LOCUS       NM_001317338            2153 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial amidoxime reducing component 2 (MTARC2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001317338 XM_005273168
VERSION     NM_001317338.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Deng,H., Cui,M., Liu,L. and Yang,F.
  TITLE     CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS
  JOURNAL   Shock 61 (5), 675-684 (2024)
   PUBMED   38010085
  REMARK    GeneRIF: CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM
            HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7
            AXIS.
REFERENCE   2  (bases 1 to 2153)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2153)
  AUTHORS   Neve,E.P., Kofeler,H., Hendriks,D.F., Nordling,A., Gogvadze,V.,
            Mkrtchian,S., Naslund,E. and Ingelman-Sundberg,M.
  TITLE     Expression and Function of mARC: Roles in Lipogenesis and Metabolic
            Activation of Ximelagatran
  JOURNAL   PLoS One 10 (9), e0138487 (2015)
   PUBMED   26378779
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2153)
  AUTHORS   Plitzko,B., Havemeyer,A., Kunze,T. and Clement,B.
  TITLE     The pivotal role of the mitochondrial amidoxime reducing component
            2 in protecting human cells against apoptotic effects of the base
            analog N6-hydroxylaminopurine
  JOURNAL   J Biol Chem 290 (16), 10126-10135 (2015)
   PUBMED   25713076
  REMARK    GeneRIF: mARC2 has a pivotal role in protecting human cells against
            apoptotic effects of the base analog N6-hydroxylaminopurine.
REFERENCE   5  (bases 1 to 2153)
  AUTHORS   Ott,G., Havemeyer,A. and Clement,B.
  TITLE     The mammalian molybdenum enzymes of mARC
  JOURNAL   J Biol Inorg Chem 20 (2), 265-275 (2015)
   PUBMED   25425164
  REMARK    Review article
REFERENCE   6  (bases 1 to 2153)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
  REMARK    GeneRIF: Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in
            their active forms.
REFERENCE   7  (bases 1 to 2153)
  AUTHORS   Chen,X., Li,X., Wang,P., Liu,Y., Zhang,Z., Zhao,G., Xu,H., Zhu,J.,
            Qin,X., Chen,S., Hu,L. and Kong,X.
  TITLE     Novel association strategy with copy number variation for
            identifying new risk Loci of human diseases
  JOURNAL   PLoS One 5 (8), e12185 (2010)
   PUBMED   20808825
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2153)
  AUTHORS   Aberg,K., Adkins,D.E., Bukszar,J., Webb,B.T., Caroff,S.N.,
            Miller,D.D., Sebat,J., Stroup,S., Fanous,A.H., Vladimirov,V.I.,
            McClay,J.L., Lieberman,J.A., Sullivan,P.F. and van den Oord,E.J.
  TITLE     Genomewide association study of movement-related adverse
            antipsychotic effects
  JOURNAL   Biol Psychiatry 67 (3), 279-282 (2010)
   PUBMED   19875103
REFERENCE   9  (bases 1 to 2153)
  AUTHORS   Havemeyer,A., Bittner,F., Wollers,S., Mendel,R., Kunze,T. and
            Clement,B.
  TITLE     Identification of the missing component in the mitochondrial
            benzamidoxime prodrug-converting system as a novel molybdenum
            enzyme
  JOURNAL   J Biol Chem 281 (46), 34796-34802 (2006)
   PUBMED   16973608
REFERENCE   10 (bases 1 to 2153)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     MOSC domains: ancient, predicted sulfur-carrier domains, present in
            diverse metal-sulfur cluster biosynthesis proteins including
            Molybdenum cofactor sulfurases
  JOURNAL   FEMS Microbiol Lett 207 (1), 55-61 (2002)
   PUBMED   11886751
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP194343.1, BC016859.1,
            AL359353.11, BC015829.2 and AA843271.1.
            
            On Jun 1, 2019 this sequence version replaced NM_001317338.1.
