LOCUS       NM_022746               7287 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens mitochondrial amidoxime reducing component 1 (MTARC1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_022746
VERSION     NM_022746.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7287)
  AUTHORS   Hou,W., Watson,C., Cecconie,T., Bolaki,M.N., Brady,J.J., Lu,Q.,
            Gatto,G.J. Jr. and Day,T.A.
  TITLE     Biochemical and functional characterization of the p.A165T missense
            variant of mitochondrial amidoxime-reducing component 1
  JOURNAL   J Biol Chem 300 (6), 107353 (2024)
   PUBMED   38723751
  REMARK    GeneRIF: Biochemical and functional characterization of the p.A165T
            missense variant of mitochondrial amidoxime-reducing component 1.
REFERENCE   2  (bases 1 to 7287)
  AUTHORS   Dutta,T., Sasidharan,K., Ciociola,E., Pennisi,G., Noto,F.R.,
            Kovooru,L., Kroon,T., Lindblom,A., Du,Y., Pirmoradian,M.,
            Wallin,S., Mancina,R.M., Linden,D. and Romeo,S.
  TITLE     Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases
            protein degradation mediated by the proteasome
  JOURNAL   Liver Int 44 (5), 1219-1232 (2024)
   PUBMED   38375985
  REMARK    GeneRIF: Mitochondrial amidoxime-reducing component 1 p.Ala165Thr
            increases protein degradation mediated by the proteasome.
REFERENCE   3  (bases 1 to 7287)
  AUTHORS   Jones,A.K., Bajrami,B., Campbell,M.K., Erzurumluoglu,A.M., Guo,Q.,
            Chen,H., Zhang,X., Zeveleva,S., Kvaskoff,D., Brunner,A.D.,
            Muller,S., Gathey,V., Dave,R.M., Tanner,J.W., Rixen,S.,
            Struwe,M.A., Phoenix,K., Klumph,K.J., Robinson,H., Veyel,D.,
            Muller,A., Noyvert,B., Bartholdy,B.A., Steixner-Kumar,A.A.,
            Stutzki,J., Drichel,D., Omland,S., Sheehan,R., Hill,J.,
            Bretschneider,T., Gottschling,D., Scheidig,A.J., Clement,B.,
            Giera,M., Ding,Z., Broadwater,J. and Warren,C.R.
  TITLE     mARC1 in MASLD: Modulation of lipid accumulation in human
            hepatocytes and adipocytes
  JOURNAL   Hepatol Commun 8 (5), e0365 (2024)
   PUBMED   38619429
  REMARK    GeneRIF: mARC1 in MASLD: Modulation of lipid accumulation in human
            hepatocytes and adipocytes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7287)
  AUTHORS   Wu,M., Tie,M., Hu,L., Yang,Y., Chen,Y., Ferguson,D., Chen,Y. and
            He,A.
  TITLE     Fatty liver disease protective MTARC1 p.A165T variant reduces the
            protein stability of MTARC1
  JOURNAL   Biochem Biophys Res Commun 702, 149655 (2024)
   PUBMED   38340654
  REMARK    GeneRIF: Fatty liver disease protective MTARC1 p.A165T variant
            reduces the protein stability of MTARC1.
REFERENCE   5  (bases 1 to 7287)
  AUTHORS   Smagris,E., Shihanian,L.M., Mintah,I.J., Bigdelou,P., Livson,Y.,
            Brown,H., Verweij,N., Hunt,C., Johnson,R.O., Greer,T.J.,
            Hartford,S.A., Hindy,G., Sun,L., Nielsen,J.B., Halasz,G.,
            Lotta,L.A., Murphy,A.J., Sleeman,M.W. and Gusarova,V.
