LOCUS       NM_002451               6032 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens methylthioadenosine phosphorylase (MTAP), transcript
            variant 1, mRNA.
ACCESSION   NM_002451
VERSION     NM_002451.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6032)
  AUTHORS   Broggi,G., Massimino,M., Failla,M., Filetti,V., Rapisarda,V.,
            Ledda,C., Lombardo,C., Loreto,C., Vigneri,P. and Caltabiano,R.
  TITLE     Concordance between CDKN2A homozygous deletion and MTAP
            immunohistochemical loss in fluoroedenite-induced pleural
            mesothelioma: An immunohistochemical and molecular study on a
            single-institution series
  JOURNAL   Pathol Res Pract 259, 155350 (2024)
   PUBMED   38781764
  REMARK    GeneRIF: Concordance between CDKN2A homozygous deletion and MTAP
            immunohistochemical loss in fluoroedenite-induced pleural
            mesothelioma: An immunohistochemical and molecular study on a
            single-institution series.
REFERENCE   2  (bases 1 to 6032)
  AUTHORS   Ngoi,N.Y.L., Tang,T.Y., Gaspar,C.F., Pavlick,D.C., Buchold,G.M.,
            Scholefield,E.L., Parimi,V., Huang,R.S.P., Janovitz,T.,
            Danziger,N., Levy,M.A., Pant,S., De Armas,A.D., Kumpula,D.,
            Ross,J.S., Javle,M. and Rodon Ahnert,J.
  TITLE     Methylthioadenosine Phosphorylase Genomic Loss in Advanced
            Gastrointestinal Cancers
  JOURNAL   Oncologist 29 (6), 493-503 (2024)
   PUBMED   38330461
  REMARK    GeneRIF: Methylthioadenosine Phosphorylase Genomic Loss in Advanced
            Gastrointestinal Cancers.
REFERENCE   3  (bases 1 to 6032)
  AUTHORS   Wang,S.N., Wang,W., Zhang,X.W., Zhang,Y.Q., Xiong,Y.L., Liu,L. and
            Teng,L.H.
  TITLE     [Methylthioadenosine phosphorylase and p16 as surrogate diagnostic
            markers for CDKN2A homozygous deletion in brain tumors]
  JOURNAL   Zhonghua Bing Li Xue Za Zhi 53 (5), 439-445 (2024)
   PUBMED   38678323
  REMARK    GeneRIF: [Methylthioadenosine phosphorylase and p16 as surrogate
            diagnostic markers for CDKN2A homozygous deletion in brain tumors].
REFERENCE   4  (bases 1 to 6032)
  AUTHORS   Lin,Z., Lei,Y., Wen,M., He,Q., Tian,D. and Xie,H.
  TITLE     MTAP-ANRIL gene fusion promotes melanoma epithelial-mesenchymal
            transition-like process by activating the JNK and p38 signaling
            pathways
  JOURNAL   Sci Rep 13 (1), 9073 (2023)
   PUBMED   37277447
  REMARK    GeneRIF: MTAP-ANRIL gene fusion promotes melanoma
            epithelial-mesenchymal transition-like process by activating the
            JNK and p38 signaling pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6032)
  AUTHORS   Chen,Y., Du,X., Gao,Y., Wu,H., Zhao,H. and Su,Y.
  TITLE     Methylthioadenosine Phosphorylase and Breast Cancer 1
            Protein-Associated Protein 1 as Biomarkers for the Peritoneal
            Mesothelioma
  JOURNAL   Cancer Control 30, 10732748231220805 (2023)
   PUBMED   38092371
  REMARK    GeneRIF: Methylthioadenosine Phosphorylase and Breast Cancer 1
            Protein-Associated Protein 1 as Biomarkers for the Peritoneal
            Mesothelioma.
REFERENCE   6  (bases 1 to 6032)
  AUTHORS   Martignetti,J.A., Desnick,R.J., Aliprandis,E., Norton,K.I.,
            Hardcastle,P., Nade,S. and Gelb,B.D.
