LOCUS       NM_022045               3067 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MDM2 binding protein (MTBP), mRNA.
ACCESSION   NM_022045
VERSION     NM_022045.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3067)
  AUTHORS   Kumagai,A. and Dunphy,W.G.
  TITLE     Binding of the Treslin-MTBP Complex to Specific Regions of the
            Human Genome Promotes the Initiation of DNA Replication
  JOURNAL   Cell Rep 32 (12), 108178 (2020)
   PUBMED   32966791
  REMARK    GeneRIF: Binding of the Treslin-MTBP Complex to Specific Regions of
            the Human Genome Promotes the Initiation of DNA Replication.
REFERENCE   2  (bases 1 to 3067)
  AUTHORS   Lu,S., Zhou,W., Wei,H., He,L. and Li,L.
  TITLE     MTBP Promotes the Invasion and Metastasis of Hepatocellular
            Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin
  JOURNAL   Dig Dis Sci 60 (12), 3681-3690 (2015)
   PUBMED   26280083
  REMARK    GeneRIF: data show that MTBP aggravates the invasion and metastasis
            of HCC by promoting the MDM2-mediated degradation of E-cadherin.
REFERENCE   3  (bases 1 to 3067)
  AUTHORS   Bi,Q., Ranjan,A., Fan,R., Agarwal,N., Welch,D.R., Weinman,S.A.,
            Ding,J. and Iwakuma,T.
  TITLE     MTBP inhibits migration and metastasis of hepatocellular carcinoma
  JOURNAL   Clin Exp Metastasis 32 (4), 301-311 (2015)
   PUBMED   25759210
  REMARK    GeneRIF: Overexpression of MTBP resulted in the suppression of the
            migratory and metastatic potential of Hepatocellular carcinoma
            cells, while its downregulation increased the migration.
REFERENCE   4  (bases 1 to 3067)
  AUTHORS   Oh,S. and Oh,S.
  TITLE     Epidemiological and genome-wide association study of gastritis or
            gastric ulcer in korean populations
  JOURNAL   Genomics Inform 12 (3), 127-133 (2014)
   PUBMED   25317112
REFERENCE   5  (bases 1 to 3067)
  AUTHORS   Grieb,B.C., Chen,X. and Eischen,C.M.
  TITLE     MTBP is overexpressed in triple-negative breast cancer and
            contributes to its growth and survival
  JOURNAL   Mol Cancer Res 12 (9), 1216-1224 (2014)
   PUBMED   24866769
  REMARK    GeneRIF: MTBP significantly contributes to breast cancer survival
            and is a potential novel therapeutic target in Triple-negative
            breast cancer .
REFERENCE   6  (bases 1 to 3067)
  AUTHORS   Agarwal,N., Tochigi,Y., Adhikari,A.S., Cui,S., Cui,Y. and
            Iwakuma,T.
  TITLE     MTBP plays a crucial role in mitotic progression and chromosome
            segregation
  JOURNAL   Cell Death Differ 18 (7), 1208-1219 (2011)
   PUBMED   21274008
  REMARK    GeneRIF: MTBP has an important role in recruiting and/or retaining
            the Mad1/Mad2 complex at the kinetochores during prometaphase, but
            its degradation is required for silencing the mitotic checkpoint.
REFERENCE   7  (bases 1 to 3067)
  AUTHORS   Odvody,J., Vincent,T., Arrate,M.P., Grieb,B., Wang,S., Garriga,J.,
            Lozano,G., Iwakuma,T., Haines,D.S. and Eischen,C.M.
  TITLE     A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell
            proliferation and lymphomagenesis
  JOURNAL   Oncogene 29 (22), 3287-3296 (2010)
   PUBMED   20305689
REFERENCE   8  (bases 1 to 3067)
  AUTHORS   Brady,M., Vlatkovic,N. and Boyd,M.T.
  TITLE     Regulation of p53 and MDM2 activity by MTBP
  JOURNAL   Mol Cell Biol 25 (2), 545-553 (2005)
   PUBMED   15632057
  REMARK    GeneRIF: Data suggest that MTBP differentially regulates the
            activity of MDM2 towards two of its most critical targets (itself
            and p53) and in doing so significantly contributes to
            MDM2-dependent p53 homeostasis in unstressed cells.
            GeneRIF: MTBP contributes to MDM2 activity and through this to
            negative regulation of p53
REFERENCE   9  (bases 1 to 3067)
  AUTHORS   Boyd,M.T., Vlatkovic,N. and Haines,D.S.
  TITLE     A novel cellular protein (MTBP) binds to MDM2 and induces a G1
            arrest that is suppressed by MDM2
  JOURNAL   J Biol Chem 275 (41), 31883-31890 (2000)
   PUBMED   10906133
  REMARK    GeneRIF: identification and characterization of mouse Mdm2 binding
            protein
REFERENCE   10 (bases 1 to 3067)
  AUTHORS   Boyd,M.T., Zimonjic,D.B., Popescu,N.C., Athwal,R. and Haines,D.S.