            
            Summary: The protein encoded by this gene is an enzyme found in the
            outer mitochondrial membrane that reduces N-hydroxylated
            substrates. The encoded protein uses molybdenum as a cofactor and
            cytochrome b5 type B and NADH cytochrome b5 reductase as accessory
            proteins. One type of substrate used is N-hydroxylated nucleotide
            base analogues, which can be toxic to a cell. Other substrates
            include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs,
            which are activated by the encoded enzyme. Multiple transcript
            variants encoding the different isoforms have been found for this
            gene. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279841.7874.1, BC016859.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BP194343.1         77-98
            23-281              BC016859.1         1-259
            282-282             AL359353.11        4947-4947
            283-737             BC016859.1         261-715
            738-738             AL359353.11        18083-18083
            739-1585            BC016859.1         717-1563
            1586-2146           BC015829.2         925-1485
            2147-2153           AA843271.1         14-20               c
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2153
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="mitochondrial amidoxime reducing component 2"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
     exon            1..482
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1218
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; MOSC domain-containing protein 2,
                     mitochondrial; MOCO sulphurase C-terminal domain
                     containing 2; moco sulfurase C-terminal domain-containing
                     protein 2; molybdenum cofactor sulfurase C-terminal
                     domain-containing protein 2"
                     /codon_start=1
                     /product="mitochondrial amidoxime reducing component 2
                     isoform a precursor"
                     /protein_id="NP_001304267.1"
                     /db_xref="CCDS:CCDS1525.1"
                     /db_xref="GeneID:54996"
                     /db_xref="HGNC:HGNC:26064"
                     /db_xref="MIM:614127"
                     /translation="MGASSSSALARLGLPARPWPRWLGVAALGLAAVALGTVAWRRAW
                     PRRRRRLQQVGTVAKLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVIKEDGHM
                     VTARQEPRLVLISIIYENNCLIFRAPDMDQLVLPSKQPSSNKLHNCRIFGLDIKGRDC
                     GNEAAKWFTNFLKTEAYRLVQFETNMKGRTSRKLLPTLDQNFQVAYPDYCPLLIMTDA
                     SLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTT
                     VDPDTGVIDRKQPLDTLKSYRLCDPSERELYKLSPLFGIYYSVEKIGSLRVGDPVYRM
                     V"
     exon            483..656
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            657..819
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..960
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1022
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1094
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1256
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2153
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1555..1560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     regulatory      1569..1574
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATGAA"
     regulatory      1578..1583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: ACTAAA"
     polyA_site      1578
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1585
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
     polyA_site      1595
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="hexamer: AATAAA"
     polyA_site      2153
                     /gene="MTARC2"
                     /gene_synonym="MARC2; MOSC2"
                     /note="major polyA site"
ORIGIN      
        1 cattaccgcg caggcttggt caccgcatta aggcattccc gctctccgcg gaactgctct
       61 gccgtctcgg cggtgaaagt gtgagagggt ccgtagttgg gtcaactttg actcctctcg
      121 cctgcccgga tccttaaggg cctcctcgtc ctcccggtct ccggtcgctg ccgggtctgt
      181 gcgccggtcc gcgcccgccc tcgctctgcc atgggcgctt ccagctcctc cgcgctggcc
      241 cgcctcggcc tcccagcccg gccctggccc aggtggctcg gggtcgccgc gctaggactg
      301 gccgccgtgg ccctggggac tgtcgcctgg cgccgcgcat ggcccaggcg gcgccggcgg
      361 ctgcagcagg tgggcaccgt ggcgaagctc tggatctacc cggtgaaatc ctgcaaaggg
      421 gtgccggtga gcgaggctga gtgcacggcc atggggctgc gcagcggcaa cctgcgggac
      481 aggttttggc tggtgattaa ggaagatgga cacatggtca ctgcccgaca ggagcctcgc
      541 ctcgtgctca tctccatcat ttatgagaat aactgcctga tcttcagggc tccagacatg
      601 gaccagctgg ttttgcctag caagcagcct tcctcaaaca aactccacaa ctgcaggata
      661 tttggccttg acattaaagg cagagactgt ggcaatgagg cagctaagtg gttcaccaac
      721 ttcttgaaaa ctgaagcgta tagattggtt caatttgaga caaacatgaa gggaagaaca
      781 tcaagaaaac ttctccccac tcttgatcag aatttccagg tggcctaccc agactactgc
      841 ccgctcctga tcatgacaga tgcctccctg gtagatttga ataccaggat ggagaagaaa
      901 atgaaaatgg agaatttcag gccaaatatt gtggtgaccg gctgtgatgc ttttgaggag
      961 gatacctggg atgaactcct aattggtagt gtagaagtga aaaaggtaat ggcatgcccc
     1021 aggtgtattt tgacaacggt ggacccagac actggagtca tagacaggaa acagccactg
     1081 gacaccctga agagctaccg cctgtgtgat ccttctgaga gggaattgta caagttgtct
     1141 ccactttttg ggatctatta ttcagtggaa aaaattggaa gcctgagagt tggtgaccct
     1201 gtgtatcgga tggtgtagtg atgagtgatg gatccactag ggtgatatgg taaagggctt
     1261 cagcaaccag gagggattga ctgagatctt aacaacagca gcaacgatac atcagcaaat
     1321 ccttattatc cagccttcaa ctatctttac cctggaaaac aatctcgatt tttgactttt
     1381 caaagttgtg tatgctccag gttaatgcaa ggaaagtatt agagggggga atatgaaagt
     1441 atatatataa attttaggta ctgaaggctt taaaaataat taagatcatc aaaaatgcta
     1501 ttttgaatgt tatcatggct attacacttt tacttcctga ctttaatatt gatgaataaa
     1561 gcaagtttaa tgaatcaact aaaaagctgc aaaaatgttt ttaaaatgtg tgccttttat
     1621 tacctatcag tctatgtttt gggagaaatg ggaagcaaca gatcactgtg tcctgatgtg
     1681 caggacgcat gttaccacac tcacaaatgc ctaatattgg tctttatgtg gccattgagt
     1741 cctgttgact ttccactcat gtgcttttta ctctagcatt atggaatctg ggctgtactt
     1801 gagtatggaa attctcttat agacttagtt ttagtactct attacacctt tactaagcca
     1861 cataaaagta atctgtttgt gtgtaactgc cagatatacc acctggaatt ccaagtaaga
     1921 taaggaagag gatgacattt aaaagagaat ggaattttga gagtaggaat gcaaggaaga
     1981 cagcatgaac atattttttt cagtgcaaat aattttttcg taacaaagaa acgaacaact
     2041 ttggtatgat cttaagcaaa aatactcact gaaatagtat gtggatgaat tcacctactt
     2101 acaattttat ggtttctttg taaataataa atgtgaatct caatcctgct tta
//