  TITLE     Divergent role of Mitochondrial Amidoxime Reducing Component 1
            (MARC1) in human and mouse
  JOURNAL   PLoS Genet 20 (3), e1011179 (2024)
   PUBMED   38437227
  REMARK    GeneRIF: Divergent role of Mitochondrial Amidoxime Reducing
            Component 1 (MARC1) in human and mouse.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7287)
  AUTHORS   Wahl,B., Reichmann,D., Niks,D., Krompholz,N., Havemeyer,A.,
            Clement,B., Messerschmidt,T., Rothkegel,M., Biester,H., Hille,R.,
            Mendel,R.R. and Bittner,F.
  TITLE     Biochemical and spectroscopic characterization of the human
            mitochondrial amidoxime reducing components hmARC-1 and hmARC-2
            suggests the existence of a new molybdenum enzyme family in
            eukaryotes
  JOURNAL   J Biol Chem 285 (48), 37847-37859 (2010)
   PUBMED   20861021
  REMARK    GeneRIF: Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in
            their active forms.
REFERENCE   7  (bases 1 to 7287)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7287)
  AUTHORS   Teslovich,T.M., Musunuru,K., Smith,A.V., Edmondson,A.C.,
            Stylianou,I.M., Koseki,M., Pirruccello,J.P., Ripatti,S.,
            Chasman,D.I., Willer,C.J., Johansen,C.T., Fouchier,S.W., Isaacs,A.,
            Peloso,G.M., Barbalic,M., Ricketts,S.L., Bis,J.C., Aulchenko,Y.S.,
            Thorleifsson,G., Feitosa,M.F., Chambers,J., Orho-Melander,M.,
            Melander,O., Johnson,T., Li,X., Guo,X., Li,M., Shin Cho,Y., Jin
            Go,M., Jin Kim,Y., Lee,J.Y., Park,T., Kim,K., Sim,X., Twee-Hee
            Ong,R., Croteau-Chonka,D.C., Lange,L.A., Smith,J.D., Song,K., Hua
            Zhao,J., Yuan,X., Luan,J., Lamina,C., Ziegler,A., Zhang,W.,
            Zee,R.Y., Wright,A.F., Witteman,J.C., Wilson,J.F., Willemsen,G.,
            Wichmann,H.E., Whitfield,J.B., Waterworth,D.M., Wareham,N.J.,
            Waeber,G., Vollenweider,P., Voight,B.F., Vitart,V.,
            Uitterlinden,A.G., Uda,M., Tuomilehto,J., Thompson,J.R., Tanaka,T.,
            Surakka,I., Stringham,H.M., Spector,T.D., Soranzo,N., Smit,J.H.,
            Sinisalo,J., Silander,K., Sijbrands,E.J., Scuteri,A., Scott,J.,
            Schlessinger,D., Sanna,S., Salomaa,V., Saharinen,J., Sabatti,C.,
            Ruokonen,A., Rudan,I., Rose,L.M., Roberts,R., Rieder,M.,
            Psaty,B.M., Pramstaller,P.P., Pichler,I., Perola,M., Penninx,B.W.,
            Pedersen,N.L., Pattaro,C., Parker,A.N., Pare,G., Oostra,B.A.,
            O'Donnell,C.J., Nieminen,M.S., Nickerson,D.A., Montgomery,G.W.,
            Meitinger,T., McPherson,R., McCarthy,M.I., McArdle,W., Masson,D.,
            Martin,N.G., Marroni,F., Mangino,M., Magnusson,P.K., Lucas,G.,