  TITLE     Assignment of the MDM2 binding protein gene (MTBP) to human
            chromosome band 8q24 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 64-65 (2000)
   PUBMED   11060448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107877.4, BC013136.1 and
            AC105142.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_022045.4.
            
            Summary: This gene encodes a protein that interacts with the
            oncoprotein mouse double minute 2. The encoded protein regulates
            progression through the cell cycle and may be involved in tumor
            formation. [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.282.1, BC013136.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305949.6/ ENSP00000303398.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC107877.4         104909-104915
            8-3066              BC013136.1         1-3059
            3067-3067           AC105142.4         92755-92755         c
FEATURES             Location/Qualifiers
     source          1..3067
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..3067
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /note="MDM2 binding protein"
                     /db_xref="GeneID:27085"
                     /db_xref="HGNC:HGNC:7417"
                     /db_xref="MIM:605927"
     exon            1..170
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2767
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /note="MDM2 (mouse double minute 2)-binding protein,
                     104kD; Mdm2, transformed 3T3 cell double minute 2, p53
                     binding protein binding protein, 104kDa"
                     /codon_start=1
                     /product="mdm2-binding protein"
                     /protein_id="NP_071328.2"
                     /db_xref="CCDS:CCDS6333.1"
                     /db_xref="GeneID:27085"
                     /db_xref="HGNC:HGNC:7417"
                     /db_xref="MIM:605927"
                     /translation="MDRYLLLVIWGEGKFPSAASREAEHGPEVSSGEGTENQPDFTAA
                     NVYHLLKRSISASINPEDSTFPACSVGGIPGSKKWFFAVQAIYGFYQFCSSDWQEIHF
                     DTEKDKIEDVLQTNIEECLGAVECFEEEDSNSRESLSLADLYEEAAENLHQLSDKLPA
                     PGRAMVDIILLLSDKDPPKLKDYLPTVGALKHLREWYSAKITIAGNHCEINCQKIAEY
                     LSANVVSLEDLRNVIDSKELWRGKIQIWERKFGFEISFPEFCLKGVTLKNFSTSNLNT
                     DFLAKKIIPSKDKNILPKVFHYYGPALEFVQMIKLSDLPSCYMSDIEFELGLTNSTKQ
                     NSVLLLEQISSLCSKVGALFVLPCTISNILIPPPNQLSSRKWKEYIAKKPKTISVPDV
                     EVKGECSSYYLLLQGNGNRRCKATLIHSANQINGSFALNLIHGKMKTKTEEAKLSFPF
                     DLLSLPHFSGEQIVQREKQLANVQVLALEECLKRRKLAKQPETVSVAELKSLLVLTRK
                     HFLDYFDAVIPKMILRKMDKIKTFNILNDFSPVEPNSSSLMETNPLEWPERHVLQNLE
                     TFEKTKQKMRTGSLPHSSEQLLGHKEGPRDSITLLDAKELLKYFTSDGLPIGDLQPLP
                     IQKGEKTFVLTPELSPGKLQVLPFEKASVCHYHGIEYCLDDRKALERDGGFSELQSRL
                     IRYETQTTCTRESFPVPTVLSPLPSPVVSSDPGSVPDGEVLQNELRTEVSRLKRRSKD
                     LNCLYPRKRLVKSESSESLLSQTTGNSNHYHHHVTSRKPQTERSLPVTCPLVPIPSCE
                     TPKLATKTSSGQKSMHESKTSRQIKESRSQKHTRILKEVVTETLKKHSITETHECFTA
                     CSQRLFEISKFYLKDLKTSRGLFEEMKKTANNNAVQVIDWVLEKTSKK"
     exon            171..251
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            252..325
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            326..477
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..536
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            537..681
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            682..799
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            800..934
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1029
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1099
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1217
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1391
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1499
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1661
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1779
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1935
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2031
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2032..2298
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2548