  TITLE     Diaphyseal medullary stenosis with malignant fibrous histiocytoma:
            a hereditary bone dysplasia/cancer syndrome maps to 9p21-22
  JOURNAL   Am J Hum Genet 64 (3), 801-807 (1999)
   PUBMED   10053015
REFERENCE   7  (bases 1 to 6032)
  AUTHORS   Della Ragione,F., Takabayashi,K., Mastropietro,S., Mercurio,C.,
            Oliva,A., Russo,G.L., Della Pietra,V., Borriello,A., Nobori,T.,
            Carson,D.A. and Zappia,V.
  TITLE     Purification and characterization of recombinant human
            5'-methylthioadenosine phosphorylase: definite identification of
            coding cDNA
  JOURNAL   Biochem Biophys Res Commun 223 (3), 514-519 (1996)
   PUBMED   8687427
REFERENCE   8  (bases 1 to 6032)
  AUTHORS   Nobori,T., Takabayashi,K., Tran,P., Orvis,L., Batova,A., Yu,A.L.
            and Carson,D.A.
  TITLE     Genomic cloning of methylthioadenosine phosphorylase: a purine
            metabolic enzyme deficient in multiple different cancers
  JOURNAL   Proc Natl Acad Sci U S A 93 (12), 6203-6208 (1996)
   PUBMED   8650244
REFERENCE   9  (bases 1 to 6032)
  AUTHORS   Olopade,O.I., Pomykala,H.M., Hagos,F., Sveen,L.W., Espinosa,R. 3rd,
            Dreyling,M.H., Gursky,S., Stadler,W.M., Le Beau,M.M. and
            Bohlander,S.K.
  TITLE     Construction of a 2.8-megabase yeast artificial chromosome contig
            and cloning of the human methylthioadenosine phosphorylase gene
            from the tumor suppressor region on 9p21
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6489-6493 (1995)
   PUBMED   7604019
REFERENCE   10 (bases 1 to 6032)
  AUTHORS   Carrera,C.J., Eddy,R.L., Shows,T.B. and Carson,D.A.
  TITLE     Assignment of the gene for methylthioadenosine phosphorylase to
            human chromosome 9 by mouse-human somatic cell hybridization
  JOURNAL   Proc Natl Acad Sci U S A 81 (9), 2665-2668 (1984)
   PUBMED   6425836
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U22233.1, L40432.1, BC026106.1,
            BM994282.1, BQ220538.1, BQ232183.1, BG576334.1, AK024734.1,
            CA440131.1 and AL359922.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002451.3.
            
            Summary: This gene encodes an enzyme that plays a major role in
            polyamine metabolism and is important for the salvage pathway of
            both adenine and methionine. The encoded enzyme is deficient in
            many cancers. Multiple alternatively spliced transcript variants
            have been described for this gene. [provided by RefSeq, Sep 2021].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: GQ891397.1, SRR1660805.213756.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644715.2/ ENSP00000494373.1
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               U22233.1           9-286
            279-765             L40432.1           276-762
            766-1889            BC026106.1         748-1871
            1890-2393           BM994282.1         95-598
            2394-2804           BQ220538.1         213-623
            2805-3142           BQ232183.1         127-464
            3143-3362           BG576334.1         1-220
            3363-4793           AK024734.1         62-1492
            4794-4922           CA440131.1         16-144              c
            4923-6032           AL359922.10        123369-124478
FEATURES             Location/Qualifiers
     source          1..6032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..6032