            Luben,R., Loos,R.J., Lokki,M.L., Lettre,G., Langenberg,C.,
            Launer,L.J., Lakatta,E.G., Laaksonen,R., Kyvik,K.O., Kronenberg,F.,
            Konig,I.R., Khaw,K.T., Kaprio,J., Kaplan,L.M., Johansson,A.,
            Jarvelin,M.R., Janssens,A.C., Ingelsson,E., Igl,W., Kees
            Hovingh,G., Hottenga,J.J., Hofman,A., Hicks,A.A., Hengstenberg,C.,
            Heid,I.M., Hayward,C., Havulinna,A.S., Hastie,N.D., Harris,T.B.,
            Haritunians,T., Hall,A.S., Gyllensten,U., Guiducci,C., Groop,L.C.,
            Gonzalez,E., Gieger,C., Freimer,N.B., Ferrucci,L., Erdmann,J.,
            Elliott,P., Ejebe,K.G., Doring,A., Dominiczak,A.F., Demissie,S.,
            Deloukas,P., de Geus,E.J., de Faire,U., Crawford,G., Collins,F.S.,
            Chen,Y.D., Caulfield,M.J., Campbell,H., Burtt,N.P.,
            Bonnycastle,L.L., Boomsma,D.I., Boekholdt,S.M., Bergman,R.N.,
            Barroso,I., Bandinelli,S., Ballantyne,C.M., Assimes,T.L.,
            Quertermous,T., Altshuler,D., Seielstad,M., Wong,T.Y., Tai,E.S.,
            Feranil,A.B., Kuzawa,C.W., Adair,L.S., Taylor,H.A. Jr.,
            Borecki,I.B., Gabriel,S.B., Wilson,J.G., Holm,H.,
            Thorsteinsdottir,U., Gudnason,V., Krauss,R.M., Mohlke,K.L.,
            Ordovas,J.M., Munroe,P.B., Kooner,J.S., Tall,A.R., Hegele,R.A.,
            Kastelein,J.J., Schadt,E.E., Rotter,J.I., Boerwinkle,E.,
            Strachan,D.P., Mooser,V., Stefansson,K., Reilly,M.P., Samani,N.J.,
            Schunkert,H., Cupples,L.A., Sandhu,M.S., Ridker,P.M., Rader,D.J.,
            van Duijn,C.M., Peltonen,L., Abecasis,G.R., Boehnke,M. and
            Kathiresan,S.
  TITLE     Biological, clinical and population relevance of 95 loci for blood
            lipids
  JOURNAL   Nature 466 (7307), 707-713 (2010)
   PUBMED   20686565
REFERENCE   9  (bases 1 to 7287)
  AUTHORS   Gruenewald,S., Wahl,B., Bittner,F., Hungeling,H., Kanzow,S.,
            Kotthaus,J., Schwering,U., Mendel,R.R. and Clement,B.
  TITLE     The fourth molybdenum containing enzyme mARC: cloning and
            involvement in the activation of N-hydroxylated prodrugs
  JOURNAL   J Med Chem 51 (24), 8173-8177 (2008)
   PUBMED   19053771
  REMARK    GeneRIF: molybdoprotein mARC1 is involved in the activation of
            N-hydroxylated prodrugs.
REFERENCE   10 (bases 1 to 7287)
  AUTHORS   Anantharaman,V. and Aravind,L.
  TITLE     MOSC domains: ancient, predicted sulfur-carrier domains, present in
            diverse metal-sulfur cluster biosynthesis proteins including
            Molybdenum cofactor sulfurases
  JOURNAL   FEMS Microbiol Lett 207 (1), 55-61 (2002)
   PUBMED   11886751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA878171.1, AK290812.1, CB048738.1, CA439234.1 and AL445423.13.
