     /db_xref="HGNC:HGNC:29121"
                     /db_xref="MIM:615766"
     exon            1..1158
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..6141
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /note="isoform 6 is encoded by transcript variant 6;
                     coiled-coil domain containing 165; SOGA family member 2;
                     PAR-1-interacting protein; microtubule cross-linking
                     factor 1; coiled-coil domain-containing protein 165"
                     /codon_start=1
                     /product="microtubule cross-linking factor 1 isoform 6"
                     /protein_id="NP_001382262.1"
                     /db_xref="CCDS:CCDS92431.1"
                     /db_xref="GeneID:23255"
                     /db_xref="HGNC:HGNC:29121"
                     /db_xref="MIM:615766"
                     /translation="METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSP
                     ARPFLKDLHARPAAPGPAVPSSGRAPAPAAPRSPNLAGKAPPSPGSLAAPGRLSRRSG
                     GVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGAEPPSAAAKGR
                     KAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSE
                     PLSDEQRLLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAA
                     GACPGGRSIPSGVSGGFAGPGVAEDVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEE
                     ELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQLQELRRELDRANKNCRI
                     LQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAE
                     DENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQ
                     LQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAE
                     LKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPF
                     GDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGE
                     GASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAP
                     SPRDSDAESDAGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASE
                     PCPTELLKAREDSEYLVTLKHEAQRLERTVERLITDTDSFLHDAGLRGGAPLPGPGLQ
                     GEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGLSPLPHLTESSSFLS
                     TVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRAD
                     GDTGSHGLGGQTCFSLELRGPPVLPEQSVSIEELQGQLVQAARLHQEETETFTNKIHK
                     MEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWL
                     LKHWRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEH
                     SPHSRVQIGDHSLRLQTADRGQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRL
                     QQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELGSSAESKGALKKEREVHQKLLA
                     DSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSP
                     RRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCS
                     ASENLYLDALSLDDEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRL
                     MDISPFLPEKGLPSTSSKEDVTPPLSPDDLKYIEEFNKSWDYTPNRGHNGGGPDLWAD
                     RTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRSHVLTEQSGLRV
                     LHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYV
                     EGARRPLDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMA
                     CQTNGSRTMGTQTVQTISVGLQTEALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLR
                     SRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQPNNRTSPGMAQKGYSESAW