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="methylthioadenosine phosphorylase"
                     /db_xref="GeneID:4507"
                     /db_xref="HGNC:HGNC:7413"
                     /db_xref="MIM:156540"
     exon            1..146
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..965
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /EC_number="2.4.2.28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MeSAdo phosphorylase; S-methyl-5'-thioadenosine
                     phosphorylase; MTAPase; MTA phosphorylase;
                     5'-methylthioadenosine phosphorylase; epididymis luminal
                     protein 249; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="S-methyl-5'-thioadenosine phosphorylase isoform
                     1"
                     /protein_id="NP_002442.2"
                     /db_xref="CCDS:CCDS6509.1"
                     /db_xref="GeneID:4507"
                     /db_xref="HGNC:HGNC:7413"
                     /db_xref="MIM:156540"
                     /translation="MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDA
                     LILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEI
                     QPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLG
                     LRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMA
                     TDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQF
                     SVLLPRH"
     exon            147..233
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            234..292
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            293..460
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            461..563
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            564..803
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            804..926
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     exon            927..6032
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2212..2217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="hexamer: AATAAA"
     polyA_site      2237
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="major polyA site"
     regulatory      4899..4904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="hexamer: AATAAA"
     polyA_site      4922
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="major polyA site"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="hexamer: ATTAAA"
     polyA_site      5105
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
     regulatory      6011..6016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
                     /note="hexamer: ATTAAA"
     polyA_site      6032
                     /gene="MTAP"
                     /gene_synonym="BDMF; c86fus; DMSFH; DMSMFH; HEL-249;
                     LGMBF; MSAP"
ORIGIN      
        1 ctccgcactg ctcactcccg cgcagtgagg ttggcacagc caccgctctg tggctcgctt
       61 ggttccctta gtcccgagcg ctcgcccact gcagattcct ttcccgtgca gacatggcct
      121 ctggcaccac caccaccgcc gtgaagattg gaataattgg tggaacaggc ctggatgatc
      181 cagaaatttt agaaggaaga actgaaaaat atgtggatac tccatttggc aagccatctg
      241 atgccttaat tttggggaag ataaaaaatg ttgattgcgt cctccttgca aggcatggaa
      301 ggcagcacac catcatgcct tcaaaggtca actaccaggc gaacatctgg gctttgaagg
      361 aagagggctg tacacatgtc atagtgacca cagcttgtgg ctccttgagg gaggagattc
      421 agcccggcga tattgtcatt attgatcagt tcattgacag gaccactatg agacctcagt
      481 ccttctatga tggaagtcat tcttgtgcca gaggagtgtg ccatattcca atggctgagc