            
            On Nov 23, 2018 this sequence version replaced NM_022746.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026043.1, BC010619.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000366910.10/
                                                  ENSP00000355877.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA878171.1         217-228
            13-1440             AK290812.1         1-1428
            1441-1521           CB048738.1         419-499
            1522-2027           CA439234.1         16-521              c
            2028-7287           AL445423.13        26292-31551
FEATURES             Location/Qualifiers
     source          1..7287
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..7287
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="mitochondrial amidoxime reducing component 1"
                     /db_xref="GeneID:64757"
                     /db_xref="HGNC:HGNC:26189"
                     /db_xref="MIM:614126"
     exon            1..307
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1046
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="MOSC domain-containing protein 1, mitochondrial;
                     MOCO sulphurase C-terminal domain containing 1; moco
                     sulfurase C-terminal domain-containing protein 1;
                     molybdenum cofactor sulfurase C-terminal domain-containing
                     protein 1"
                     /codon_start=1
                     /product="mitochondrial amidoxime-reducing component 1
                     precursor"
                     /protein_id="NP_073583.3"
                     /db_xref="CCDS:CCDS1526.1"
                     /db_xref="GeneID:64757"
                     /db_xref="HGNC:HGNC:26189"
                     /db_xref="MIM:614126"
                     /translation="MGAAGSSALARFVLLAQSRPGWLGVAALGLTAVALGAVAWRRAW
                     PTRRRRLLQQVGTVAQLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVINQEGN
                     MVTARQEPRLVLISLTCDGDTLTLSAAYTKDLLLPIKTPTTNAVHKCRVHGLEIEGRD
                     CGEATAQWITSFLKSQPYRLVHFEPHMRPRRPHQIADLFRPKDQIAYSDTSPFLILSE
                     ASLADLNSRLEKKVKATNFRPNIVISGCDVYAEDSWDELLIGDVELKRVMACSRCILT
                     TVDPDTGVMSRKEPLETLKSYRQCDPSERKLYGKSPLFGQYFVLENPGTIKVGDPVYL
                     LGQ"
     exon            308..481
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            482..644
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..785
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            786..847
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..919
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     exon            920..7287
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="major polyA site"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="hexamer: AGTAAA"
     polyA_site      2631
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
     regulatory      7264..7269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
                     /note="hexamer: AATAAA"
     polyA_site      7287