                     ARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGPG
                     QETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLE
                     HALKEERRQAAHGPPGLHSDSHSLGDTAEPGPMEELPCSALAPSLEPCFSRPERPANR
                     RPPSRWAPHSPTASQPQSPGDPTSLEEHGGEEPPEEQPHRDASLHGLSQYNSL"
     exon            1159..1383
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1542
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1602
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..2916
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            2917..3072
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3195
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3426
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3621
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3622..3789
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            3790..4044
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4045..4341
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4342..4373
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..5907
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..7079
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7057..7062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /note="hexamer: AATAAA"
     polyA_site      7079
                     /gene="MTCL1"
                     /gene_synonym="CCDC165; KIAA0802; SOGA2"
                     /note="major polyA site"
ORIGIN      
        1 agtgatgaga gagcgcgcgg ggaggctgca cgccgccgcc gccgccgccg ccgccgtcgt
       61 cgtccggagc atctgctgcc tgagctgctg ccggcggacc cggccatgga gacactgaac
      121 ggccccgcgg gcggaggtgc cccggacgcg aagctgcagc cgcccggcca gcaccaccgc
      181 caccaccacc tccacccggt ggccgaaagg cggcggctgc accgtgcgcc ctcgcccgcc
      241 agacccttcc tcaaggacct gcacgcccgg cccgccgcgc ccggcccggc cgtcccctcc
      301 tcgggccgag ccccggctcc cgccgccccg cgctcgccca acctcgcggg caaagcgccg
      361 ccctcgccgg ggtccctggc cgcgcccggc cgcctctctc ggcgcagtgg cggcgtcccg
      421 ggcgcgaagg acaagccccc gccgggcgcc ggggccagag cggcgggcgg tgccaaggct
      481 gccctgggaa gcaggagggc ggcgcgcgtg gcgcccgcgg agccgctgtc ccgggctggg
      541 aagcctcccg gagccgagcc gccgtctgcc gctgccaagg gccgcaaagc caagcgcggc
      601 tcccgggcgc cacccgcccg caccgtcggc cccccgaccc cggccgcccg gatccctgcc
      661 gtgaccctcg cggtgacctc ggtggccggg tccccggccc gctgctcgcg catcagccac
      721 acggacagca gctccgacct ctctgactgc ccctccgaac ccctgtccga cgagcagcgc
      781 ctgctccctg ccgccagcag cgacgccgaa tccggcacgg gctccagcga ccgtgaaccc
      841 ccacgaggag cgccgacgcc gagccccgca gcccgaggag cgccgccggg cagccccgag
      901 cccccagcgc tcctcgccgc gcccctcgcc gcgggcgcct gtcccggggg ccggagcatc
      961 ccgagcgggg tttcgggggg tttcgcgggg cccggcgtgg cggaggatgt ccgggggcgc
     1021 tcgccaccgg agcgaccagt ccccgggacc cccaaggagc ccagcctggg cgagcagtct
     1081 cggctcgtgc cagcggcgga ggaagaagag ctgctgcggg agatggagga gctgcgctcg
     1141 gagaacgact atctcaagga tgagttagat gaactccgtg ctgagatgga agagatgaga
     1201 gacagttatt tagaggaaga tgtttaccag ctgcaggaac ttcggcgaga actggaccgc
     1261 gctaataaaa actgccgaat cctgcagtac cgtcttcgga aagccgagca gaaaagcctg
     1321 aaagtggctg agacgggtca ggtggatggt gagcttattc gaagcctgga gcaggacttg
     1381 aaggtagcca aagatgtatc tgtcagattg caccacgaac ttaagacggt ggaggaaaag
     1441 cgcgctaaag ctgaggatga aaacgaaact ctccgacagc agatgattga agtggaaata
     1501 tccaaacagg ccctccagaa tgagctggag agactgaaag agagttccct aaaaagaaga