      541 cgttttgccc caaaacgaga gaggttctta tagagactgc taagaagcta ggactccggt
      601 gccactcaaa ggggacaatg gtcacaatcg agggacctcg ttttagctcc cgggcagaaa
      661 gcttcatgtt ccgcacctgg ggggcggatg ttatcaacat gaccacagtt ccagaggtgg
      721 ttcttgctaa ggaggctgga atttgttacg caagtatcgc catggcgaca gattatgact
      781 gctggaagga gcacgaggaa gcagtttcgg tggaccgggt cttaaagacc ctgaaagaaa
      841 acgctaataa agccaaaagc ttactgctca ctaccatacc tcagataggg tccacagaat
      901 ggtcagaaac cctccataac ctgaagaata tggcccagtt ttctgtttta ttaccaagac
      961 attaaagtag catggctgcc caggagaaaa gaagacattc taattccagt cattttggga
     1021 attcctgctt aacttgaaaa aaatatggga aagacatgca gctttcatgc ccttgcctat
     1081 caaagagtat gttgtaagaa agacaagaca ttgtgtgtat tagagactcc tgaatgattt
     1141 agacaacttc aaaatacaga agaaaagcaa atgactagta aacatgtggg aaaaaatatt
     1201 acattttaag ggggaaaaaa aaacccacca ttctcttctc cccctattaa atttgcaaca
     1261 ataaagggtg gagggtaatc tctactttcc tatactgcca aagaatgtga ggaagaaatg
     1321 ggactctttg gttatttatt gatgcgactg taaattggta cagtatttct ggagggcaat
     1381 ttggtaaaat gcatcaaaag acttaaaaat acggacgtac tttgtgctgg gaactctaca
     1441 tctagcaatt tctctttaaa accatatcag agatgcatac aaagaattat atataaagaa
     1501 gggtgtttaa taatgatagt tataataata aataattgaa acaatctgaa tcccttgcaa
     1561 ttggaggtaa attatgtctt agttataatt agattgtgaa tcagccaact gaaaatcctt
     1621 tttgcatatt tcaatgtcct aaaaagacac ggttgctcta tatatgaagt gaaaaaagga
     1681 tatggtagca ttttatagta ctagttttgc tttaaaatgc tatgtaaata tacaaaaaaa
     1741 ctagaaagaa atatatataa ccttgttatt gtatttgggg gagggatact gggataattt
     1801 ttattttctt tgaatctttc tgtgtcttca catttttcta cagtgaattt aatcaaatag
     1861 taaagttgtt gtaaaaataa aagtggattt agaaagatcc agttcttgaa aacactgttt
     1921 ctggtaatga agcagaattt aagttggtaa tattaaggtg aatgtcattt aagggagtta
     1981 catctttatt ctgctaaaga agaggatcat tgatttctgt acagtcagaa cagtacttgg
     2041 gtttgcaaca gctttctgag aaaagctagg tgtttaatag tttaactgaa agtttaacta
     2101 tttaaaagac taaatgcaca ttttatggta tctgatattt taaaaagtaa tgtttgattc
     2161 tcctttttat gagttaaatt attttatacg agttggtaat ttttgctttt taataaagtg
     2221 gaagcttgct tttttaactc tttttttatt gttattttat agaaatgctt tttgttggcc
     2281 gggcacagtt gctcatccat gtaatcccag cactgtggga ggccgagacg ggtggatcac
     2341 aaggtcagga gatcgagacc atcctggcta atgcgttgaa actccgtctc tactaaaaat
     2401 acaaaaaatt agctgggcgt ggtggtgggc acctgtagtc ccagctactc aggaggctga
     2461 ggcaggagaa tggtgtgaac ctgggaggtg gagcttgcag tgagcagagc ttgcagtgag
     2521 acgagcttgt gccactgcac tccagcctgg gcaacagagt aagactcagt ctcaaaaaaa
     2581 aaaaaaagag tgaaatgctt tttgtttgct tcagtttttt atcatgggga gatctttttc
     2641 ctcagaattg ttttcttttc actgtaggct attacaggat acttcaggat caagatacag
     2701 aaccttttat ttaaagagtt tgtaaagtca atgtgtttgt ttgtgtctct gagattgact
     2761 tcaagataat aagctgctaa ttgtaaacaa aacagttacc ctccagtatt aatatgactc
     2821 attagtgtga gccatttggg tcaagtatga ttatgaccct tggacttcct gatgtagtat
     2881 taaatttcaa ctctggttat ccattagcaa tctgtagaga acttaatgaa cctgaaccca
     2941 ggcttctcta gctctggtaa cgtgtgattg ttttcactac aatatgatac atagatggta
     3001 ccttactttt cctcattctt aataggtgtc taagaatgtc agggcaaaag tatgggcatt
     3061 tttcttgcta tgttcagaaa gtacagttct ctccaacttg cagaggtact tttcttgatt
     3121 aaatagcctt ctctagcaac atcattttca gactaactaa atgaatgcag tatactcttt
     3181 tctttgttct caatcattca ctccttatgc aaagccaata taattttcct cataccttat
     3241 gcttgaggat attgttgaag aacacttcct ggaacacttc tcacttgtga tgctgtacta