                     /gene="MTARC1"
                     /gene_synonym="MARC1; MOSC1"
ORIGIN      
        1 cttgccgccg ccacctcgcg gagaagccag ccatgggcgc cgccggctcc tccgcgctgg
       61 cgcgctttgt cctcctcgcg caatcccggc ccgggtggct cggggttgcc gcgctgggcc
      121 tgaccgcggt ggcgctgggg gctgtcgcct ggcgccgcgc atggcccacg cggcgccggc
      181 ggctgctgca gcaggtgggc acagtggcgc agctctggat ctaccctgtg aaatcctgca
      241 agggggtgcc ggtgagcgag gcggagtgca cggccatggg gctgcgcagc ggcaacctgc
      301 gggacaggtt ttggcttgtg atcaaccagg agggaaacat ggttactgct cgccaggaac
      361 ctcgcctggt cctgatttcc ctgacctgcg atggtgacac cctgactctc agtgcagcct
      421 acacaaagga cctactactg cctatcaaaa cgcccaccac aaatgcagtg cacaagtgca
      481 gagtgcacgg cctggagata gagggcaggg actgtggcga ggccaccgcc cagtggataa
      541 ccagcttcct gaagtcacag ccctaccgcc tggtgcactt cgagcctcac atgcgaccga
      601 gacgtcctca tcaaatagca gacttgttcc gacccaagga ccagattgct tactcagaca
      661 ccagcccatt cttgatcctt tctgaggcgt cgctggcgga tctcaactcc aggctagaga
      721 agaaagttaa agcaaccaac ttcaggccca atattgtaat ttcaggatgc gatgtctatg
      781 cagaggattc ttgggatgag cttcttattg gtgacgtgga actgaaaagg gtgatggctt
      841 gttccagatg cattttaacc acagtggacc cagacaccgg tgtcatgagc aggaaggaac
      901 cgctggaaac actgaagagt tatcgccagt gtgacccttc agaacgaaag ttatatggaa
      961 aatcaccact ctttgggcag tattttgtgc tggaaaaccc agggaccatc aaagtgggag
     1021 accctgtgta cctgctgggc cagtaatggg aaccgtatgt cctggaatat tagatgcctt
     1081 ttaaaaatgt tctcaaaaat gacaacactt gaagcatggt gtttcagaac tgagacctct
     1141 acattttctt taaatttgtg attttcacat ttttcgtctt ttggacttct ggtgtctcaa
     1201 tgcttcaatg tcccagtgca aaaagtaaag aaatatagtc tcaataactt agtaggactt
     1261 cagtaagtca cttaaatgac aagacaggat tctgaaaact ccccgtttaa ctgattatgg
     1321 aatagttctt tctcctgctt ctccgtttat ctaccaagag cgcagacttg catcctgtca
     1381 ctaccactcg ttagagaaag agaagaagag aaagaggaag agtgggtggg ctggaagaat
     1441 atcctagaat gtgttattgc ccctgttcat gaggtacgca atgaaaatta aattgcaccc
     1501 caaatatggc tggaatgcca cttccctttt cttctcaagc cccgggctag cttttgaaat
     1561 ggcataaaga ctgaggtgac cttcaggaag cactgcagat attaattttc catagatctg
     1621 gatctggccc tgctgcttct cagacagcat tggatttcct aaaggtgctc aggaggatgg
     1681 ttgtgtagtc atggaggacc cctggatcct tgccattccc ctcagctaat gacggagtgc
     1741 tccttctcca gttccgggtg aaaaagttct gaattctgtg gaggagaaga aaagtgattc
     1801 agtgatttca gatagactac tgaaaacctt taaaggggga aaaggaaagc atatgtcagt
     1861 tgtttaaaac ccaatatcta ttttttaact gattgtataa ctctaagatc tgatgaagta
     1921 tattttttat tgccattttg tcctttgatt atattgggaa gttgactaaa cttgaaaaat
     1981 gtttttaaaa ctgtgaataa atggaagcta ctttgactag tttcagatct tactaacttc
     2041 ttggcacaaa gttagactgt gaaagctgac tgaggctggg cacaggggct catgcctgta
     2101 attccagcac tttgggaggc caaggtggga gaatggcttg agcccaggag tttgagacca
     2161 gcccagaaaa tataatggga tcctgtcgct acaaaatgtt tttaaaatgc actcggtgtg
     2221 gtggtgtgtg cctgcagtcc tggctatggc tactcgggag gatgaggtag aaggattggt
     2281 tgagcccagg agcgggagat tgaggctgca gtgagttatg attgcaccac tacactccag
     2341 cctgagtgat agagtgagac cctatctcta aaaaagaaac aggaaaaaaa aagaaagctg