     1561 agcactcggg aaatgtacaa ggagaagaaa acctttaacc aggatgacag tgccgatttg
     1621 aggtgccagc tccagtttgc caaagaggaa gccttcctga tgcgcaaaaa gatggccaag
     1681 ctaggaaggg agaaggacga gctggagcag gagctccaga agtacaagtc cctctatggg
     1741 gatgtggaca gtcccctgcc cacgggggaa gcaggcgggc cccccagcac ccgggaggcc
     1801 gagctgaagc tgcggctaaa gctggtggag gaggaagcca acatcttggg ccggaagatc
     1861 gtggagctgg aggtggagaa ccgtggcctc aaggcagaga tggaggacat gcggggccag
     1921 caggagcggg agggcccggg tcgggaccac gcacccagca ttcctacctc acccttcggt
     1981 gactccctgg agtcctccac tgagctccgc cgccacctgc agtttgtaga agaggaagcg
     2041 gagttgctcc ggaggtccat ctccgagatc gaagaccaca accggcaact gacccacgag
     2101 ctcagcaagt ttaagtttga gcctccccgg gagccgggct ggctaggaga gggtgcaagt
     2161 cctggtgccg ggggtggggc ccccctgcag gaggagctga agtcagccag gctgcagatc
     2221 agcgagctca gcggcaaggt gctcaaactg cagcacgaga accacgcgct gctgtccaac
     2281 atccagcgct gcgacctggc agcccacctg gggctgcgtg cccccagtcc ccgggacagc
     2341 gatgccgaga gtgatgcggg caagaaggag agtgatgggg aggagagccg cctgccccag
     2401 cccaagcggg aagggcctgt tggcggggag agtgactcgg aggaaatgtt tgagaagacg
     2461 tcgggcttcg ggagcgggaa gccatcggag gccagcgagc catgccccac ggagctcctg
     2521 aaggcccggg aggactctga gtacctagtg accctaaaac acgaggccca gcggctagag
     2581 cggacggtgg agcgcctcat cacggacacc gacagcttcc tccatgatgc ggggctgcgg
     2641 ggtggtgcgc ccttaccggg gcctggcctc cagggcgaag aggagcaggg tgagggggac
     2701 cagcaggagc cccagctgct ggggaccatc aacgccaaga tgaaggcttt caagaaagag
     2761 ctgcaggcct tcctggagca ggtgaaccgc attggggatg gcctatcccc cttgccccac
     2821 ctcacagagt cctctagctt cctctccact gtgacttccg tgtcccggga ctcccccatc
     2881 gggaacctgg ggaaggagct gggcccagac ttgcagtcca gactgaaaga gcagctggag
     2941 tggcagctcg ggccggcccg aggggacgag cgggagagcc tgcgcctccg agccgcgcgg
     3001 gagctgcacc gccgcgcaga cggggacacc gggagccacg ggctgggagg ccagacctgc
     3061 ttcagcctgg agctcagggg cccccccgtt ttacctgagc agagtgtatc catagaggag
     3121 ctacagggtc agctcgtgca ggcggccaga ctgcatcaag aggagacaga gacatttaca
     3181 aacaagatcc ataagatgga ggaggagcac ctctatgcct tgaggtggaa agaactggaa
     3241 atgcacagcc tggctttgca aaacaccctc catgagcgaa cctggagtga tgagaagaat
     3301 ctgatgcagc aggagctccg gtccttgaag cagaacattt tcctcttcta cgtcaaactc
     3361 aggtggctgc tgaaacactg gcggcaaggg aagcagatgg aggaggaagg agaggagttc
     3421 actgagggtg aacatccaga gaccctctcc aggctcgggg agcttggagt ccaggggggt
     3481 caccaggcgg atggcccaga ccacgacagt gaccgaggct gtggctttcc agtgggggag
     3541 cactccccac actcccgggt gcagattgga gatcacagct tgcggctgca gaccgcggac
     3601 aggggacagc cccacaaaca ggtggtggaa aaccagcagc tgttcagcgc cttcaaggcc
     3661 ttgctggagg acttccgtgc ggagctgcgg gaggatgagc gtgcccgact acggctgcag
     3721 cagcaatatg ccagcgacaa ggcggcctgg gacgtggagt gggccgtgct caagtgccgt
     3781 ctggaacagc tggaagagaa gactgagaac aagttgggag aactaggctc ctccgctgag
     3841 agcaaggggg ccttgaagaa ggagagagag gtgcaccaga agctcctggc agacagtcac
     3901 agcctggtca tggacctgcg ctggcagatc catcacagcg agaagaactg gaaccgggag
     3961 aaggtggaac ttctcgaccg cctggacaga gatcggcagg agtgggagcg gcagaagaag
     4021 gaattcttgt ggaggataga gcagttgcag aaagagaaca gtccccggag aggtggcagt
     4081 ttcctctgtg atcaaaaaga cggcaacgtt cgcccctttc cccaccaggg aagcctccgc
     4141 atgccccgtc cagtggccat gtggccttgt gcagatgctg actccatccc gtttgaagac
     4201 cggccgctgt ccaagctgaa ggagtcggac aggtgctcgg ccagtgagaa tctctacctg
     4261 gatgccttgt ccctggatga cgagccagaa gagccaccag cccacaggcc cgagagggag