     3301 attttttttt tttaatttaa gctagtatac taagtgaaca ccatggtcag ttgtgagcat
     3361 tttggtttcc gcaaaggatg gatggtgagc atcatgggaa agctgtagtt tagtgactta
     3421 gcccttagtg attaatagat ttgcatgtac atagaagtct ttgttggcct tataatctgc
     3481 tgttatattt ggcatggatt ttcatggttt tgagaatgac atcctggccc tgtggtcccc
     3541 gagggtcatg gtccttgtga cctggcccct gttcactgcc cccttcgcta gcacgagttg
     3601 ctgtgcaggg ctggaggtag ctaccatggc ttgtttcaag gaaggaaact ctggtacggt
     3661 ggcaccctca ggagtggagg acagtgaact tccttgaaga gggagtgact aaggtgacct
     3721 ccaacctgcc ctgagccagc tgccctgcag gtgccacgtg agcctgctct ggcatccaca
     3781 ggatgctcct ggagcctctt ctctggctgc tacctcaggg catggttgtg gccccaccaa
     3841 cacctatttt ccaaataatt attcattctt gtgacagtgg cctgaacatg tttttaattt
     3901 tctcaacaag catttagcca gcacttatcc agtgaaacaa tttgataagg tttcaaggag
     3961 tatctgatgg gttaggaagt cacgaaatga ggagttcttg ccacatttgc agagtccctc
     4021 cttgataagg tttggcggtg tccccaccca aatctcatgt tgaattgtag ttcccataat
     4081 ccccacatgt tgtgggaggg acccagtggg aggtaattaa atcatggggg tggttacccc
     4141 cacactgctg ttctcatgat actgagttct cacaagtcct gtttgtttta taaggggctt
     4201 ttcccccttt tgctcaacac ttcttcctgc catcatgtga agaaggacgt gtttgtttcc
     4261 ccttctgcca cgattgtaag tttcctgagg ccttcccagc tatgtggaac tgtgagttaa
     4321 ttaaacctct ttcctttata aattacccag tcatgggcag tcctttacag cagcatgaga
     4381 atggactaat acactcctca aatgttttga agattgttgc accttggaac taccagtgtg
     4441 cacacaatct ggctcaatgt atatattggc ccagcaaggc aaagaactga agttccagga
     4501 tggaagaacc tgtgttctcc tcataatagt atagaataat tcaagatagg caagaaggac
     4561 agcagtaaat gaagaccatg gaagaaaaga aggaatgcca aagatcgagg aaatctacca
     4621 agactagtag ggtagtccag aagaagctgt ttcagggcct gttgccagct atgcctttga
     4681 gaacctcggg atcccaaaga atgaggggaa tttcttcaga aagacaatct cggcatgcat
     4741 tatttctttg ttttgaagat tcactcatgt tgcatgcatc tgtagcttgt gcctttttta
     4801 ttgcctagta gtattctgtc atatgcctat cttacaattt gattatctat tcacctgttg
     4861 atgaatgttt gaattttttc catttgagga attttatgaa taaagctgct ataagcatga
     4921 aattacaagt ctttttgtga acatattttc acttgtgcaa atgcctatac tcccaccagt
     4981 aatttgtaag aattcttgac aaagcttggt attgtcagcg tttttaattt tagccattct
     5041 attgggtata ttttgatatc tcgtggtttt gatttgcatt tttctgatta aagatgttga
     5101 acttcttttc atgtgcttat tggccattca catatttcgt gaactatctg tacaaatatt
     5161 tttgtttatt aaaaaattag attgttttgt tttattattg aatagtaaga attgtttata
     5221 tattctggat acactctttt tcagatatgt gtgttgtgac tattcttagt ctttagcttg
     5281 ccttttcatt ttcttaatta tgtctttcaa agaacaagtt tttcattttg acgaagccta
     5341 gtttatcaat tttttttatg gttggtgctt tttgtgtgtt ccaagaaatc tttgcctact
     5401 catttaatta cctgtgtgcc cttgtcaaaa tcatttaatt ttgactactc acttaattac
     5461 cttgcctact catttaatta cctgtgtgcc cttgtcaaaa tttactgttt atctgtgaat
     5521 ctggatgatc tatttatgtc atttatctat gtgtctcttc ttatgccagt accccactgt
     5581 cttgattatt gtggctttat ggtgtcttga aattaagtat tgttaagctt tgcaatcttt
     5641 tccaagattg ttttggctat aggtcctttc tttataaagt ttatattaag cttctccatt
     5701 tttctttaag aaaaaatctg ctggaatggc actgaatttt taggtcgatt tgggaagaat
     5761 tgacaatatt gaacctttca atcgatggac atggtatgtt tctgcattta tttgggcctt
     5821 ttaaaattta tctcagcaat attttgtagt tttagtgaag aagtcttgta tatatctttt
     5881 gttaaatgta ttcctaaata ttttgtggaa atgttactgt aaatagtact ttaatttcat
     5941 ttttaagttt attgctggta tacagaaata tgttttattt ttgtatattg actttatatt
     6001 ctgtaatctt attaaattca cttagttcag ta
//
