LOCUS       NM_017898               2146 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial amidoxime reducing component 2 (MTARC2),
            transcript variant 2, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017898
VERSION     NM_017898.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2146)
  AUTHORS   Deng,H., Cui,M., Liu,L. and Yang,F.
  TITLE     CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS
  JOURNAL   Shock 61 (5), 675-684 (2024)
   PUBMED   38010085
  REMARK    GeneRIF: CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS.
REFERENCE   2  (bases 1 to 2146)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2146)
  AUTHORS   Neve,E.P., Kofeler,H., Hendriks,D.F., Nordling,A., Gogvadze,V.,
            Mkrtchian,S., Naslund,E. and Ingelman-Sundberg,M.
  TITLE     Expression and Function of mARC: Roles in Lipogenesis and Metabolic
            Activation of Ximelagatran
  JOURNAL   PLoS One 10 (9), e0138487 (2015)
   PUBMED   26378779
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2146)
  AUTHORS   Plitzko,B., Havemeyer,A., Kunze,T. and Clement,B.
  TITLE     The pivotal role of the mitochondrial amidoxime reducing component
            2 in protecting human cells against apoptotic effects of the base
            analog N6-hydroxylaminopurine
  JOURNAL   J Biol Chem 290 (16), 10126-10135 (2015)
   PUBMED   25713076
  REMARK    GeneRIF: mARC2 has a pivotal role in protecting human cells against
            apoptotic effects of the base analog N6-hydroxylaminopurine.
REFERENCE   5  (bases 1 to 2146)
  AUTHORS   Ott,G., Havemeyer,A. and Clement,B.
  TITLE     The mammalian molybdenum enzymes of mARC
  JOURNAL   J Biol Inorg Chem 20 (2), 265-275 (2015)
   PUBMED   25425164
  REMARK    Review article
REFERENCE   6  (bases 1 to 2146)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
  REMARK    GeneRIF: Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in
            their active forms.
REFERENCE   7  (bases 1 to 2146)
  AUTHORS   Chen,X., Li,X., Wang,P., Liu,Y., Zhang,Z., Zhao,G., Xu,H., Zhu,J.,
            Qin,X., Chen,S., Hu,L. and Kong,X.
  TITLE     Novel association strategy with copy number variation for
            identifying new risk Loci of human diseases
  JOURNAL   PLoS One 5 (8), e12185 (2010)
   PUBMED   20808825
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2146)
  AUTHORS   Aberg,K., Adkins,D.E., Bukszar,J., Webb,B.T., Caroff,S.N.,
            Miller,D.D., Sebat,J., Stroup,S., Fanous,A.H., Vladimirov,V.I.,
            McClay,J.L., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genomewide association study of movement-related adverse
            antipsychotic effects
  JOURNAL   Biol Psychiatry 67 (3), 279-282 (2010)
   PUBMED   19875103
REFERENCE   9  (bases 1 to 2146)
  AUTHORS   Havemeyer,A., Bittner,F., Wollers,S., Mendel,R., Kunze,T. and
            Clement,B.
  TITLE     Identification of the missing component in the mitochondrial
            benzamidoxime prodrug-converting system as a novel molybdenum
            enzyme
  JOURNAL   J Biol Chem 281 (46), 34796-34802 (2006)
   PUBMED   16973608
REFERENCE   10 (bases 1 to 2146)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     MOSC domains: ancient, predicted sulfur-carrier domains, present in
            diverse metal-sulfur cluster biosynthesis proteins including
            Molybdenum cofactor sulfurases
  JOURNAL   FEMS Microbiol Lett 207 (1), 55-61 (2002)
   PUBMED   11886751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP194343.1, BC011973.1,
            BC015829.2 and AA843271.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017898.4.