     2401 actgaggtga atgggcaaag ccagtaattc tgacacctga ccacagctgg gtcttctgca
     2461 taatggacct cctcacccac agcctcccag gcaagcaccc atgtttgaag gactatcaag
     2521 tcaacatgct ttttaccaaa agctgcacat ttttcacttt gattttataa aagaggtcag
     2581 taatcgctga aatctagctg agccctgaag taaagttctg agcaaagagg tgcatgtgct
     2641 tgttttatgg ttggtgaatt attacagttt gttttctgca tgcttggcat gaggtgaata
     2701 attacatcaa ttttccagag aacctgggcc atcaccttcc ccaacaagtc cagttgatgt
     2761 tgaaactaca gatagattga gacaaagcga agtgttcagc aagtagcatt actaatggga
     2821 ccgggggacc cgtgggagag tgagtgtaca caggatttag gaaaccatgt gaatatgggc
     2881 tctctgggaa tagccaatag gtagggagca atcagaaacc caaggtttgg tggctcttcc
     2941 taggtattta taattagtgg caagtgaaag ccttagtcct gaatttctaa ccacttgtaa
     3001 gaactaacag ccacttctct gtgccccgtc cgggcagtaa ccatcattct ccatggacag
     3061 gctctcgggg tagctagctc tgcagggcag cacccacgtg gaagggagca cccagaaacc
     3121 ctcctcactg ggcagacctg tccttctgtg cctcacagtg tgaggaagat tcctgtttga
     3181 agagagaagt tccagtgacc tctagaatct cagagtagtt gccaagcttt ctgtcagtga
     3241 gatttaaagg ccatttactt gtgtttattt tatatttaat gagttggtta atgccagaga
     3301 caaagctgat atcccattta ttttggatac tgagcatttg cacactattc cacttgaaat
     3361 atagaatcag gaatgtaggc catcccagac tttcagatct tacaacagca aatgacagat
     3421 gtttgagatc aggccaaaat atccaccctc ggtgggcatc tcctctgtgt ggcaacttat
     3481 gctgcagcca cagtggggag tcacaaactc agagctggag gtcttgaaaa ggacaatgtg
     3541 ggccaggctc cggaggggct gcctaaaggc ttgcttttgt gactctcctg cagaaaatgt
     3601 tagaaacttc caaccgaaag acgagggcag caacttatac acacgaaggc agaaagaaat
     3661 tggggaaggg gaggctgttg gaattcaggc cgttgtccta tagggagaaa tactcctcct
     3721 ctccttctcc ctttactgat aacggggcat ggtgaggaga tgagcttgtg agggtctgcc
     3781 agtttggtaa gagtgcatgg ggaggttggg taaattagac tagccaaatg ggacttcggg
     3841 aaaccattta tgaggctgtc accaacagtg atggcaggct gaaattccag gcaagtgctc
     3901 ccagcattcc aagagtgtat caaattaaag caacccatga tggtggagaa cagatacatt
     3961 aaagttcctt gaaaatgaca gagtggctct cagaccagac cttgattgtg ggtataatcg
     4021 gagtgttgct accacaccct aacactgcat ttcccgtgtt ttattggtcc atggaattct
     4081 gaaagtttgc ctttcgggat gcttctaaaa acaattccat ggaccagtaa gtttggaaag
     4141 tcctgcgtgc ctcacttctc ttcaaaggca aaaggctctg gagaggcctt catgaagaca
     4201 tctgtgttta atgctgccct tcccaaaggt ctgtttttga ctgtcttttg agaaatgatc
     4261 ctctgatctc taggcagaat gccagtgagc caaggaatcc cagttagcag gaggggtgca
     4321 ctcatgggaa gactgaagaa gttaaaagtt cccgccaagt gaaggagacc tatcttggga
     4381 cacttcccct tgtcctctcc cttgcccctc ttgctggagt aaaaggatgg aactgggact
     4441 tgataggtta aaggaggtgt ggagaagtgt cttagaccag ctctcctgtt gtgggcctta
     4501 gggagaagca ctctctttct tcgggatcat tttccaaaca tgcatttttg gatggatagg
     4561 gtggatcagg gtgagggaag ggaaaccaaa ctctctctaa ccttgccctt acagcaatac
     4621 ctgtgatgta agttacaaaa ccacctgtga tgaaagtgct ccaggatgct tcatgcacca
     4681 gggaggggtg ccctgtttct cttctgctag cttctccttt cttttttttt tttcttcttt
     4741 tttttgagac agtgtctcac tctgttgcca ggctggagtg cagtggtgag atctcagctc
     4801 actgcagcct ctgcctccca ggttcaagca attcttctgc ctcagcctcc cgagtagctg