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2662
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2663..2728
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..3067
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3044..3049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /note="hexamer: AATAAA"
     polyA_site      3067
                     /gene="MTBP"
                     /gene_synonym="MDM2BP"
                     /note="major polyA site"
ORIGIN      
        1 ctgtttggat gtggaagccg agacctaaag ttggggggtg atctctgagg agatggatcg
       61 gtacctgctg ctggtgatct ggggggaagg aaaattcccg tcggcggcca gtagggaggc
      121 agaacatggg ccagaggtgt cgtcgggtga gggtactgag aatcagccgg acttcacagc
      181 agcaaatgtt tatcacctct tgaaaagaag cattagtgct tcaattaatc cagaagatag
      241 tactttccct gcctgttcag tgggaggtat acctggttcc aagaagtggt tctttgcagt
      301 gcaggcaata tatggatttt atcagttttg tagttctgat tggcaagaga tacattttga
      361 tacagaaaaa gataaaattg aagatgttct tcaaacgaat atcgaagaat gtttgggtgc
      421 tgttgagtgt tttgaagaag aagacagtaa tagcagggaa tcattatcct tggctgatct
      481 ctatgaagaa gctgcagaaa atttgcatca gctgtcagac aagcttcctg ctcctggtag
      541 agcaatggta gatataatac tgttgctttc tgacaaagat cctcctaaat tgaaagacta
      601 tttacctact gtaggagcat taaaacattt gagagaatgg tattcagcaa agatcactat
      661 agcaggaaat cattgtgaaa taaactgtca gaaaattgca gaataccttt ctgctaatgt
      721 tgtatcttta gaagatctca gaaatgttat tgactcaaag gaattatgga gggggaaaat
      781 acagatatgg gaaagaaagt ttggatttga aattagtttt cctgaatttt gtttaaaggg
      841 agtcacactt aagaatttta gtacttctaa tttaaatact gacttccttg ccaaaaagat
      901 cataccatca aaggataaga atattttgcc aaaggttttc cattattatg gccctgcttt
      961 agaatttgtg cagatgataa aattatcaga tctaccctcc tgctatatgt cggatattga
     1021 atttgagtta ggattgacaa acagtaccaa acagaattct gtgttgctgt tggagcagat
     1081 ttcttctctg tgtagcaagg ttggtgctct ttttgtattg ccatgtacca ttagtaacat
     1141 actgattcca cctcccaacc aactcagttc aagaaaatgg aaggaatata tagctaaaaa
     1201 gcctaaaaca atcagtgttc cagatgttga agtgaaagga gagtgttcta gctattatct
     1261 cttgttacaa ggtaatggca atagaagatg taaagccaca ttgattcact cagccaacca
     1321 gatcaatggc tcatttgcac tcaatttaat tcatggaaag atgaaaacaa agacagaaga
     1381 agccaaattg agttttcctt ttgacttatt atcacttcca catttttctg gggagcagat
     1441 tgtacagaga gagaaacagt tagctaatgt tcaagtttta gctttggaag aatgcctaaa
     1501 aagacgaaag ttggcaaagc agcctgaaac agtttctgtt gctgaactca aaagtctgtt
     1561 agtactcaca aggaaacact ttttagatta ttttgatgct gtgattccta aaatgattct
     1621 aagaaagatg gacaaaatta aaaccttcaa tatattaaat gattttagtc cagtggaacc
     1681 taattcctca agtctaatgg aaaccaatcc tctggaatgg ccagaaaggc atgttcttca
     1741 aaatttggaa acttttgaaa aaactaaaca aaaaatgaga actggttcat tacctcattc
     1801 atctgaacag ttgctgggcc acaaagaggg tcctcgggac tcaatcacat tgttggatgc
     1861 taaagaattg ctgaagtact ttacctcaga tggattaccc attggagatc ttcaaccttt
     1921 accgattcaa aagggggaaa agacttttgt tttgacacca gaacttagtc ctgggaaact
     1981 tcaggtctta ccttttgaga aagcctcagt atgtcattat catggaattg aatattgctt
     2041 ggatgaccga aaagctttgg aaagagatgg aggattttct gaacttcagt ctcgtcttat
     2101 tcgttatgaa actcaaacta cctgcaccag agaaagtttt ccagtaccta ctgtgttgag
     2161 ccctcttcca tctcctgtag tttcgtcaga tcctggaagt gtccctgacg gagaagtttt
     2221 acaaaatgaa cttcgaactg aagtatcccg attgaaacgg agatctaaag atctgaattg
     2281 cctttatccc agaaaaagac ttgtgaaatc tgaaagttca gagtctcttc tttctcagac
     2341 aactggtaat agtaatcact atcatcatca tgtgacatcc agaaagccac aaacagaacg
     2401 gtccttacca gtgacttgtc cattggttcc aattcctagc tgtgaaactc caaaacttgc
     2461 tacaaagacc agttcaggtc aaaaaagtat gcatgaatca aaaacatcaa ggcaaattaa
     2521 ggaatcaaga tcacagaaac acacacggat actgaaagaa gtagttactg aaaccctgaa
     2581 gaaacacagt attaccgaga ctcatgaatg tttcactgca tgcagccagc gtctctttga
     2641 aatctctaag ttctatctaa aggatcttaa aacttcaagg ggtctatttg aagaaatgaa
     2701 gaaaacagca aacaacaatg ctgtacaggt gattgactgg gtattagaaa agacaagcaa
     2761 gaaatgatac ataatcattc tctttaagac aattataaat tggatggagc tattattcac
     2821 tacttctttt cttagtttga aaattataaa caaattttaa gctttattca aagaatagat
     2881 gttatatttc taaagaattt catgaatata tattctatat ttgtatagtt tgagggatgc
     2941 tatgttaatg tatttttaat tagatacata ttttgtaaag tgttactata ttttaaagtt
     3001 atttttatat gttttaaaat gtttactctt atttaattat tacaataaac agaatttttt
     3061 tttttta
//
