LOCUS       NM_001331042            1857 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial amidoxime reducing component 2 (MTARC2),
            transcript variant 3, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001331042 XM_017001581
VERSION     NM_001331042.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1857)
  AUTHORS   Deng,H., Cui,M., Liu,L. and Yang,F.
  TITLE     CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS
  JOURNAL   Shock 61 (5), 675-684 (2024)
   PUBMED   38010085
  REMARK    GeneRIF: CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS.
REFERENCE   2  (bases 1 to 1857)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1857)
  AUTHORS   Neve,E.P., Kofeler,H., Hendriks,D.F., Nordling,A., Gogvadze,V.,
            Mkrtchian,S., Naslund,E. and Ingelman-Sundberg,M.
  TITLE     Expression and Function of mARC: Roles in Lipogenesis and Metabolic
            Activation of Ximelagatran
  JOURNAL   PLoS One 10 (9), e0138487 (2015)
   PUBMED   26378779
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1857)
  AUTHORS   Plitzko,B., Havemeyer,A., Kunze,T. and Clement,B.
  TITLE     The pivotal role of the mitochondrial amidoxime reducing component
            2 in protecting human cells against apoptotic effects of the base
            analog N6-hydroxylaminopurine
  JOURNAL   J Biol Chem 290 (16), 10126-10135 (2015)
   PUBMED   25713076
  REMARK    GeneRIF: mARC2 has a pivotal role in protecting human cells against
            apoptotic effects of the base analog N6-hydroxylaminopurine.
REFERENCE   5  (bases 1 to 1857)
  AUTHORS   Ott,G., Havemeyer,A. and Clement,B.
  TITLE     The mammalian molybdenum enzymes of mARC
  JOURNAL   J Biol Inorg Chem 20 (2), 265-275 (2015)
   PUBMED   25425164
  REMARK    Review article
REFERENCE   6  (bases 1 to 1857)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
  REMARK    GeneRIF: Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in
            their active forms.
REFERENCE   7  (bases 1 to 1857)
  AUTHORS   Chen,X., Li,X., Wang,P., Liu,Y., Zhang,Z., Zhao,G., Xu,H., Zhu,J.,
            Qin,X., Chen,S., Hu,L. and Kong,X.
  TITLE     Novel association strategy with copy number variation for
            identifying new risk Loci of human diseases
  JOURNAL   PLoS One 5 (8), e12185 (2010)
   PUBMED   20808825
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1857)
  AUTHORS   Aberg,K., Adkins,D.E., Bukszar,J., Webb,B.T., Caroff,S.N.,
            Miller,D.D., Sebat,J., Stroup,S., Fanous,A.H., Vladimirov,V.I.,
            McClay,J.L., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genomewide association study of movement-related adverse
            antipsychotic effects
  JOURNAL   Biol Psychiatry 67 (3), 279-282 (2010)
   PUBMED   19875103
REFERENCE   9  (bases 1 to 1857)
  AUTHORS   Havemeyer,A., Bittner,F., Wollers,S., Mendel,R., Kunze,T. and
            Clement,B.
  TITLE     Identification of the missing component in the mitochondrial
            benzamidoxime prodrug-converting system as a novel molybdenum
            enzyme
  JOURNAL   J Biol Chem 281 (46), 34796-34802 (2006)
   PUBMED   16973608
REFERENCE   10 (bases 1 to 1857)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     MOSC domains: ancient, predicted sulfur-carrier domains, present in
            diverse metal-sulfur cluster biosynthesis proteins including
            Molybdenum cofactor sulfurases
  JOURNAL   FEMS Microbiol Lett 207 (1), 55-61 (2002)
   PUBMED   11886751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359353.11 and AL606726.8.
            
            On May 31, 2019 this sequence version replaced NM_001331042.1.