     4321 ttcaggaacc gcctccctga ggaagaagaa aatcacaaag gaaatcttca aagggcggtg
     4381 tccgtgtcct ccatgtctga gttccagcgt ctaatggaca tctccccctt cctgcctgag
     4441 aagggcctgc cgtccaccag cagcaaggag gatgtcaccc cacccctgtc tccagacgac
     4501 ctcaagtaca tcgaggagtt caacaagagc tgggactaca cacccaacag gggccacaat
     4561 ggtggggggc cggacctttg ggccgacagg accgaggtgg ggcgggcagg gcacgaggac
     4621 agcacagagc ctttccccga ctcctcctgg tacctaacca caagtgtcac catgaccacg
     4681 gacaccatga ccagcccaga gcactgccag aagcagccac tgcggagcca cgtcctcacc
     4741 gagcagtcgg ggttgcgcgt gttacacagc ccgcctgccg tgcgcagggt cgacagcatc
     4801 acggcggcag gtggtgaggg tccctttccc acaagcagag ccagagggag cccgggagac
     4861 accaagggag gccctccaga acccatgctc agcaggtggc cttgcacctc ccccaggcac
     4921 tcccgggact atgtggaggg ggcacggcgc ccccttgata gtcccctctg tacctccctg
     4981 gggtttgcct ccccactgca cagcctggag atgtccaaga acttgagtga tgacatgaag
     5041 gaggtggcct tctctgtcag gaatgccatc tgctccggcc ctggcgagct gcaagtcaag
     5101 gacatggcct gccagaccaa tgggtcccgg acgatgggga cccagactgt tcagaccatc
     5161 agtgtgggct tgcagactga agccctgcgt ggcagcggtg tcaccagcag cccccacaag
     5221 tgtctcactc caaaggctgg gggcggtgct acacccgtgt cgtctccttc ccggagcctt
     5281 aggagcagac aggtggcccc tgccatcgag aaggtgcagg ccaagtttga acgcacatgc
     5341 tgctccccca agtatggttc tcccaagctg cagaggaagc ccctccccaa agccgaccag
     5401 ccaaataaca ggacgtcacc agggatggcc cagaaagggt acagtgagtc agcctgggcc
     5461 cgctccacca ccacaaggga gagccccgtg cacaccacca ttaatgatgg cctctccagc
     5521 ctcttcaaca tcattgacca cagccccgtg gtgcaggacc ccttccagaa ggggctgcgg
     5581 gccggcagtc ggtctcgctc agcagagccc cgaccagagc tgggcccagg ccaggaaaca
     5641 ggcaccaatt cccgaggaag gtcgcctagc cccattgggg tggggtcaga gatgtgcagg
     5701 gaggaagggg gagagggcac gccagtgaag caggacttat ctgctccccc tggctacacg
     5761 ctcactgaga acgtggcccg gatcctcaac aagaagctgc tggaacatgc cttaaaggag
     5821 gagaggaggc aggctgccca cgggcccccg ggtctccaca gtgacagcca ctcgctgggg
     5881 gacacagccg agccagggcc catggaggaa ctaccttgtt ctgcactagc tccatcccta
     5941 gagccctgct tctccaggcc cgagagacca gcaaaccgtc gccctccgtc ccgttgggcc
     6001 ccacattccc ccactgcctc acagcctcag tcacccggag acccgacgtc cttggaggag
     6061 catggtggcg aggagccgcc cgaggagcag ccacaccgag atgcaagctt gcatggatta
     6121 tcacagtata attcactgta atttgcataa ccacaccatc accatgaaca aaactctgcc
     6181 caacaggaga gatctagttt tctcaaggtc aaagaatgtt ttttaaaaac acaaagctgc
     6241 tgaatgttca acctgtgaaa ctgagatgtt tctagaatga aacagtaaat gtgcctgtaa
     6301 taacttaatt tttttcatag ctcagaaaac tatttttgtc tccatctttt ttacacacag
     6361 tatattaaac gaaaaggtaa ataaggtata aatagattta aaaaataaaa gttttaaaaa
     6421 atgtacattt taagagattc tgaacaccct cgctgtcaat acctgactgc ctctgttaaa
     6481 tttgcactgt tacattttgg ttcagtttat ttccatgttg aattagagtg gattaagtta
     6541 attttatttt gtcagtgtta ctgtttttta cgaatttttt aatgcttcag actgtctgat
     6601 tcagtgaact ttttgtagtg aaaaagccat gaagccagta gacaagacag atattctgta
     6661 tgctggaggg gatacaggat gattttgaaa aggtacaaag tcctcagtgg gcttagaaaa
     6721 ttcactgtat gatccttata ttatcctact tggcttgcac gtcttcgggt gcatgtatat
     6781 accgctactg tgtcctcgcc atcacctaaa tgtgactcag tctgttccac tgtaatatgt
     6841 tgtgaatttc cttgtactgt acttttattg ttggtcttct tgcatcgatg atccaacagc
     6901 aacaccattt ttaaattatt gtgaaaagat taactggcaa tgtacagagt ttactcaaag
     6961 ttttcttaag ggaaaacact acaaaaagtc acaaggatac caaatggaaa cacatgatga
     7021 tgcctctggg tctgtatgag accgtgatga agtagaaata aagcccttct gagatggca
//