     4861 gtgtgtctgg agttggttcc ttctggtggg ttcttggtct cgctgacttc aagaatgaag
     4921 ccacagacct tcgcagtgag tgttacagct cttaaaggtg gcacggaccc aaagtgagca
     4981 gtagcaagat ttattgtgga gagcgaaaga acaaagcttc ggaaggggac ccaaatgggc
     5041 tgctgctgct ggctggggtg gccacctttt attcccttat ttgtccctgc ccatgtcctg
     5101 ctgattgctc cattttacag agtgctgatt ggtccatttt acagagtgct gattggtgca
     5161 tttacaatcc tttagctaga cacagagtgc cgattggtga gtttttacag tgctgattgg
     5221 tgcatttaca atcctttagc tagacacaga acactgactg gtgcatttat aatcctctag
     5281 ctagaaagaa aagttctcca agtccccact agacccagga agtccagctg gcttcacctc
     5341 tcactgggac tacaggtgca caccaccaca cccagctaat ttttgtattt ttagtagaga
     5401 cggggtttca ccatgttgtt caggatggtc tcgaactctt gatctcgtga tctgcccgcc
     5461 tcggcctccc aaagtgctgg gattacagtt gtgagccacc acgcccggcc ctagcttttc
     5521 ctttctgttg caagtcctct caactagtgt tgccttccac cctacaaagc agaattacct
     5581 cagaagtcct atggccctga ctctatctat gtctgcacaa agcactactg tgctttgctg
     5641 tctgcaagaa cagagattgt ttgcttcaac cactttctct gaatggatga atgagttatg
     5701 atgatatcta aagttaccca atttcaagca agaggaagaa tctggctcgg taccacagat
     5761 gttcttggaa ttgggatagt aaaaaagtcc ctgaggcatc ccttggtctg ctctgaccac
     5821 actctcttca caggaagagg cttgggccac agctctgact ataactctgc tcttcctcca
     5881 aacacagctg aggaattggg tggtggggca cctgctccca tgctctgtgg cctggctcag
     5941 agagaagagt tgccttaatt acattattat tcttcctgga caggctgtag gttgtgtaaa
     6001 gtaacaaaaa ggactgagaa gtgacttccc attcagcctc ttccaaggcc atttttgata
     6061 ggcaggtcaa attcactcac atttggttat ttgttggcca gtctagtgca ttcacccttg
     6121 ctggtcctca gtcatgctcc tttaccttta cagagcatcc tagactgctc ttcctcttac
     6181 cttccttgtg aaacccacaa cccctagtcc ctccccttcc ctggcatttg ttatgccctc
     6241 taccaatccc tgacctggta ttggtcagtc tccaatcctg gtggatccct gtgggaacta
     6301 agttaagtct aacttttgtc tccctcttta gaatttactg ggagtactgt aaataaacta
     6361 ttgttgttat aattatttct gattaacatt tttacaccta acaaagtctc agagagattg
     6421 aatttactgg gttgaaggga ggagcacctt ccacatgacc tgcccagcaa ttaaagccgc
     6481 ttgttagtcc gaggcccagg acggccgagg acagctggag agctcttcgt tgcaggcagc
     6541 tctggttaac atcaaccggg aaagctcttt gtaaacacat gaataattga tcgtccagcg
     6601 ctcacatagc taccgcggat ctgagcccgt atgactcatt tgcgagccat tcctgtcgtc
     6661 tggatgccat aacattggag gaatgatgat cgtttcttgg aggttcttct gtggccagag
     6721 ttgccaagac caaggctgta atggtttgtt atgatgacct ttgttattcc attaggctca
     6781 attgctttaa aaaatgatgt gtgcatactt taggaacgtt tttacccttt atgttgacct
     6841 gacatcatag tttatattat aaaatgtatt aatgacagaa gagtgttttc atgtcccaag
     6901 gacaaatttt aacaaccata atctgccctc agtcatcata aatataaatg tattggtcaa
     6961 acagatctcg ttaatgtggc caagataaat gcaagtctat attttaaggc agtcgaagtc
     7021 ctagagaata tatctggagc ttttgtgggg ctaagagatc ttgtatatat gctatcaaaa
     7081 ggctgagaaa attaacatgt tcccccctct gattttgcat tggacagata taaatgtctt
     7141 ggggatgtca agtaagattg ttcacatagt ttctggacac cattaatgcc tgatggggtg
     7201 aatcttagtt cttaaagcta tattctgctc attatgctca cagggctttt gaaaagagaa
     7261 caaaataaag atttcaagtc ttagcaa
//