            
            Summary: The protein encoded by this gene is an enzyme found in the
            outer mitochondrial membrane that reduces N-hydroxylated
            substrates. The encoded protein uses molybdenum as a cofactor and
            cytochrome b5 type B and NADH cytochrome b5 reductase as accessory
            proteins. One type of substrate used is N-hydroxylated nucleotide
            base analogues, which can be toxic to a cell. Other substrates
            include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs,
            which are activated by the encoded enzyme. Multiple transcript
            variants encoding the different isoforms have been found for this
            gene. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (3) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct C-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1003815.1, AL136931.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               AL359353.11        4666-5147
            483-656             AL359353.11        11291-11464
            657-819             AL359353.11        18002-18164
            820-960             AL359353.11        19254-19394
            961-1857            AL606726.8         8348-9244
FEATURES             Location/Qualifiers
     source          1..1857
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..1857
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="mitochondrial amidoxime reducing component 2"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
     exon            1..482
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..984
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; MOSC domain-containing protein 2,
                     mitochondrial; MOCO sulphurase C-terminal domain
                     containing 2; moco sulfurase C-terminal domain-containing
                     protein 2; molybdenum cofactor sulfurase C-terminal
                     domain-containing protein 2"
                     /codon_start=1
                     /product="mitochondrial amidoxime reducing component 2
                     isoform b precursor"
                     /protein_id="NP_001317971.1"
                     /db_xref="CCDS:CCDS81425.1"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
                     /translation="MGASSSSALARLGLPARPWPRWLGVAALGLAAVALGTVAWRRAW
                     PRRRRRLQQVGTVAKLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVIKEDGHM
                     VTARQEPRLVLISIIYENNCLIFRAPDMDQLVLPSKQPSSNKLHNCRIFGLDIKGRDC
                     GNEAAKWFTNFLKTEAYRLVQFETNMKGRTSRKLLPTLDQNFQVAYPDYCPLLIMTDA
                     SLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEASATRRD"
     exon            483..656
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..819
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..960
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1857
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATGAA"
     regulatory      1282..1287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: ACTAAA"
     polyA_site      1282
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1289
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1299
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
     regulatory      1830..1835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     polyA_site      1857
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
ORIGIN      
        1 cattaccgcg caggcttggt caccgcatta aggcattccc gctctccgcg gaactgctct
       61 gccgtctcgg cggtgaaagt gtgagagggt ccgtagttgg gtcaactttg actcctctcg
      121 cctgcccgga tccttaaggg cctcctcgtc ctcccggtct ccggtcgctg ccgggtctgt
      181 gcgccggtcc gcgcccgccc tcgctctgcc atgggcgctt ccagctcctc cgcgctggcc
      241 cgcctcggcc tcccagcccg gccctggccc aggtggctcg gggtcgccgc gctaggactg
      301 gccgccgtgg ccctggggac tgtcgcctgg cgccgcgcat ggcccaggcg gcgccggcgg
      361 ctgcagcagg tgggcaccgt ggcgaagctc tggatctacc cggtgaaatc ctgcaaaggg
      421 gtgccggtga gcgaggctga gtgcacggcc atggggctgc gcagcggcaa cctgcgggac
      481 aggttttggc tggtgattaa ggaagatgga cacatggtca ctgcccgaca ggagcctcgc
      541 ctcgtgctca tctccatcat ttatgagaat aactgcctga tcttcagggc tccagacatg
      601 gaccagctgg ttttgcctag caagcagcct tcctcaaaca aactccacaa ctgcaggata
      661 tttggccttg acattaaagg cagagactgt ggcaatgagg cagctaagtg gttcaccaac
      721 ttcttgaaaa ctgaagcgta tagattggtt caatttgaga caaacatgaa gggaagaaca
      781 tcaagaaaac ttctccccac tcttgatcag aatttccagg tggcctaccc agactactgc
      841 ccgctcctga tcatgacaga tgcctccctg gtagatttga ataccaggat ggagaagaaa
      901 atgaaaatgg agaatttcag gccaaatatt gtggtgaccg gctgtgatgc ttttgaggag
      961 gcttcagcaa ccaggaggga ttgactgaga tcttaacaac agcagcaacg atacatcagc
     1021 aaatccttat tatccagcct tcaactatct ttaccctgga aaacaatctc gatttttgac
     1081 ttttcaaagt tgtgtatgct ccaggttaat gcaaggaaag tattagaggg gggaatatga
     1141 aagtatatat ataaatttta ggtactgaag gctttaaaaa taattaagat catcaaaaat
     1201 gctattttga atgttatcat ggctattaca cttttacttc ctgactttaa tattgatgaa
     1261 taaagcaagt ttaatgaatc aactaaaaag ctgcaaaaat gtttttaaaa tgtgtgcctt
     1321 ttattaccta tcagtctatg ttttgggaga aatgggaagc aacagatcac tgtgtcctga
     1381 tgtgcaggac gcatgttacc acactcacaa atgcctaata ttggtcttta tgtggccatt
     1441 gagtcctgtt gactttccac tcatgtgctt tttactctag cattatggaa tctgggctgt
     1501 acttgagtat ggaaattctc ttatagactt agttttagta ctctattaca cctttactaa
     1561 gccacataaa agtaatctgt ttgtgtgtaa ctgccagata taccacctgg aattccaagt
     1621 aagataagga agaggatgac atttaaaaga gaatggaatt ttgagagtag gaatgcaagg
     1681 aagacagcat gaacatattt ttttcagtgc aaataatttt ttcgtaacaa agaaacgaac
     1741 aactttggta tgatcttaag caaaaatact cactgaaata gtatgtggat gaattcacct
     1801 acttacaatt ttatggtttc tttgtaaata ataaatgtga atctcaatcc tgcttta
//