            
            Summary: The protein encoded by this gene is an enzyme found in the
            outer mitochondrial membrane that reduces N-hydroxylated
            substrates. The encoded protein uses molybdenum as a cofactor and
            cytochrome b5 type B and NADH cytochrome b5 reductase as accessory
            proteins. One type of substrate used is N-hydroxylated nucleotide
            base analogues, which can be toxic to a cell. Other substrates
            include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs,
            which are activated by the encoded enzyme. Multiple transcript
            variants encoding the different isoforms have been found for this
            gene. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.155315.1,
                                           SRR1803615.188041.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000366913.8/
                                                  ENSP00000355880.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BP194343.1         77-88
            13-1588             BC011973.1         1-1576
            1589-2139           BC015829.2         935-1485
            2140-2146           AA843271.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..2146
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2146
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="mitochondrial amidoxime reducing component 2"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
     exon            1..482
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1218
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; MOSC domain-containing protein 2,
                     mitochondrial; MOCO sulphurase C-terminal domain
                     containing 2; moco sulfurase C-terminal domain-containing
                     protein 2; molybdenum cofactor sulfurase C-terminal
                     domain-containing protein 2"
                     /codon_start=1
                     /product="mitochondrial amidoxime reducing component 2
                     isoform a precursor"
                     /protein_id="NP_060368.2"
                     /db_xref="CCDS:CCDS1525.1"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
                     /translation="MGASSSSALARLGLPARPWPRWLGVAALGLAAVALGTVAWRRAW
                     PRRRRRLQQVGTVAKLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVIKEDGHM
                     VTARQEPRLVLISIIYENNCLIFRAPDMDQLVLPSKQPSSNKLHNCRIFGLDIKGRDC
                     GNEAAKWFTNFLKTEAYRLVQFETNMKGRTSRKLLPTLDQNFQVAYPDYCPLLIMTDA
                     SLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTT
                     VDPDTGVIDRKQPLDTLKSYRLCDPSERELYKLSPLFGIYYSVEKIGSLRVGDPVYRM
                     V"
     exon            483..656
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..819
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..960
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1022
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1094
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1249
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..2146
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1548..1553
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     regulatory      1562..1567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATGAA"
     regulatory      1571..1576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: ACTAAA"
     polyA_site      1571
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1578
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1588
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     polyA_site      2146
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
ORIGIN      
        1 cattaccgcg caggcttggt caccgcatta aggcattccc gctctccgcg gaactgctct
       61 gccgtctcgg cggtgaaagt gtgagagggt ccgtagttgg gtcaactttg actcctctcg
      121 cctgcccgga tccttaaggg cctcctcgtc ctcccggtct ccggtcgctg ccgggtctgt
      181 gcgccggtcc gcgcccgccc tcgctctgcc atgggcgctt ccagctcctc cgcgctggcc
      241 cgcctcggcc tcccagcccg gccctggccc aggtggctcg gggtcgccgc gctaggactg
      301 gccgccgtgg ccctggggac tgtcgcctgg cgccgcgcat ggcccaggcg gcgccggcgg
      361 ctgcagcagg tgggcaccgt ggcgaagctc tggatctacc cggtgaaatc ctgcaaaggg
      421 gtgccggtga gcgaggctga gtgcacggcc atggggctgc gcagcggcaa cctgcgggac
      481 aggttttggc tggtgattaa ggaagatgga cacatggtca ctgcccgaca ggagcctcgc
      541 ctcgtgctca tctccatcat ttatgagaat aactgcctga tcttcagggc tccagacatg
      601 gaccagctgg ttttgcctag caagcagcct tcctcaaaca aactccacaa ctgcaggata
      661 tttggccttg acattaaagg cagagactgt ggcaatgagg cagctaagtg gttcaccaac
      721 ttcttgaaaa ctgaagcgta tagattggtt caatttgaga caaacatgaa gggaagaaca
      781 tcaagaaaac ttctccccac tcttgatcag aatttccagg tggcctaccc agactactgc
      841 ccgctcctga tcatgacaga tgcctccctg gtagatttga ataccaggat ggagaagaaa
      901 atgaaaatgg agaatttcag gccaaatatt gtggtgaccg gctgtgatgc ttttgaggag
      961 gatacctggg atgaactcct aattggtagt gtagaagtga aaaaggtaat ggcatgcccc
     1021 aggtgtattt tgacaacggt ggacccagac actggagtca tagacaggaa acagccactg
     1081 gacaccctga agagctaccg cctgtgtgat ccttctgaga gggaattgta caagttgtct
     1141 ccactttttg ggatctatta ttcagtggaa aaaattggaa gcctgagagt tggtgaccct
     1201 gtgtatcgga tggtgtagtg atgagtgatg gatccactag ggtgatatgg cttcagcaac
     1261 caggagggat tgactgagat cttaacaaca gcagcaacga tacatcagca aatccttatt
     1321 atccagcctt caactatctt taccctggaa aacaatctcg atttttgact tttcaaagtt
     1381 gtgtatgctc caggttaatg caaggaaagt attagagggg ggaatatgaa agtatatata
     1441 taaattttag gtactgaagg ctttaaaaat aattaagatc atcaaaaatg ctattttgaa
     1501 tgttatcatg gctattacac ttttacttcc tgactttaat attgatgaat aaagcaagtt
     1561 taatgaatca actaaaaagc tgcaaaaatg tttttaaaat gtgtgccttt tattacctat
     1621 cagtctatgt tttgggagaa atgggaagca acagatcact gtgtcctgat gtgcaggacg
     1681 catgttacca cactcacaaa tgcctaatat tggtctttat gtggccattg agtcctgttg
     1741 actttccact catgtgcttt ttactctagc attatggaat ctgggctgta cttgagtatg
     1801 gaaattctct tatagactta gttttagtac tctattacac ctttactaag ccacataaaa
     1861 gtaatctgtt tgtgtgtaac tgccagatat accacctgga attccaagta agataaggaa
     1921 gaggatgaca tttaaaagag aatggaattt tgagagtagg aatgcaagga agacagcatg
     1981 aacatatttt tttcagtgca aataattttt tcgtaacaaa gaaacgaaca actttggtat
     2041 gatcttaagc aaaaatactc actgaaatag tatgtggatg aattcaccta cttacaattt
     2101 tatggtttct ttgtaaataa taaatgtgaa tctcaatcct gcttta
//
